Restraining cell cycle progression apoptotic cells cell cycle. Medical search. Frequent questions

In conclusion, the present study indicated that propofol inhibited the proliferation and invasion, but enhanced the apoptosis of GC cells by regulating the circ‑PVT1/miR‑195‑5p/ETS1 axis. (spandidos-publications.com)
In GC, Yang et al ( 7 ) reported that propofol suppressed the proliferation of SGC-7901 and MGC-803 cells by promoting inhibitor of growth 3 ( 7 ). (spandidos-publications.com)
Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
Increasing evidence indicates that EBV miRNAs target the host mRNAs involved in cell proliferation, apoptosis and transformation. (ijbs.com)
For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation. (nature.com)
Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. (biomedcentral.com)
A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. (cancerindex.org)
Since mesenchymal stem cells (MSCs) have effective immune-modulatory features, inhibit T-lymphocyte proliferation, and have a high regenerative capacity, they can play a vital role in the reconstruction of injured tissues, including bronchioles, in pulmonary diseases. (biomedcentral.com)
This decreases the level of reactive oxygen species (ROS) and promotes lung malignancy cell proliferation [34]. (geogise.com)
The cases explained above suggest that the LKB1CAMPK-HDAC10-G6PD-ROS pathway might be important to tumor cell proliferation. (geogise.com)
However, in RCC cells, suppressed expression of HDAC10 significantly promotes the CP-640186 phosphorylation of -catenin and thus plays a part in anti-proliferation [31] (Physique 1A). (geogise.com)
The signaling pathways: HDAC10-let-7f-2/miR-98-HMGA2-cyclin A2 arrests the G2/M transition and finally inhibits lung malignancy cell proliferation. (geogise.com)
SDC-1 overexpression inhibited cell proliferation via suppressing CyclinD1 and c-Myc expression, meanwhile stimulated cell apoptosis via increasing the expression levels of B-cell lymphoma-2-associated x (Bax) and Cleaved-Caspase-3. (biomedcentral.com)
Growth of cancer cells is regulated by the balance between cell proliferation and apoptosis, which is a normal physiological process serving to eliminate unwanted cells and maintain homeostasis in healthy tissue. (nutraculture.com)
Our simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. (biomedcentral.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
CyclinE is a cell cycle regulatory protein which regulates the G1-S phase transition during cell proliferation. (biomedcentral.com)
During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
By focusing on the critical roles of different metabolic programs, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism, as well as their essential regulators in modulating Treg proliferation, migration, and function, we hope to provide new insights into Treg cell-targeted antitumor immunotherapies. (biomedcentral.com)
pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
Silibinin effectively suppressed YD10B and Ca9-22 cell proliferation and colony formation in a dose-dependent manner. (jcancer.org)
Excessive proliferation, apoptotic evasion, and migratory spread are all hallmarks of tumorigenesis. (stanford.edu)
It promotes cell proliferation and restrains differentiation. (ashpublications.org)
MYC induces proliferation, but at the same time it can induce cell death. (ashpublications.org)
Augments the ability of dendritic cells to stimulate naive T-cell proliferation. (cusabio.com)
While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. (hindawi.com)
For example, circRNA_000166 can function as an oncogene by promoting the proliferation of CRC cells and by limiting apoptosis. (hindawi.com)
β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
Previous research has demonstrated that β -catenin can contribute to malignant progression and distant metastasis in CRC by promoting proliferation, limiting apoptosis, and accelerating epithelial-mesenchymal transition [ 11 , 12 ]. (hindawi.com)

