Response to genotoxic stress. Medical search. Frequent questions

Oxidative stress, DNA methylation, and telomere length changes in peripheral blood mononuclear cells after pulmonary exposure to metal-rich welding nanoparticles. (cdc.gov)
Also, oxidative stress markers increased at 24 h in the PBMCs recovered from the MMA-SS group compared to other group. (cdc.gov)
Cr, Ni) and soluble (e.g, Cr, Mn) metals in MMA-SS fume, that are different from the GMA-MS fume, may enhance lung toxicity, as well as induce markers of oxidative stress and increase telomere length in PBMCs. (cdc.gov)
SM can activate various cellular and molecular mechanisms related to oxidative stress (OS) and inflammatory responses throughout the reproductive system, which can cause decreased spermatogenesis and impaired sperm quality via damage to tissue function and structure. (nih.gov)
Oxidative stress is crucial to the biology of tumors. (hindawi.com)
nevertheless here, we developed a forecasting model based on oxidative stress to forecast the result of CRC survival and enhance clinical judgment. (hindawi.com)
For the purpose of choosing prognostic genes, the expression of oxidative stress-related genes (OXEGs) was found. (hindawi.com)
The oxidative stress factor plays a significant role in numerous stages of tumor advancement, including the transformation of normal cells into tumor cells, proliferation, tumor angiogenesis, and metastasis [ 5 - 8 ]. (hindawi.com)
The term "tumor of oxidative stress" refers to an improper regulation mechanism of oxidative signaling and oxidative damage of macromolecules caused by an imbalance in the body's oxidation and antioxidation system of mutual limitation [ 9 ]. (hindawi.com)
One of the problems arising from the misfolded Huntingtin is the increase in oxidative stress, which is common in many neurological diseases such as Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis and Creutzfeldt-Jakob disease. (benthamscience.com)
Filip, M. Oxidative stress in neurodegenerative diseases. (benthamscience.com)
Zuo, L. Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications. (benthamscience.com)
Andersen, J.K. Oxidative stress in neurodegeneration: cause or consequence? (benthamscience.com)
Bailey, D.M. 13 reasons why the brain is susceptible to oxidative stress. (benthamscience.com)
Since this mutagenic response was inhibited in the presence of catalase as antioxidant, the authors concluded that oxidative stress in form of the generation and release of ROS and/or depletion of antioxidants may significantly contribute to this response. (ecetoc.org)
Although data were available for eight of the ten KCC, genotoxicity, oxidative stress, inflammation, and cell proliferation/cell death represent the KCCs with the most data. (sweeteners.org)
Human bronchial epithelial cells were exposed to the nine CNT/F (0-24g/ml) to determine cell viability, inflammation, cellular oxidative stress, micronuclei formation, and DNA double-strand breakage. (cdc.gov)
Cellular oxidative stress, DNA double strand breaks, and micronuclei formation consistently clustered together and with larger physical CNT/F dimensions and agglomerate characteristics but were distinct from inflammatory protein changes. (cdc.gov)

Activation of the p53 tumor suppressor upon DNA damage elicits either cell cycle arrest or apoptosis, and the precise mechanism governing cell fate after p53 response has not been well defined. (figshare.com)
This is in agreement with previous regulatory decisions, and is consistent with the lack of tumor response in two-year rodent cancer bioassays. (sweeteners.org)

Although RPS27L mRNA levels were consistently induced after diverse p53 activating signals, its change in protein level was stimuli-dependent: it was up-regulated when cells were arrested in response to DNA-damaging agents Adriamycin or VP16 but was down-regulated when cells underwent apoptosis in response to antimetabolite agent 5-fluorouracil. (figshare.com)
Depletion of RPS27L resulted in deficiency in DNA damage checkpoints, leading to conversion of DNA damage-induced p53 response from cell cycle arrest to apoptosis. (figshare.com)
BRCA1 expression mediates apoptosis, cell cycle arrest and decreased viability in response to doxorubicin treatment. (conicet.gov.ar)

These findings define a novel transcriptional pathway through which BRCA1 orchestrates cell fate decisions in response to genotoxic insults, and suggest that BRCA1 status should be considered for new chemotherapeutic treatment strategies in prostate cancer. (conicet.gov.ar)
In previous studies of recurrently amplified 1q21 genes in myeloma, we identified ILF2 as a modulator of the DNA repair pathway, which promotes adaptive responses to genotoxic stress. (lls.org)
In addition, the p21 mRNA level was elevated in 1,4-BQ-treated cells, suggesting that human CD34(+) cells utilize the p53 pathway in response to 1,4-BQ-induced DNA damage. (rti.org)
These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. (rti.org)
In response to diverse stresses, the canonical NF-κB pathway gets activated primarily to protect the cells and maintain their genomic integrity. (sciencecentral.in)

