Responses of patients. Medical search. Frequent questions

One potential use for the technology could be, for example, to have the chatbot draft responses that physicians could then edit, and randomized trials could assess whether using AI assistants might improve responses, lower clinician burnout, and also improve patient outcomes. (ubergizmo.com)
Overall, while the study suggests that chatbots such as ChatGPT may have potential in clinical settings, further research is needed to fully understand their impact on patient outcomes and the healthcare profession. (ubergizmo.com)
Saffron Cordery, Interim Chief Executive, NHS Providers - "We welcome this framework as a key tool to ensure that investigation processes and responses by trusts lead to effective learning and improvement, contributing to better patient safety and outcomes - the top priority of trust leaders. (england.nhs.uk)
However, the outcomes of patients receiving the T cell co-stimulation modulator abatacept were dependent on ACPA status with better responses observed in those who were positive for anti-CCP antibodies, compared to those who didn't have these antibodies,' Dr Harrold concluded. (news-medical.net)
For the 566 patients who initiated abatacept, double positive status was associated with a significantly greater response compared with double negative status on all outcomes (disease activity measures and achievement of remission). (news-medical.net)
With over 100 years of experience in the healthcare industry and more than 50,000 employees globally, the company helps improve outcomes more efficiently for patients, healthcare providers, researchers and life sciences companies around the world. (webwire.com)
A complete molecular remission is associated with superior outcomes in patients with Philadelphia chromosome-positive ALL," said Short. (mdanderson.org)
The combination of PD-1/L1 immune checkpoint inhibitors and chemotherapy can shrink solid tumors and improve outcomes in cancer patients. (scienceboard.net)
The same group has now correlated CX3CR1 expression to outcomes in NSCLC patients treated with chemo-immunotherapy. (scienceboard.net)
A sample of this blood was aliquoted for performance of the ISI, and patients were followed for clinical outcomes. (plos.org)
Investigators emphasized the need for further research exploring the drivers of these inequitable outcomes as well as a reassessment of treat-to-target strategies in these patient populations. (consultantlive.com)
Peer Review Comments and CDC Responses for "Recommendations for Providers Counseling Male Patients and Parents Regarding Male Circumcision and the Prevention of HIV Infection, STIs, and other Health Outcomes" and "Background, Methods, and Synthesis of Scientific Information Used to Inform the 'Recommendations for Providers Counseling Male Patients and Parents Regarding Male Circumcision and the Prevention of HIV infection, STIs, and other Health Outcomes. (cdc.gov)
Best responses on treatment were associated with survival outcomes using log-rank and COX regression with a landmark analysis at 2 months. (bvsalud.org)

This combination treatment approach "might have great benefit in young patients," the investigators wrote June 13 in Clinical Cancer Research . (cancer.gov)
This develops trust, and allows anyone who might identify patient safety concerns to speak up, including health care professionals, non-clinical staff, patients, and their families. (health.mil)
Once proof of concept has been reached, the clinical translation of these tracers would initially help improve the success rate and efficiency of immunotherapy clinical trials by enabling more advanced stratification of patient cohorts and in turn increasing speed to market of immunotherapies. (webwire.com)
Patients with axial spondyloarthrtitis (AxSpA) who have not previously been treated with a biologic are much more likely to have a clinical response from secukinumab, according to new data presented during the 2022 American College of Rheumatology Convergence Meeting in Philadelphia. (consultantlive.com)
However, if a patient was assessed for clinical conditions prior to bDMARD use, there was significantly better drug survival rates at 6 months and 12 months in patients naïve to bDMARD (82.7% and 76.9 months, respectively). (consultantlive.com)
In a study conducted with TURKBIO real-life data, we found that secukinumab treatment in patients with AxSpA had better clinical response and higher drug survival rates in biologically naive patients, similar to TNFi treatment," the authors wrote. (consultantlive.com)
Pooled patient data from early rheumatoid arthritis (RA) clinical trials (n = 1,342) of methotrexate (MTX), tumor necrosis factor (TNF) inhibitor monotherapy (adalimumab and etanercept), and the combination of the two (adalimumab or infliximab plus MTX) were used for the primary analyses. (nih.gov)
To corroborate the preclinical findings, Dr. Brekken noted that an ongoing Phase 2 clinical trial testing the AXL inhibitor used in this study, known as bemcentinib and produced by BerGenBio ASA, showed promising results in NSCLC patients carrying the STK11/LKB1 mutation who are being co-treated with PD-1/PD-L1 inhibitors. (utsouthwestern.edu)
In patients with systemic lupus erythematosus receiving rituximab and belimumab, Black and Indo-Asian patients were less likely to obtain major clinical response. (consultantlive.com)
In addition to a lower likelihood of achieving major clinical response, other research has shown racial and ethnic minorities with lupus were more likely to develop kidney, neurological, and blood manifestations when compared with White patients.2 They were also at a greater risk of developing severe manifestations such as lupus nephritis, antiphospholipid syndrome, and thrombocytopenia earlier than White patients. (consultantlive.com)
Major clinical response was defined as Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ≤4 at the end of the study period. (consultantlive.com)
At 12 months, approximately half (56.3%, n = 901) of patients achieved major clinical response. (consultantlive.com)
For those receiving belimumab, Black (.65 [.44 - .96]) and Indo-Asian patients (.29 [.09 - .93]) were also less likely to obtain major clinical response. (consultantlive.com)
The research team discovered new network-based biomarkers by analyzing the clinical results of more than 700 patients with three different cancers (melanoma, gastric cancer , and bladder cancer) and the transcriptome data of the patients' cancer tissues. (medicalxpress.com)
Six patients (10%) experienced clinical worsening, including death in two (not study drug-related). (ersjournals.com)
If clinical trials show that we can safely discontinue ibrutinib in some patients who achieve a CR, data in this article would suggest that patients without bulky lymphadenopathy who are treated in the front-line setting might be those likely to be able to discontinue ibrutinib. (medscape.com)
However, in the presence of HIV infection it is critically important to assess the clinical and bacteriologic response. (cdc.gov)
This study aimed to determine the prevalence of antibiotic therapy in patients with COVID-19 infection and explore the association of antibiotic prescribing with patients' demographics and clinical characteristics. (who.int)
We retrospectively evaluated the organ response (OR) and long-term survival of newly diagnosed AL amyloidosis patients who received first-line bortezomib -containing induction therapy , aiming to identify the clinical indication of a 50% reduction in the difference between involved and uninvolved free light chains (dFLC) after first cycle of treatment . (bvsalud.org)

