Results cytoplasmic nuclear localization signals. Medical search. Frequent questions

We show that TMEM53 acts as an inhibitor of BMP-SMAD signaling by preventing SMAD accumulation in the cell nucleus and that its deficiency enhances osteogenic differentiation by overactivating the BMP signaling pathway. (nature.com)
Our findings establish a previously unreported SBD entity and demonstrate a regulatory mechanism in the BMP signaling pathway that impacts bone formation and development. (nature.com)
ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? (babraham.ac.uk)
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. (bath.ac.uk)
In glutathione S-transferase pull-down assays, TDP-43 bound to karyopherin-alphas, thereby confirming the classical nuclear import pathway for the import of TDP-43. (crick.ac.uk)
β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation. (biomedcentral.com)
The aberrant activation of Wnt/-catenin signaling pathway is known as to be an important concern in tumorigenesis and development of CRC [2, 3]. (opioid-receptors.com)
The sign of the Wnt/-catenin pathway may be the build up and nuclear localization of -catenin [4, 5]. (opioid-receptors.com)
Within this research, we shown the critical function of miR-224 in activating Wnt/-catenin signaling pathway during colorectal development. (opioid-receptors.com)
Furthermore, we showed that both of Wnt/-catenin signaling pathway suppressors GSK3 and SFRP2 are real downstream goals of miR-224. (opioid-receptors.com)
In addition, our study showed that TGF-β activated LINC01980 transcription through the canonical TGF-β/SMAD signaling pathway in HCC. (researchsquare.com)
Negative regulation of the PI3K/Akt signalling pathway is facilitated by the inositol polyphosphate 3-phosphatase PTEN, or by members of the inositol polyphosphate 5-phosphatase family, which both degrade PtdIns(3,4,5)P3. (monash.edu)
2006). The PI3K/Akt signalling pathway is strongly implicated in breast cancer, and published gene array studies have suggested that PIPP mRNA expression is positively associated estrogen receptor positive breast cancers and improved prognosis (van 't Veer et al. (monash.edu)
Hence, this review is supposed to serve as a refresher of the existing understanding about the physiologic and pathogenic assignments of WNT/-catenin signaling pathway, also to put together potential therapeutic possibilities by concentrating on the canonical WNT pathway. (icsv20.org)
A fuller picture of the WNT signaling pathway surfaced when T-cell aspect/lymphocyte enhancer aspect (TCF/LEF) transcription elements had been defined as WNT nuclear effectors 9, 10 and Frizzleds (FZDs) had been defined as WNT obligate receptors 11, working as well as co-receptors, such as for example low-density lipoprotein-receptor-related proteins (LRPs)/Arrow 12. (icsv20.org)
WNT palmitoylation is vital for WNT signaling and it is completed by PORC, an ardent ER-localized O-acyltransferase and extremely conserved element of the WNT pathway 32, 33. (icsv20.org)
Dysregulation of WNT signaling pathway is normally associated with several human illnesses 17-27. (icsv20.org)
Biologically, the canonical WNT/-catenin signaling pathway usually plays crucial functions in regulating cell fate, proliferation and survival, while the non-canonical WNT signaling is usually more associated with differentiation, cell polarity and migration 25-27. (icsv20.org)

Using a mixed strain assay, inhibitors targeting either the CPD or PPD heme pathways were identified through a decrease in one fluorescent signal but not the other. (bvsalud.org)
Heat shock can trigger several signaling pathways known to protect cells against cellular insults. (uw.edu)
Calcium mineral stations are essential mediators of several varied procedures c-Kit-IN-2 such as for example hormone and neurotransmitter launch, activation of intracellular signalling pathways, pacemaker adjustments or activity in gene manifestation. (cell-signaling-pathways.com)
Thanks to the continuous research to understand the molecular aspects of OC in an attempt to better understand and consequently treat the disease Currently, the extensive genomic analysis has identified some common hyperactive intracellular signaling pathways responsible for the development and progression of OC in patients [ 5 , 6 ]. (hindawi.com)
Tumor suppressors, oncogenes and alternatively deregulated upstream signalling pathways can directly influence the RNA polymerase I activity inducing hyper activation of rRNA transcription in cancer cells. (biomedcentral.com)
Nucleolar activity is also influenced by the interaction between pathways activated from extracellular signals in order to coordinate ribosome synthesis and cell proliferation [ 6 ]. (biomedcentral.com)
Generally, these receptors explain their function on the cell membrane where, after the binding with growth factors or neuregulin undergo to homo or hetero oligomerization with the activation of the intrinsic tyrosine kinase activity and the subsequent recruitment of proteins involved in the cytoplasmic signalling pathways. (biomedcentral.com)
Traditionally, WNT signaling is usually classified into two large groups: the canonical WNT (or -catenin-dependent) and non-canonical WNT (or -catenin-independent) pathways. (icsv20.org)

