AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
DenervationMuscle DenervationAutonomic DenervationSympathectomyParasympathectomySympathetic Nervous SystemSympathectomy, ChemicalMuscular AtrophyGanglionectomyMusclesPressoreceptorsNeuromuscular JunctionMuscle, SkeletalVagotomyNerve RegenerationBlood PressureCarotid SinusKidneyVagus NerveCranial Nerve DiseasesReceptors, CholinergicNorepinephrineSciatic Nerve3-IodobenzylguanidineOxidopamineAutonomic Nervous System DiseasesParasympathetic Nervous SystemCarotid BodyReflexDiaphragmNeurons, EfferentRats, Inbred StrainsDogsTime FactorsRats, Sprague-DawleyGlossopharyngeal NerveAdrenergic FibersRats, WistarMotor NeuronsHeart RateHindlimbElectric StimulationHydroxydopaminesHeartMuscle ContractionElectromyographyChemoreceptor CellsMotor EndplateMuscle ProteinsBaroreflexNatriuresisEdrophoniumMuscle Fibers, SkeletalMuscle Fibers, Fast-TwitchTyramineShy-Drager SyndromeTrigeminal NerveDiuresisHyperhidrosisSympatholyticsCatsCapsaicinEphedrineRenal ArterySinus of ValsalvaHypoglossal NerveSodium CyanideAutonomic Fibers, PreganglionicAutonomic Fibers, PostganglionicStellate GanglionPrimary DysautonomiasHypertensionNerve DegenerationPure Autonomic FailureAtrophyMyogeninAxonsGanglia, SympatheticCatecholaminesAcetylcholinePeripheral NervesTongueNeurons, AfferentNerve FibersMuscle DevelopmentNeural ConductionBotulinum ToxinsAcetylcholinesteraseTibial NerveSinoatrial NodeIodobenzenesNerve CrushNerve EndingsCatheter AblationAfferent PathwaysNervous System Physiological PhenomenaTetrodotoxinNictitating MembraneAutonomic Nervous SystemMuscle Fibers, Slow-Twitch
Radiofrequency denervationHypertensionRenal sympatheticSympathetic nerveClinicalSplenicFacet jointChronicNerveCBSETInterventionalEfficacyReductionEndovascularShamExtrajunctionalInnervationPeripheralDeterminantsNervesFindingsStimuliProcedureAffectsReceptorAdultTrialsFunctionalDysfunctionLiverComments and ResponsesBalloonPatientsMusclesStimulusDoseTreatmentDopaminergicPainDynamicsInflammatoryFoundMuscleDevelopmentEnergy
Radiofrequency denervation13
  • Radiofrequency denervation of the facet joints is performed via a well-established method. (iasp-pain.org)
  • Catheter-based radiofrequency denervation of the renal arteries is currently used to treat hypertension in more than 80 countries, largely on the basis of evidence from nonrandomized studies and unblinded randomized trials showing large reductions in blood pressure (BP) after renal denervation. (jwatch.org)
  • Various therapeutic techniques in the treatment of facet-related pain have been described in the literature, including intraarticular lumbar facet joint steroid injections and radiofrequency denervation. (nih.gov)
  • In this study, we compared the effectiveness of intraarticular facet joint steroid injections and radiofrequency denervation. (nih.gov)
  • Our randomized, double-blind, controlled study included patients who received intraarticular steroid infiltrations in the lumbar facet joints (L3/L4-L5/S1) and patients who underwent radiofrequency denervation of L3/L4-L5/S1 segments. (nih.gov)
  • Intraarticular steroid infiltration or radiofrequency denervation appear to be a managing option for chronic function-limiting low back pain of facet origin with favorable short- and midterm results in terms of pain relief and function improvement, but improvements were similar in both groups. (nih.gov)
  • In three randomised trials, treatment of chronic low back pain (CLBP) with radiofrequency denervation resulted in either no improvement or no clinically important improvement in pain, according to a study published by the Journal of the American Medical Association ( JAMA ). (spinalnewsinternational.com)
  • Even though radiofrequency denervation is a commonly-used treatment, high-quality evidence for its effectiveness is lacking. (spinalnewsinternational.com)
  • Participants in the intervention group received radiofrequency denervation as well, which is usually a one-time procedure, but the maximum number of treatments in the trial was three. (spinalnewsinternational.com)
  • The researchers found that two trials assessing radiofrequency denervation for the sacroiliac joints and a combination of the facet joints, sacroiliac joints, or intervertebral disks showed a statistically significant but not clinically important improvement in pain intensity three months after the intervention. (spinalnewsinternational.com)
  • No clinically important or statistically significant differences between the groups were shown in the trial assessing radiofrequency denervation for facet joint pain. (spinalnewsinternational.com)
  • The findings do not support the use of radiofrequency denervation to treat chronic low back pain from these sources," the authors write. (spinalnewsinternational.com)
  • Because the aim of the study was to provide evidence of the added value of radiofrequency denervation in a multidisciplinary setting, as done in daily practice, the study was limited by a lack of both participant and clinician blinding. (spinalnewsinternational.com)
