• Here we describe the comprehensive methodology used previously for the identification and functional characterization of MYC-responsive elements in the integrin α1 subunit (ITGA1) gene using a combination of in silico analysis, site-directed mutagenesis, and chromatin immunoprecipitation. (springer.com)
  • These mutations disrupted two out of five potential vitamin D receptor elements (VDRE) identified in SERPINC1 with different software. (sigmaaldrich.com)
  • The plant hormone auxin regulates plant physiology by modulating the interaction of transcription factors with auxin response elements (AuxREs) of the affected genes. (sciencemag.org)
  • Fluorescent resonance energy transfer analysis of wild-type AR and a transcriptionally compromised mutant at the hormone response element showed that intramolecular interactions between the N and C termini of AR play a key functional role in vivo compared to intermolecular interactions between two neighboring ARs. (pubmedcentralcanada.ca)
  • GRE TGTTCT half-sites may overlap with other DNA-binding sites in composite GREs ( 4 ), and TGTCTC sites may overlap with constitutive elements in composite AuxREs ( 3 ). (sciencemag.org)
  • Hormones such as auxin regulate growth and development of plants by altering expression of early response genes ( 1 ). (sciencemag.org)
  • One can think of these two types of elements as `shift workers' that use very different strategies to regulate the expression patterns of the same genes at different stages of embryonic development. (biologists.org)
  • The 30kb fragment containing the human CRP gene was sequenced and analysed for the presence of elements that may be responsible for the low basal levels of expression of the gene and for sequences that are responsible for the sexually dimorphic pattern of expression of the human CRP gene in transgenic mice. (gla.ac.uk)
  • Remarkably, a simple combination of activator-binding sites and Capicua motifs is sufficient to establish complex patterns of gene expression in response to both Torso and EGFR activation in different tissues. (biologists.org)
  • The network is used to characterize the functional role of microRNA response element (MRE) to mediate interactions between miRNAs targeting the MRE. (hindawi.com)
  • Cadmium could enhance the androgen response when both androgen and cadmium were applied together to the reporter-transfected cells. (cdc.gov)
  • Cells from the donated blood samples will be examined for their response to exposed environmental stress ex vivo. (clinicaltrials.gov)
  • Interaction between the viral protein Rev and the RNA motifs known as Rev response elements (RREs) is required for transport of unspliced and partially spliced human immunodeficiency virus (HIV)-1 and HIV-2 RNAs from the nucleus to the cytoplasm during the later stages of virus replication. (sigmaaldrich.com)
  • Response Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • These studies have shown that PRE/TRE elements have dual potential for the epigenetic maintenance of both activated and silenced states. (biologists.org)
  • Importantly, we have shown that p53 response elements (REs) associated with cell cycle arrest are often exposed on the nucleosomal surface, suggesting a new role of nucleosomes in mediating the p53 binding and subsequent gene induction. (aacrjournals.org)
  • In the first three hours of development, the initiator elements are in control: the output of each homeotic gene depends on the local concentrations of segmentation gene products (these are activators and repressors that are present in different concentrations at different positions of the embryo). (biologists.org)