• Coadministration with other CNS depressants, especially opioids, should be avoided unless no other alternatives are available as coadministration significantly increases the risk for profound sedation, respiratory depression, coma, and death. (pdr.net)
  • Limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation. (pdr.net)
  • Monitor closely for signs of respiratory depression and sedation. (medscape.com)
  • alfentanil and nabilone both increase sedation. (medscape.com)
  • Finally, unlike mu opioids, NOP receptor agonists did not produce reinforcing effects, respiratory depressant, sedation, or itchpruritic side effects, indicating that NOP receptor agonists may be a new generation of novel analgesics without abuse liability. (dtic.mil)
  • In addition, detailed narrative text for each case was reviewed potentiate sedation and respiratory depression, increasing the for information about xylazine use or presence among drug risk for fatal overdose. (cdc.gov)
  • Profiling adverse respiratory events and vomiting when using propofol for emergency department procedural sedation. (tentgallery.in)
  • Loperamide is an opioid that doesn't cross the blood-brain barrier, so it doesn't cause any central effects like analgesia, respiratory depression, or sedation. (greek.doctor)
  • Monitor for hypotension, respiratory depression, and profound sedation. (medscape.com)
  • Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. (drugs.com)
  • Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants: Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. (drugs.com)
  • 4. The policy states that ketamine, propofol, etomidate, and alfentanil can all be safely administered in the ED for procedural sedation and analgesia. (hospitalprocedures.org)
  • Combining nalbuphine with fentanyl ( Duragesic ), alfentanil ( Alfenta ), buprenorphine ( Subutex ), and other opioid medications increases sedation and may cause withdrawal symptoms in narcotic addicts. (hdkino.org)
  • Reduced sedation, losing a useful early warning sign of opioid toxicity and resulting in levels closer to respiratory depressant levels. (anesthesiaexam.com)
  • Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic. (scielo.br)
  • Clinical manifestations from a significant exposure to fentanyl, which include euphoria, sedation, and respiratory depression, are the same as exposure to other opioids such as morphine and heroin. (cdc.gov)
  • Scholars@Duke publication: Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. (duke.edu)
  • This study determined the effects of parecoxib on the pharmacokinetics and pharmacodynamics of the CYP3A substrates fentanyl and alfentanil compared with the CYP3A inhibitor troleandomycin. (duke.edu)
  • RESULTS: There were no significant differences between the placebo and parecoxib treatments in alfentanil or fentanyl plasma concentration, maximum observed plasma concentration, area under the plasma time-concentration time curve, clearance, elimination half-life, or volume of distribution. (duke.edu)
  • However, disposition of alfentanil, and to a lesser extent fentanyl, was significantly altered by troleandomycin. (duke.edu)
  • CONCLUSIONS: Single-dose parecoxib does not alter fentanyl or alfentanil disposition or clinical effects and does not appear to cause significant CYP3A drug interactions. (duke.edu)
  • CYP3A inhibition decreases alfentanil clearance more than fentanyl clearance, confirming that the extraction ratio influences the consequence of altered hepatic drug metabolism. (duke.edu)
  • Trefentanil is most similar to short-acting fentanyl analogues such as alfentanil. (fubinaca.com)
  • Trefentanil has very similar effects to alfentanil, much like those of fentanyl itself but more potent and shorter lasting. (fubinaca.com)
  • Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. (fubinaca.com)
  • The risk of respiratory depression is especially high with potent fentanyl analogues such as alfentanil and trefentanil , and these drugs pose a significant risk of death if used outside of a hospital setting with appropriate artificial breathing apparatus available. (fubinaca.com)
  • Fentanyl and its derivatives (ie, sufentanil, alfentanil, remifentanil, carfentanil) are the only opioids that have been described as potential aerosolized opioid agents. (medscape.com)
  • Alfentanil, sufentanil, and remifentanil have similar potency as fentanyl, but shorter duration of action. (greek.doctor)
  • Fentanyl modulates the respiratory frequency fluctuation of heart rate variability (HRV). (anesthesiaexam.com)
  • Respiratory rate decreases significantly and end tidal CO2 showeda non significant increase following single doses of epidural fentanyl (1.5 µg/kg). (anesthesiaexam.com)
  • Continuous epidural fentanyl infusion (0.5 µg/kg/hr) started 60 min after the bolus dose had no effect on end tidal CO2 concentration or respiratory rate for up to 18 hours. (anesthesiaexam.com)
  • high doses of the delta agonist peptide DPDPE produced respiratory depression in sheep, but in tests on mice the non-peptide delta agonist SNC-80 produced respiratory depression only at the very high dose of 40 mg/kg. (wikipedia.org)