Hypertension16
Renal sympathetic5
  • The latest meta-analysis of sham-controlled randomized trials shows that catheter-based renal sympathetic denervation produces clinically meaningful reductions in blood pressure with acceptable safety, but the strategy is not yet regarded as ready for prime time. (medscape.com)
  • Clinical trials of renal sympathetic denervation have shown signicant reduction in blood pressure, which was associated with a reduction in local renal norepinephrine spillover as well as a reduction of whole body sympathetic activation in resistant hypertensive patients. (icrjournal.com)
  • Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity. (cbset.org)
  • This study aims to evaluate the effects and safety of laparoscopic-based perivascular renal sympathetic nerve denervation (RDN) in a porcine model fed a high-fat diet. (biomedcentral.com)
  • Currently, percutaneous endovascular catheter-based renal sympathetic nerve denervation (RDN) has been regarded as a promising method for the treatment of resistant hypertension [ 3 ]. (biomedcentral.com)
Sympathetic nerve1
Clinical6
  • Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model. (cbset.org)
  • The reviewer diagnosis was compared with the working clinical diagnosis drawn from the medical history, SPECT scan result, long term follow-up and in some cases the known response to dopaminergic medications. (bmj.com)
  • It is likely that a significant proportion of the 4-15% of de novo patients recruited for recent clinical trials with antiparkinsonian drugs who have no evidence of nigrostriatal dopamine denervation on functional imaging (subjects without evidence of dopaminergic deficit (SWEDDs)) have tremulous syndromes other than PD. (bmj.com)
  • This is supported by long term follow-up showing minimal clinical deterioration, no response to dopaminergic therapy and in some cases no evidence on repeat functional imaging of dopamine denervation. (bmj.com)
  • To understand the determinants of successful clinical response to this treatment, we integrated porcine and computational models of intravascular radiofrequency RDN. (cbset.org)
  • The external monitoring indicators of sympathetic denervation are reviewed to facilitate the clinical diagnosis of sympathetic diseases and the results of sympathectomy. (biomedres.info)
Splenic1
  • Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience. (cbset.org)
Facet joint1
  • Radiofrequency facet joint denervation efficiency based on the severity of spondylarthrosis and in osteoporotic vertebral compression fractures. (iasp-pain.org)
Chronic3
  • PURPOSE: Hyperglycemia and abnormal glucose tolerance tests observed in some patients with chronic Chagas' disease suggest the possibility of morphological changes in pancreatic islets and/or denervation. (scielo.br)
  • During chronic denervation, the accumulation of interstitial cells begins within 1 wk and it is maximal by 3 wk. (rupress.org)
  • [5] In those with chronic pain, the pain processing system may malfunction, causing large amounts of pain in response to non-serious events. (wikipedia.org)
Nerve8
  • Denervation is any loss of nerve supply regardless of the cause. (wikipedia.org)
  • Denervation may be the result of nerve injury. (wikipedia.org)
  • In addition to peripheral nerve injury, denervation is used as a medical procedure for various benefits resulting from eliminating nerve supply to a specific area of the body. (wikipedia.org)
  • Its primary, direct indication is a positive response to a nerve block injection (MBB). (iasp-pain.org)
  • Using in situ hybridization, cholinergic denervation was found to cause a significant decrease of basal brain-derived neurotrophic factor messenger RNA levels in the hippocampal formation and piriform cortex, whereas gene expression for nerve growth factor, neurotrophin-3, and TrkB and TrkC was unchanged. (lu.se)
  • This case report aimed to present a successful pericapsular nerve group (PENG) block and FN and AON radiofrequency (RF) denervation method using ultrasonography (USG) imaging in a patient with DMD. (ekja.org)
  • Pressure on or injury to the ulnar nerve may cause denervation and paralysis of the muscles supplied by the nerve. (medscape.com)
  • 9. Subject has had previous radiofrequency ablation (including non-lesional pulsed radiofrequency), balloon compression, gamma knife, or chemical denervation (e.g. glycerol treatments) of a division or branch of the trigeminal nerve being targeted in this study. (who.int)
CBSET1
  • CBSET has developed specialized expertise in the development and application of minimally invasive device-based interventional therapies for renal denervation. (cbset.org)
Interventional2
  • This meta-analysis, to bve presented at Transcatheter Cardiovacular Therapeutics (TCT) 2021, was based on seven blinded trials, all of which associated denervation with a reduction in systolic ambulatory BP, according to Yousif Ahmad, BMBS, PhD , an interventional cardiologist at Yale University, New Haven, Conn. (medscape.com)
