• We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-γ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)
  • Anesthetized pigs underwent 90 min of regional LV ischemia and 90 min of reperfusion. (diabetesjournals.org)
  • Male C57Bl/6 mice were subjected to focal cerebral ischemia and periods of reperfusion (0, 8 and 24 h). (biomedcentral.com)
  • However, a de-ramified morphology was prominent when ischemia was coupled to reperfusion. (biomedcentral.com)
  • The extension of the necrotic core into the penumbra is influenced by additional factors such as regional differences in the composition of brain tissue, the vulnerability of different cell types to ischemia, residual tissue perfusion and additional events such as reperfusion [ 2 - 4 ]. (biomedcentral.com)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • Experimental ischemia of 15, 30, or 60 min length, followed by 30 min of reperfusion, was produced in situ in the cat small intestine by means of an adjustable arterial clamp. (edu.au)
  • The rate of free radical formation was followed intermittently with ESR and a modified spin trapping technique in the control period prior to ischemia and at various times during reperfusion. (edu.au)
  • Cumulative radical production during the 30 min reperfusion period rose from about 3 μmol × 100 g−1 after 15 min ischemia to approximately 4.5 μmol × 100 g−1 after 30 min and 8-10 μmol × 100 g−1 after 60 or 120 min ischemia. (edu.au)
  • Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
  • The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
  • A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)
  • These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
  • yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
  • An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
  • A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
  • Background Dexmedetomidine has been shown to confer direct renoprotection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury in preclinical studies. (medscape.com)
  • The ROMICAT-II trial compared the effectiveness of a coronary computed tomographic angiography (CCTA) based evaluation strategy with that of standard evaluation in the emergency department in reducing hospital stay length for patients with symptoms suggestive of an acute coronary syndrome. (nih.gov)
  • Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography (ROMICAT-I), a blinded observational study involving patients in the emergency department with suspected acute coronary syndromes, and other studies have shown that normal findings on CCTA have a very high negative predictive value for ruling out acute coronary syndromes during the index hospitalization and the occurrence of major adverse cardiovascular events over the next 2 years. (nih.gov)
  • The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
  • 30%) with acute symptoms of right lower-extremity ischemia. (medscape.com)
  • Before ischemia, acute troglitazone treatment had no effect on LV function, electrocardiogram, or substrate utilization. (diabetesjournals.org)
  • Results also indicated a 10)% limb salvage with no cases of acute limb ischemia. (massdevice.com)
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • Microglia were both hyper- and de-ramified in striatal and cortical brain regions (respectively) after 60 min of focal cerebral ischemia. (biomedcentral.com)
  • When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
  • These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
  • It helps assess heart wall thickness (eg, in hypertrophy or atrophy) and motion and provides information about ischemia and infarction. (msdmanuals.com)
  • For example, if rectal cancer is found at the time of exploration, end ileostomy should be performed in anticipation of postoperative pelvic irradiation. (medscape.com)
  • There was no difference regarding postoperative length of hospital stay ( p = 0.37), complications ( p = 0.86), or positive margins ( p = 0.93).Conclusions: in early experience, RPN appears to be a feasible and safe alternative to its laparoscopic counterpart with decreased warm ischaemia times noted. (soton.ac.uk)
  • Blood samples will be taken at four time points: baseline, postoperative day 1, postoperative day 4 and at hospital discharge, or after a maximum of seven postoperative days. (frontiersin.org)
  • Analyses of intraoperative hemodynamics and blood loss, postoperative renal function, patient and graft survival, and length of hospital stay have shown excellent results. (elsevierpure.com)
  • The postoperative outcomes included length of stay (LOS), creatinine variation (Modification of Diet in Renal Disease group), Clavien complications and pathological results. (bjuinternational.com)
  • We recorded perioperative and postoperative data, including operative time, estimated blood loss, and duration of hospital stay. (ectrx.org)
  • The secondary outcomes were mechanical ventilation (MV) duration, intensive care unit (ICU) stay and hospital length of stay(LOS), and postoperative mortality (in-hospital or within 30 days). (medscape.com)
  • PCI is an image-guided, minimally invasive treatment to open a coronary artery blockage (stenosis) that is causing a reduced blood flow (ischemia) to heart tissue. (philips.com)
  • This is thought to be due to local tissue ischemia from pressure combined with tissue hypoxia from carbon monoxide. (bestpub.com)
  • The Gore Japan IDE clinical study has once again proven that the Viabahn device effectively covers and seals off diseased tissue, enabling high patencies regardless of lesion length. (massdevice.com)
