Resistant cell. Medical search. Frequent questions

For example, workers in meat industries tend to exhibit a higher prevalence of colonization with methicillin-resistant Staphylococcus aureus than the general population. (cdc.gov)

The expression of the anti-apoptotic protein BCL2 has been shown to be deregulated in T-cell acute lymphoblastic leukemia (T-ALL), where different T-ALL cells display a differential response to the BCL2-specific inhibitor venetoclax. (lu.se)

Multidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as P-glycoprotein (P-gp). (thescipub.com)
The drug accumulation of a human multidrug resistance 1 (mdr1) gene-transfected mouse lymphoma cell line and a multidrug resistance protein (MRP)-expressing human breast cancer cell line MDA-MB-231 was compared in the presence of sixteen flavonoids and five isoflavonoids. (iiarjournals.org)
The expression of the 170-kDa P-glycoprotein (P-gp) (MDR1) and 190-kDa multidrug resistance protein (MRP) in both cell lines was confirmed by immunocytochemistry. (iiarjournals.org)
A very thin man perhaps in his early forties, told me about how he struggled with multidrug resistant TB and how he - despite his medication - thought he'd never survive his nine-year sentence, since he was also HIV positive. (who.int)
Health facilities in the state should institute effective antimicrobial stewardship, intensify surveillance and screening of Staphylococcus aureus for MRSA strains to guard against dissemination of multidrug resistant strains in both hospital and community settings because of the clinical implications. (who.int)

To overcome the lack of SCLC samples, the team developed novel disease models by isolating circulating tumor cells from a simple blood draw. (medindia.net)
These SCLC models, called circulating tumor cell-derived xenografts (CDX), are unique to each patient and provide an opportunity to assess treatment response to novel targeted therapies, as well as changes that may occur in response to therapy. (medindia.net)
We hypothesize that differences in gene and protein expression between tumor cells, called intratumoral heterogeneity, contribute to the rapid development of platinum chemotherapy resistance," said Stewart. (medindia.net)
These differences between tumor cells result in ITH. (medindia.net)
Cells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both present in the same tumor," said Stewart. (medindia.net)
MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. (up.pt)
For metastasis from a primary tumor site, cancer cells must lose cell-cell adhesion and acquire motility to invade adjacent cell layers [ 6 ]. (biomedcentral.com)
In the clonal extinction patients, NAC eliminated the tumor cells, leaving only normal cell types post-treatment. (medindia.net)
Clonal persistent patients harbored a larger number of residual tumor cells with genotypes and phenotypes that were altered in response to NAC. (medindia.net)
Our data support a model of chemoresistance in which two modes of evolution, adaptive and acquired, were operating to establish chemo-resistant tumor mass," said Navin. (medindia.net)
An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells. (greenmedinfo.com)
The T cells given in this study will come from the patient and will have a genetic circuit/logic gate put in them that makes them able to recognize alkaline phosphatase, germ line/placental (ALPG/P) and mesothelin (MSLN), 2 proteins on the surface of tumor cells. (survivornet.com)

Pneumococcal isolates from sickle cell disease patients from Tennessee were subjected to multilocus sequence typing to characterize antimicrobial drug-resistant strains. (cdc.gov)
Twenty-one percent of strains were resistant to cefotaxime and penicillin. (cdc.gov)
Of the 14 cephalosporin-resistant strains, 9 were sequence types previously described as highly cephalosporin resistant, while resistance was found for the first time in 3 clones: Maryland 6B , ST660, and a novel clone, ST1753. (cdc.gov)
Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

The prevalence of colonization with pneumococci is generally the same in healthy persons (12%) and sickle cell disease patients (7%) ( 2 ). (cdc.gov)