In addition, flow cytometry and Transwell assays were used to evaluate the apoptosis and invasive ability of GC cells, respectively. (spandidos-publications.com)
It was identified that propofol inhibited the viability and invasion, but promoted apoptosis of HGC‑27 and AGS cells in a dose‑dependent manner. (spandidos-publications.com)
In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
In our previous studies, we showed that bitter melon extract (BME) exerts a strong anti-proliferative effect by inducing caspase-dependent apoptosis in breast cancer cells [ 6 ], although the in vivo effect of BME was not examined in breast cancer model. (oncotarget.com)
Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (cancerindex.org)
HDAC10 and cell apoptosis Malignancy cells will not pass away in a scenario that too little apoptosis happens [40]. (geogise.com)
Numbers of proteins and signaling are involved in cell apoptosis. (geogise.com)
It has been established that overexpressed anti-apoptotic proteins (such as those in the Bcl-2 family) as well as down-regulated proteins (such as for example Bet, BAK) and BIK may disrupt the total amount between apoptosis and anti-apoptosis [41,42]. (geogise.com)
By concentrating on AKT, HDAC10 impacts the appearance of B-cell lymphoma-2 (BCL2) aswell as BCL2 antagonist/killer (BAK), which induces apoptosis in lung carcinoma [29]. (geogise.com)
In colorectal tumor, inhibited HDAC10 appearance promotes cell apoptosis by depleting transcription aspect 7 like 2 (TCF7L2), which attenuates the Wnt pathway [43]. (geogise.com)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
Next, SW480, SW620 and LOVO cell viability, apoptosis, migration and adhesion were assessed to explore the effects of exogenous overexpressed SDC-1 on colorectal carcinoma. (biomedcentral.com)
Nutraculture™ Phycocyanin™ induces apoptosis in the existing and proliferating cancer cells and being a natural antioxidant, it also helps getting rid of any cancer promoting oxidative stress. (nutraculture.com)
It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)
The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
Further studies showed that apoptosis and replication may work together to enhance the cytotoxicity of oncoVV-lectins in a cell-type dependent manner. (mdpi.com)
Flow cytometry assessed cell apoptosis. (biomedcentral.com)
APS induced autophagy and suppressed apoptosis in SONFH cell model. (biomedcentral.com)
Recently, APS was reported to improve SONFH via regulating cell autophagy and apoptosis [ 9 ]. (biomedcentral.com)
Genetic activation of the NF-κB pathway induces apoptosis in these cells, whereas inhibition of NF-κB by an IκBα superrepressor provides a selective advantage in vivo. (ashpublications.org)
Furthermore, in human Burkitt lymphoma cells we find that NF-κB activation induces apoptosis. (ashpublications.org)
We conclude that c-MYC overexpression sensitizes cells to NF-κB-induced apoptosis, and persistent inactivity of NF-κB signaling is a prerequisite for MYC-mediated tumorigenesis. (ashpublications.org)

Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
Cell and HDAC10 metastasis Tumor cell metastasis is certainly a multistep procedure including cell adhesion, invasion, dissemination and migration at faraway organs [47,48]. (geogise.com)
Thus, it is urgent to explore novel targets that may provide potential resolutions for metastasis in colorectal carcinoma cells. (biomedcentral.com)
A new investigation proposing piRNA as a prognostic and diagnostic biomarker in the treatment of CRC Therefore, this review focuses on the role of piRNAs in the initiation, progression, and metastasis of CRC and its molecular mechanisms to understand its function and provide a better therapeutic strategy. (jcimcr.org)

In recent years, epithelial-mesenchymal transition (EMT) has been suggested to play a key role in the process of embryonic development, differentiation of tissues and organs, chronic inflammation and fibrosis, as well as cancer progression ( 14 ). (spandidos-publications.com)
Autophagy is an evolutionally conserved catabolic process in all eukaryotic cells and contributes to organelle turnover, protein degradation, and differentiation [ 7 , 8 ]. (oncotarget.com)
Cancer is the uncontrolled growth of cells in the body, which is caused by the stepwise accumulation of mutations that affect cell growth control, differentiation and survival. (nutraculture.com)
Cell fate decisions within these hierarchical brain cell lineages are tightly controlled and irreversible: e.g. cells in the state of differentiation will not turn into progenitor cells or stem cells. (stanford.edu)
This is especially true for malignant glioma cells, which simultaneously express markers of different lineages and states exhibiting incomplete differentiation. (stanford.edu)
Additionally, decreased activity and abnormal differentiation of bone marrow mesenchymal stem cells may be an important mechanism in the occurrence and development of SONFH [ 5 ]. (biomedcentral.com)
Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. (cusabio.com)