Following integration across all data, and accounting for study quality and relevance, the totality of the evidence demonstrated an overall lack of genotoxic and carcinogenic activity for steviol glycosides. (sweeteners.org)
The current systematic evaluation of all available evidence from human, animal, and mechanistic data affirms the lack of genotoxic and carcinogenic potential of steviol glycosides. (sweeteners.org)

The unfolded protein response (UPR) is a major mechanism that detects and alleviates protein-folding stresses in the endoplasmic reticulum. (elifesciences.org)
Epithelial cells lining mucosal surfaces of the gastrointestinal and respiratory tracts uniquely express ERN2/IRE1β, a paralogue of the most evolutionarily conserved endoplasmic reticulum stress sensor ERN1/IRE1α. (jci.org)

Although BRCA1 interaction with key proteins involved in DNA repair is well known, its role as a co-regulator in the transcriptional response to DNA damage remains poorly understood. (conicet.gov.ar)
In this study we show that BRCA1 plays a central role in the transcriptional response to genotoxic stress in prostate cancer. (conicet.gov.ar)
Furthermore, we demonstrate that BRCA1 targets GADD153 promoter to increase its transcription in response to DNA damage. (conicet.gov.ar)
Finally, GADD153 depletion significantly abrogates BRCA1 influence on cell cycle progression and cell death in response to doxorubicin treatment. (conicet.gov.ar)

Poly(ADP-Ribose)Polymerase activation and automodification are early responses to genotoxic stress. (preprints.org)

Certain benzene metabolites, including benzoquinone (BQ), are genotoxic and mutagenic. (rti.org)

Sulfur mustard (SM) is a chemical warfare agent which is cytotoxic in nature, and at the molecular level, SM acts as DNA alkylating agent leading to genotoxic and reproductive effects. (nih.gov)
however, it also adversely affects various tissues of the body and ultimately exhibits long-term complications including genotoxic and reproductive effects, even in the next generations. (nih.gov)
The chronic genotoxic and reproductive complications of SM have been observed in the next generation, such as reproductive hormones disturbances, testicular atrophy, deficiency of sperm cells, retarded growth of sperm and male infertility. (nih.gov)
In this review, we aimed to investigate chronic genotoxic and reproductive effects of SM and their molecular mechanisms in the next generations. (nih.gov)

The Predictive Adaptive Response (PAR) hypothesis describes a type of developmental plasticity in which early life cues influence the development of a phenotype that is normally adapted to environmental conditions later in life. (ashdin.com)
Gluckman and colleagues took this a step further by coining the term "predictive adaptive response" (PAR) to describe the mechanism by which organisms anticipate their adult environment and regulate early ontogenetic development accordingly. (ashdin.com)
We argue that environmental variation has led to the evolution of adaptive plasticity of neural and behavioral development in response to developmental support cues, where neural development is stimulated under conditions that support associated costs. (ashdin.com)
When parental care is compromised, offspring grow less and adopt a more resilient stress-responsive strategy, increasing their chances of surviving adversity, similar to existing ideas about the adaptive value of early-life stress programming. (ashdin.com)

especially no inflammatory responses, increased mutation frequencies in the presence of significant pulmonary inflammation and epithelial cell hyperplasia were observed immediately after the exposure period in the mid and high dose groups. (ecetoc.org)

Investigating the role of the histone acetyltransferase CBP in orchestrating cellular response to genotoxic stress involved in breast tumorigenesis and response to chemotherapy. (sharjah.ac.ae)
The histone acetyltransferase Tip60 regulates the apoptotic response to ultraviolet (UV) irradiation. (rupress.org)

In response to endogenous and exogenous insults, malignant cells mostly have an intensive DNA repair capacity that allows them to proliferate and survive. (nature.com)

Similar but distinct recruitment of certain DNA damage response proteins also occurs during infection. (mdpi.com)
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. (thermofisher.com)
Here, we report another member of F-box family proteins, FBXO32, as a potential activator of NF-κB signaling during genotoxic stress and inflammatory response. (sciencecentral.in)
The pivotal presents a number of significant challenges, and these have role played by IgE in allergic responses to proteins, and in aller- been the subject of previous commentaries and reviews (Kimber gic asthma, is well established. (cdc.gov)

Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. (thermofisher.com)
Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. (thermofisher.com)

Maintaining the genomic machinery is not a flawless process: DNA damage, genotoxic stresses, and defects in the repair pathways can all contribute to destabilizing the complex molecular networks keeping the genome intact. (biomedcentral.com)
The E3 ubiquitin ligase RAD18 is well known for the maintenance of genome stability and cell survival through many DNA damage response (DDR) pathways such as translesion DNA synthesis (TLS) and homologous recombination repair (HRR) [ 4 , 5 ]. (nature.com)