High-level cephalosporin resistance was described in the 1990s in healthy children from Tennessee, but its prevalence in sickle cell disease patients is unknown. (cdc.gov)
High-level cephalosporin resistance exists in more settings than initially recognized, and its high prevalence in sickle cell disease patients may decrease the efficacy of third-generation cephalosporins in invasive pneumococcal disease. (cdc.gov)
Children with sickle cell disease have an increased risk for invasive infection from this pathogen. (cdc.gov)
Before the routine use of prophylactic measures, invasive pneumococcal disease was 600 times more likely to develop in patients with sickle cell disease than in their healthy peers ( 1 ). (cdc.gov)
Thus, colonization with pneumococci is viewed as a high-risk event for sickle cell disease patients. (cdc.gov)
However, penicillin-resistant pneumococci are consistently more common in children with sickle cell disease (62% versus 41% in healthy children) ( 2 ). (cdc.gov)
A similarly high incidence of penicillin resistance (55%) in pneumococci infecting sickle cell disease patients was reported by Daw et al. (cdc.gov)
The epidemiology of the cephalosporin-resistant TN 23F -4 clone in sickle cell disease patients is unknown. (cdc.gov)
In this study, we reexamined pneumococci collected from sickle cell disease patients in Memphis, Tennessee, from 1994 to 1995, the time of the original description of the TN 23F -4 clone, to determine the prevalence of this clone and any other highly cephalosporin-resistant clones circulating in the sickle cell disease population. (cdc.gov)

Researchers at the Mayo Clinic in Florida have found that the use of a combination of two drugs resulted in a 70 percent destruction of chemotherapy resistant ovarian cancer cells. (medicaldaily.com)
This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. (hindawi.com)

Poor clinical outcomes are mainly due to chemotherapy-resistant small cell lung cancer, which often accounts for nearly 14 percent of all lung cancers. (medindia.net)

Evidence has been obtained for the formation of a new molecular species of the enzyme dihydrofolate reductase in an amethopterin-resistant strain of the mouse lymphocytic leukemia L4946. (karger.com)
Although the genetic basis for these observations is not yet understood, it is clear that the production of dihydrofolate reductase by Chinese hamster lung cells is complex and probably involves the expression of multiple dihydrofolate reductase genes and/or alleles. (researchwithrutgers.com)

Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
Effective BiRd Therapy after the Addition of Clarithromycin for Lenalidomide and Dexamethasone Resistant Multiple Myeloma Ineligible for Stem Cell Transplantation]. (bvsalud.org)

mRNA of ghrelin receptors(GHS-R1a and GHS-R1b), as well as, protein levels of GHS-R1a, were expressed abundantly in A2780 cells. (hindawi.com)
AG treatment did not affect the mRNA and protein levels of GHS-R1a and GHS-R1b in both control and Cis-treated cells. (hindawi.com)
Pyrotinib decreased significantly the IC50 values of 5-FU and the thymidylate synthase (TS) mRNA expression levels in the 5-FU-resistant SKBR-3/FU and MDA-MB-453/FU cell lines and the parental cell lines and increased significantly the intracellular concentration of 5-FU in SKBR-3/FU and MDA-MB-453/FU cells. (techscience.com)
In addition, pyrotinib reduced the ABCG2 mRNA and protein expression levels in SKBR-3/FU and MDA-MB- 453/FU cells and downregulated the protein expression levels of pAKT, pHER2, and pHER4 in all four cell lines. (techscience.com)
We observed increased expression of LUM in drug-resistant cell lines at both the mRNA and the protein level. (oncotarget.com)

