Responses lymphocyte transfusion. Medical search. Frequent questions

Natural killer (NK) cells and predominantly CD8+ cytotoxic T cells control proliferating B lymphocytes infected with EBV. (medscape.com)
Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
HLH is a rare disease, characterized by impaired function of natural killer and cytotoxic T-lymphocytes that results in an unchecked inflammatory response. (cdc.gov)
Tremelimumab is an antibody that blocks Cytotoxic T lymphocyte antigen4. (mesotheliomahelp.org)
Cytotoxic lymphocyte production follows the rise of HIV in the blood. (arizona.edu)
When a donor organ expresses MHC molecules that are different from the recipient, the latter will often mount a cytotoxic T cell response to the organ and reject it. (openstax.org)
Hemophagocytic syndrome (HPS) is a potentially fatal condition due to dysregulated lymphocyte activation and proliferation, mainly characterised by impaired or inactive natural killer (NK) cells and cytotoxic T cells, which leads to macrophage hyperactivation and over-expression of cytokines [ 1 ]. (biomedcentral.com)
This results in cross-linking of T-cells and myeloma cells and induces a potent cytotoxic T-lymphocyte response against BCMA-expressing cells. (medscape.com)

Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
Vaccination strategies eliciting CTL responses specific for tumor-specific and self-antigens have shown promising results in recent clinical trials. (lifeboat.com)
T cells are central to the process of transplant rejection through allorecognition of foreign antigens leading to their activation, and the orchestration of an effector response that results in organ damage. (lu.se)
In contrast, autoimmunity is an immune response to the self's own antigens. (stockingisthenewplanking.com)
Autoimmune disease occurs when a specific adaptive immune response is mounted against self antigens. (stockingisthenewplanking.com)
Alloimmunization refers to an immune response to foreign antigens from another human, most commonly occurring after pregnancy or blood transfusions. (stockingisthenewplanking.com)
In these cases, foreign cells that contain specific antigens, or proteins on the cell surface that can generate an immune response, are present in the body. (stockingisthenewplanking.com)
T lymphocytes are responsible for cell-mediated immunity , so named because the T cells themselves latch onto the antigens of the invader and then initiate reactions that lead to the destruction of the nonself matter. (britannica.com)
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
The antibodies specifically bind to the antigens that induced the immune response. (cdc.gov)
The disease can also affect a person who receives a blood transfusion from a close relative who is homozygous for certain human leukocyte antigens (HLA). (biologydictionary.net)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
ABO grouping is based on presence or absence of two surface antigens RBC, antigen A and antigen B. The plasma of an individual also contains two antibodies produced in response of antigens. (ncertbooksolutions.com)
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)

Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
Irradiated blood is used to prevent transfusion-associated graft-versus host disease (TA-GvHD) in people who received bone marrow transplants or transfusions of blood components. (biologydictionary.net)

Five patients had progressive disease, two patients had stable disease, and one patient experienced a partial response after receiving donor lymphocyte infusions and IFN-α. (aacrjournals.org)
Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare, usually fatal, complication of blood transfusion wherein donor lymphocytes in a transfused blood component mount an immunodestructive response against recipient tissues. (sitaralabels.com)
During blood transfusion, blood of donor has to be matched with blood of recipients to avoid clumping of RBCs. (ncertbooksolutions.com)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (bvsalud.org)

B lymphocytes make antibodies, which are proteins that specifically target bacteria, viruses, and other foreign materials. (com.ng)
If the same parent has a second Rh-positive child, IgG antibodies against Rh-positive blood mounted during this secondary response cross the placenta and attack the fetal blood, causing anemia. (openstax.org)
The treatment for this disease is to give the carrier anti-Rh antibodies (RhoGAM) during the first pregnancy to destroy Rh-positive fetal red blood cells from entering their system and causing the anti-Rh antibody response in the first place. (openstax.org)

It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)