JungHo Kong et al, Network-based machine learning approach to predict immunotherapy response in cancer patients, Nature Communications (2022). (medicalxpress.com)

Omaveloxolone in combination with checkpoint blockade had activity in both naïve and checkpoint inhibitor refractory melanoma patients. (news-medical.net)
She added: 'This is one of the first studies to demonstrate a meaningful response rate in the checkpoint inhibitor refractory melanoma population. (news-medical.net)
A combination of ponatinib and blinatumomab was found to be safe and highly effective in patients with newly diagnosed or relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
CHICAGO, June 3, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the first-ever results from the Phase 1b RedirecTT-1 study of TECVAYLI ® (teclistamab-cqyv), a first-in-class BCMAxCD3 bispecific antibody, and talquetamab, a first-in-class GPRC5DxCD3 bispecific antibody, showing a high overall response rate (ORR) among patients with relapsed or refractory multiple myeloma (RRMM). (jnj.com)
By combining teclistamab and talquetamab, two bispecific antibodies that have demonstrated high efficacy responses in targeting distinct antigens, we evaluated the potential of this unique combination regimen for patients who were resistant or refractory to multiple lines of therapy," said Yael Cohen, M.D., Head of Myeloma Unit, Hematology Institute, Tel-Aviv Sourasky Medical Center, Israel, and principal study investigator. (jnj.com)
Thirty-one patients (9.5%) received ibrutinib as first-line therapy and the rest had relapsed/refractory disease and had previously received a median of three therapies. (medscape.com)

The Brooklyn VA Medical Center in New York will start accepting some non-veterans patients in an effort to help local community needs in the fight against coronavirus. (militarytimes.com)
The move comes after weeks of discussion about VA's "fourth mission" in response to the ongoing coronavirus outbreak but also amid news reports that department hospitals in the city are already experiencing shortages in staffing, protective equipment and other critical needs. (militarytimes.com)
Veterans Affairs leaders on Friday made public their emergency response plan to the ongoing coronavirus pandemic, warning that the outbreak "could last 18 months or longer" and that nearly one-third of its workforce may be sidelined by the illness. (militarytimes.com)
The ongoing coronavirus disease (COVID-19) pandemic is exacerbating optimal antibiotic stewardship and the promotion of bacterial resistance due to the over-prescribing of antibiotics for patients with COVID-19. (who.int)

one demonstrated blunted antibody responses in IBD patients taking infliximab , while the other showed that full vaccination was less effective at preventing SARS-CoV-2 infection among patients with IBD than nonimmunosuppressed individuals. (medscape.com)
To better characterize antibody responses after receiving an mRNA vaccination series, Weaver and colleagues launched the PREVENT-COVID trial, including the present dataset of 787 patients with IBD older than 12 years, all of whom provided serum samples 8 weeks after completing an mRNA vaccine series. (medscape.com)
She described a dataset of about 500 IBD patients in which booster vaccines overcame poor antibody responses to the initial vaccine series. (medscape.com)

The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2016) showed that the presence of an antibody (anti-CPP ) in the bloodstream of patients with rheumatoid arthritis (RA) correlates with response to different drug treatments. (news-medical.net)
Objective To evaluate the efficacy and safety of tabalumab, a monoclonal antibody that neutralises membrane-bound and soluble B-cell activating factor (BAFF), in patients with active rheumatoid arthritis (RA) who showed inadequate response to tumour necrosis factor (TNF) inhibitors. (bmj.com)

The study showed that the successful treatment of mice with checkpoint inhibitors increases the frequency of CX3CR1-positive T cells, and that the presence of the biomarker correlates with response and survival in non-small cell lung cancer (NSCLC) patients. (scienceboard.net)

Autologous patient-specific tumor antigen response (apSTAR) technology is a new cancer treatment procedure being developed by IMULAN BioTherapeutics, LLC and Veterinary Cancer Therapeutics, LLC for comparative oncology. (wikipedia.org)

Can Patient Age Affect Response to Checkpoint Inhibitors? (cancer.gov)
Immune checkpoint inhibitors -drugs that unleash an immune response against cancer-work astonishingly well for some people with advanced melanoma but do not work at all for many others. (cancer.gov)
The researchers also identified a potential strategy to improve responses to checkpoint inhibitors in younger people. (cancer.gov)
The findings suggest that cytotoxic T cell activity is suppressed by regulatory T cells in melanoma tumors of younger patients, the researchers wrote, limiting the effectiveness of immune checkpoint inhibitors. (cancer.gov)
The researchers wondered if altering the ratio of regulatory to cytotoxic T cells in mice would change the response to checkpoint inhibitors. (cancer.gov)
Administering omaveloxolone with checkpoint inhibitors may improve the antitumor response of these immunotherapies. (news-medical.net)
The study included 30 patients with unresectable or metastatic melanoma, of whom seven were naïve to checkpoint inhibitors and 23 had prior checkpoint inhibitor treatment. (news-medical.net)
These cells are key for effective response to ICBs known as PD-1/PD-L1 inhibitors that are commonly used to treat NSCLCs. (utsouthwestern.edu)
Under these circumstances, the research team led by Professor Sanguk Kim (Department of Life Sciences) at POSTECH is gaining attention as they have improved the accuracy of predicting patient response to immune checkpoint inhibitors (ICIs) by using network-based machine learning. (medicalxpress.com)
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). (ersjournals.com)
Methods Patients on stable methotrexate and with inadequate response to one or more TNF inhibitors were randomised to placebo (n=35), 30 mg tabalumab (n=35) or 80 mg tabalumab (n=30) given intravenously at 0, 3 and 6 weeks. (bmj.com)
2 Many patients continue to have active disease despite treatment with biological disease-modifying antirheumatic drugs (bDMARDs), including TNF inhibitors, and are in need of new treatment options. (bmj.com)