  • At the same time mucosal damage became more pronounced, suggesting a causal connection between tissue damage and radical formation. (edu.au)
  • coronary artery bypass graft operation has been shown to be a safe and feasible procedure with the potential benefits of reduced operative bleeding and myocardial damage without prolonging intraoperative support or total operating time. (medicus.ru)
  • The presence of intraoperative ischemia and necrosis was defined as "strangulation. (ircmj.com)
  • The RPN group had significantly less warm ischaemic time than the LPN group ( p = 0.0008). (soton.ac.uk)
  • Preoperative recipient mechanical ventilation, preoperative prothrombin time, donor sodium level, donor length of hospital stay, and warm ischemia time approached significance. (mssm.edu)
  • 2) Warm ischemia time can be shortened because there is no need for the infrahepatic vena cava anastomosis. (elsevierpure.com)
  • The operative data included operative duration, warm ischaemia time (WIT) and estimated blood loss (EBL). (bjuinternational.com)
  • Results: The mean operative time was 144.35 ± 22.79 minutes, and the mean warm ischemia time was 184.35 ± 4.97 seconds. (ectrx.org)
  • Amsterdam, the Netherlands and New Orleans, U.S. - At the American College of Cardiology's (ACC) annual meeting in New Orleans, U.S., Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced the results of the DEFINE PCI [1] study, which assessed the level of residual ischemia found in patients after percutaneous coronary interventions (PCI). (philips.com)
  • Of the patients with residual ischemia, the study showed that 81.6% of those patients had an untreated focal stenosis (narrowing of an artery). (philips.com)
  • Further analysis of the study data showed that if all focal stenoses had been identified and successfully treated, only 1 in 20 patients would still have residual ischemia. (philips.com)
  • The fact that nearly one-quarter of patients had residual ischemia despite an angiographically successful result, mostly due to focal lesions that can easily be treated, has important implications for improving outcomes of patients undergoing stent implantation globally," said Gregg W. Stone, MD, Professor of Medicine at Columbia University Medical Center. (philips.com)
  • A pooled analysis did not reveal significant differences in terms of operative time, ischemia time, blood loss, transfusions, or positive margins. (univr.it)
  • Systemic heparin was used to achieve an activated clotting time of ≥250 s. (biomedcentral.com)
  • Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength. (wikipedia.org)
  • The strength-duration time constant (chronaxie) and rheobase are parameters that describe the strength-duration curve-the curve that relates the intensity of a threshold stimulus to its duration. (wikipedia.org)
  • When the duration of a stimulus is prolonged, charge transfer and membrane potential rise exponentially to a plateau (instead of increasing linearly with time). (wikipedia.org)
  • The Gore Viabahn endoprosthesis, for the first time in endovascular history, may replace bypass surgery for femoro-popliteal disease," Japan IDE clinical study principal investigator Dr. Takao Ohki said in prepared remarks. (massdevice.com)
  • and then heart is stopped for some time so that the surgeon can perform the bypass. (drnishantchandel.com)
  • Abstract-- An integrated method for clustering of QRS com- duces the amount of time the operator needs to spend. (lu.se)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • Background In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. (unav.edu)
  • Ischemia was induced in male (M-Isch) and female (F-Isch) rats with sc. (biomedcentral.com)
  • Focusing on studies comparing standard resection ver-sus enucleation, advantages with tumor enucleation in terms of avoidance of artery clamping, overall/major complications, length of stay, and renal function were found. (univr.it)
  • Our study has highlighted sex-specific alterations in systolic and diastolic function shortly after ischemia, and provided a comprehensive look at the underlying proteomic changes and the influence of estrogens and their metabolites. (biomedcentral.com)
  • If you ever suspect a blockage, remember that time is critical-when in doubt, reach out to your vet. (bestiepaws.com)
  • The primary outcome was the length of the hospital stay, defined as the time from presentation in the emergency department to the time of the discharge order. (nih.gov)
  • Eighty-eight percent is an extremely high primary patency for these long complex lesions with an average length of 22 cm, especially given the scrutiny of the study design: a prospective, multicenter IDE clinical study that was core lab adjudicated and reviewed by the Japanese regulatory authority. (massdevice.com)
  • The microglia process length/cell and number of endpoints/cell was quantified from immunofluorescent confocal images of brain regions using a skeleton analysis method developed for this study. (biomedcentral.com)
  • Gait analysis can be carried out, and can be applied in the study of diseases such as CNS ischemia, SCI, and Neurotrauma, for example. (harvardapparatus.com)
  • [9] In a study using the pectoralis major tendon as a reference intraoperatively reconstruction of the height of the humerus prosthesis measured by evaluating the radiological humeral length in comparison to the contralateral side within 7 mm +/- 7 mm could be shown. (beemed.com)
  • Note: Even though this patient received pre-op clearance for hip surgery, the detection of ischemia on the PET study provided prognostically useful information to assist in the management of this patient's progressive CAD. (mobilecardiacpet.com)