  • Atrial septostomy, Potts anastomosis, and pulmonary artery denervation are interventional procedures serving this purpose. (revespcardiol.org)
Efficacy2
  • Although one of these trials, RADIANCE-HTN SOLO associated denervation with efficacy and safety out to 12 months , Ahmad concluded that the mean follow-up of 4.5 months is not sufficient to consider long-term effects. (medscape.com)
  • Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. (cbset.org)
Reduction2
  • The control arm had a significant reduction in blood pressure, and I think at a minimum, that amount should be subtracted from prior reports of the magnitude of blood pressure reduction with renal artery denervation. (jwatch.org)
  • Looking at a higher response threshold, 50% reduction on the VAS scale, there were still substantial improvements in patients who underwent the therapy. (medpagetoday.com)
Endovascular1
Sham1
Extrajunctional2
  • General properties of rat skeletal muscle (extrajunctional membrane and contractile properties) are subjected to tight physiological neural regulation, as indicated by their striking alterations (up- or down-regulation) following denervation. (architalbiol.org)
  • The stronger response to denervation of extrajunctional membrane properties with respect to pure paralysis is best explained by actions of factors released during wallerian degeneration of the transected nerves. (architalbiol.org)
Innervation1
  • As long as the remaining innervation stays anatomically coherent, denervation reduces phasic variations in extracellular DA, but the DA tone is not changed. (jneurosci.org)
Peripheral3
  • Aged animals showed an attenuated entrainment response to noradrenergic stimulation as well as decreased adrenergic receptor mRNA expression in target peripheral organs. (nature.com)
  • 2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
  • In the present study TMT was used to assess the detection of the serum polyclonal IgG responses against NFs, measured by ELISA, as a peripheral marker of neurotoxicity. (cdc.gov)
Determinants1
Nerves1
  • If the nerves lost to denervation are part of the neuronal communication to a specific function in the body then altered or a loss of physiological functioning can occur. (wikipedia.org)
Findings3
  • What do you consider the most likely explanation for the discrepancy between the findings from SYMPLICITY HTN-3 and those from previous studies of renal denervation? (jwatch.org)
  • The inclusion criteria were based first on magnetic resonance imaging findings showing hypertrophy of the facet joints L3/L4-L5/S1 and a positive response to an intraarticular test infiltration of the facet joints L3/L4-L5/S1 with local anesthetics. (nih.gov)
  • We have previously published findings in the anaesthetised in vivo pig, that cisapride and mebeverine when infused IL into the sigmoid colon resulted in a pharmacological dose dependent responses, which was more efficacious and localised than systemic administration of these drugs. (annals.edu.sg)
Stimuli2
  • Entrainment or phase adaptation is an important function of the circadian clock system that allows the adjustment of circadian dynamics in response to external stimuli. (nature.com)
  • When subjected to 40 rapid hippocampal kindling stimulations with 5-min intervals, these animals exhibited increased number of generalized seizures and a higher mean seizure grade in response to the first five stimulations, and required fewer stimuli to develop focal behavioural seizures, as compared to non-lesioned rats. (lu.se)
Procedure4
  • However, renal denervation is used less frequently in recent years due to new evidence suggesting that blood pressure is not significantly reduced after the procedure and there are even recommendations against using the procedure since there has been little proof to show that renal denervation leads to reduced blood pressure. (wikipedia.org)
  • What would be the best CPT code to reflect a vaginal denervation procedure? (augs.org)
  • Per the AUGS Coding Committee, the Ingelman-Sundberg denervation procedure does not have a specific CPT code assigned to capture the work and intensity of the procedure. (augs.org)
  • Based on the information provided the committee's response would be to code 58999, unlisted procedure, female genital system, non-obstetric. (augs.org)
Affects2
  • This phenomenon appears with moderate denervation (50-80%), and affects mainly signaling by high-affinity DA receptors (e.g., high-affinity D 2 - and D 3 -type receptors). (jneurosci.org)
  • Denervation affects the muscle activation process that is brought on by the development and propagation of an action potential and the ensuing release of calcium. (wikipedia.org)
Receptor1
  • The two mechanisms described above appear at stages of denervation where tonic DA levels and tonic receptor occupancy appear normal. (jneurosci.org)
Adult1
  • Inhibition of TAK1 does not attenuate denervation-induced muscle wasting in adult mice. (jci.org)
Trials1