Supportive care included transfusion of packed red blood cells, platelets, cryoprecipitate, and fresh frozen plasma. (cdc.gov)
Between 4 and 30 days after transfusion, the resulting cascading immune response causes fever, rash, diarrhea, hepatitis, and reduced levels of red blood cells, white blood cells, and platelets (pancytopenia). (biologydictionary.net)

Alloimmune (isoimmune) response results in graft rejection, which is manifested as deterioration or complete loss of graft function. (stockingisthenewplanking.com)
Unless the T-lymphocytes are destroyed, they will graft themselves in the recipient's tissues. (biologydictionary.net)
Transfusion-Associated Graft Versus Host Disease. (biologydictionary.net)
CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)

HIV specifically infects and reduces the number of CD4+ subsets of T lymphocytes. (bdbiosciences.com)
We provide instrument options for complete CD4 testing, and assays, tubes and reagents for determining percentage and absolute counts of human lymphocyte subsets in peripheral whole blood. (bdbiosciences.com)

The humoral immune response directed against EBV structural proteins is the basis for the test used to diagnose EBV infectious mononucleosis, but the T-lymphocyte cellular response is critical in determining the clinical expression of EBV infection. (medscape.com)
Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)
BD Biosciences offers robust clinical solutions for assessment of lymphocyte populations in persons living with HIV. (bdbiosciences.com)
Achieving hematologic complete response is an important treatment goal, and today's approval based on this clinical endpoint will provide doctors and the larger medical community with a new option to treat newly diagnosed patients. (biospace.com)

10. Lymphocytes make and release antibody molecules and protect us against the formation of cancer cells. (studylib.net)
During the birth of a first Rh-positive child, the birth parent makes a primary anti-Rh antibody response to the fetal blood cells that enter the pregnant person's bloodstream. (openstax.org)

Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
Interestingly, vaccination-induced Trm cell responses strongly suppressed the growth of B16F10 melanoma, independently of circulating memory CD8 + T cells, and were able to infiltrate tumors. (lifeboat.com)
T lymphocytes help regulate the function of other immune cells and directly attack various infected cells and tumors. (com.ng)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
The major efficacy outcome measure was radiographic progression-free survival per Response Evaluation Criteria in Solid Tumors version 1.1 for soft tissue and Prostate Cancer Working Group 3 criteria for bone, assessed by blinded independent central review. (ascopost.com)

Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)

Transfusion of neutrophils is generally not effective since they do not remain in the body for very long. (com.ng)

His research is focused on the mechanisms that regulate the immunological response of T lymphocytes, especially strategies to manipulate those responses in clinically relevant areas, including autoimmunity, allergies, vaccinations, and tumor therapy. (euroacadti.eu)

Ineffective T-cell response may cause excessive and uncontrolled B-cell proliferation, resulting in B-lymphocyte malignancies (eg, B-cell lymphomas). (medscape.com)
Lymphocytosis observed in the reticuloendothelial system (RES) is caused by a proliferation of EBV-infected B lymphocytes and similar proliferation in the lymphatic tissue of the oropharynx causes pharyngitis. (medscape.com)

Epstein-Barr virus infection of B lymphocytes results in a humoral and cellular response to the virus. (medscape.com)
The immune response to EBV infection is fever, which occurs because of cytokine release consequent to B-lymphocyte invasion by EBV. (medscape.com)
Initial treatment of HLH involves the use of corticosteroids, etoposide, or other drugs to block the hyperinflammatory response and specific therapy for the inciting infection if available ( 7 ). (cdc.gov)
If your doctor determines that your lymphocyte count is high, the test result might be evidence of one of the following conditions: Infection (bacterial, viral, other) Cancer of the blood or lymphatic system. (stockingisthenewplanking.com)
11. Phagocytosis is the production of white blood cells in response to an infection. (studylib.net)
In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
Rarely, infection by tachyzoites occurs from ingestion of unpasteurized milk or by direct entry into the bloodstream through a blood transfusion or laboratory accident. (medscape.com)
An immune response against virus causes some protection but a chronic persistent infection is established. (arizona.edu)