Previous studies have investigated the inhibitory effect of propofol on cancer cells in a variety of tumors, such as breast ( 2 ), lung ( 3 ) pancreatic ( 4 ), ovarian ( 5 ), hepatic ( 6 ) and gastric cancer (GC) ( 7 , 8 ). (spandidos-publications.com)
CircRNA-PVT1 (circ-PVT1) has been reported to function as an oncogenic circRNA in tumors, such as oral squamous cell carcinoma, head and neck squamous cell carcinoma, and osteosarcoma ( 13 - 15 ). (spandidos-publications.com)
Further, we observed the increased p62 accumulation, induction of autophagy and apoptotic cell death in tumors from BME-fed animals. (oncotarget.com)
AMP-activated protein kinase (AMPK) regulates biological functions in tumors that are mediated by liver kinase B1 (LKB1), such as cell survival and transcription, via the mTOR pathway [33]. (geogise.com)
We think that defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity that makes treatment of human brain tumors so challenging. (stanford.edu)
Defects in cell fate control could explain many key defects present in brain tumors Of special emphasis, we study the establishment of cell fates within normal hierarchical brain lineages for comparison to the dysregulated cell-fate hierarchies seen in brain tumors. (stanford.edu)
T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging. (mdc-berlin.de)

This review expounds the up- or down-regulation of lncRNAs in OSCC and the molecular mechanisms by which lncRNAs perform their function in the malignant cell. (biomedcentral.com)
Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
Cancer is not a chaotic malignant cell mass, but a delicate "hostile" organ, where many other cells are recruited and domesticated to become "accomplices", thereby protecting themselves from recognition and attack by the immune system [ 1 ]. (biomedcentral.com)
3 Increased amounts of MYC protein are found in many types of human cancer because control mechanisms keeping MYC in check are inactivated during malignant transformation of cells. (ashpublications.org)

A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma. (sdbonline.org)

The role of autophagy in cancer onset and progression appears still controversial. (nature.com)
On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. (nature.com)
In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity. (nature.com)
Since cancer stem cells have been hypothesized to play a role in refractory/relapsing cancers, in the present work we investigated if autophagy could represent a constitutive cytoprotection mechanism for glioblastoma stem-like cells (GSCs) and if the modulation of autophagic process could affect GBM growth and survival. (nature.com)
Autophagy is a regulated mechanism of the cell that leads to the disassembly of unnecessary or dysfunctional components. (nature.com)
Hence, thanks to this complex mechanism, autophagy can provide energy supply to the cell and can represent a key cytoprotection mechanism allowing cell survival in unfavorable microenvironmental conditions such as those often found by cancer cells 7 . (nature.com)
Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)

The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)

the molecular level, we confirmed, for the first time, that RES upregulated FoxO1 transcriptional activity by inhibiting the PI3K/AKT signaling pathway, and hence promoted resistance to oxidative damage and restrained osteoclastogenesis. (cusabio.com)

Combined with miRNAs-based transcriptome sequencing assay, it was found that Tanshinone IIA downregulated miR-125b level and upregulated its target gene STARD13 (StAR-related lipid transfer protein 13) level, thus inactivating the miR-125b/STARD13 axis, which had been previously confirmed to promote breast cancer progression. (biomedcentral.com)

An objective of this study was to investigate the role of SDC-1 in colorectal carcinoma cells. (biomedcentral.com)
In general, the evidence from this study suggested that SDC-1 suppressed cell growth, migration through blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells. (biomedcentral.com)
In this paper, we verified the mRNA and protein expression of SDC-1 in human colorectal carcinoma tissues and focused on the biological cellular effects of SDC-1 on human colorectal carcinoma cell lines (SW620, SW480 and LOVO), by evaluating cell viability, apoptosis, migration and adhesion. (biomedcentral.com)
Here, we used circRNA microarray sequencing technology to analyze the different circRNAs between CRC tissues and normal tissues and explore the role of circIFT80 in progression of colorectal cancer. (hindawi.com)
In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. (hindawi.com)
Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor. (sdbonline.org)
The previous work has shown that Tanshinone IIA could ameliorate inflammation microenvironment in colorectal cancer via repressing miRNA-155 expression ( 8 ) and exert an anti-angiogenic effect in vascular endothelial cells via inhibiting the VEGF/VEGFR2 pathway [ 9 ]. (biomedcentral.com)

