Loading...
  • redox
  • Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between ROS-signaling and other aspects of intracellular signaling networks. (uiowa.edu)
  • This knowledge may allow us to devise better treatment protocols based on redox control of the cell cycle. (uiowa.edu)
  • processes
  • Nuclear factor-κB (NFκB) is a transcription factor with a pivotal role in inducing genes involved in physiological processes as well as in the response to injury and infection. (naver.com)
  • During a normal embryologic processes, or during cell injury (such as ischemia-reperfusion injury during heart attacks and strokes) or during developments and processes in cancer, an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and fragmentation of the DNA and nucleus. (wikipedia.org)
  • It plays an important role during embryonal development as programmed cell death and accompanies a variety of normal involutional processes in which it serves as a mechanism to remove "unwanted" cells. (wikipedia.org)
  • nuclear
  • RESEARCH DESIGN AND METHODS FOXO1 was tested in vivo by DNA binding activity and by nuclear translocation in microvascular cells in retinal trypsin digests. (diabetesjournals.org)
  • Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. (naver.com)
  • Oxidative stress and nuclear factor-κB activation ∗ ∗ Bowie A and O'Neill LAJ, unpublished results. (naver.com)
  • pathways
  • When naïve B-cells encounter an antigen, one of the pathways that they can follow is through the germinal center environment. (wikipedia.org)
  • MicroRNAs (miRNAs) participate in pathways fundamental to B cell development like B cell receptor (BCR) signalling, B cell migration/adhesion, cell-cell interactions in immune niches, and the production and class-switching of immunoglobulins. (wikipedia.org)
  • This pathways allows for 4′-phosphopantetheine to be replenished in the cell and allows for the conversion to coenzyme A through enzymes, PPAT and PPCK. (wikipedia.org)
  • cyclin
  • Next, the absence of cyclin A1 commits the neuron to division, but the cell lacks the ability to re-differentiate. (wikipedia.org)
  • It is thought that this hysteretic behavior ensures that cells commit to mitosis even if cyclin B1 levels falter. (wikipedia.org)
  • role
  • In this review article, we discuss the role of oxidative stress in the tissue destruction manifest in periodontitis, and the mechanisms that protect against this oxidative stress. (frontiersin.org)
  • CONCLUSIONS FOXO1 plays an important role in rat retinal microvascular cell loss in type 1 and type 2 diabetic rats and can be linked to the effect of high glucose on FOXO1 activation. (diabetesjournals.org)
  • We recently showed that diabetes-induced tumor necrosis factor (TNF)-α plays an important role in microvascular cell loss ( 16 ). (diabetesjournals.org)
  • Using the dietary isothiocyanate sulforaphane (SFN) to activate NRF2, chromatin immunoprecipitation sequencing (ChIP-seq) identified several hundred novel NRF2-mediated targets beyond its role in oxidative stress. (hindawi.com)
  • 1995). In the past decade, research has shown that neuronal cell cycle reentry plays a fundamental role in the pathogenesis of AD. (wikipedia.org)
  • Glutathione plays a key role in maintaining proper function and preventing oxidative stress in human cells. (wikipedia.org)
  • Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. (wikipedia.org)
  • sequences
  • The latter DNA sequences have been recognized as antioxidant/electrophile response elements or NF-E2-binding motifs, to which Nrf2-sMaf heterodimers and p45 NF-E2-sMaf heterodimers bind, respectively. (wikipedia.org)
  • radiation
  • Radiation also resulted in changes to T cells. (mdpi.com)
  • At six months post-radiation, increased T cells were observed in the adipose tissues. (mdpi.com)
  • Thus, MnTE-2-PyP treatment maintains normal fibroblast function and T cell immunity months after radiation exposure. (mdpi.com)
  • We believe that one of the reasons MnTE-2-PyP is a potent radioprotector is due to its protection of multiple cell types from radiation damage. (mdpi.com)
  • Because of the unresponsiveness of many gliomas to RT and alkylators, and the toxicity of these adjuvant therapies ( e.g. , radiation-induced necrosis, alkylation-induced bone marrow suppression), prognostic indicators of response are urgently needed. (aacrjournals.org)
  • suppressor
  • GCB DLBCL shows amplification of the oncogenic mir-17-92 microRNA cluster and deletion of the tumor suppressor PTEN but these events have not been found in ABC DLBCL B-cells form in the bone marrow and undergo gene rearrangement in order to develop B-cell receptors (BCRs) that bind to a specific antigen. (wikipedia.org)
  • mammalian cells
  • For example, ser/thr phosphatases PP2Cα/β suppress activity of p38s MAPK through direct interaction as well as suppression of MKKs/TAK1 in mammalian cells. (wikipedia.org)
  • mechanism
  • Steps: The action of GR proceeds through two distinct half reactions, a reductive half mechanism followed by an oxidative half. (wikipedia.org)
  • In the oxidative half of the mechanism, Cys63 nucleophilically attacks the nearest sulfide unit in the GSSG molecule (promoted by His467), which creates a mixed disulfide bond (GS-Cys58) and a GS− anion. (wikipedia.org)
  • Coenzyme A is one of five essential coenzymes that is necessary in the reaction mechanism of the citric acid cycle. (wikipedia.org)
  • Though Wee1 is a fairly conserved negative regulator of mitotic entry, no general mechanism of cell size control in G2 has yet been elucidated. (wikipedia.org)
  • inflammatory
  • It is caused by a dysregulation of the host inflammatory response to bacterial infection, which leads to soft and hard tissue destruction. (frontiersin.org)
  • Tissue destruction in periodontitis is considered to result from an excessive inflammatory response to bacterial plaque. (frontiersin.org)
  • This is followed by fragmentation into apoptotic bodies that are quickly removed by phagocytes, thereby preventing an inflammatory response. (wikipedia.org)
  • Under inflammatory conditions and conditions of T cell activation, leukocytes are retained in the brain by cytokine and chemokine production, which can lead to the breakdown of the BBB, thus increasing the quinolinic acid that enters the brain. (wikipedia.org)
  • The gliotoxic effects of quinolinic acid further amplify the inflammatory response. (wikipedia.org)