In an effort to understand the variable severity of the disease amongst dogs, the team will study the role and types of lymphocytes present in Ehrlichia-positive dogs to determine if increased lymphocyte counts and a large number of genetically identical lymphocytes are associated with disease severity. (akcchf.org)
Current HAART use was independently associated with low risk of in-hospital mortality (OR 0.33), while central nervous system symptoms (OR 4.12), sepsis (OR 6.98) and low total lymphocyte counts (OR 3.60) were associated with increased risk. (who.int)

A count significantly higher than 3,000 lymphocytes in a microliter of blood is generally considered to be lymphocytosis in adults. (stockingisthenewplanking.com)
This episode paralleled with a massive CD8 T- lymphocyte expansion (CD3-663, CD4 106, CD8-568 cells/microliter) following granulocyte infusions, which peaked at day +10 post HSCT. (ebmt.org)

Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)

A scanning electron micrograph of a human T lymphocyte (or T cell) from the immune system of a healthy person. (britannica.com)
The key cells of the immune system are the white blood cells known as lymphocytes. (britannica.com)
The risk of developing TA-GvHD is small, but patients who should take the precaution of using irradiated blood include those with a weakened immune system due to Hodgkin's disease, people who have taken certain chemotherapy drugs, unborn babies, and babies who need exchange transfusions. (biologydictionary.net)
If the person's own immune system is incapable of mounting an immune response to them, the T-lymphocytes get the upper hand and attack the recipient's body as if it were a foreign invader. (biologydictionary.net)
Even though it has not been able to cure the cancer, it can enhance the immune system response to mesothelioma cancer. (mesotheliomahelp.org)
CTLA4 is a protein found on the cells of the immune system, which may prevent immune cells from attacking cancer cells by slowing the immune response, allowing the cancer to grow and spread. (mesotheliomahelp.org)
Tremelimumab blocks the lymphocyte CTLA4 from slowing the immune system which enhances the immune response against mesothelioma (MSKCC, 2014). (mesotheliomahelp.org)

This process occurs in lymph nodes and regulates immune responses. (arizona.edu)

However, more patients achieved transfusion independence with momelotinib than with ruxolitinib, and objective laboratory measures of anemia (eg, hemoglobin, serum iron, transferrin saturation) also favored momelotinib. (medscape.com)

The production of cytokines and cell divisions that regulate the immune response for protection also cause HIV replication. (arizona.edu)

T lymphocytes ( T cells ) and B lymphocytes ( B cells ). (britannica.com)
Twenty-six patients were infused with CART cells (median 81 days after leukapheresis) and were analyzed for the overall response (OR) 3 months later. (frontiersin.org)
Low frequency of differentiated CD3 + CD27 - CD28 - T cells at leukapheresis represents a novel pre-infusion blood biomarker predicting a favorable response to CART cell treatment in r/r DLBCL patients. (frontiersin.org)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
The effects of UC-MSCs on the responses of fibroblast-like synoviocytes (FLSs) and T cells in RA patients were explored. (biomedcentral.com)
His research has been focusing on the characterization of the natural immune responses towards malignant cells. (euroacadti.eu)
Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (merckmanuals.com)
One approach is to remove the immune cells from the patient's blood and treat them in a lab to get them to react to tumor cells, the immune cells are then given back to the patients as blood transfusion, where it is hoped they will cause the body's immune cell system to attack the cancer (American Cancer Society, 2014). (mesotheliomahelp.org)
The viruses attach to and enter T lymphocytes that bear the CD4 protein (T helper cells) on their surfaces. (crisaafrica.org)
The immune response is weakened as memory T cells (CD4 + CCR5 + ) are destroyed. (arizona.edu)
There is a rapid turnover of CD4+ T cells that ultimately leads to their destruction and to a change in lymphoid tissues that prevent immune responses. (arizona.edu)
The immune responses to transplanted organs and to cancer cells are both important medical issues. (openstax.org)
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. (ox.ac.uk)
Genetic HPS is heterogeneous and arises from defects in the critical regulatory pathways responsible for the natural termination of immune responses that lead to the failure of the homeostatic removal of cells that are superfluous or dangerous to the host. (biomedcentral.com)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)