These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. (brenda-enzymes.info)
Furthermore, the subcellular localization of HOXA7 changed from nuclear to cytoplasmic during follicular maturation [13] predominantly. (cancerhugs.com)
Nonetheless, 2009 data has shown for that to start with time that the subcellular localization selleck chemicals of Kaiso while in the cytoplasm of the cell is straight connected using the bad prognosis of patients with lung cancer, and close to 85 to 95% of lung cancers are non small cell. (screeninglibraries.com)
However, in an investigation of BRAF localisation using fluorescence microscopy combined with subcellular fractionation of Green Fluorescent Protein (GFP)-tagged proteins expressed in NIH3T3 cells, surprisingly, we detected N-terminally truncated BRAF (ΔBRAF) in both nuclear and cytoplasmic compartments. (bath.ac.uk)
To assess the role of NES2 in regulating ESE-1 subcellular localization and subsequent transformation potency, we site-specifically mutagenized NES2, within full-length GFP-ESE-1 and GFP-NES2-SAR reporter constructs. (biomedcentral.com)
These data highlight that ESE-1 contains NLS and NES signals that play a critical role in regulating its subcellular localization and function, and that an intact SAR domain mediates MEC transformation exclusively in the cytoplasm, via a novel nontranscriptional mechanism, whereby the SAR motif is accessible for ligand and/or protein interactions. (biomedcentral.com)

Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
Binding of BMP2/4 to their receptors initiates the signal transduction cascade by inducing phosphorylation of SMAD1/5/9, which can then form hetero-complexes with SMAD4 followed by translocation into the nucleus to upregulate osteogenesis-related genes. (nature.com)
However, the mechanism by which nuclear translocation is regulated remains unclear. (nature.com)
Immunofluorescence of 293T cells, transfected with plasmids expressing GFP-tagged BRCA2 fragments, suggests that the C terminus of BRCA2 is responsible for nuclear translocation. (biomedcentral.com)
Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion (PubMed:17114460). (arigobio.cn)
Similar results were obtained using ΔBRAF tagged with the hormone-binding domain of the oestrogen receptor (hbER) and with the KIAA1549-ΔBRAF translocation mutant found in human pilocytic astrocytomas. (bath.ac.uk)
Here we show that GFP-ΔBRAF nuclear translocation does not involve a canonical Nuclear Localisation Signal (NLS), but is suppressed by N-terminal sequences. (bath.ac.uk)
When Wnt signaling is definitely activated, -catenin is definitely discharged GNGT1 from your degradation of complicated leading to the translocation of -catenin into nucleus, where it affiliates using the T-cell element/lymphoid enhancer element (TCF/LEF) category of transcription elements to activate particular Wnt focus on genes [10, 11]. (opioid-receptors.com)
We demonstrated that promotion aftereffect of miR-224 on proliferation and invasion of individual CRC cells could possibly be manifested partly with the deposition and nuclear translocation of -catenin and eventually up-regulation of its transcriptional goals c-Myc [22, 23] and CyclinD1 [24, 25]. (opioid-receptors.com)