  • In contrast both the peptide delta agonist Deltorphin II and the non-peptide delta agonist (+)-BW373U86 actually stimulated respiratory function and blocked the respiratory depressant effect of the potent μ-opioid agonist alfentanil, without affecting pain relief. (wikipedia.org)
  • Avoid the use of acetaminophen/caffeine/dihydrocodeine bitartrate in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine. (drugs.com)
  • Alfentanil ( Alfenta ) is a parenteral short-acting opioid painkiller, used for anaesthesia in surgery. (the-medical-dictionary.com)
  • In experiments with rabbits, they reportedly tested a combination of alfentanil or remifentanil together with a specific opioid antagonist (naloxone) seeking to identify the optimal agonist/antagonist ratio while maintaining immobilization and markedly reducing respiratory depression. (medscape.com)
  • Third, NOP receptor agonists produced antinociceptive effects comparable to clinically used mu opioids such as morphine and alfentanil in three different primate pain models, indicating that the analgesic effectiveness of NOP receptor agonists may be similar to that of mu opioid analgesics in humans. (dtic.mil)
  • It thus seems likely that while δ-opioid agonists can produce respiratory depression at very high doses, at lower doses they have the opposite effect, a fact that may make mixed mu/delta agonists such as DPI-3290 potentially very useful drugs that might be much safer than the μ agonists currently used for pain relief. (wikipedia.org)
  • Opioid effects were determined by pupillometry, respiratory rate, and Visual Analog Scale scores. (duke.edu)
  • According to the abstract by Hess et al, a major drawback of opioid use is the development of respiratory depression, particularly if administered at higher doses inducing immobilization. (medscape.com)
  • 10. Abelson AL, Armitage-Chan E, Lindsey JC, Wetmore LA. A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy. (scielo.br)
  • Ultra-Rapid Metabolism of Codeine and Other Risk Factors for Life-Threatening Respiratory Depression in Children: Life-threatening respiratory depression and death have occurred in children who received codeine. (drugs.com)
  • Use triazolam with caution in individuals with significant pulmonary disease or respiratory insufficiency, such as chronic obstructive pulmonary disease (COPD) or sleep apnea because the drug can exacerbate respiratory depression. (pdr.net)
  • If signs and symptoms of respiratory depression or apnea occur, consider discontinuation. (pdr.net)
  • The most commonly reported complication was related to respiration, with respiratory depression or apnea noted intraoperatively in 0.3% of cats. (vin.com)
  • In comparative studies, trefentanil was slightly more potent and shorter acting than alfentanil as an analgesic, but induced significantly more severe respiratory depression. (fubinaca.com)
  • Renal transplant recipients without severe cardiac or respiratory problems are extubated after surgery. (biogenericpublishers.com)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its corresponding coronavirus disease (COVID-19) was first reported as a cluster of pneumonia cases in. (annals.edu.sg)
  • Several studies clearly demonstrate that the use of capnography decreases the incidence of hypoxia and respiratory events, but there is still insufficient evidence that capnography decreases the incidence of "serious adverse respiratory events. (hospitalprocedures.org)
  • Like other narcotics nalbuphine can cause respiratory depression (decreased rate or depth of breathing ). (hdkino.org)
  • Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, and death. (pdr.net)
  • Adverse reactions associated with infusions greater than 24 hours in duration include ARDS, respiratory failure, and agitation. (pharmacyhq.com)
  • Using data and can cause respiratory depression, slowed heart rate, and from 38 states and DC, CDC examined xylazine-positive and hypotension ( 2 ). (cdc.gov)
  • As toxicity increases, the patient may become comatose and develop respiratory depression with airway compromise. (medscape.com)
  • It is important for overdose prevention and response messages to highlight the potential presence of xylazine in IMF products and emphasize the need for respiratory and cardiovascular support to address the sedative effects of xylazine. (cdc.gov)
  • The use of inhalants for maintenance of anesthesia in veterinary practice is frequent and the most commonly reported complications relate to intubation and respiratory arrest. (vin.com)
  • Monitor for respiratory depression, especially during initiation of acetaminophen/caffeine/dihydrocodeine bitartrate or following a dose increase. (drugs.com)
  • Serious, life-threatening, or fatal respiratory depression may occur with use of oxymorphone. (drugs.com)
  • Closely monitor patients with compromised respiratory function. (pdr.net)
  • It has a lower risk for respiratory depression than other opioids, but when it develops, it's more difficult to antagonise. (greek.doctor)
  • Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. (scielo.br)
  • The Effect of the Lithotomy-Trendelenburg Position on Respiratory and Hemodynamic Changes during General Anesthesia. (ekja.org)