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  • lymphocyte
  • Pubmed ID: 24375454 The DNA damage response (DDR) alerts the immune system to the danger posed by DNA damage through the induction of damage-associated molecular pattern molecules, chemokines, and ligands for activating immune receptors such as lymphocyte function-associated antigen 1 (LFA-1), NKG2D, and DNAX accessory molecule 1 (DNAM-1). (jove.com)
  • cytokines
  • In patients with tuberculous pleuritis, expression of mRNA for the Th1 cytokines gamma interferon and IL-2 is greater in pleural fluid mononuclear cells than in blood mononuclear cells, and concentrations of gamma interferon are 15-fold higher than those in serum. (asmscience.org)
  • One strategy for developing antituberculosis vaccines is to characterize the T cells and cytokines that mediate clearance of bacilli during the primary immune response as well as the memory T-cell subpopulations and cytokines that protect against tuberculosis from exogenous reinfection and endogenous reactivation. (asmscience.org)
  • T-Cell Responses and Cytokines, p 417-435. (asmscience.org)
  • Furthermore, it was shown that Th17 cells are gradually increased in the tumor microenvironment during tumor development ( 17 ) and that IL-17 up-regulates the production of a variety of proinflammatory cytokines ( 18 ) and proangiogenic factors ( 19 ) to promote tumor development ( 20 ). (jimmunol.org)
  • stimulation
  • We offer a large variety of positive and negative control peptide pools for antigen specific T cell stimulation as well as kit to produce TCR-engineered reference samples for performance control. (jpt.com)
  • Recent studies using SurVaxM, a multi-epitope cryptic peptide, survivin, mimic show specific CD8+ T cell responses, as well as specific CD4+ T cell stimulation. (omicsonline.org)
  • antibody
  • Peptide microarrays that display overlapping peptide scans through antigens from infectious organisms or tumor associated antigens for antibody or serum profiling. (jpt.com)
  • recipients genetically deficient in B cells and with antibody-mediated depletion of host B cells. (neuroart2006.com)
  • N cells are a interesting focus on as Rituximab especially, a humanized monoclonal antibody against human being Compact disc20 utilized to deal with Compact disc20+ lymphomas, greatly depletes nonmalignant N cells (7) and offers been suitable in dealing with individuals with autoimmune diseases (8). (neuroart2006.com)
  • vitro
  • We first determined previously unknown DP4-restricted CD4(+) T-cell epitopes derived from cytomegalovirus pp65, to which sustained Th1-biased recall responses were induced in vitro by using DP4-aAPC. (jpt.com)
  • Disseminated tuberculosis reflects an ineffective immune response, manifested by a high frequency of negative tuberculin skin tests and failure of T lymphocytes to proliferate in vitro in response to M. tuberculosis antigens. (asmscience.org)
  • alloreactive
  • In MHC-mismatched GVHD, receiver APCs possess also been demonstrated to become crucial and their exhaustion by alloreactive NK cells reduces GVHD (3, 4). (neuroart2006.com)
  • The presence of class-switched donor-derived antibodies against miHAs has also correlated with the presence of chronic GVHD, suggesting that alloreactive CD4 cells interact with donor W cells, and it is usually therefore affordable that donor T cells also interact with recipient W cells (11). (neuroart2006.com)
  • mast cells
  • Results from activation of TH2 CD4+ helper T cells by environmental antigens, leading to the production of IgE antibodies, which become attached to mast cells. (brainscape.com)
  • Indeed, the realization that IgE was the "long-sought" reaginic Ab that causes allergic reactions sparked an exciting time of research that also led to the identification of its culprit target cells, mast cells and basophils, which express high-affinity receptors for IgE (FcεRI). (jimmunol.org)
  • lymphocytes
  • Genes for the pattern recognition receptors (PRRs) of the innate immune system have become fixed in the germ line during evolution, unlike the recombinant genes generated in somatic cells, which determine clonotypic recognition by T and B lymphocytes in the acquired immune response. (asmscience.org)
  • The cytotoxic activities of tumor infiltrating lymphocytes and draining lymph node cells against LL/2, and IFN-γ secretion were significantly increased by the therapy with DCs and OK-PSA in wild-type mice but not in TLR4−/− mice. (aacrjournals.org)
  • antibodies
  • One level of immunosuppression for inducing graft acceptance involves antibodies specific for T-cells of the recipient leading to donorspecific tolerance (e.g. by using of anti-CD4 monoclonal antibodies = aCD4mAb). (hu-berlin.de)
  • Activation
  • For example, platelets that con-stitutively express CD40L can interact with CD40 at the cell surface of dendritic cells leading to their activation in a bleeding tissue. (clicktocurecancer.info)
  • None of these existing models provides a convincing mechanism explaining how abacavir induces adverse reactions through the activation of CD8 + cells in a strictly HLA-B*57:01-restricted manner, as was described in a groundbreaking paper by the McCluskey group ( 2 ). (pnas.org)
  • IFNgamma profoundly affects a variety of immune responses, including activation of antigen presenting cells. (hu-berlin.de)
  • cancer
  • In previous cancer vaccine clinical trials targeting survivin, induction of specific CD8(+) T-cell responses did not consistently lead to clinical responses. (jpt.com)
  • In this article, we aimed to elucidate DP4-restricted CD4(+) T-cell responses against survivin in cancer patients. (jpt.com)
  • 13 Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore. (sciencemag.org)
  • The cells of many different forms of cancer express survivin [ 1 ] and in some cases expression is related to tumor grade [ 9 , 10 , 21 ]. (omicsonline.org)
  • Targeting the lactic acid-induced proinflammatory response may be a useful approach for treating cancer. (jimmunol.org)
  • Initially, the immune system protects the host from cancer development and, indeed, the infiltration of NK cells in cancers is associated with a favorable prognosis ( 1 ). (jimmunol.org)
  • survivin
  • Survivin vaccine strategies for the most part have focused upon particular regional epitopes of the molecule that are bound by MHC class I and can lead to a cytotoxic T cell response. (omicsonline.org)
  • destruction
  • Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. (frontiersin.org)
  • Type 1 diabetes (T1D) mellitus is a metabolic disease caused by loss of tolerance to self and consequent autoimmune destruction of insulin-producing pancreatic β-cells ( 1 ). (frontiersin.org)
  • Immunology
  • 5 Department of Gene and Cell Medicine and Institute for Immunology, Icahn Medical Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. (sciencemag.org)
  • disparate
  • In MHC course I (MHCI) and MHC Course II (MHCII) disparate versions of GVHD, add-back of sponsor type N cells to MK-8033 otherwise GVHD-resistant MHCII- or donorhost chimeras did not restore GVHD, whereas splenic dendritic cells partially did so (5). (neuroart2006.com)
  • Moreover, these experiments did not address MK-8033 the role of B cells in an MHC-matched, multiple miHA disparate GVHD model, akin to the majority of human alloSCTs. (neuroart2006.com)