We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. (frontiersin.org)
Individuals with chronic Q fever showed strong class II epitope-specific cultured ELISpot responses largely overlapping with the peptide repertoire identified previously for convalescents. (biorxiv.org)
In conclusion, we have validated and expanded a previously published set candidate epitopes for a novel T-cell targeted subunit Q fever vaccine in the context of chronic Q fever patients and demonstrated that they successfully mounted a T-cell response comparable to that of convalescents. (biorxiv.org)
Finally, we demonstrate that individuals treated for chronic Q fever mount a broader ex vivo response to class II epitopes than convalescents, which could be explored for diagnostic purposes. (biorxiv.org)
About 10% of patients with acute CSC have multiple recurrences or progression to a chronic course [ 4 , 11 ]. (plos.org)
Persistent serous retinal detachment in a patient with chronic CSC can lead to permanent visual impairment due to RPE decompensation and disruption of the photoreceptor ellipsoid zone [ 1 , 2 , 12 , 13 ]. (plos.org)
Several novel gene variants may help explain the response of patients with chronic obstructive pulmonary disease (COPD) to inhaled bronchodilators, according to a meta-analysis reported today (Oct. 25) at the American Society of Human Genetics 2013 meeting in Boston. (ashg.org)
For example, as far back as 1980, Schreter 1 described a relationship between chronic somatic symptoms and borderline personality disorder among patients in group psychotherapy. (psychiatrist.com)
The multivariable logistic analysis showed chronic migraine (OR 0.05 [95% CI 0.00-0.82], p = 0.036) and the number of previously failed preventive medication classes (OR 0.55 [95% CI 0.33-0.92], p = 0.024] were independently associated with treatment response. (iasp-pain.org)
Chronic migraine and multiple failures from preventive medication are associated with poor galcanezumab response. (iasp-pain.org)
NEW YORK (Reuters Health) - In patients with chronic lymphocytic leukemia (CLL), initial therapy with ibrutinib is among the factors that increase the likelihood of a complete response, according to pooled data from two trials. (medscape.com)
Only 442 patients have been evacuated across the Rafah border since 27 December 2008, most for injuries and some for chronic conditions. (who.int)

Clinicians and researchers are eagerly searching for factors that can help identify patients that are most likely to have good responses . (cancer.gov)
In an analysis of more than 500 patients, researchers found that older people with melanoma appeared to respond better to checkpoint inhibitor treatment than younger people. (cancer.gov)
For every decade of age, the probability that a patient was resistant to pembrolizumab treatment dropped by 13%, the researchers observed. (cancer.gov)
This diversity within cancers has become more apparent with newer analytical tools, and now researchers are beginning to understand how it influences responses to therapy. (mdanderson.org)
Researchers at Ben-Gurion University of the Negev have developed a new bio-sensing technology that predicts cancer patients' response to immune checkpoint inhibitor (ICI) immunotherapy . (timesofisrael.com)
May 15, 2023 -- Researchers have found a biomarker that provides an early indication of whether a patient is responding to chemo-immunotherapy. (scienceboard.net)
In 2021, researchers at the University of Southern California identified the expression of CX3CR1 on T cells as a way to show if a patient was responding to a checkpoint inhibitor. (scienceboard.net)
Drawing on extensive prior research revealing significant differences in the immune systems of women and men, Iwasaki led a team of researchers to examine sex differences in immune response to SARS-CoV-2, the virus that causes COVID-19. (yale.edu)
The researchers collected nasal, saliva, and blood samples from non-infected control subjects as well as patients with the disease. (yale.edu)
In contrast, the researchers found that female patients had more robust activation than men of T-cells, white blood cells of the adaptive immune system that can recognize individual invading viruses and eliminate them. (yale.edu)
Based on these findings, the researchers suggest exploring therapeutic interventions and vaccine strategies that elevate T-cell immune response to the virus in male patients and that dampen innate immune activation during early stages of the disease in female patients. (yale.edu)
In this study, researchers developed and pilot-tested safety checklists for emergency response driving (ERD) and patient transport in Finland. (ahrq.gov)
For this randomized phase 2 study, researchers compared the safety and efficacy of immunosuppression plus ELTR vs immunosuppression alone among pediatric patients with newly diagnosed severe or very severe aplastic anemia. (thalassaemia.org.cy)
The researchers conclude, "The CR (complete response) rate with continued longer-term ibrutinib treatment was higher than in previous reports. (medscape.com)

We prospectively recruited and followed up patients with migraine who received monthly galcanezumab treatment in a single university hospital from June 2020 to October 2021. (iasp-pain.org)

1 Eighty-two patients across all study cohorts and 27 patients treated at the RP2R were evaluable for response. (jnj.com)

The investigators concluded that the differential effect of anti-CCP antibody status on treatment response may be due to differences in the mechanism of action between the treatment agents. (news-medical.net)
The investigators collected follow-up data from 184 patients with axial spondyloarthritis, 28.3% (n = 52) of which were bDMARD naïve and 71.7% (n = 132) of which had used at least 1 bDMARD prior to secukinumab. (consultantlive.com)
To describe the different responses of patients with moderate-to-severe SLE in the United Kingdom (UK) according to ethnic background, investigators analyzed patients with SLE initiating rituximab, belimumab, or standard of care in the British Isles Lupus Assessment Group-Biologics Register (BILAG-BR) trial over a 12-month period. (consultantlive.com)

Some pediatric patients with newly diagnosed acquired aplastic anemia may be more likely to have a complete response with immunosuppressive treatment combined with eltrombopag (ELTR) compared with immunosuppression alone, according to research published in Blood Advances . (thalassaemia.org.cy)

