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  • cytotoxic drugs
  • 2 Even as new molecularly targeted therapies emerge, the success of cytotoxic chemotherapy, coupled with the accumulating data of the potential value of integrating molecularly targeted therapies with classic cytotoxic drugs, 3 suggests that the chemotherapeutic drugs and radiotherapeutic modalities utilized today are likely to remain the foundation of therapy for the foreseeable future. (mhmedical.com)
  • They observed that Ewing sarcoma cells cultured in porous 3D electrospun poly(ε-caprolactone) scaffolds not only were more resistant to traditional cytotoxic drugs than were cells in 2D monolayer culture, but also exhibited remarkable differences in the expression pattern of the insulin-like growth factor-1 receptor/mammalian target of rapamycin pathway. (genengnews.com)
  • Knockdown of PKMYT1 lowers the EC 50 of MK-1775 by five-fold but has no effect on the cell-based response to other cytotoxic drugs. (aacrjournals.org)
  • modality
  • In fact, specific Chk1 inhibitors have been developed and are currently in clinical trials as an additional modality in combination with conventional drugs ( 8 ). (aacrjournals.org)
  • antibody
  • The secondary objective is to: determine the effects of priming with a clade 1 vaccine on antibody responses to revaccination with a clade 2 vaccine. (clinicaltrials.gov)
  • The primary objective of this study is to evaluate the relationship between first influenza A virus exposure (inferred by age), vaccine history, and baseline serum antibody and Memory B cell (MBC) specificity, and the magnitude and breadth of the subsequent B cell response to seasonal influenza vaccine in healthy adults and children. (clinicaltrials.gov)
  • The secondary objective is to determine the durability of the antibody response and relationship between acute and durable antibody. (clinicaltrials.gov)
  • refs
  • Advances in imaging are transforming our understanding of angiogenesis and the evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human disease (for reviews, see refs. (aacrjournals.org)
  • Response to genotoxic insults involves sensing of DNA damage by a class of protein kinases, including ATM, ATR, and DNA-PK, followed by activation of Chk1 and Chk2 kinases that cause temporal cell cycle arrest, as well as promote assembly of DNA repair complexes at the damaged sites at chromosomes (see refs. (aacrjournals.org)
  • agents
  • 4 The principle of combining agents with different mechanisms of action, especially those that are synergistic on a mechanistic basis, was thus defined early in the development of successful childhood leukemia therapy, and the combination of MTX and 6MP remains a cornerstone of ALL therapy today. (mhmedical.com)
  • The disease does respond to chemotherapy, both with single agents and combinations of drugs. (healthcentral.com)
  • delivery
  • Microsurgical interventions mimicking local delivery of antiangiogenesis drugs were done by ligating arteries upstream from feeder vessels branching to the prostate. (aacrjournals.org)
  • Chemotherapy is hampered by the diffusion-limited drug delivery to hypoxic regions from distant vasculature. (aacrjournals.org)
  • The application of nanotechnology todrug delivery has already had a significant impact on many areas of medicine and change the scale and methods of drug delivery (12). (ac.ir)
  • Among the different carriers for controlled drug delivery, there has been rising interest in nano-sized self-aggregates composed of natural polysaccharides such as curdlan (16), dextran (17), alginate (18) and chitosan (19). (ac.ir)
  • potential
  • In response to the steadily increasing number of reports of human infection with avian influenza A (H5N1) viruses, there is now a world-wide effort to develop and test potential candidate vaccines for this and other avian viruses with pandemic potential. (clinicaltrials.gov)
  • Doctors take potential damage to normal cells into account when planning a course of radiation therapy. (cancer.gov)
  • To begin addressing potential response markers for MK-1775 monotherapy, we focused on PKMYT1, a kinase functionally related to WEE1. (aacrjournals.org)
  • Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug. (hindawi.com)
  • study
  • The study will be designed as a prospective surveillance of the immune response to seasonal influenza vaccination in 240 healthy children and adults ages 9 and over. (clinicaltrials.gov)
  • The primary hypothesis being tested in this study is that there will be differences in the specificity and magnitude of the HA-specific B cell response depending on the age, previous vaccine history and baseline B cell reactivity. (clinicaltrials.gov)
  • Various
  • Various different therapies have been tried over the years in the hope of preventing these Taxol induced neuropathies including NSAIDs and steroids, which did not help. (denvernaturopathic.com)
  • damage
  • ATR is a highly versatile player in the DNA damage response (DDR) that signals DNA damage via CHK1 phosphorylation to the S and G2/M cell cycle checkpoints and to promote DNA repair. (springer.com)
  • It is activated by ssDNA, principally occurring due to replication stress that is caused by unrepaired endogenous DNA damage or induced by a variety of anticancer chemotherapy and ionizing radiation. (springer.com)
  • dose
  • For many pediatric cancers, administration of each chemotherapy agent at the maximum dose intensity, defined as the amount of drug administered per unit of time (eg, mg/m 2 per week), correlates with an improved outcome. (mhmedical.com)
  • To describe the immune response following a single dose of typhoid Vi polysaccharide vaccine in subjects aged 2 years and above. (clinicaltrials.gov)
  • development
  • Professor Rockwell taught radiation biology, pharmacology, cancer biology, ethics, and career development skills in several Yale courses and lecture series. (yale.edu)
  • Researchers weigh in on the impact of incorrectly labeled cell lines on cancer research and drug development. (genengnews.com)
  • Thus, we need to focus on the development of new drugs having potent anti-cancer effect and lower side effect. (ac.ir)