  • Multivariate logistic regression analysis identified UNOS status and length of donor hospital stay as independent predictors of survival. (mssm.edu)
  • The ICU and hospital lengths of stay were 11 (4, 33) and 16 (5, 40) days, respectively. (sccm.org)
  • The median hospital length of stay was identical at 7 days in both groups. (medscape.com)
  • Median time to target lesion reintervention or graft abandonment with the Viabahn was reportedly 2 times that of PTA alone, and placement of the Viabahn led to 27% fewer interventions at the target lesion and in the dialysis access circuit over 2-years, when compared to PTA. (massdevice.com)
  • Survival of left lateral segment recipients, at median follow-up time, was 76% versus 80% in patients receiving a trisegment. (mssm.edu)
  • No significant difference in clinical parameters between the two groups was observed except for the length of hospitalization that was significantly longer in the hemodialysis patients (9 vs. 6 days, P=0.005). (bvsalud.org)
  • Mesenteric ischemia was suspected in 3 (7.5%) patients, but not confirmed. (sccm.org)
  • Although the Impella device allows maintenance of patients without VT, they are still in cardiogenic shock, so close hemodynamic monitoring is required at all times. (clevelandclinic.org)
  • Future trials are needed to determine the dose and timing of dexmedetomidine in improving outcomes, especially in patients with decreased baseline kidney function. (medscape.com)
  • There was no difference between the two groups regarding operative times ( p = 0.58), estimated blood loss ( p = 0.76), or conversion rates ( p = 0.84). (soton.ac.uk)
  • We apply MMA on time-course metabolomics data collected from biopsies during subnormothermic machine perfusion (SNMP) of nine discarded human livers that were rejected for transplantation. (confex.com)
  • Between the groups, length of time between incarceration and hospital admission, demographic and clinical data, and physical examination findings, Risk factors for strangulation and mortality were determined with univariate and multivariate analyses. (ircmj.com)
  • This sign represents a true soaking of the tissues with carbon monoxide over a significant length of time and is typically found at autopsy. (bestpub.com)
  • The length of the edge between reactions is weighted such that if the two reactions are involved in metabolites that are statistically significant, their edge distance is shorter. (confex.com)
  • An automated analysis package is available for automatic analysis of a batch of experiments, saving time in analysis, and making the results more consistent and less operator dependent. (harvardapparatus.com)
  • This indicates that if the precise locations causing ischemia are better detected prior to stenting, patient outcomes may be improved. (philips.com)
  • The one-year patient outcomes were consistent with fractional flow reserve (FFR), while iFR involved less procedural time, reduced patient discomfort, and reduced cost [6]. (philips.com)
  • Blistering of the skin over pressure-bearing areas may be present, especially if the patient was unconscious for an extended period of time. (bestpub.com)
  • The COHgb level must be interpreted in light of the patient's exposure history and length of time away from CO exposure, as levels gradually fall once the patient is removed from the exposure. (cdc.gov)
  • These variables are inversely related: as the strength of the applied current increases, the time required to stimulate the membrane decreases (and vice versa) to maintain a constant effect. (wikipedia.org)
  • Rather, its genotoxic effects are limited to indirect clastogenicity occurring in select cell types, and only when high dose and time thresholds are exceeded. (cdc.gov)
  • Ischemia is the most common cause of cardiovascular disease and myocardial damage in the developed world. (southcarolinablues.com)
  • Several key parts of the MMA algorithm are parallelizable and was therefore able to complete a full run in 2.7 hours, with a total cost of $8.40 for the 3 hours of server time. (confex.com)
  • Say you want to create a systematic random sample of 1, people from a population of 10, Though we know that Hai Di Lao is probably one of the best mala hot pots in Singapore, not everyone has the time to queue for two to three hours. (corriegarth.com)
  • The team consists of a gastroenterology fellow, one or more medicine residents, and at times, fourth-year medical students, all of whom are supervised by a gastroenterology attending. (buffalo.edu)
  • Physical exam findings depend on the time between exposure adn presentation to the hospital. (bestpub.com)
  • At the same time, life level. (who.int)
  • The instrument combines the video of a freely moving rodent with the data supplied by the mat including up to 6000 sensors that cover the full length of a corridor at the end of which lies the animal's home cage. (harvardapparatus.com)
  • Time Frame: Immediately after the surgery. (who.int)
  • Time Frame: During the surgery. (who.int)
  • For the placenta to function properly, there must be sufficient time between contractions for the placenta to recharge with a fresh supply of oxygen-rich blood. (abclawcenters.com)
  • For a network this large, computing the adjacency distance matrix requires 7439 C 2 , or 2.77 10 7 computations for the initial network, which causes total run times on the order of days with a laptop, rendering the method impractical for repeated analysis. (confex.com)