ChatGPT appears to be 'significantly more empathetic' than doctors when responding to patient questions, according to a recent study. (ubergizmo.com)
We know immunotherapies can transform patients lives when they are effective, however, low patient response rates, the potential of serious adverse effects and high costs all mean we need to significantly improve how we more accurately predict the efficacy of an immunotherapy, explains Sanka Thiru, Global Product Leader, Molecular Imaging Oncology at GE Healthcare s Pharmaceutical Diagnostics business. (webwire.com)
In addition, older men - but not older women - were observed to have significantly worse T-cell responses than younger patients. (yale.edu)
Patients who respond to these treatments tend to survive significantly longer compared to those treated with chemotherapy, radiation, and/or surgery. (utsouthwestern.edu)
In an internal medicine outpatient sample from a resident provider clinic, patients with borderline personality disorder characteristics endorsed significantly more physical symptoms on a medical review of systems than those without such characteristics, suggesting a somatic overlay in individuals with this Axis II disorder. (psychiatrist.com)
Results: The MMP patients showed physiological activation during the baseline period and significantly more physiological activation during the recovery period compared to the controls. (quintpub.com)
Multivariate analysis in the overall population showed that being treatment-naive significantly increased the likelihood of complete response (odds ratio, 2.65), compared to having had at least one previous therapy. (medscape.com)
Complete response also was significantly associated with not having bulky disease (OR, 4.97). (medscape.com)

Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. (frontiersin.org)
She elaborates, "In the study, these patients underwent imaging with a PSMA PET scan and had treatment based on the results of the scan findings. (medindia.net)
Among patients with a negative PSMA, 44 percent (27 of 60) underwent SRT, while 56 percent (33 of 60) did not. (medindia.net)
This retrospective, interventional study investigated the medical records of 45 eyes of 44 patients with CSC who underwent IBVIs and completed at least 2-year follow-up period. (plos.org)
Methods: Fifty-five patients who underwent dental implant surgery were evaluated. (bvsalud.org)

Artificial intelligence developer Tempus is partnering with Eli Lilly to provide broader access to genomic testing to patients with advanced/metastatic. (scienceboard.net)
Extension of overall survival beyond objective responses in patients with metastatic renal cell carcinoma treated with high-dose interleukin-2. (bvsalud.org)
In metastatic renal cell carcinoma (mRCC), survival benefit associated with objective response rates of 16-20 % with high- dose interleukin-2 (HDIL-2) is well established and discussed. (bvsalud.org)

This is the only way to ensure we reinforce surveillance and better understand the evolution of the disease, while scaling up readiness and response to curb any further spread. (who.int)

they found that the proportion of responses rated as "empathetic" or "very empathetic" was higher for ChatGPT than for physicians and that the chatbot appeared to score higher than doctors on the quality of responses to patients. (ubergizmo.com)
The two organizations will develop Artificial Intelligence (AI) powered apps and PET tracers to help physicians identify the most suitable treatment for each individual patient. (webwire.com)
Spurred by the sharp rise in e-mail messaging during the covid pandemic, a growing number of health systems around the country have started charging patients when physicians and other clinicians send replies to their messages. (nakedcapitalism.com)
However, only a fraction of patients have durable responses and physicians lack the means to predict who will respond before starting treatment. (scienceboard.net)
A patient may identify nurses and physicians by name and even post details about their own perceived medical care across various social media platforms. (ashrm.org)

However, the problem with cancer immunotherapy is that only approximately 30% of cancer patients receive benefits from its therapeutic effect, and the current diagnostic techniques do not accurately predict the patient's response to the treatment. (medicalxpress.com)

A 10% or greater increase of the CX3CR1-positive subset in circulating CD8+ T cells from baseline was associated with response to chemo-immunotherapy after four weeks. (scienceboard.net)
Response to opioid" was defined as 1) an absolute value of ≥10 mm improvement on the visual analogue scale (VAS) and 2) a relative value of ≥10% improvement from baseline VAS. (ersjournals.com)
At all time points, including baseline, the group of patients who achieved remission at 1 year had lower average SDAI values than did those whose disease activity was high at 1 year. (nih.gov)
Most (85.2%, n = 1364) patients were receiving glucocorticoids at baseline, with a median dose of 7 (4.5 - 11.1) mg daily. (consultantlive.com)
At baseline, Black patients had a higher SLEDAI-2K score when compared with White patients. (consultantlive.com)
Black, East Asian/Chinese, and multiple/mixed background patients received a higher glucocorticoid dose at baseline. (consultantlive.com)
At baseline, in the ELTR and immunosuppression-only groups, the median ages were 10.5 and 8.7 years, 71.4% and 61.2% of patients were male sex, and 36.7% and 42.9% had SAA within their respective group while 63.3% and 57.1% had vSAA, respectively. (thalassaemia.org.cy)
We defined the treatment response with ≥ 50% reduction in moderate/severe headache days in the 3rd month of treatment compared to baseline. (iasp-pain.org)
Methods: Physiological activation and emotional reactivity were assessed in 22 MMP patients and 23 controls during baseline, stressor, and recovery periods. (quintpub.com)

Potential predictors of anti-CGRP(-R) mAb response were tested by using the univariable and multivariable logistic regression analyses. (iasp-pain.org)
Univariate and multivariable logistic regression was used to compare COVID-19 patients who were prescribed antibiotics with those who were not. (who.int)