This is contrary to humans, where VHL-1 mutations cause a disease characterized by angiomas, renal carcinomas and various other tumors as a direct result of aberrant HIF-1 activation. (uw.edu)
Correspondingly, loss of DNA methyltransferase function results in aberrant imprinting and abnormal post-fertilization development. (biomedcentral.com)
In this study, we have shown that RNAi-mediated PIPP knockdown in mouse fibroblasts and the aggressive human breast cancer cell line, MDA-MB-231, results in enhanced anchorage-independent cell growth, increased cell proliferation under conditions of serum-starvation, decreased cell death in response to induction of apoptosis, aberrant polarity and increased in vivo tumour growth in xenograft studies. (monash.edu)
We propose a model whereby PIPP negatively regulates PI3K/Akt signalling at the plasma membrane in quiescent cells, and upon loss of PIPP, or mislocalisation of PIPP to the nucleus, increased PtdIns(3,4,5)P3-mediated signalling may lead to hyperproliferation, aberrant polarisation, anchorage-independent cell growth and increased cell survival, ultimately promoting breast cancer development. (monash.edu)

Our data indicate that plakoglobin promotes tumor cluster formation in IMPC and downregulates apoptosis in the cell clusters through activation of PI3K/Akt/Bcl-2 signaling. (jcancer.org)
In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
In response to cell stimulation, phosphoinositide 3-kinase (PI3K) is recruited to the plasma membrane where it transiently generates the second messenger lipid PtdIns(3,4,5)P3, which in turn recruits and activates specific proteins such as Akt to regulate a plethora of intracellular signalling cascades to promote cell proliferation, polarisation and survival. (monash.edu)
Collectively, this data suggests that PIPP negatively regulates PI3K/Akt signalling in mouse fibroblasts and human breast cancer cells. (monash.edu)

Additionally, other C17orf98 transcription factors, like RBPJ-Kappa are involved in proliferation and signalling. (wikipedia.org)
Moreover, the EGF-induced KGN proliferation was abrogated, and the activation of downstream signaling was diminished when HOXA7 was knocked down. (cancerhugs.com)
This differential localization indicated that HOXA7 underwent cell type- and stage-specific adjustments during ovarian folliculogenesis, which most likely led to the rules of granulosa cell proliferation. (cancerhugs.com)
Extending these observations, colon biopsies from E. faecalis -colonized IL-10 −/− mice exhibited crypt hyperplasia and increased staining for macrophages, TNF-α, netrin-1, NF-κB, Tnfrsf1b, and the proliferation marker proliferating cell nuclear antigen while also displaying a reduction in epithelial cell apoptosis. (aacrjournals.org)
Since the EGFR signalling promotes proliferation in tumor the EGFR receptors often represent a marker of resistance with poor prognosis. (biomedcentral.com)

One such mechanism may be defective nuclear import of TDP-43 protein, as a disruption of its nuclear localization signal leads to mislocalization and aggregation of TDP-43 in the cytoplasm. (crick.ac.uk)
Poly‐GA promoted cytoplasmic mislocalization and aggregation of TDP‐43 non‐cell‐autonomously, and anti‐GA antibodies ameliorated TDP‐43 mislocalization in both donor and receiver cells. (synergy-munich.de)

Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)
Nuclear GFP-ΔBRAF retains MEK/ERK activating potential and is associated with the accumulation of phosphorylated MEK and ERK in the nucleus. (bath.ac.uk)
In order to explore the factors that regulate the nuclear import of TDP-43, we used a small interfering RNA library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopherin-beta1 and cellular apoptosis susceptibility protein resulted in marked cytoplasmic accumulation of TDP-43. (crick.ac.uk)
Importantly, proteasome inhibition led to the accumulation of TDP‐43 ubiquitinated within the nuclear localization signal (NLS) at lysine 95. (synergy-munich.de)
A fraction of esophageal squamous cell carcinomas have abnormal nuclear accumulation of β-catenin accompanied with increased cyclin D1 expression. (biomedcentral.com)

Fusion proteins containing all three zinc fingers were found in the nucleus, but those containing only two zinc fingers were predominantly cytoplasmic. (wustl.edu)
These information are steady with all the results found in the K562 cell line in which expression of the Kaiso is predominantly cytoplasmic. (screeninglibraries.com)

Non-canonical WNT signaling can be initiated by WNT conversation with Frizzled receptors, or RYK and ROR receptor tyrosine kinases, and regulates small GTPases (such as RhoA, Rac and Cdc42) in DVL-dependent manner. (icsv20.org)
Non-canonical WNT signaling can also activate calcium flux and kinase cascades, including protein kinase C (PKC), calcium/calmodulin-dependent protein kinase II (CaMKII) and JUN N-terminal kinase (JNK), leading to the activation of AP1- and NFAT-regulated gene expression 25-27. (icsv20.org)

Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion (By similarity). (arigobio.cn)
Regulation at the protein level includes modulation of its cell surface expression, cathepsin L-mediated processing, cellular uptake, secretion, and cytoplasmic vs. nuclear localization. (pafr-signal.com)
heparanase secretion and signaling functions and for maintaining the 3D structure of the active enzyme. (pafr-signal.com)
The lipid the different parts of WNTs are necessary for effective signaling, including WNT proteins secretion 30, 31. (icsv20.org)

Immunohistochemistry analysis of normal breast tissue revealed that the PIPP protein exhibits both a cytoplasmic and nuclear localisation in luminal mammary epithelial cells. (monash.edu)

Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
This study identifies two nuclear localisation signals (NLSs) within BRCA2 and makes the important observation that they are downstream of all known cancer-associated truncating mutations in BRCA2 . (biomedcentral.com)
If the nuclear exclusion of truncated BRCA2 proteins is also observed in primary tumour samples, then individuals with truncating mutations in BRCA2 could be screened by immunostaining. (biomedcentral.com)
Spain BH, Larson CJ, Shihabuddin LS, Gage FH, Verma IM: Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations. (biomedcentral.com)
Such mutations result in a WT1 protein that lacks a functional nuclear localization signal. (medscape.com)
In the mouse, mutations of the oocyte-specific isoform of the DNA methyltransferase Dnmt1 (Dnmt1o) and of the methyltransferase-like Dnmt3L gene result in specific failures of imprint establishment or maintenance, at multiple loci. (biomedcentral.com)
Mutations in β-catenin or axin genes are not responsible for this abnormal localization of β-catenin. (biomedcentral.com)

It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. (nih.gov)
Understand Nuclear Receptors through our introduction to this family of intracellular transcription factors that regulate gene expression. (indigobiosciences.com)
The proline rich inositol polyphosphate 5-phosphatase (PIPP) is a relatively uncharacterised member of the 5-phosphatase family which hydrolyses PtdIns(3,4,5)P3 in vivo to negatively regulate Akt signalling in the neuronal-like PC12 cell line (Ooms et al. (monash.edu)

O-GlcNAc post-translational modification occurs on Ser/Thr residues, specifically on oncogenes, tumor suppressors, and proteins involved in growth factor signaling. (wikipedia.org)

Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
Heparanase also augments cell adhesion and signaling cascades leading to enhanced phosphorylation of selected protein kinases and increased transcription of genes associated with aggressive tumor progression. (pafr-signal.com)
This signaling cascade involves a variety of posttranslational modifications, such as SUMOylation, ubiquitylation and phosphorylation, of several key proteins including ATM. (oaepublish.com)
Here, we show that NEMO phosphorylation by GSK-3β leads to NEMO localization into multivesicular bodies (MVBs). (mdpi.com)

To identify its nuclear localization signal (NLS), wild type NGFI-A and various mutants were transfected into COS cells and their cellular location assayed by indirect immunofluorescence. (wustl.edu)
To determine the minimal region(s) of NGFI-A sufficient to direct nuclear localization, the cellular location of various NGFI-A/β- galactosidase fusion proteins was examined. (wustl.edu)
Analysis of the expression of chosen nuclear import factors in post-mortem brain samples from patients with TDP-43 positive frontotemporal lobar degeneration, and spinal cord samples from patients with amyotrophic lateral sclerosis, revealed a considerable reduction in expression of cellular apoptosis susceptibility protein in frontotemporal lobar degeneration. (crick.ac.uk)
We propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration. (crick.ac.uk)

There are no ER membrane retention signals, nor peroxisomal targeting signal. (wikipedia.org)
Otherwise the protein could be cytoplasmic, nuclear or peroxisomal. (brenda-enzymes.info)
Please consult a specific prediction server for nuclear, cytoplasmic or peroxisomal localization. (brenda-enzymes.info)

Gcn4p contains two nuclear localization signals (NLS) which function independently of the presence or absence of amino acids. (uni-luebeck.de)

