• We determine the structure of the Khovanov homology groups in homological grading 1 of positive links. (hu-berlin.de)
  • The BRCA2 R3052W mutated protein exacerbates genome instability, is unable to rescue homology-directed repair, and fails to complement cell survival following exposure to PARP inhibitors and crosslinking drugs. (frontiersin.org)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • The results illuminate the molecular mechanism of a critical biochemical step in the licensing of eukaryotic replication origins. (imperial.ac.uk)
  • Due to the structural and biochemical homology between IGF-2 and insulin, elevated levels of IGF-2 can result in hypoglycemia. (medscape.com)
  • A mutation or deletion of any of the genes that code for enzymes involved in cortisol or aldosterone synthesis results in congenital adrenal hyperplasia. (medscape.com)
  • X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
  • The results are in accord with the general observation that with increasing temperature, the role of electrostatic interactions in protein stability increases. (nih.gov)
  • The results showed that the Ea of juvenile yellowfin tuna muscles in response to high temperature (34°C) was significantly lower than that of the control (28°C), and it also increased ETS. (bvsalud.org)
  • Storage of the product at ambient temperature likely allowed botulism spores to produce botulinum toxin, resulting in severe illness and death. (cdc.gov)
  • Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A, is the most common form of CAH, accounting for more than 90% of cases. (medscape.com)
  • In this work, homology models of both proteins were constructed and analyzed for a number of structural properties. (nih.gov)
  • Nevertheless, while Q44R led to recovery of viruses that maintained the mutation, Q44D resulted in selection of infective viruses with substitution D44E with acidic charge but with structural features similar to those of the parental virus, suggesting that Q44 is involved in functions other than 3A dimerization. (asm.org)
  • Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Homology Medicines, Inc. (NASDAQ: FIXX) between June 10, 2019 and February 18, 2022, inclusive (the "Class Period"), of the important May 24, 2022 lead plaintiff deadline . (globenewswire.com)
  • Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)
  • Preliminary results show 85% homology with a Presbyterian minister from Des Moines. (scienceblog.com)
  • More concretely, we show that the first Khovanov homology is supported in a single quantum grading determined by the Seifert genus of the link, where the group is free abelian and of rank determined by the Seifert graph of any of its positive link diagrams. (hu-berlin.de)
  • We also show that several infinite families of Heegaard Floer L-space knots have vanishing first Khovanov homology. (hu-berlin.de)
  • The simulation results show that the adaptive fault-tolerant federated algorithm can greatly improve the positioning accuracy, which is 83.4% higher than that of the absolute positioning accuracy of a single UAV. (bvsalud.org)
  • The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)
  • Clinical results and laboratory examination findings vary with each disorder. (medscape.com)
  • However, for surveillance purposes, CDC will accept results obtained from NAAT approved by the Food and Drug Administration (FDA) and used according to the approved product labeling on the package insert, or a test produced and validated in accordance with applicable FDA and Clinical Laboratory Improvement Amendments regulations. (cdc.gov)
  • Increased insulin resistance (IR) and immune tolerance in pregnant women result in metabolic and immunological alterations, which may aggravate the development of gestational diabetes mellitus (GDM). (hindawi.com)
  • Annotation-free delineation of prokaryotic homology groups. (nih.gov)
  • Various software resources are also required to enable users to conveniently connect their experimental results with publicly, and application specific, bioinformatics databases and tools. (lu.se)
  • The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
  • The comparison of the models reveals that the higher stability of HydSL can be attributed to increased inter-subunit electrostatic interactions: the homology models reliably predict that HydSL contains at least five more inter-subunit ion pairs than HupSL. (nih.gov)
  • However it is still not crystallized for birds and only advanced homology models are available. (nature.com)
  • The BRCA2 R3052W mutation fails to complement chemotherapeutic sensitivity and homology-directed repair functions in BRCA2 knockout cells. (frontiersin.org)
  • In particular, for a positive link, the first Khovanov homology is vanishing if and only if the link is fibered. (hu-berlin.de)
  • Moreover, we extend these results to (p,q)-cables of positive knots whenever q≥p. (hu-berlin.de)
  • Because many laboratories use tests that do not routinely distinguish Mycobacterium tuberculosis from closely related species, these laboratories report culture results as being positive or negative for " Mycobacterium tuberculosis complex. (cdc.gov)
  • Concentrations of each chemical will be determined based on the results of single chemical exposures. (cdc.gov)
  • GenX/PFOA or ADONA/PFOA exposures will results in synergistic effect compared to single chemical exposure. (cdc.gov)
  • Would you like email updates of new search results? (nih.gov)
  • Table representation of search results timeline featuring number of search results per year. (nih.gov)
  • We further obtain results for the 3-torus and lens spaces. (hu-berlin.de)
  • In 2008, total world production was about 576,000 metric tons with a total export value estimated around 2.4 billions USD ( http://www.fao.org/fishery/statistics/en ). (biomedcentral.com)
  • In the present article, we perform cortical type analysis of the neocortex of adult rats, Rhesus macaques, and humans to propose hypotheses on homology of cortical areas applying the principles of the Hypothesis on the Dual Origin of the Neocortex. (springer.com)
  • The results of luciferase reporter assay revealed that miR-338-3p and G6PC2 were the potential targets of has_circ_0046060. (hindawi.com)
  • Research to practice potential : results of this study will emphasize importance of cleaning turnout gear, and proper handling of AFFF waste. (cdc.gov)
  • As one ingredient of the proofs of the above results we generalize computations of the homotopical invariants of contact structures to contact surgeries with more general surgery coefficients which might be of independent interest. (hu-berlin.de)
  • Results obtained at the individual level showed, as expected, that leader developing behavior was negatively related to employees' health complaints through two mediators: organizational commitment and emotional exhaustion. (bvsalud.org)