While further study of larger patient groups with longer follow-up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice. (medindia.net)
A team, led by Semih Gulle, Dokuz Eylul University School of Medicine Division of Rheumatology, evaluated secukinumab in patients with axial spondyloarthrtitis from the TURKBIO cohort. (consultantlive.com)
The data were similar when scores on the DAS28 and CDAI were used and were fully validated in the independent cohort of patients with late RA. (nih.gov)
An observational single-center study of prospective cohort of patients presenting to the ED during the early COVID-19 pandemic with respiratory symptoms and a CBC drawn within 4.5 hours of initial vital signs. (plos.org)
range, 2-10 for patients in the RP2R dosing cohort, n=34). (jnj.com)
1 The median duration of response was not reached in the overall study population or RP2R cohort. (jnj.com)
1 The median follow-up for patients receiving the RP2R was 8.1 months (range, 0.7-15.0), and median PFS was NE for patients in the RP2R cohort (95 percent CI: 9.9-NE). (jnj.com)

Most (90.4%, n = 1447) patients were female and the median age was 39.9 (31.0 - 50.6) years. (consultantlive.com)

As the COVID-19 pandemic rapidly developed, the MHS fast-tracked efforts to preserve patient safety. (health.mil)
Patient safety and ethical implications of healthcare sick leave policies in the pandemic era. (ahrq.gov)
Assess the IntelliSep Index (ISI) for risk stratification of patients presenting to the Emergency Department (ED) with respiratory symptoms suspected of COVID-19 during the pandemic. (plos.org)
The ISI rapidly risk-stratifies patients presenting to the ED during the early COVID-19 pandemic with signs or suspicion of respiratory infection. (plos.org)
Throughout this pandemic, as hospitals filled with patients under investigation for COVID-19, clinicians attempted to discern high-risk patients at who need aggressive intervention from lower-risk patients who may benefit from a more conservative approach [ 13 ]. (plos.org)
In light of the protracted nature of the COVID-19 pandemic, countries may wish to conduct periodic reviews during the event so they can continue to reflect on the ongoing response and revise national and subnational response strategies and plans as needed. (who.int)

We have other viable treatment options for NSCLC patients, so the biomarker can help us identify patients who might have better results with an alternative therapy. (scienceboard.net)
NSCLC patients whose cancers are driven by mutations in a gene called KRAS usually have a high response rate to ICBs. (utsouthwestern.edu)
However, Dr. Brekken explained, about 20% of NSCLC tumors also carry mutations in a gene known as STK11/LKB1, which is associated with poor response to ICB therapy. (utsouthwestern.edu)
Additional experiments showed that these immune cells were also largely absent in human NSCLC tumors carrying STK11/LKB1 mutations, suggesting that the lack of ICB response in these patients stems from a deficiency of these cells. (utsouthwestern.edu)

The study demonstrates that PSMA PET can independently predict treatment response to SRT. (medindia.net)
GE Healthcare is partnering with multiple companies and academic institutions to develop a portfolio of targeted Positron Emission Tomography (PET) tracers to better predict and monitor patient response to immunotherapies. (webwire.com)
Before now there existed biomarkers to predict the success of ICI on a patient, but these tests had only a 10-15% response, according to Elkabets. (timesofisrael.com)
This study aimed to discover which patient characteristics predict those most likely to gain improvement in breathlessness. (ersjournals.com)
By utilizing the network-based biomarkers, the team successfully developed artificial intelligence that could predict the response to anticancer treatment. (medicalxpress.com)
In their previous study, the research team had developed machine learning that could predict drug responses to chemotherapy in patients with gastric or bladder cancer. (medicalxpress.com)
This study has shown that artificial intelligence using the interactions between genes in a biological network could successfully predict the patient response to not only chemotherapy, but also immunotherapy in multiple cancer types. (medicalxpress.com)

Kang HM, Choi JH, Koh HJ, Lee SC (2020) Long-term treatment response after intravitreal bevacizumab injections for patients with central serous chorioretinopathy. (plos.org)

