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  • mRNA expression
  • The authors demonstrate that the anorectic effect of resistin is associated with the low levels of mRNA expression of orexigenic (agouti-related protein and neuropeptide Y) and the increased mRNA expression of anorexigenic (cocaine and amphetamine-regulated transcript) neuropeptides in the arcuate nucleus of the hypothalamus. (hindawi.com)
  • Hcy (300-1000 μmol/l) also increased mRNA expression of resistin in primary rat adipocytes in a time- and concentration-dependent manner, with maximal induction at 24 h of approximately fourfold with 1,000 μmol/l. (diabetesjournals.org)
  • Circulating resistin is increased in obese insulin-resistant rodents ( 6 ) and humans ( 7 ), and fasting decreases resistin mRNA expression ( 6 , 13 ). (diabetesjournals.org)
  • action of resistin
  • The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). (hindawi.com)
  • This review provides an insight into the biological action of resistin and its possible role in periodontitis influenced diabetes mellitus and diabetes induced periodontitis. (hindawi.com)
  • central resistin
  • Central resistin administration appears to have a dual effect on metabolic homeostasis, first by acutely inhibiting feeding [ 10 ] and second by controlling glucose homeostasis and inducing hepatic insulin resistance [ 8 , 11 ]. (hindawi.com)
  • Recently, it has been demonstrated that central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion and even that this regulation is opposite in peripheral organs in comparison with central effect [ 12 ]. (hindawi.com)
  • In addition, it is demonstrated that chronic central resistin infusion results in decreased body weight and major changes in peripheral expression of lipogenic enzymes, in a tissue-specific and nutrition-dependent manner [ 12 ]. (hindawi.com)
  • Central resistin treatment inhibited insulin-dependent phosphorylation of insulin receptor (IR), AKT, and extracellular signal-related kinase 1/2 associated with reduced IR expression and with upregulation of suppressor of cytokine signaling-3 and phosphotyrosine phosphatase 1B, two negative regulators of insulin signaling. (diabetesjournals.org)
  • Additionally, central resistin promotes the activation of the serine kinases Jun NH 2 -terminal kinase and p38 mitogen-activated protein kinase, enhances the serine phosphorylation of insulin receptor substrate-1, and increases the expression of the proinflammatory cytokine interleukin-6 in the hypothalamus and key peripheral insulin-sensitive tissues. (diabetesjournals.org)
  • Central resistin also modulates glucose homeostasis, lipid metabolism, and food intake and impairs liver insulin sensitivity ( 24 - 27 ). (diabetesjournals.org)
  • molecule
  • It has also been demonstrated that resistin upregulates intercellular adhesion molecule-1 (ICAM1) vascular cell-adhesion molecule-1 (VCAM1) and chemokine (C-C motif) ligand 2 (CCL2), all of which are occupied in chemotactic pathways involved in leukocyte recruitment to sites of infection. (wikipedia.org)
  • circulates
  • Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26. (prospecbio.com)
  • Mouse resistin circulates in blood as a homodimeric protein consisting of two 94 amino acid polypeptides, which are disulfide-linked via Cys26. (creativebiomart.net)
  • lipid metabolism
  • Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism. (hindawi.com)
  • glucose
  • have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. (prospecbio.com)
  • RESULTS- Hcy impaired glucose transport and, particularly, the insulin signaling pathway as shown by decreased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate (IRS)-1, increased serine phosphorylation of IRS-1, and inhibited Akt phosphorylation both in vitro and in vivo, and these impairments were accompanied by an increase in resistin expression. (diabetesjournals.org)
  • cardiovascular
  • Fontana A, Spadaro S, Copetti M (2015) Association between resistin levels and all-cause and cardiovascular mortality: a new study and a systematic review and meta-analysis. (springer.com)
  • resistin adversely impacts the effects of statins, the main cholesterol-reducing drug used in the treatment and prevention of cardiovascular disease. (wikipedia.org)
  • obese
  • They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. (prospecbio.com)
  • metabolism
  • Also they show that resistin exerts a nutritional status dependent inhibitory effect on hypothalamic fatty acid metabolism, as indicated by increased phosphorylation levels of both AMP-activated protein kinase and its downstream target acetyl-coenzyme A carboxylase, associated with decreased expression of fatty acid synthase in the hypothalamus. (hindawi.com)
  • Mitchell Lazar (born 1956) is an endocrinologist and physician-scientist widely known for his discovery of the hormone resistin and his contributions to the transcriptional regulation of metabolism. (wikipedia.org)
  • molecular
  • However, the resistin receptor and the molecular mechanisms mediating its effects in the hypothalamus, crucial for energy homeostasis control, and key insulin-sensitive tissues are still unknown. (diabetesjournals.org)
  • Taken together, our findings clearly identify TLR4 as the binding site for resistin in the hypothalamus and bring new insight into the molecular mechanisms involved in resistin-induced inflammation and insulin resistance in the whole animal. (diabetesjournals.org)
  • protein
  • In addition, Hcy-induced resistin expression attenuated by treatment with reactive oxygen species (ROS) scavengers, protein kinase C (PKC), and nuclear factor (NF)-κB inhibitors implies a role in the process for ROS, PKC, and NF-κB. (diabetesjournals.org)
  • In 3T3-L1 cells, resistin was demonstrated to be a key mediator of GIP stimulation of lipoprotein lipase (LPL) activity, involving activation of protein kinase B (PKB) and reduced phosphorylation of liver kinase B1 (LKB1) and AMP-activated protein kinase (AMPK). (diabetesjournals.org)
  • 2001
  • Resistin was discovered in 2001 by the group of Dr Mitchell A. Lazar from the University of Pennsylvania School of Medicine. (wikipedia.org)