NEW YORK (GenomeWeb) - Researchers with Cincinnati Children's Hospital have developed a metagenomic sequencing protocol for fecal samples to detect bacteria resistant to multiple drugs, in order to prevent the spread of infection with such bugs. (genomeweb.com)
The researchers sequenced the fecal microbiomes of 17 inpatient samples, who were deemed at a higher risk to becoming infected with drug resistant bacteria due to prolonged hospital stays, as well as 11 outpatient samples, who were deemed at a lower risk. (genomeweb.com)
Now, a 4-month randomized controlled trial in people with non-alcoholic fatty liver disease (NAFLD) indicates that daily intake of resistant starch can alter gut bacteria composition and lower liver triglycerides and liver enzymes associated with liver injury and inflammation. (eurekalert.org)
So, Li and her team wanted to investigate if resistant starch-a type of fiber known to encourage the growth of beneficial gut bacteria-can help treat NAFLD. (eurekalert.org)
Resistant Bacteria Abundant on Nursing Students' Cell. (cloroxpro.com)
A research team led by scientists at Hong Kong Baptist University (HKBU) has developed a novel cell sensor with a barcode-like micro-channel structure, designed to enable rapid and low-cost screening of drug-resistant bacteria. (cleanroomtechnology.com)
The researchers aimed to find a rapid and cost-effective strategy to screen bacterial samples onsite, with advanced laboratory testing arranged only for those suspected of containing drug-resistant bacteria. (cleanroomtechnology.com)
Users can finish the onsite screening within three hours by scanning the "barcode" with a mobile app developed by the researchers, and it will indicate whether any drug-resistant pathogenic bacteria is present in the sample. (cleanroomtechnology.com)
We hope that it will benefit the routine screening of drug-resistant bacteria in the food industry, public areas and healthcare facilities as it does not require advanced clinical facilities or professional testing skills," said Dr Ren. (cleanroomtechnology.com)

These include leukaemic reticuloendotheliosis (hairy cell leukaemia), Gaucher's disease, HIV-induced encephalopathy, osteoclastoma and osteoporosis, and metabolic bone diseases. (wikipedia.org)
Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis. (medscape.com)

Additionally, the positive culture rates of S.aureus in different samples and the antibiotic-resistant profile were investigated. (springer.com)
The research team tested E. coli and S. aureus with the "barcode" cell sensor and the results were consistent with those of the conventional AST. (cleanroomtechnology.com)
Methicillin resistant S. aureus (MRSA) has become a major public health predicament worldwide. (who.int)
resistant S. aureus (VRSA) in clinical samples The study was approved by the Health Ethics impacted negatively on the efficacy of vancomycin Committee of the State Ministry of Health and the 6 leading to treatment failures. (who.int)

In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
Human Umbilical Cord Mesenchymal Stem Cell-induced Osterix, Bone Morphogenetic Protein-2, and Tartrate-resistant Acid Phosphatase Expression in Osteoporotic Mandibular Bone. (physiciansweekly.com)
The aim of this study was to prove that human umbilical cord mesenchymal stem cell (hUCMSC) therapy conducted according to the mandibular osteoporotic model will increase Osterix (Osx) and bone morphogenetic protein-2 (BMP-2) expression, while reducing tartrate-resistant acid phosphatase (TRAP) expression. (physiciansweekly.com)
protein patterns of subjects with leish- Cell culture maniasis [17]. (who.int)
Sample preparation (protein and drug-resistant L. tropica parasites extraction) niasis, early diagnosis and appropriate [8]. (who.int)
And in the lab test, if oseltamivir doesn't inhibit the function of the neuraminidase protein, we call the virus oseltamivir-resistant. (cdc.gov)

However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)

We found several distinctions between sensitive and resistant models detected at the single-cell level, which testified to single cell sequencing's potential usefulness for understanding how these cancers may develop resistance. (medindia.net)
The team also found that SCLC models sensitive to chemotherapy had more cells that expressed two genes, ASCL1 and DLL3, while those that were chemoresistant had fewer cells expressing those genes or had undergone a process called epithelial-to-mesenchymal transition (EMT), which also has been shown to play a role in therapy resistance in other cancers. (medindia.net)
Why are Some Breast Cancers Resistant to Chemotherapy? (medindia.net)
Most skin cancers are basal cell cancer. (medlineplus.gov)
Most basal cell cancers occur on skin that is regularly exposed to sunlight or other ultraviolet radiation. (medlineplus.gov)
A skin biopsy must be done to confirm basal cell cancer or other skin cancers. (medlineplus.gov)
Some basal cell cancers return in the same location. (medlineplus.gov)
However, in view of the excellent chemosensitivity of germ cell cancers, clinical judgment can be used if surgical management would significantly increase postoperative morbidity. (medscape.com)

Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)