The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. (arigobio.cn)

Sequence analysis of BRCA2 revealed the presence of four potential nuclear localisation signals (NLSs), three near the C terminus. (biomedcentral.com)
RAD51, a nuclear protein, has been shown to interact with the 6174delT form of BRCA2, which lacks the NLSs and is localised to the cytoplasm. (biomedcentral.com)

In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)
Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)

BRCA2 is localised to the nucleus and the functions ascribed to it are nuclear functions. (biomedcentral.com)
Western blots of nuclear and cytoplasmic fractions of BRCA2 mutant cells. (biomedcentral.com)
BRCA2 nuclear localization and export sequences are listed. (frontiersin.org)

The source of host mRNAs from which the cytoplasmic NSVs snatch capped-RNA leader sequences has remained elusive. (wur.nl)

The same effect is achieved for the entire Gcn4p in a yrb1 yeast mutant strain impaired in the nuclear import machinery. (uni-luebeck.de)
However, DNA binding per se is not required for nuclear localization, as an NGFI-A mutant (AY339G), which does not bind DNA, is still faithfully directed to the nucleus. (wustl.edu)
As a result three different BRAF inhibitors (BRAFi) have now been approved for BRAFV600E/K- mutant melanoma and have transformed the treatment of this disease. (babraham.ac.uk)
The mutant cytoplasmic WT1 protein is thought to sequester some of the wild-type WT1 protein in the cytoplasm, resulting in a reduced amount of nuclear WT1. (medscape.com)

Pathogenic variants in the patients impair the TMEM53-mediated blocking effect, thus leading to overactivated BMP signaling that promotes bone formation and contributes to the SBD phenotype. (nature.com)

Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). (arigobio.cn)

However, whether lncRNAs are involved in the TGF-β/SMAD signaling and SMADs transcriptional regulation during HCC tumorigenesis and metastasis is still poorly understood. (researchsquare.com)

RAF-MEK-ERK signalling is normally thought to occur in the cytoplasm of the cell. (bath.ac.uk)

The IkB alpha antibody outcomes recommend a previously unidentified part from the 2/1 subunit in skeletal c-Kit-IN-2 muscle tissue and support the participation of this proteins in extracellular signalling. (cell-signaling-pathways.com)

The signaling cascade transducing nuclear DNA damage signals through retrograde nuclear-to-cytoplasmic signaling to activate NF-kB. (oaepublish.com)

The sequential modifications of NEMO guide its cytoplasmic/nuclear localization which bridges the nuclear DNA damage and cytoplasmic NF-kB activation. (oaepublish.com)

A feasible function for EGF and EGFR signaling at choose phases of follicle maturation continues to be previously proposed and it is backed by many observations of the consequences of EGF on steroidogenesis, oocyte maturation, and cumulus enlargement [17,18]. (cancerhugs.com)

Unlike receptors found on the cell surface, members of the nuclear hormone receptor (NR) superfamily are restricted to metazoan organisms such as nematodes, insects, and vertebrates. (indigobiosciences.com)

ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a unique 40-amino acid serine and aspartic acid rich (SAR) subdomain, whereas, ESE-1's nuclear transcriptional property is required to maintain the transformed phenotype of MCF7, ZR-75-1 and T47D breast cancer cells. (biomedcentral.com)
While previous publications have established ESE-1's transcription factor function, we have reported that ESE-1 initiates transformation of MECs via a novel non-nuclear, non-transcriptional mechanism [ 13 ]. (biomedcentral.com)

The process by which a chemical or physical signal is transmitted through a cell as a series of molecular events is called signal transduction. (screeninglibraries.com)
β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. (biomedcentral.com)

To map the minimal functional nuclear localization (NLS) and nuclear export (NES) signals, we fused in-frame putative NLS and NES motifs between GFP and the SAR domain. (biomedcentral.com)

A widespread theme among each one of these scientific studies is that though Wnt11 expression can be regulated by canon ical Wnt signals, this regulation is highly dependent on transcription variables on top of that to, or besides, TCF LEF family members, for instance, Kaiso p120ctn. (screeninglibraries.com)
Most cytoplasmic-replicating negative-strand RNA viruses (NSVs) initiate genome transcription by cap snatching. (wur.nl)
Altogether, the results implicate a more complex situation in which, besides PB, additional cytoplasmic sources are used during transcription/cap snatching of cytoplasmic-replicating and segmented NSVs. (wur.nl)