On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and reduction of TNF-α secretion, increased cell viability and diminished cell injury in addition to reduced oxidative stress. (frontiersin.org)
Cells under aerobic conditions utilize oxidative phosphorylation in mitochondria to sustain energy demands. (biomedcentral.com)

New sequencing technologies have shown that a large number of aberrantly expressed lncRNAs are associated with multiple cancer types and indicated they have emerged as an important class of pervasive genes during the development and progression of cancer. (biomedcentral.com)
Further studies are now needed to elucidate the molecular mechanisms underlying circRNA action in the development and progression of cancers. (hindawi.com)

Western blotting was performed to detect the protein levels of cyclin‑dependent kinase inhibitor P21 (P21), B‑cell lymphoma‑2 (Bcl‑2), matrix metalloproteinase 9 (MMP9) and E26 oncogene homolog 1 (ETS1). (spandidos-publications.com)
Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. (wikipedia.org)
pRb binds and inhibits E2 promoter-binding-protein-dimerization partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. (wikipedia.org)
Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
In this study, we observed that BME treatment induces autophagosome-bound Long chain 3 (LC3)-B and accumulates protein p62/SQSTM1 (p62) in breast cancer cells. (oncotarget.com)
STUDY QUESTION: Is the ratio of endometrial T-box expressed in T cell (T-bet) and GATA-binding protein 3 (GATA3) changed in patients with recurrent miscarriage (RM) compared to fertile controls? (bvsalud.org)
Additionally, SDC-1 overexpression restrained cell migration via inhibiting the protein expression of matrix metallopeptidase 9 (MMP-9), and elicited cell adhesion through increasing intercellular cell adhesion molecule-1 (ICAM-1). (biomedcentral.com)
Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the pathogenesis of autoimmune diseases and cancer. (biomedcentral.com)
Unlike miRNAs whose central function is to restrain mRNA translation by inducing degradation, lncRNAs can act as numerous roles to exert their functions by directly or indirectly interacting with DNA, RNA or protein, even can encode some short peptides (Fig. 3 a-d) [ 6 ]. (biomedcentral.com)
Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2). (stanford.edu)
Here, we demonstrate that the S phase checkpoint protein CHK1 is maintained in a low phosphorylation state in Spi1/PU.1-overexpressing cells and provide evidence that this is not due to negative control of its primary kinase ATR. (oncotarget.com)
And a recent study demonstrates that Tanshinone IIA restrains migratory and invasive ability of cervix carcinoma stem cells by suppressing the transcriptional activity of YAP (Yes-associated protein) [ 11 ]. (biomedcentral.com)
The study has previously revealed that miR-125b faciliates cell migratory ability breast cancer via targeting STARD13 (StAR-related lipid transfer protein 13) [ 20 ]. (biomedcentral.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)
Unlike normal cells, cancer cells reprogram cellular energetics as a result of oncogenic transformations [ 4 ]. (biomedcentral.com)

The expression levels of circ‑PVT1 and ETS1 were increased in GC tissues and cells, and miR‑195‑5p was decreased. (spandidos-publications.com)
But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
We examined the expression level of lncRNA CASP5 in GBM tissues as well as GBM cell lines. (cancerindex.org)
We observed that lncRNA CASP5 was highly expressed in GBM tissues and cell lines. (cancerindex.org)
Paraffin-embedded endometrial tissues were sectioned into 4 µm thick slides, and immunohistochemistry (IHC)staining was carried out for detecting endometrial immune cells, including CD56+ uNK cells, Foxp3+ Tregs, CD163+ M2 macrophages, CD1a+ DCs, and CD8+ T cells. (bvsalud.org)
In this review, we discuss the common and distinct metabolic profiles of Tregs in peripheral tissues and the TME, as well as the differences between Tregs and other conventional T cells in their metabolic preferences. (biomedcentral.com)