The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
For a large percentage of patients, highly sensitive tests were conducted regularly to detect any remaining leukemia cells after the transplantation. (disabled-world.com)
Transplantation of inhibitory neuron cell therapy is a novel therapeutic strategy that has shown promise in preclinical studies and could potentially provide a non-tissue-destructive therapeutic option for suppressing seizures in people with drug-resistant focal epilepsy. (ca.gov)

SCLC has a variety of differences at the cellular and genetic level, from the way genes are expressed to which cell-signaling pathways are involved. (medindia.net)
Induction of 2'-deoxycytidine kinase (dCK) by 5-azacytidine (5-Aza-C) in a dCK-deficient HL-60 cell line resistant to 1-beta-D-arabinofuranosylcytosine (Ara-C) (HL-60/Ara-C) was examined by measurement of the incorporation of [3H]deoxycytidine ([3H] dCyd) into cellular DNA, the kinetic properties of purified dCK, the cytotoxic potency (IC50 values), and the DNA methylation patterns of 5-Aza-C-treated and untreated cells. (aspetjournals.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
This study observed some iodinated radiographic contrast media, diatrizoate, iopromide and iotrolan affected the cellular energetic state and the kinetics of P-gp in drug-sensitive K562 and drug resistant K562/adr cell lines using spectrophotometer and spectrofluorometer. (thescipub.com)
EMT, a highly conserved cellular program in many important phases of embryonic development, is a biological process through which epithelial cells lose their epithelial cobblestone phenotype and acquire fibroblastic and mesenchymal-like phenotypes. (biomedcentral.com)
Cell Metabolism ( @Cell_Metabolism ), published by Cell Press, is a monthly journal that publishes reports of novel results in metabolic biology, from molecular and cellular biology to translational studies. (eurekalert.org)
To answer how a cell becomes resistant to chemotherapy, one must understand that cancer often begins with a clone - a single mutated cell that either can be destroyed by the immune system, or mutated further as subclones, genetic aberrations resulting in an ever-evolving cellular pathway to cancer. (medindia.net)
To mimic this complex multiscale architecture, Qin and colleagues led by Hua-Xin Peng, designed a metacomposite based on a global cellular network of open-cell polyurethane (PU) foam with large porous chambers. (materialstoday.com)

Moreover, we discovered and validated that the resistant cell lines could be selectively targeted by inhibiting squalene synthase, providing a new and promising strategy to directly inhibit cholesterol synthesis in AML drug resistant cells. (kent.ac.uk)

Further understanding of small cell lung cancer affecting intratumoral heterogeneity (ITH) is important to identify populations of cells that may drive certain pathways associated with aggressive resistance to chemotherapy. (medindia.net)
A more thorough understanding of ITH is important to identify populations of cells that may drive certain pathways associated with aggressive resistance to chemotherapy. (medindia.net)

By analyzing patients' fecal samples, the team found the resistant starch group had a different microbiota composition and functionality compared with the control. (eurekalert.org)

The cell culture zone consists of a set of micro-channels filled with fluids that contain cell culture media as well as different concentrations of the antibiotic. (cleanroomtechnology.com)

This leaves investigators like Byers and Stewart with few SCLC samples with which to conduct genomic and biomarker analyses of drug-resistant tumors. (medindia.net)
The cells, placed under the mouse's skin, develop tumors representative of the patient from whom they were derived. (medindia.net)
To study intratumoral heterogeneity (ITH) in SCLC, the investigators performed single-cell sequencing of CDX models to identify gene expression differences between individual cells from chemotherapy-sensitive CDX tumors compared to those that remain resistant. (medindia.net)

MDR TB includes the subcategory of extensively drug-resistant TB (XDR TB), which is MDR TB with additional resistance to any fluoroquinolone and to at least one of three injectable anti-TB drugs (i.e., kanamycin, capreomycin, or amikacin). (cdc.gov)

Breast cancer cell resistance to chemotherapy may be pre-existing and the cells may even adapt to become resistant when confronted by the chemotherapy itself, according to a new study from the University of Texas MD Anderson. (medindia.net)