Earlier reports have pointed towards cytoplasmic-RNA processing bodies (P body, PB), although several questions have remained unsolved. (wur.nl)

Protein stability is dependent on amino acid limitation and cis signals within Gcn4p which are recognized by cyclin-dependent protein kinases, including Pho85p. (uni-luebeck.de)
The initial case for the participation of WNT signaling in individual cancers was produced when the hereditary cancers symptoms termed familial adenomatous polyposis (FAP) gene item, adenomatous polyposis coli (APC) 13, 14, was discovered to connect to -catenin 15, 16, and was afterwards shown to enjoy a critical function in managing -catenin proteins stability. (icsv20.org)

Activated NF-kB then translocates into the nucleus, and drive transactivation of anti-apoptotic genes, inflammatory cytokines, and oncogenic miRNAs, resulting in therapeutic resistance and aggressive metastasis in cancer cells. (oaepublish.com)
Lnc408-CBY1-β-catenin signaling axis might serve as a new diagnostic and therapeutic target for breast cancer. (nature.com)
Four (8%) esophageal cancer tissues showed high nuclear β-catenin staining. (biomedcentral.com)
Am L Vet Ers The year of 2010;Seventy one:169-175)Background: The united states Preventative Services Job Drive suggested versus prostate-specific antigen (PSA) screening process pertaining to cancer of prostate primarily based totally on 2 large long-term randomized-controlled tests (RCTs) as well as a organized review of damages resulting from screening process. (chk-signal.com)
The ER81 ETS protein, for example, is activated in human breast cancer cells by the oncoprotein HER-2, resulting in over-expression of the prosurvival telomerase reverse transcriptase (hTERT) gene [ 6 ]. (biomedcentral.com)

Our results establish a previously unreported SBD entity (craniotubular dysplasia, Ikegawa type) and contribute to a better understanding of the regulation of BMP signaling and bone formation. (nature.com)
Our final results as a result indicate the cooperation in between B catenin TCF and Kaiso p120ctn in adverse regulation of Wnt11. (screeninglibraries.com)
could result from inappropriate cleavage of heparan sulfate (HS), tight regulation of heparanase expression and function are essential. (pafr-signal.com)

Using the results of this screen, we are creating transgenic worms that overexpress these genes under specific nematode promoters. (uw.edu)
Our results showed the roles of PpHDZs on root formation, which is helpful to better understand the classification and function of peach HD-Zip genes. (biomedcentral.com)

Here, we discover a previously unknown type of SBD in four independent families caused by bi-allelic loss-of-function pathogenic variants in TMEM53 , which encodes a nuclear envelope transmembrane protein. (nature.com)
In this study, we discover a previously unknown type of SBD and identify its causal gene, TMEM53 , which encodes nuclear envelope transmembrane (NET) protein 53 (TMEM53, also known as NET4). (nature.com)
Although the complete proteins topology isn't known, evidence shows that a little part of the peptide can be a transmembrane section with a brief cytoplasmic tail. (cell-signaling-pathways.com)

May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. (nih.gov)

These effects were blocked by anti-TNF-α antibody or by pretreatment with an inhibitor of NF-κB signaling. (aacrjournals.org)

Expression of NLS-truncated Gcn4p results in an increased cytoplasmic fraction and an overall stabilization of the protein. (uni-luebeck.de)

EGF signaling takes on a significant part in cell differentiation and development [16]. (cancerhugs.com)
Our results suggest that heat exposure partially inhibits neomycin-induced hair cell damage. (uw.edu)
β-catenin binds to both the cytoplasmic domain of cadherin and the amino-terminal domain of β-catenin and mediates cell adhesion. (biomedcentral.com)
Generally in most cell/tissues contexts, WNTs become short-range signaling 23. (icsv20.org)