Additional data are forthcoming on a larger subset of participants in the PREVENT-COVID study which will allow for analysis of factors associated with humoral immune response and potential optimization of immunization strategies. (medscape.com)
A recent study suggested that people whose tumors contained fewer regulatory T cells than cytotoxic T cells had better responses to immunotherapy treatment . (cancer.gov)
A recent study published in the journal Jama Internal Medicine found that patients rate the responses of ChatGPT - a computer program designed to simulate online conversations with humans - as more empathetic and of higher quality than those of doctors. (ubergizmo.com)
In this study, we have assessed the NY-ESO-I autoantibody response in patients with lung cancer by a serum ELISA. (nih.gov)
This study evaluated the impact of anti-CCP and RF antibodies on treatment response separately in patients initiating abatacept or TNFi. (news-medical.net)
When the study team investigated the relationship with anti-CCP and RF separately, the responses shown were driven by seropositivity to anti-CCP antibodies alone and that RF was not an independent factor influencing response. (news-medical.net)
A novel compound may restore immune response in patients with melanoma , according to a study presented at the ESMO Immuno Oncology Congress 2017. (news-medical.net)
Commenting on the study for ESMO, Dr Olivier Michielin, head of Personalised Analytical Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, said: 'Omaveloxolone's novel mechanism of action is to block MDSCs, cells known to suppress the immune response. (news-medical.net)
This study tested a new combination therapy in immuno oncology and found encouraging response rates with omaveloxolone plus ipilimumab or nivolumab in patients who were checkpoint inhibitor naïve or resistant. (news-medical.net)
In a study in The Journal of Nuclear Medicine , the research team demonstrates that PET scans can identify which of these prostate cancer patients would benefit from salvage radiation treatment (SRT). (medindia.net)
Results of the study, which ultimately included 146 men of whom 99 received SRT, show an overall treatment response after SRT of 72 percent. (medindia.net)
Emmett points out, "The results of the study show that PSMA PET is more predictive of a treatment response than PSA level, surgical margins or seminal vesical involvement. (medindia.net)
Genetic variants in patients hold the answer for why advanced prostate cancer is resistant to standard therapy, says study. (medindia.net)
The effect of each treatment on the forced expiratory volume in 1 s (FEV 1 ), provocative concentration of methacholine causing a 20% decline in FEV 1 (PC 20 ), early and late asthmatic responses, and allergen-induced inflammation were measured.RESULTS: Seventeen subjects completed the study. (hindawi.com)
This discovery of the addition of AXL-targeted therapy to immunotherapy provides an important clue and path forward to enhance the benefits of immunotherapy for more patients with lung cancer," said study co-leader John D. Minna, M.D. , Professor of Internal Medicine and Pharmacology and Director of the Hamon Center for Therapeutic Oncology Research. (utsouthwestern.edu)
The results from three of these patients are reported in the new study. (utsouthwestern.edu)
The controlled study examined the effect of wintertime exercise on cardiovascular function among CAD patients. (oulu.fi)
The study demonstrated that dynamic and static exercise performed in a cold environment increases cardiac workload of stable CAD patients by ca. 20% compared with the corresponding exercise in a neutral environment. (oulu.fi)
The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. (scirp.org)
In the present study, the response of blood pressure, pulse rate [12] , and skin blood flow to the CWC test was evaluated to determine the sympathetic response to mental stress in essential hypertensive patients treated with different types of antihypertensive drugs. (scirp.org)
The study required no patient-centered activity beyond standard of care and treating clinicians were unaware of study enrollment and ISI test results. (plos.org)
Patient consent and medical direction for the study was conducted independently at the study facilities under the direction of Drs. Caffery, Thomas, and O'Neal, who have no financial interest in Cytovale. (plos.org)
According to the findings of this study, patient endorsement of multiple symptoms on the review of systems suggests the possible presence of borderline personality symptomatology. (psychiatrist.com)
In this study, there was no pattern of symptom endorsement on the medical review of systems by patients with borderline personality symptomatology (ie, no specific symptoms suggest this Axis II pathology). (psychiatrist.com)
This study helps detect patients who will respond to immunotherapy in advance and establish treatment plans, resulting in customized precision medicine with more patients to benefit from cancer treatments. (medicalxpress.com)
Predictors of galcanezumab response in a real-world study of Korean patients with migraine. (iasp-pain.org)
To assess factors associated with galcanezumab response in a real-world study of Korean patients with migraine. (iasp-pain.org)
32 patients (52%) experienced study drug-related adverse events and 10 (16%) experienced serious adverse events (2 (3%) study drug-related, none during the PDE5i treatment-free period). (ersjournals.com)
The emotional and physiological differences between the groups across study periods were more pronounced in pain patients reporting a traumatic stressor. (quintpub.com)
Study results suggest the use of these HRV indices may improve understanding of the role of excitatory and inhibitory mechanisms in patients with MMP conditions. (quintpub.com)
The high overall response rates characterized in this study are encouraging and support the continued evaluation of this regimen as a combination therapy. (jnj.com)
Results from the study showed that responses were high across all dose levels. (jnj.com)
This study investigated the perspective of international patients on individual symptoms of atopic dermatitis (eczema) in determining treatment response. (lu.se)
A study by Palilonis et al, using the 2014 Nationwide Emergency Department Sample, found that among patients aged 13-25 years, 12.9% of 20,787 burn injury-related emergency department visits involved a codiagnosis of intoxication. (medscape.com)

The recently developed immune checkpoint inhibitor has considerably improved the survival rate of patients with cancer. (medicalxpress.com)
Oncologist Dr. Jennifer A. Woyach of The Ohio State University, in Columbus, told Reuters Health by email, "These retrospective data, as well as the studies showing longer progression-free survival for those patients receiving ibrutinib as earlier lines of therapy, suggest that we should be using ibrutinib in the front-line setting rather than saving it for a salvage therapy. (medscape.com)
Based on recently emerged data on efficacy of cancer immunotherapy , we hypothesized that the survival benefit with HDIL-2 extends beyond those achieving objective responses, i.e., to those who achieve stable disease as the best response to treatment . (bvsalud.org)
No significant differences in progression-free survival (HR 0.74, 95 % CI 0.48-1.1, p = 0.14) or overall survival (HR 0.66, 95 % CI 0.39-1.09, p = 0.11) were observed between patients achieving partial response versus stable disease . (bvsalud.org)
Significant differences in progression-free survival (HR 0.13, 95 % CI 0.09-0.22, p survival (HR 0.33, 95 % CI 0.23-0.48, p patients achieving stable disease compared to those with progressive disease and who were not evaluable. (bvsalud.org)
Survival benefit with HDIL-2 is achieved in ~50 % patients and extends beyond those achieving objective responses. (bvsalud.org)
At least partial hematological response after first cycle of treatment predicts organ response and long-term survival for patients with AL amyloidosis receiving bortezomib-based treatment. (bvsalud.org)
These results demonstrated that early reduction of dFLC after the first cycle of treatment is predictive of achieving an OR and long-term survival in AL patients receiving bortezomib . (bvsalud.org)

Serre-yu Wong, MD, PhD , of Icahn School of Medicine at Mount Sinai, New York, agreed that the findings should offer some reassurance to patients with IBD and their care providers. (medscape.com)
What the findings call for, said Dr. Sharon, "is more translational research to understand the differences between patients that respond or fail to respond" to checkpoint inhibitor treatment. (cancer.gov)
These findings answer questions about COVID-19 that point the way toward a more effective, targeted response to this disease. (yale.edu)
Our findings indicate that intensive and dynamic treatment strategies that include a closer look at disease activity at 3 months in patients with early and late RA is warranted. (nih.gov)

Conversely, there were no significant differences in responses between anti-CCP/RF groups in the 1,715 TNFi users. (news-medical.net)
Results At week 16, no significant differences were observed in the combined tabalumab group versus placebo in ACR50 (12.7% vs 2.9%, p=0.101) or ACR20 response rates (27.0% vs 17.1%, p=0.198). (bmj.com)

Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) is well recognized as a powerful diagnostic tool in the initial staging of patients with multiple myeloma (MM). The aim of this paper is to perform a systematic review about the usefulness of FDG-PET or PET/CT in evaluating the response to treatment in patients with MM. Methods . (hindawi.com)

Medication errors in overweight and obese pediatric patients: a systematic review. (ahrq.gov)