The irradiation process kills the donor's T-lymphocytes which are the main cause of TA-GvHD. (biologydictionary.net)

Allergic reactions The most common complications of transfusion are Febrile nonhemolytic reactions Chill-rigor reactions The most serious complications, which have very high mortality rates, are Acute hemolytic. (merckmanuals.com)
Because fever and chills also herald a severe hemolytic transfusion reaction, all febrile reactions must be investigated as for acute hemolytic transfusion reaction, as with any transfusion reaction. (merckmanuals.com)

About 20 people die yearly in the US as a result of acute hemolytic transfusion reaction. (merckmanuals.com)
ABO incompatibility is the most common cause of acute hemolytic transfusion reaction. (merckmanuals.com)
Figure 21.30 Erythroblastosis Fetalis Erythroblastosis fetalis (hemolytic disease of the newborn) is the result of an immune response in an Rh-negative person who has multiple children with an Rh-positive person. (openstax.org)

Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocytes. (nebraska.edu)

On rare occasion, EBV is spread via blood transfusion and organ transplantation. (medscape.com)
Definition of Autoimmune Disease Autoimmune diseases develop when the auto-reactive B lymphocytes (autoantibodies) and T lymphocytes described above cause a pathological and/or functional damage to the organ/tissue containing the target autoantigen(s). (stockingisthenewplanking.com)
Autoimmune disease occurs when the body's immune response mistakenly targets an individual's tissue, eventually leading to organ destruction or dysfunction [1,2]. (stockingisthenewplanking.com)
Histologically, if a biopsy of a transplanted organ exhibits massive infiltration of T lymphocytes within the first weeks after transplant, it is a sign that the transplant is likely to fail. (openstax.org)

Active hemorrhage resulting in shock is one of the few evidence-based established indications for transfusion. (medscape.com)

Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)

Recommendations based on radiation dose and physiologic response are made for treatment of the hematopoietic syndrome. (nebraska.edu)

Tissue transplantation is more complicated than blood transfusions because of two characteristics of MHC molecules. (openstax.org)

Researchers have discovered a direct correlation between penetrating lymphocytes and mesothelioma prognosis, indicating that enhanced immune response may improve patient outcome (Selby, 2014). (mesotheliomahelp.org)

She was a professor of transfusion medicine at the University of Cincinnati, and contributed to research articles in academic journals including The New England Journal of Medicine, Lupus, Nephron, Transfusion, Immunological Investigations, Journal of Surgical Research, and Human Immunology. (wikipedia.org)
She also contributed to a textbook, Transfusion Immunology and Medicine (1995). (wikipedia.org)
Transfusion Immunology and Medicine. (wikipedia.org)

This work highlights the therapeutic potential of vaccination-induced Trm cell responses to achieve potent protection against skin malignancies. (lifeboat.com)

Mary Anna Thrall, DVM, MS of Ross University School of Veterinary Medicine and her team will investigate "The Role of Lymphocytes in Canine Monocytic Ehrlichiosis (CME) ," an important tick-borne disease in dogs caused by the pathogen, Ehrlichia canis. (akcchf.org)
As far as medicine is concerned, the immune response in this scenario does the patient no good at all and causes significant harm. (openstax.org)

The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. (ox.ac.uk)

Early recognition of symptoms suggestive of a transfusion reaction and prompt reporting to the blood bank are essential. (merckmanuals.com)

The rationale behind this approach was to restrain the inflammatory response Tmem33 by IL-6 blockade and to provide neutralizing COVID-19 immunoglobulins by convalescent Apremilast (CC 10004) plasma. (engineering-gdfsuez.com)