Bone formation represents a heritable trait regulated by many signals and complex mechanisms. (nature.com)
These resistance mechanisms frequently involve reinstatement of ERK1/2 signalling and BRAFi are now deployed in combination with one of three approved MEK1/2 inhibitors (MEKi) to provide more durable, but still transient, clinical responses. (babraham.ac.uk)
Moreover, Kaiso uses classical nuclear transport mechanisms as a result of interaction with Importin B nuclear. (screeninglibraries.com)
Therefore, alternative mechanisms by which Wnt/-catenin signaling had been triggered in CRC might can be found. (opioid-receptors.com)

abstract = "TAR DNA-binding protein-43 (TDP-43) is a highly conserved, ubiquitously expressed nuclear protein that was recently identified as the disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). (elsevierpure.com)

Mutational analyses of the exon3 of the β-catenin gene and Axin gene were performed on tumors with nuclear β-catenin expression. (biomedcentral.com)
Significantly, A90V is located between the bipartite nuclear localization signal sequence of TDP-43 and the in vitro expression of TDP-43-A90V led to its sequestration with endogenous TDP-43 as insoluble cytoplasmic aggregates. (elsevierpure.com)
In leg imaginal discs, hth expression is limited to the domain of exd function and this domain is complementary to the domain in which the Wingless (WG) and Decapentaplegic (DPP) signals are active. (biologists.com)
We demonstrate that WG and DPP act together through their targets Distal-less ( Dll ) and dachshund ( dac ) to restrict hth expression, and therefore EXD's nuclear localization, to the most proximal regions of the leg disc. (biologists.com)

When the zinc finger structure was altered by mutating a zinc-chelating cysteine residue in any one of the three zinc fingers, the resulting domain was no longer capable of directing β-galactosidase to the nucleus. (wustl.edu)
Prior to the first meiotic division, homologous chromosomes pair, synapse, and recombine to ensure their proper disjunction at anaphase I. Additionally, telomeres tethered at the nuclear envelope cluster in the bouquet configuration where they are subjected to dramatic pulling forces acting from outside of the nucleus. (biorxiv.org)
These attachment sites are linked to actin-bundles that surround the nucleus via an Ndj1-Mps3-Csm4 protein bridge that spans the inner and outer nuclear membranes. (biorxiv.org)
TSWV and RSV N proteins also co-localized with Ran GTPase-activating protein 2 (RanGAP2), a nucleo-cytoplasmic shuttling factor, in the perinuclear region, and partly in the nucleus when co-expressed with its WPP domain containing a nuclear-localization signal. (wur.nl)

A pho85A mutation stabilizes Gcn4p without affecting nuclear import. (uni-luebeck.de)
It's been popular that inactivating mutation of APC gene continues to NVP-231 manufacture be regarded as an important event for constitutive activation of Wnt/-catenin signaling mutation that leads to carcinogenesis and development in CRC [12, 13]. (opioid-receptors.com)

An intriguing facet of our effects is read review the partnership be tween cytoplasmic Kaiso to your prognosis expected in blast crisis. (screeninglibraries.com)
Although many forms of treatment modalities have already been developed lately for the individuals with CRC, the medical results of prognosis is still poor in individuals with advanced CRC. (opioid-receptors.com)

Results are confirmed in the tertiary structure, however, alpha helix and beta sheet numbers differ slightly (see diagram on right). (wikipedia.org)

Anatomy26

Organisms20

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes65

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Pathway20

Pathways8

Subcellular7

Translocation9

Aberrant4

PI3K4

Proliferation5

Mislocalization and aggregation2

Accumulation5

Predominantly2

Canonical2

Secretion4

Mammary epithelial1

Mutations7

Regulate3

Proteins involved1

Phosphorylation4

Cellular4

Peroxisomal3

Amino Acids1

Regulates1

NLSs2

Tumor2

BRCA23

MRNAs1

Mutant4

Promotes1

Sequences1

SMAD1

Cytoplasm of the cell1

Extracellular1

Activate1

NEMO1

EGFR1

Receptors1

Transcriptional2

Transduction2

Functional1

Transcription3

Processing bodies1

Stability2

Cancer5

Regulation3

Genes2

Transmembrane3

Retention1

Inhibitor1

Stabilization1

Cell4

Mechanisms4

Abstract1

Expression4

Nucleus4

Mutation2

Prognosis2

Tertiary structure1