Although genomic alterations have been extensively characterized in AML [ 1 ], little is known about the determining events that favor the accumulation of mutations and the progression from the pre-leukemic to leukemic stage. (oncotarget.com)

Dr. Petritsch is an expert in oligodendrocyte progenitor cells, and cancer stem cells, and her team's emphasis is on intra-tumoral heterogeneity, in vitro and in vivo cancer model development, and tumor-immune interactions. (stanford.edu)
To determine the general biological conse quence of BRG1 re expression in SK MEL5 cells, we investigated if BRG1 promotes alterations in the ability of melanoma cells for being invasive in vitro. (histaminereceptor-signal.com)
In vitro mammary spheroid formation, flow cytometry assay on CD24 − /CD44 + sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells. (biomedcentral.com)

Severe disease progression of patients infected with SFTSV has further been associated with increased cytokine and chemokine responses ( 7 ) and increased viremias throughout the course of disease ( 6 ). (cdc.gov)

Cigarette smoke exerts inflammatory and suppressive effects on immune cells, alters mucosal immunity and promotes autoimmunity, resulting in oral cancers [ 10 ]. (biomedcentral.com)
However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions, leading to the development of radioresistance. (nature.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
To evaluate the endometrial immune microenvironment of patients with recurrent miscarriage (RM), a digital immunohistochemistry image analysis platform was developed and validated to quantitatively analyze endometrial immune cells during the mid-luteal phase. (bvsalud.org)
The percentage of endometrial immune cells was calculated by dividing the number of immune cells in the total endometrial cells. (bvsalud.org)
Using the commercial image analysis system, quantitative evaluation of endometrial immune cells, which are difficult or impossible to analyze with conventional image analysis, could be easily, and accurately analyzed. (bvsalud.org)
This methodology can be applied to quantitatively characterize the endometrium microenvironment, including interaction between immune cells, and its heterogeneity for different reproductive failure patients. (bvsalud.org)
The platform for quantitative evaluation of endometrial immune cells may be of important clinical significance for the diagnosis and treatment of RM patients. (bvsalud.org)
Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
Substantial cells are divided into immune cells and non-immune cells. (biomedcentral.com)
The infiltrating immune cells in the TME constitute the main body of TIME. (biomedcentral.com)

Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. (biomedcentral.com)
Tumor cell hierarchies are poorly understood, providing no explanation for why tumor cells with stem-like, progenitor-like, and differentiated features co-exist and interact with normal brain cells and immune-infiltrating cells within a single tumor entity, and how this heterogeneity relates to the lack of active immune infiltration. (stanford.edu)
The c-MYC (MYC) transcription factor has been implicated in the control of many aspects of tumor cell biology. (ashpublications.org)

This explains why sufferers of sporadic retinoblastoma are not at increased risk of cancers later in life, as both alleles are functional in all their other cells. (wikipedia.org)
Invasion- and migration-related substances, such as for example matrix metalloproteinases (MMPs), and S100A10 are dysregulated in a variety of cancers cell lines [49C51]. (geogise.com)

In the present study, GC cell lines (HGC‑27 and AGS) were treated with various concentrations of propofol, and an MTT assay was performed to detect the cell viability. (spandidos-publications.com)

By using patient-derived cells from brain surgeries, we investigate cell fate decision mechanisms in the normal brain and in brain malignancies. (stanford.edu)
Noncoding RNAs, including circRNAs, microRNAs, and lncRNAs, have become a significant focus of research attention due to their crucial role in regulating the progression of multiple malignancies [ 5 ], including bladder cancer, gastric cancer, nasopharyngeal carcinoma, and pancreatic cancer. (hindawi.com)