This is a consequence of the fact that the fetus is not genetically identical to the birth parent, and thus the parent is capable of mounting an immune response against it. (openstax.org)

High mutation rates of HIV also allow virus to escape adaptive immune responses. (arizona.edu)
Adenosine deaminase deficiency with mosaicism for a "second-site suppressor" of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy. (lu.se)

To reduce morbidity and mortality as a result of uncontrolled hemorrhage, patients needing a massive transfusion, specifically addressed in detail later in this chapter, must be quickly identified so that immediate interventions can prevent the development of the lethal triad of coagulopathy, hypothermia, and acidosis. (medscape.com)
[ 1 ] Massive transfusion protocols (MTPs) should be institutionally monitored by a blood utilization committee that can track initiation, cessation, component wastage, storage of blood products outside of the blood bank, transport standards, and compliance with applicable Food and Drug Administration (FDA) standards. (medscape.com)

Memory CD8 + T cell responses have the potential to mediate long-lasting protection against cancers. (lifeboat.com)

The minimum radiation dose to kill the T-lymphocytes of 25 Gy10. (biologydictionary.net)

Autoreactive T-lymphocytes behave just like "normal" ones, namely, they recognize antigenic peptides presented to them in the context of a host's antigen presenting HLA molecule and become activated if the appropriate signals are provided. (stockingisthenewplanking.com)

Are lymphocytes elevated in autoimmune disease? (stockingisthenewplanking.com)
A Single Cell Approach Reveals Immune Cell Dynamics in Inflammatory Bowel Disease (IBD) and Highlights Association of CD8 Intraepithelial Lymphocytes (IELs) With Response to Vedolizumab Treatment. (upenn.edu)

If any of these symptoms (other than localized urticaria and itching) occur, the transfusion should be stopped immediately and the IV line kept open with normal saline. (merckmanuals.com)

Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)
The most common type of white blood cell is the neutrophil, which is the "immediate response" cell and accounts for 55 to 70 percent of the total white blood cell count. (com.ng)
The other major type of white blood cell is a lymphocyte. (com.ng)

Allogenic transplantation activates the immune response, which leads to transplant rejection. (actanaturae.ru)
With the use of tissue typing and anti-rejection drugs, transplantation of organs and the control of the anti-transplant immune response have made huge strides in the past 50 years. (openstax.org)

Which type of immune response is an autoimmune disorder? (stockingisthenewplanking.com)
Autoimmune diseases, such as ankylosing spondylitis, are caused by dysfunction in immune responses. (bdbiosciences.com)

The earliest known blood transfusions occurred in 1665, and the first human blood transfusion was performed by Dr. Philip Syng Physick in 1795. (medscape.com)
The first transfusion of human blood for the treatment of hemorrhage was performed by Dr. James Blundell in London in 1818. (medscape.com)

Anatomy1

Diseases1

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena1

Humanities2

Information Science1

Named Groups1

Health Care4

Cytotoxic8

Antigens16

Bone marrow3

Donor5

Antibodies3

Immunosuppressive Agents1

Platelets2

Graft4

Subsets2

Clinical4

Antibody2

Tumors5

Platelet1

Neutrophils1

Immunological Response1

Proliferation2

Infection8

Counts2

Microliter2

Populations1

Immune system7

Lymph nodes1

Hemoglobin1

Regulate1

Cells15

Allogeneic2

Irradiation1

Reactions2

Hemolytic3

Peripheral1

Organ4

Indications1

Cytokine1

Hematopoietic1

Molecules1

Prognosis1

Immunology3

Potent1

Medicine2

Contribution1

Reaction1

Inflammatory response1

Mounting an immune response1

Mutation2

Massive2

Cancers1

Radiation dose1

Recognize1

Disease2

Symptoms1

White bloo3

Transplantation2

Autoimmune2

Human2