Also known as laser-assisted immunotherapy, apSTAR is an experimental cancer treatment for solid tumors that uses an autologous vaccine-like approach to stimulate immune responses. (wikipedia.org)
And in an analysis of melanoma tumor samples from a separate group of more than 200 patients, the tumors of younger patients also had more regulatory T cells and fewer cytotoxic T cells than those of older patients. (cancer.gov)
Patients with NY-ESO-1 expressing tumors have been shown to bear circulating autoantibodies against this antigen. (nih.gov)
Because CX3CR1 changes before tumors shrink, it could serve as a noninvasive, early treatment biomarker that is assessed when patients attend their first check-up appointment. (scienceboard.net)

While immune checkpoint blockade immunotherapy has revolutionized the treatment of lung cancer, unfortunately the majority of lung cancer patients still do not have long-term benefit from such therapy. (utsouthwestern.edu)

Most patients with inflammatory bowel disease (IBD) develop a humoral immune response after completing an mRNA SARS-CoV-2 vaccine series, according to data from almost 800 patients. (medscape.com)

Combining multiple modules from the Ascom Healthcare Platform gives clinicians deep yet comprehensive patient information. (ascom.com)
It is hoped that these PET tracers, which would accurately screen immune mechanisms in real-time, would give clinicians a more comprehensive understanding of a patient s entire tumor environment and its heterogeneity, enabling more successful selection of therapies and earlier, more accurate monitoring of their efficacy. (webwire.com)
O ver the years, clinicians have intermittently reported somatization in some patients with borderline personality disorder. (psychiatrist.com)

We must avoid having two different responses to monkeypox - one for Western countries which are only now experiencing significant transmission and another for Africa," said Dr Matshidiso Moeti, WHO Regional Director for Africa. (who.int)

Dr Sean O'Kelly, Chief Inspector of Hospitals and Interim Chief Inspector of Primary Medical Services, Care Quality Commission - "We welcome the publication of NHS England's new Patient Safety Incident Response Framework (PSIRF) and the focus it places on effective learning and compassionate, meaningful engagement with those affected when incidents occur. (england.nhs.uk)
Building patient trust in hospitals: a combination of hospital-related factors and health care clinician behaviors. (ahrq.gov)
Many injured and chronically ill patients have been unable to reach hospitals because of movement restrictions. (who.int)

We are heartbroken to share that the walrus calf admitted to the ASLC Wildlife Response Program on August 1, 2023, passed away this morning after his condition took a turn for the worse. (alaskasealife.org)

In an effort to prevent spread of the virus, VA has asked veteran patients to call ahead to medical centers before visiting to minimize the chance of exposing others to the illness. (militarytimes.com)

Anti-receptor binding domain IgG antibodies specific to SARS-CoV-2 were detectable in 95% of patients, with "generally similar" results across vaccine type, age group, and medication class, apart from corticosteroid users, who had an 86% antibody detection rate, reported lead author Kimberly N. Weaver, MD , of the University of North Carolina at Chapel Hill, and colleagues. (medscape.com)
The research is novel because it looks at the impact of PSMA PET/CT on patient responses to treatment, not just on whether the PET scan results in changed management," explains Louise Emmett, MD, of the St. Vincent's Hospital, Sydney, Australia. (medindia.net)
The results indicate that stable CAD patients probably benefit from year-round regular dynamic exercise, but the cardiovascular responses following static exercise in the cold should be examined further. (oulu.fi)
The meta-analysis used statistical methods to combine results from four individual studies with a total of 5,789 Caucasian patients with moderate to severe COPD. (ashg.org)
Conclusion: These results provide further evidence of physiological activation and emotional responding in MMP patients that differentiates them from matched pain-free controls. (quintpub.com)
These results may be of use in determining the face validity of scales from a crosscultural patients' perspective. (lu.se)

The main outcome measure was long-term treatment outcome after IVBIs in patients with CSC. (plos.org)
In the presentation today, Dr. Hardin reported the top SNPs that thus far have been associated with each BDR outcome, but emphasized that additional analysis may reveal other SNPs with equally or greater influence on COPD patients' response. (ashg.org)
The primary outcome was the proportion of patients achieving an American College of Rheumatology 50% response (ACR50) at week 16 (all tabalumab-treated patients vs placebo). (bmj.com)
Patients were approached via Harmonising Outcome Measures for Eczema (HOME) collaborators and selfselected to take part in the on-line survey. (lu.se)
The major determinant of the outcome of treatment is patient adherence to the drug regimen. (cdc.gov)

What I find alarming is that, late in the article, one health system is working with the biggest electronic records provider, Epic, has developed a chatbot to draft responses that will then supposedly be reviewed by the provider. (nakedcapitalism.com)

Dr. O'Brien added, "Achieving CR raises the possibility of treatment discontinuation for patients. (medscape.com)

Cardiac and renal responses were observed in 44.3 and 53.1% of patients , respectively. (bvsalud.org)

After chemotherapy treatment and disease remission, patients traditionally undergo a stem cell transplant to reduce the chance of disease recurrence. (mdanderson.org)

More accurate and easier to implement than current methods, the technology has the potential to improve the effectiveness of immunotherapy and spare patients toxicity and debilitating side effects. (timesofisrael.com)
Molecular imaging modalities such as Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT have emerged in the recent years as useful methods in the initial staging and treatment planning of patients affected by MM. (hindawi.com)

It is known, that both cold exposure and moderate sustained exercise separately increase cardiac workload, but their combined effects on cardiovascular responses are not well known. (oulu.fi)

Responders and non-responders were compared in terms of demographics, disease characteristics and severity, and previous response to migraine prophylactic treatments. (iasp-pain.org)
Aims: To investigate (1) differences in heart rate variability (HRV) indices between masticatory muscle pain (MMP) patients and pain-free controls at rest, during a stressor condition, and during a post-stressor recovery period, and (2) factors including psychological distress, social environment, and family-of-origin characteristics in the MMP sample compared to a pain-free matched control sample. (quintpub.com)

