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HLA AntigensHLA-DR3 AntigenHLA-DR AntigensAntigensHLA-DR4 AntigenHLA-DR Serological SubtypesHLA-DQ AntigensAntigens, BacterialHLA-DR2 AntigenAntigens, NeoplasmHistocompatibility Antigens Class IIAntigens, SurfaceAntigens, ViralHistocompatibility Antigens Class IHLA-DR7 AntigenHistocompatibility TestingHLA-DR1 AntigenKeratoconjunctivitis SiccaGold Sodium ThiomalateHLA-DRB1 ChainsAntigens, ProtozoanEpitopesMolecular Sequence DataAntigens, Polyomavirus TransformingGenes, MHC Class IIH-2 AntigensAntigens, CDHLA-A AntigensAmino Acid SequenceAntigens, FungalAllelesHLA-B AntigensAntigens, HelminthEpitopes, T-LymphocyteHLA-D AntigensAntibodies, MonoclonalCD4-Positive T-LymphocytesHistocompatibility AntigensCarcinoembryonic AntigenReceptors, Antigen, T-CellHLA-A2 AntigenAntigens, Viral, TumorT-LymphocytesHaplotypesDiabetes Mellitus, Type 1Proliferating Cell Nuclear AntigenAntigens, CD8Receptors, Antigen, B-CellProstate-Specific AntigenLymphocyte ActivationO AntigensArthritis, RheumatoidImmunoglobulin GEnzyme-Linked Immunosorbent AssayCell LineDipeptidyl Peptidase 4Cross ReactionsAntigens, CD15Antigens, Tumor-Associated, CarbohydrateHLA-C AntigensMice, Inbred BALB CAntigens, CD3Genetic Predisposition to DiseaseBase SequenceBlood Group AntigensAntibody SpecificityHepatitis B Surface AntigensB-LymphocytesT-Lymphocytes, CytotoxicAntigens, CD4Fluorescent Antibody TechniqueHLA-DQ beta-ChainsAntigens, CD45Antigen-Antibody ReactionsHLA-B7 AntigenAntibody FormationMice, Inbred C57BLAntigens, CD1Receptors, AntigenHLA-A1 AntigenFlow CytometryImmunizationHLA-B27 AntigenCells, CulturedHepatitis B AntigensHLA-B8 AntigenImmune SeraAntigens, Differentiation, T-LymphocyteAntigen-Presenting CellsAntibodies, BacterialAntigens, DifferentiationInterferon-gammaPeptidesCD8-Positive T-LymphocytesCytotoxicity, ImmunologicAutoantigensAntibodiesAntigens, CD80Major Histocompatibility ComplexImmunoenzyme Techniques
AllelesTissue AntigensTransgenic mouseHaplotypesPeptidesAntibodyMoleculesHumanDRB10201ProteinsCross-reactGlycoproteins0701AntibodiesPolymorphismFrequenciesLymphocytesGeneticsImmuneRecognizeTumorHeterodimericLymphomaReactivityCellsPsoriasisEpitopesProteinMajorPotentRiskAssociationPatientsPresenceStatus
Alleles3
Tissue Antigens1
Transgenic mouse2
  • Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
  • Methods Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (bmj.com)
Haplotypes4
  • The most frequent A-B-DR-DQ haplotypes in Korea are found at ~3/4 the Korean frequencies in Japan, except A33-Cw7-B44-DR7-DQ2, which indicates that DR7 likely spread into Korea after the Japan's Yayoi migration when most of the Korean contribution occurred. (wikipedia.org)
  • The genetic susceptibility to celiac disease is conferred by well-identified haplotypes in the human leukocyte antigen (HLA) class II region (ie, DR3 or DR5/DR7 or HLA DR4). (medscape.com)
  • Gluten is the single major environmental factor that triggers celiac disease, which has a narrow and highly specific association with class II haplotypes of HLA DQ2 (haplotypes DR-17 or DR5/7) and, to a lesser extent, DQ8 (haplotype DR-4). (medscape.com)
  • HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)
Peptides7
  • MHC class II candidate epitopes from these proteins were computer-assisted predicted and used as synthetic peptides for in vitro stimulation by human CD4+ T cells. (uni-goettingen.de)
  • Several class-II epitope candidates in SVN and PR3 were identified by examining human T cell responses to synthetic peptides. (uni-goettingen.de)
  • HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
  • The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. (thermofisher.com)
  • Modified peptides showed enhanced binding to HLA-A2 compared with the native sequences and immunization of HLA-A2 transgenic mice generated high avidity modification specific CD8 responses that killed peptide expressing target cells. (bmj.com)
  • Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
  • The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
Antibody8
  • The TU169 monoclonal antibody specifically binds to the human Major Histocompatibility Complex (MHC) Class II HLA-DQ1 and DQ2 antigens and weakly to HLA-DQ3. (bdbiosciences.com)
  • This antibody does not cross-react with HLA-DR2 and HLA-DR7. (bdbiosciences.com)
  • Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Ramos cell lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
  • The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)
  • Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Molecules8
  • In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. (novusbio.com)
  • HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
  • Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
  • The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
  • In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
  • HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
  • HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
  • HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
Human7
  • The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
  • Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
  • Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. (thermofisher.com)
  • HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)
  • Following this model, the human immune system is divided into two major classes: Cellular Immunity, located in the mucous membranes of the gastrointestinal and respiratory tracts and their respective lymph nodes (outer defenses), and Humoral Immunity, with production of antigen-specific antibodies by plasma cells in the bone marrow (inner defenses). (medicalveritas.org)
  • During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
  • The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
DRB12
  • HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products. (wikipedia.org)
  • The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
02011
  • DR7:DQA1*0201:DQB1*0202 is associated with Graves' disease. (wikipedia.org)
Proteins3
  • The central goal of the work was to identify MHC class II peptide epitopes in such proteins, which exhibit a tumor-associated expression and which were already well-known target antigens of cytotoxic T cell reactions. (uni-goettingen.de)
  • These genes code for proteins that are involved in cell-cell adhesions (CTNNA3), glutathione conjugation for xenobiotic metabolism (GST gene family), and immune system response (HLA gene family). (cdc.gov)
  • Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (bmj.com)
Cross-react1
  • It does not cross react with HLA-DP and HLA-DQ. (novusbio.com)
Glycoproteins1
  • HLA-DQ antigens exits as heterodimers comprised of polymorphic transmembrane HLA-DQ alpha and beta glycoproteins. (bdbiosciences.com)
07011
  • The serological reaction of DR7 is excellent for *0701. (wikipedia.org)
Antibodies1
Polymorphism1
  • HLA class II polymorphism in cystic fibrosis. (nih.gov)
Frequencies1
  • Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. (musc.edu)
Lymphocytes3
Genetics1
Immune1
  • The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
Recognize1
  • Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
Tumor3
  • Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. (novusbio.com)
  • Because the main effort has been to induce CTL responses, a logical way to enhance the potency of these tumor vaccines is to include CD4+ T cell epitopes for the same tumor antigen. (uni-goettingen.de)
  • Furthermore, the SVN10-specific T cells recognized SVN antigen from various tumor cell lines. (uni-goettingen.de)
Heterodimeric1
  • HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. (novusbio.com)
Lymphoma1
  • In this work, proteinase 3 (PR3) and survivin (SVN) were selected as candidate antigens associated with leukemia and lymphoma. (uni-goettingen.de)
Reactivity1
  • Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
Cells3
  • HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
  • Experiments in animal models have demonstrated the importance of antigen-specific CD4+ T cells in the elimination of tumors. (uni-goettingen.de)
  • During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
Psoriasis2
  • DR7 is positively associated with psoriasis vulgaris. (wikipedia.org)
  • In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. (bvsalud.org)
Epitopes1
  • Thus, the identification of the naturally processed SVN epitope, together with the previous finding of class I-restricted SVN epitopes, provide a basis for the combined application of class I- and II-restricted SVN epitopes to induce potent, long-term CD4+ and CD8+ T cell responses against various tumors. (uni-goettingen.de)
Protein1
  • Protein network functions for the DA-associated genes from this review include: antigen processing, lymphocyte activation, cytokine production regulation, and response to oxidative stress. (cdc.gov)
Major1
  • This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and whether "HLA-DR3 Antigen" was a major or minor topic of these publications. (musc.edu)
Potent1
  • Memory response becomes more potent and faster after subsequent exposures to an antigen . (amboss.com)
Risk3
  • DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. (wikipedia.org)
  • DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk transhaplotype. (wikipedia.org)
  • PORs 4.38-4.97) and three studies on HLA-DR1 (decreased DA risk, POR 0.24). (cdc.gov)
Association1
  • OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)
Patients1
  • In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. (bvsalud.org)
Presence1
  • CONCLUSION: In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen. (bvsalud.org)
Status1
  • Differences in the first sign(s) or symptom(s) were compared across diagnoses and between HLA-B27 status. (bvsalud.org)