APS inhibited SP1 expression and SP1 overexpression reversed effects of APS on SONFH cell model. (biomedcentral.com)
NF-κB up-regulates Fas and predisposes to Fas-induced cell death, which is caspase-8 mediated and can be prevented by CFLAR overexpression. (ashpublications.org)
We previously showed that constitutive overexpression of the oncogenic transcription factor Spi1/PU.1 leads to pre-leukemic cells that have a shortened S phase duration with an increased replication fork speed and increased mutability in the absence of DNA breaks. (oncotarget.com)
Notably, miR-125b overexpression enhanced the stemness of breast cancer cells, and miR-125b overexpression or STARD13 knockdown impaired the inhibitory effects of Tanshinone IIA on the stemness of breast cancer cells. (biomedcentral.com)

Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. (biomedcentral.com)
The mechanisms of radiation-induced lung injury (RILI) and the mechanisms by which mesenchymal stem cells (MSCs) alleviate it. (biomedcentral.com)
The purpose of this study was to investigate the expression pattern of Mage-D1 in rat tooth germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. (researchsquare.com)
Ectomesenchymal stem cells (EMSCs) derived from the cranial neural crest are significant in tooth development and dental mineralization. (researchsquare.com)
Her postdoctoral studies on neural stem cells and asymmetric cell division in the Lab of Dr. Yuh Nung Jan at the Howard Hughes Medical Institute and University of San Francisco, California implied for the first time a minus-end directed myosin in the process of cell fate determination. (stanford.edu)
She returned to UCSF to conduct translational research, and apply her combined expertise in stem cells and signaling on the study of brain neoplasms and human stem and progenitor cells. (stanford.edu)
Proper cell fate decisions by neuroglia stem cells are critical for growing the cell lineages that form the brain during development and to maintain adult brain homeostasis. (stanford.edu)
In the healthy brain, neuroglia stem cells generate progenitors, which in turn give rise to differentiating cells that will eventually acquire their final functional state. (stanford.edu)
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research, Brisbane, Australia. (edu.au)
Ingrid Winkler's research focuses on understanding how micro-environments protect and instruct Stem Cells. (edu.au)
Her innovative research has already led to several discoveries, such as a novel strategy to protect normal Haematopoietic Stem Cells from chemotherapy or radiation damage. (edu.au)

During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
Alveolar epithelial cells participate in the pathogenesis of fibrosis, producing pro-inflammatory mediators, and undergoing epithelial-to-mesenchymal transition (EMT). (biomedcentral.com)
The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
The biology and therapeutic application of mesenchymal cells. (edu.au)

May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. (cusabio.com)

Inactivation of the MYC-induced apoptotic program is therefore a prerequisite for tumorigenesis. (ashpublications.org)

Perturbed cell cycle is also a growth-regulation way in malignancy cell [35]. (geogise.com)
Down regulation of BRG1 in WM 266 4 cells inhibits melanoma invasiveness Most established melanoma cell lines express high levels of BRG1, such as two metastatic melanoma cell lines, A375SM and WM 266 4. (histaminereceptor-signal.com)

During recovery, counterregulatory mechanisms take place, and the activated cells return to the homeostatic state. (frontiersin.org)
Conversely, these mechanisms demand high energy consumption, promoting important metabolic changes in the cell. (frontiersin.org)
Two mechanisms are involved in the generation of mature piRNAs: a primary synthesis mechanism that is carried out in both somatic and germ cells and a 'ping pong' amplification mechanism that is only formed in the germline [9,20]. (jcimcr.org)
Her research identified conserved mechanisms of cell fate determination in mammalian brain progenitors and led to a paradigm shift in understanding how brain progenitor cells self-renew and differentiate. (stanford.edu)
The mechanisms for cell fate decisions in the human brain are largely unknown. (stanford.edu)
To elucidate the mechanisms by which BRG1 professional motes invasion, we taken care of cells with an inhibitor of MMP2/MMP9 and performed invasion assays. (histaminereceptor-signal.com)
Therefore, there is an urgent need to identify the molecular mechanisms underlying the progression of CRC. (hindawi.com)