  • The benefit was about the same whether renal denervation was or was not performed on the background of antihypertensive drugs, which was permitted in five of the seven trials. (medscape.com)
Functional2
  • Finally, TAK1 activity is highly upregulated during overload-induced skeletal muscle growth, and inactivation of TAK1 prevents myofiber hypertrophy in response to functional overload. (jci.org)
  • Several models used to study stress-related disorders that produces functional and behavioral responses, involving endogenous substances as modulators or stress markers, and interestingly, the restraint stress (RS) induces the release of oxytocin (OT) into the circulation. (usp.br)
Dysfunction1
  • Denervation can have many harmful side effects such as increased risk of infection and tissue dysfunction. (wikipedia.org)
Liver2
  • 2009). As a critical target organ of insulin, liver pathogenesis in response to PM2.5 is important to consider. (deepdyve.com)
  • Morphometric analysis of the human common hepatic artery (CHA) reveals a rich and accessible target for sympathetic liver denervation. (cbset.org)
Comments and Responses1
  • You must declare any conflicts of interest related to your comments and responses. (medscape.com)
Balloon1
  • 8. Subject has had previous radiofrequency ablation (including non-lesional pulsed radiofrequency), balloon compression, gamma knife, or chemical denervation (e.g. glycerol treatments) of the Gasserian ganglion. (who.int)
Patients2
  • 24 of 29 patients in the steroid injection group and 26 of 27 patients in the denervation group completed the 6-month follow-up. (nih.gov)
  • Elderly patients who lack sural sensory responses can still be diagnosed with small fiber neuropathy. (medscape.com)
Muscles1
  • Characteristics of the response at the junctional sites of frog muscles are as follows. (rupress.org)
Stimulus1
  • After obtaining appropriate stimulus responses, 3 ml of 2% lidocaine was administered into the injection site. (ekja.org)
Dose4
  • Pretreatment of the animals with reserpine (3 mcg kg-l, i.p., total dose) did not modify the dose-response curve to 5-HT except for the lowest dose. (erowid.org)
  • Cocaine (10-6 M) induced a significant shift to the left of the dose-response curve to 5-HT but the maximum response was the same as in the control. (erowid.org)
  • IL cisapride produced a dose-dependent response in the dose range 1 × 10 -9 M to 3 × 10 -1 & l-3 × 10 -7 M in the ileum, and 3 × 10 -11 to 3 × 10 -9 M in the colonic segments, IL cisapride was significantly more effective than IA delivery of equivalent doses. (annals.edu.sg)
  • IL instilled mebeverine (1 × 10 -6 M) inhibited the carbachol dose response of the ileal and colonic segments more than an equivalent dose of mebeverine infused IA. (annals.edu.sg)
Treatment1
  • Considering that most treatment options are insufficient at managing the hip pain caused by severe joint deformity and contractures, an increasing importance has been placed on denervation methods for the hip joint [ 1 ]. (ekja.org)
Dopaminergic1
  • This decrease in density of dendritic spines is assumed to be a response to the loss of the dopaminergic input to the spines. (jneurosci.org)
Pain1
  • Following an acute polio infection diagnosis symptoms such as fatiguability, general weakness and pain are believed to be correlated to muscle denervation. (wikipedia.org)
Dynamics1
  • However, when denervation reaches 50%, a mismatch between time scales of DA dynamics and bursts and pauses in firing patterns arises ( Grace and Bunney, 1984b ). (jneurosci.org)
Inflammatory1
  • In general, causes of anisocoria that have a mechanical or inflammatory origin tend to produce a sluggish pupillary response to light, unlike Horner syndrome and physiologic anisocoria. (aao.org)
Found2
  • I found that progressive denervation may alter DA signaling by three independent mechanisms depending on degree of denervation and macroscopic morphology of the lesion. (jneurosci.org)
  • Using in situ hybridization, cholinergic denervation was found to cause a significant decrease of basal brain-derived neurotrophic factor messenger RNA levels in the hippocampal formation and piriform. (lu.se)
Muscle4
  • The motor unit areas soon increase to a point where reinnervation is no longer possible causing an uncompensated denervation of motor units which leads to muscle atrophy and loss of muscular strength. (wikipedia.org)
  • In regard to skeletal muscle denervation there are two distinct diagnoses: entrapment and compressive neuropathies or non-entrapment neuropathies. (wikipedia.org)
  • Following denervation, muscular atrophy and degeneration occurs within affected skeletal muscle tissue. (wikipedia.org)
  • The ptosis is due to denervation of the tarsal muscle (Müller muscle) in both the upper and the lower eyelids, producing a noticeably narrower palpebral fissure and the false impression of enophthalmos. (aao.org)
Development1
  • This square wave response usually accompanies the development of sudden "on-off" responses. (bcmj.org)
Energy2