The cellular response to DNA damage involves an intricate network of enzymes responsible for sensing, signaling, and repairing damaged DNA, as well as the regulation of cell cycle checkpoints that collectively maintain genomic integrity 2 . (nature.com)

Together our results demonstrate a new mechanism explaining hypoxia-induced resistance involving the alteration of the response to DSB in D283-MED cells, but also highlight the cell type to cell type diversity and the necessity to take into account the differing tumour genetic make-up when considering re-sensitisation therapeutic protocols. (biomedcentral.com)
genotoxic damage, and to enhance resistance to temozolomide (TMZ) in glioma. (climat2050.org)

UV irradiation represents a major challenge to genomic integrity throughout the evolution of terrestrial organisms, resulting in the development of specific mechanisms that govern the cellular response to UV-induced DNA damage. (rupress.org)

Human bone marrow CD34(+) hematopoietic progenitor cells (HPC) were exposed in vitro to 1,4-BQ to assess cytotoxicity, genotoxicity, and DNA damage responses and the molecular mechanisms associated with these events. (rti.org)

Importantly, the measurement of telomere length in cells isolated from peripheral blood may serve as a potential biomarker of response in the assessment of toxicity associated with welding fumes. (cdc.gov)

Here, we employed MPO knockout genotoxic effects [7] possibly associated with carcinogenesis (e.g. (cdc.gov)

Implicit in such an inflammatory/proliferative driven mechanism is the existence of a threshold for such responses, i.e. that particle exposures not eliciting persistent pulmonary inflammation should also not pose a lung tumorigenic hazard. (ecetoc.org)
These findings support the discussed mechanism that inflammatory cell-derived reactive oxidants and increased cell proliferation play a key role in the pathogenesis of rat lung tumours in response to PSP and are consistent with the existence of a threshold (Oberdörster 1996, Greim et al, 2001). (ecetoc.org)

The development of rat lung tumours in response to chronic inhalation of PSP is a well-established phenomenon. (ecetoc.org)

We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)

The intracellular roles of NPM include a wide range of metabolic processes such as ribosome biogenesis, proliferation, cell cycle control, migration, DNA repair, non-programmed cell death, stress sensor ( 3 , 4 ). (frontiersin.org)

The critical tumour suppressor p53 plays a major role in response to DNA damage and, more generally, to genotoxic stress. (portlandpress.com)
It has been previously shown that F-box protein βTRCP1 has limited role in directing the proteasomal degradation of IκBα during stress conditions. (sciencecentral.in)

Our results provide direct evidence for the participation of MPO - one of the key-orchestrators of inflammatory response - in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations. (cdc.gov)

Here we consider the relevance of IgE antibody responses for the development of a chemical respiratory allergy to diisocyanates. (cdc.gov)

Métodos: Se desarrolló una revisión bibliográfica en un margen de tiempo de 100 años, entre 1916 y 2016, con el objetivo de rastrear la evidencia actual validada y la evidencia histórica que aborda los estudios sobre la mitocondria. (researchgate.net)

ERN2 acted by splicing Xbp1 mRNA to expand ER function and prevent ER stress in goblet cells. (jci.org)
T follicular helper (TFH) cells are essential for developing protective Ab responses following vaccination. (bvsalud.org)

In this study, we show that Tip60 is required for the early DNA damage response (DDR) to UV, including the phosphorylation of histone 2AX, c-Jun N-terminal kinases (JNKs), and ataxia telangiectasia-related substrates. (rupress.org)

Olig2 SUMOylation enhances its genetic targeting ability, which in turn occludes p53 recruitment to promoter for DNA-damage responses. (climat2050.org)

The more soluble and chemically complex MMA-SS sample induced a more persistent and greater inflammatory response compared to the other groups. (cdc.gov)

These findings suggest that genotoxic (e.g. (cdc.gov)

The gene, called ATM (ataxia-telangiectasia mutated), is a member of a family of phosphatidylinositol-3-kinase-related genes involved in cell cycle control, intracellular protein transport, and DNA damage response. (medscape.com)

However, most if not all of these particulate materials are not considered to be inherently genotoxic. (ecetoc.org)

Anatomy20

Organisms8

Diseases7

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes74

Disciplines and Occupations1

Information Science3

Health Care4

Oxidative stress18

Tumor2

Apoptosis3

Pathway5

Carcinogenic2

Endoplasmic reticulum2

BRCA14

Poly-ADP ribose1

Mutagenic1

Reproductive4

Adaptive4

Mutation1

Histone acetyltransferase2

Insults1

Proteins4

Cellular stress2

Genome2

Regulation1

Resistance2

Genomic1

Molecular mechanisms1

Biomarker1

Effects1

Mechanism2

Chronic1

Transcriptional1

Repair1

Role2

Vivo1

Relevance1

20161

Cells2

Phosphorylation1

Promoter1

Persistent1

Suggest1

Cell1

Materials1