Cell ProliferationHEK293 CellsCell DivisionCells, CulturedSignal TransductionCell Line, TumorApoptosisCell CycleCell DifferentiationCell LineBromodeoxyuridineRNA, MessengerCell SurvivalCell MovementBlotting, WesternImmunohistochemistryPhosphorylationProliferating Cell Nuclear AntigenLymphocyte ActivationMice, Inbred C57BLReverse Transcriptase Polymerase Chain ReactionTransfectionKi-67 AntigenRNA, Small InterferingTumor Cells, CulturedGene Expression Regulation, NeoplasticDown-RegulationCell Growth ProcessesGene Expression RegulationDose-Response Relationship, DrugEpithelial CellsMice, KnockoutFlow CytometryT-LymphocytesGene ExpressionCyclin D1Time FactorsStem CellsUp-RegulationMolecular Sequence DataMice, NudeRNA InterferenceThymidineMice, TransgenicFibroblastsTranscription FactorsProto-Oncogene Proteins c-aktMuscle, Smooth, VascularCell CountCyclin-Dependent Kinase Inhibitor p27Enzyme ActivationMice, Inbred BALB CCell Transformation, NeoplasticEnzyme InhibitorsDNACell Cycle ProteinsHyperplasiaExtracellular Signal-Regulated MAP KinasesRats, Sprague-DawleyGene Knockdown TechniquesBase SequenceDNA-Binding ProteinsMutationGrowth InhibitorsMyocytes, Smooth MuscleProto-Oncogene ProteinsProtein-Serine-Threonine KinasesRecombinant ProteinsMitogensProto-Oncogene Proteins c-mycCyclin-Dependent Kinase Inhibitor p21MAP Kinase Signaling SystemAntineoplastic AgentsMitogen-Activated Protein Kinase 3Gene Expression Regulation, DevelopmentalModels, BiologicalPhenotypeG1 PhaseMitogen-Activated Protein Kinase 1Breast NeoplasmsProtein BindingDisease Models, AnimalNuclear ProteinsAmino Acid SequenceCell AdhesionPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorMitogen-Activated Protein KinasesFibroblast Growth Factor 2Growth SubstancesTransforming Growth Factor betaTumor Suppressor ProteinsNeovascularization, PathologicInterleukin-2Tumor Suppressor Protein p53S PhaseGene Expression ProfilingMitosisMitotic IndexNeoplasm Proteins