• The interaction of C3a and C5a with their cognate receptors induces pleiotropic effector functions, translating the danger information from the fluid phase into defined cellular responses. (pubmedcentralcanada.ca)
  • Taken together, the structural data now accumulated for anaphylatoxins permit molecular modelling of these proteins, designates favored conformational arrangements of the native structures, and specifically localizes the effector sites. (nih.gov)
  • Support for a causal role for altered anaphylatoxin production in human disease comes from reports of exaggerated complement production in the lungs of asthmatics as well as the association of asthma with polymorphisms in C3/C3aR genes. (springer.com)
  • A number of studies characterized transcriptomics of macrophages following interaction with modified LDL, and revealed alteration of the expression of genes responsible for inflammatory response and cholesterol metabolism. (eurekaselect.com)
  • The emerging paradigm is that C3a production at the airway surface serves as a common pathway for the induction of airway hyperresponsiveness to a variety of asthma triggers (ie, allergens, viral infections, particulate matter, ozone, smoke), whereas C5/C5a plays a dual immunoregulatory role by protecting against Th2-mediated immune responses during initiation of responses and a proinflammatory role once immune responses are established. (springer.com)
  • Furthermore, elements at the essential active site have been defined with such precision that models are proposed detailing the exact nature of ligand interactions between anaphylatoxins and specific cellular receptors. (nih.gov)
  • A variety of responses to anaphylatoxins are known to occur at the cellular level and are mediated in a hormone-like fashion. (nih.gov)
  • The anaphylatoxin protein chains very in length from 74 to 78 residues and no fewer than 30% of the residues are homologous when comparing C3a, C4a, and C5a within or between species. (nih.gov)
  • To date, immunological insufficiency related to hyperglycemia has primarily focused on inhibition of neutrophil responses [ 10 - 12 ]. (hindawi.com)
  • In the present study, we examined the responses to IC activation by combining several FcγR deficiencies with dysfunction of complement, specifically at the level of the C5aR. (jimmunol.org)
  • Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin. (jhu.edu)
  • Here we asked whether C5a generated locally in response to CNV recruits IL-17-producing T-cells to the eye. (arvojournals.org)