1 Patients with EMD who received the RP2R achieved an 85.7 percent (6/7) ORR, and median duration of response was not reached at a median follow-up of 7.2 months (range, 0.7-14.2). (jnj.com)

Still, experts caution that chatbots cannot replace the human relationship and caregiving that is a vital part of the healthcare process - patients may feel more comfortable receiving medical advice from a chatbot, but for many patients, the human touch is an important aspect of care. (ubergizmo.com)
A human doctor is able to adjust their language, manner, and approach in response to social cues and interactions, whereas a chatbot will produce more generic language without awareness of social contexts. (ubergizmo.com)

This EACR conference will focus on the most recent studies that have uncovered novel molecular pathways involved in response anticancer therapy. (eortc.org)
In addition, because it uses the memory and adaptability of the immune system, patients who have benefited from its therapeutic effects experience sustained anticancer effects. (medicalxpress.com)
The team further proved that the treatment response prediction based on the newly discovered biomarkers was superior to that based on conventional anticancer treatment biomarkers including immunotherapy targets and tumor microenvironment markers. (medicalxpress.com)

These data suggest that a gene signature of IL-17 airway epithelial response distinguishes a biologically, radiographically, and clinically distinct COPD subgroup that may benefit from personalized therapy. (nih.gov)

Patient safety means providing ready, reliable care to service members, veterans, and dependents no matter the circumstances. (health.mil)
The theme for this year's Patient Safety Awareness Week, March 13-19, is "Standardizing Safety Solutions: Uniting for Ready, Reliable Care. (health.mil)
The MHS adopted HRO concepts to improve health care access, quality, transparency, and patient engagement. (health.mil)
Patient safety is paramount in all aspects of health care delivery. (health.mil)
A better understanding of the relationship between anti-CCP antibodies and treatment response has the potential to advance patient care,' said Dr Leslie R. Harrold of the University of Massachusetts, Worcester, MA, US and Corrona, LLC Southborough, MA, US. (news-medical.net)
Helps reduce duplication leaving more time for direct patient care. (ascom.com)
Centralised creation, management and tracking of tasks, staff workflow improvements and monitoring help improve patient experiences and supports patient-centered care. (ascom.com)
Watch Telligence at work in the real world of everyday patient care-and see how it represents a true evolution beyond conventional nurse call systems. (ascom.com)
Our personalized portal helps you refer your patients and communicate with their MD Anderson care team. (mdanderson.org)
But on Sunday, in response to a request from the Federal Emergency Management Agency, VA agreed to make available 50 beds (35 acute care and 15 intensive care unit) to "non-veteran, non-COVID patients to help assist New York City in its response efforts. (militarytimes.com)
Checklists have been implemented in a variety of specialties and settings to improve safe patient care. (ahrq.gov)
Most (n = 1177) patients initiated rituximab, 193 received belimumab, and 231 received standard of care. (consultantlive.com)
6 April 2017 - The WHO emergency response team and Ministry of Health officials visited cholera patients at the Banadir Hospital cholera treatment centre in Mogadishu to review care activities, available services and assess support needs. (who.int)
ORRP helps address care continuity and risk reduction for patients by alerting state health agencies about law enforcement events that might disrupt patients' access to care and supporting state and local capacity building to prepare for and respond to disruptions in care. (cdc.gov)
ORRP helps ensure all agencies act quickly so patients can get the care they need. (cdc.gov)
CDC does not participate in active law enforcement investigations taken by federal or state agencies, nor does CDC deploy health professionals to states in response to disruptions in patient care. (cdc.gov)
How many patients do you currently take care of at the reporting location? (cdc.gov)
The aim of both the HITECH Act and the ACA is to enhance efficiency and to improve quality in the health care system, including increasing the adoption rate of electronic health records, expanding access to care, and improving patient health. (cdc.gov)
Emergency admission rooms, intensive care units and operating theatres have been under enormous pressure, particularly at the Shifa Hospital, which has received the most severely injured patients. (who.int)
Its intensive-care unit is operating at full capacity, with patients admitted as fast as they can be moved out. (who.int)
The information comes from MedlinePlus , an authoritative up-to-date health information resource for patients, families and health care providers, and the websites of other NIH Institutes. (medlineplus.gov)
Since MedlinePlus Connect helps EHRs identify patient-specific education resources, MedlinePlus Connect may assist eligible health care providers in meeting the patient-specific education resources criteria for meaningful use of certified EHR technology. (medlineplus.gov)

Patients who reach a moderate or low disease activity status after 3-6 months of therapy may require switching to alternative therapies. (nih.gov)
A panel of speakers involved in cutting-edge studies on the biological and cellular bases for therapeutic response in cancer will share their vision on how these disruptive discoveries could be exploited to rethink cancer therapies to ultimately improve therapeutics. (eortc.org)

Anxiety is often observed in dental procedures and may cause promote alteration in the physiological responses during implant surgeries. (bvsalud.org)

Outcomes13

Clinical19

Immunotherapy Response1

Refractory6

Coronavirus4

Antibody responses3

Rheumatoid arthritis2

Correlates with response1

Tumor antigen1

Inhibitors12

Chronic12

Researchers14

20211

Evaluable for response1

Investigators3

Newly diagnosed1

Significantly8

Underwent5

Metastatic3

Readiness and Response1

Physicians5

Patient's response1

Baseline9

Logistic regression2

Cohort7

Median age1

Pandemic6

NSCLC4

Predict7

20201

Study34

Survival8

Findings4

Significant differences2

Multiple myeloma1

Pediatric patients1

Tumors4

Lung cancer patients1

Humoral1

Clinicians3

Different responses1

Hospitals3

20231

Centers1

Results6

Outcome5

Draft responses1

Treatment Discontinuation1

Renal1

Chemotherapy1

Methods2

Cardiac1

Characteristics2

85.71

Chatbot2

Anticancer3

Biologically1

Care22

Therapies2

Physiological1