Additionally, we observed that BME treatment in breast cancer cells increases phospho-AMPK expression and inhibits the mTOR/Akt signaling pathway. (oncotarget.com)

One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. (wikipedia.org)

In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. (intechopen.com)

These results could be reversed by ETS1 upregulation or miR‑195‑5p‑knockdown in GC cells. (spandidos-publications.com)
Here, we show, by microarray analysis, that wtp53 lost the target gene activation following stable knockdown of HIPK2 (HIPK2i) in colon cancer cell line. (aacrjournals.org)

52] reported that HDAC10 displays low appearance amounts in pulmonary large cell carcinoma cells and it is subject to legislation by connexin 43 (Cx43). (geogise.com)

Additionally, the treatment with propofol could lead to decreased circ‑PVT1 expression in GC cells. (spandidos-publications.com)
Additionally, the effects of transfection with circ‑PVT1 small interfering RNA (si‑circ‑PVT1) on HGC‑27 and AGS cells could be reversed by treatment with miR‑195‑5p inhibitor. (spandidos-publications.com)
Additionally, Tanshinone IIA enhanced adriamycin sensitivity and attenuated adriamycin resistance of breast cancer cells. (biomedcentral.com)

An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. (biomedcentral.com)
Hyperperfusion is among the keys to the starting point and progression of microvascular problems in diabetes. (cancercurehere.com)

This drug has recently demonstrated the ability to downregulate ET-1 production in ECV304 cells by interfering with transcription of preproET-1 (PPET-1) gene expression [19]. (cancercurehere.com)
We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. (aacrjournals.org)
To do so, MYC controls transcription of multiple genes involved in cell growth and metabolism, vasculogenesis, cell adhesion, and genomic stability. (ashpublications.org)
The NF-κB transcription factor is also linked to tumor initiation and progression. (ashpublications.org)

Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)

Over the course of her career, Dr Winkler has produced 49 peer-reviewed articles, including a recent landmark study in Nature Medicine 2012, describing a key component of the bone marrow vascular niche (E-selectin) in regulating Haematopoietic Stem Cell self-renewal and chemo-sensitivity and last year her research was recognized to be among 'Ten of the Best Research Projects'in Australia by the National Health & Medical Research Council. (edu.au)

Propofol could inhibit Bcl‑2 and MMP9 expression, and increase P21 expression in GC cells. (spandidos-publications.com)
EBV miRNAs also inhibit the expression of viral antigens, thereby enabling infected cells to escape immune recognition. (ijbs.com)

Notably, we found that the expression of the CHK1 phosphatase PP1α is increased in Spi1/PU.1-overexpressing cells. (oncotarget.com)

Oncogenes trigger replicative stress that can lead to genetic instability, which participates in cancer progression. (oncotarget.com)

Remarkably, EBV-encoded miRNAs are abundantly expressed in latently-infected cells and serve important function in viral infection and pathogenesis. (ijbs.com)
Intriguingly, EBV miRNAs directly suppress host antiviral immunity by interfering with antigen presentation and immune cell activation. (ijbs.com)

In normal wound healing, this inflammation response may subside and induce a vicious cycle of further inflammation once radiation pneumonitis happens, finally leading to the poor prognosis. (biomedcentral.com)

PARTICIPANTS/MATERIALS, SETTING, METHODS: Endometrium samples were collected at mid-luteal phase of the menstrual cycle prior to IVF treatment or pregnancy. (bvsalud.org)

Both cell-derived microstructures and extracellular matrix components play critical roles in the preorganization and oriented deposition of calcium phosphate and serve as passive supports in dentine and enamel. (researchsquare.com)
Circular RNAs (circRNAs) are a form of noncoding and closed loop RNA molecules and play vital roles in the progression of various types of cancer in humans. (hindawi.com)
Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear. (biomedcentral.com)

Among them, Treg cells, which represent the master regulatory cells and participate in the maintenance of immune homeostasis, are regarded as the chief obstacle to antitumor immunity [ 18 ]. (biomedcentral.com)
Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. (encyclopedia.pub)
On the contrary, melatonin is currently considered a universal cell protector with signaling actions in a myriad of biochemical processes essential for cell and tissue homeostasis [ 13 ] [ 14 ] . (encyclopedia.pub)

In this study, we investigated the role and mechanism of action of TBHQ on 5-fluorouracil-induced (5-FU-induced) human intestinal epithelial cell (HIEC) injury and intestinal mucositis in mice. (biomedcentral.com)
12 ] found that ferroptosis is involved in intestinal epithelial cell death in ulcerative colitis and suggested it as a potential therapeutic target for that disease. (biomedcentral.com)

The consensus of researchers studying RILI is that ionizing radiation could induce damage to epithelial cells and endothelial cells, dysfunction of the blood-air barrier, and increase vascular permeability. (biomedcentral.com)

8 log 10 PFU/mL, hemorrhagic hepatic lesions, splenomegaly, and large amounts of HRTV antigen in mononuclear cells and hematopoietic cells in the spleen. (cdc.gov)

The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)

We have previously shown the anti-proliferative activity of bitter melon extract (BME) in breast cancer cells. (oncotarget.com)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
Phycocyanin lowers the amount of cyclooxygenase-2 which is up regulated in cancer cells. (nutraculture.com)
Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
Our previous studies demonstrated that arming vaccinia viruses with marine lectins enhanced the antitumor efficacy in several cancer cells. (mdpi.com)
This study aims to compare the efficacy of oncolytic vaccinia viruses harboring Tachypleus tridentatus lectin (oncoVV-TTL), Aphrocallistes vastus lectin (oncoVV-AVL), white-spotted charr lectin (oncoVV-WCL), and Asterina pectinifera lectin (oncoVV-APL) in breast cancer cells (BC). (mdpi.com)
New ways to sensitise cancer cells to standard cancer therapy. (edu.au)
Otto Warburg noticed that cancer cells utilize far more glucose than normal cells and reprogram their metabolism largely to glycolysis even in oxygen-rich conditions [ 2 ]. (biomedcentral.com)
Tanshinone IIA attenuated the stemness of breast cancer cells, evident by downregulating the expression of stemness markers, hindering the capacity of spheroid formation, decreasing the CD24 − /CD44 + sub-population in a concentration-dependent manner and reducing the tumor-initiating ability of breast cancer cells. (biomedcentral.com)

TME consists of cell component, the extracellular matrix (ECM) and abundant soluble signaling molecules. (biomedcentral.com)
ECM is a macromolecular substance secreted by cells into the extracellular space and constitutes a complex network that supports tissue structure and the physiological activities of cells, including collagen, elastin fibrils, proteinases, proteoglycans (PGs), glycoproteins and glycosaminoglycans (GAGs). (biomedcentral.com)

Anatomy26

Organisms11

Diseases7

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes74

Disciplines and Occupations1

Information Science3

Health Care1

Proliferation37

Apoptosis26

Metastasis4

Differentiation7

Tumors7

Malignant4

Head and neck squamous cell carc2

Autophagy7

Proteins3

Resistance to oxidative1

Breast cancer progression1

Colorectal7

Oxidative2

Development and progression2

Protein14

Cellular3

Tissues6

Accumulation of mutations1

Vitro3

Disease progression1

Immune cells14

Tumor cell3

Cancers2

Viability1

Malignancies2

Overexpression4

Stem cells11

Mesenchymal4

Dendritic cells1

Tumorigenesis1

Regulation2

Mechanisms7

Inhibits1

Excessive1

Degradation1

Knockdown2

Carcinoma1

Additionally3

Microvascular2

Transcription4

Programmed cell2

Bone marrow1

Inhibit2

Notably1

Participates1

MiRNAs2

Inflammation1

Methods1

Roles3

Homeostasis3

Epithelial cell2

Endothelial cells1

Hematopoietic cells1

Migration1

Cancer cells9

Extracellular2