Doxorubicin- (DOX), topotecan- (TOP) and vincristine- (VIN) resistant variants of the W1 ovarian cancer cell line were used in this study. (oncotarget.com)
In this study, we explored the contribution of c-Jun N-terminal kinases (JNK) signaling to the mesenchymal phenotypes and the aberrant motile capacity of MDR cells utilizing a well characterized MDR cell line KB/VCR, which is established from KB human epidermoid carcinoma cells by vincristine (VCR), and its parental cell line KB. (biomedcentral.com)

To understand how cells developed venetoclax resistance, we monitored the expression of BCL2, BCL2L1, and MCL1 over the treatment period and compared gene expression between resistant cells and parental sensitive cells. (lu.se)
We observed a different trend of regulation in terms of BCL2 family gene expression and global gene expression profile including genes reported to be expressed in cancer stem cells. (lu.se)
Genes prone to being cancer-resistant are pre-existing and adaptively selected by the initial chemotherapy, but require further changes in gene expression programs to become fully resistant. (medindia.net)
Our data showed that resistant genotypes, or genes prone to being cancer-resistant, were pre-existing and adaptively selected by the initial treatment known as neo-adjuvant chemotherapy, but also requires further changes in gene expression programs to become fully resistant. (medindia.net)

a) Platinum resistant disease is defined as progression of disease within six months of platinum regimen. (survivornet.com)
No more than 3 lines of prior therapy for the treatment of platinum resistant disease is permitted. (survivornet.com)

Sickle cell anemia patients have 600 times the risk for invasive pneumococcal disease than their healthy peers. (cdc.gov)
Sixty-four nasopharyngeal isolates were collected from 42 patients between July 1994 and December 1995 at the Mid-South Sickle Cell Center ( 3 ). (cdc.gov)
In about half of these patients, no remaining CLL cells were detected in the blood in the long term, which was highly predictive for the lack of recurrence for the follow-up period (up to eight years, on average about four years). (disabled-world.com)
This means that there are likely multiple cell populations in SCLC patients who have not yet been treated. (medindia.net)
In this study, we observed that the expression of anti-apoptotic BCL2 family genes, such as BCL2, BCL2L1, and MCL1, is highly varied in T-ALL patients, and inhibitors targeting proteins coded by these genes display differential responses in T-ALL cell lines. (lu.se)
one-third of epilepsy patients are drug-resistant. (ca.gov)
Galvão A, Segers I, Smitz J, Tournaye H, De Vos M. In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation. (springer.com)
Among them, 100 patients also received a resistant starch powder derived from maize while the other 100 received calorie-matched non-resistant corn starch as a control. (eurekalert.org)
After the 4-month experiment, participants who received the resistant starch treatment had nearly 40% lower liver triglyceride levels compared to patients in the control group. (eurekalert.org)
In addition, patients who had the resistant starch treatment also saw reductions in liver enzymes and inflammatory factors associated with NAFLD. (eurekalert.org)
Our study shows resistant starch's impact in improving patients' liver conditions is independent of body weight changes," says Yueqiong Ni, the paper's co-first author at Shanghai Sixth People's Hospital and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute (HKI) in Germany. (eurekalert.org)
When the team transplanted fecal microbiota from resistant starch-treatment patients to mice fed with a high-fat high-cholesterol diet, the mice saw a significant reduction in liver weight and liver triglyceride levels and improved liver tissue grading compared with mice that received microbiota from the control group. (eurekalert.org)
It is a scary diagnosis, and even though chemotherapy can be effective as standard-of-care, many patients become resistant to treatment. (medindia.net)
Using single-cell DNA and RNA sequencing, his team performed a detailed analysis of eight clonal persistent patients, measuring miniscule portions of DNA and RNA and found responses to NAC were pre-existing, thus adaptively selected. (medindia.net)
The group of anxiety patients that is resistant to the treatment has been shown to have very poor quality of life and have highest rate of suicidal attempts than any other disorders. (nature.com)
Dr. Mark Fishman , Co-Founder and Chair of the Medical and Scientific Advisory Boards added, "ANC-501 has been shown to impact a definable subset of patients with treatment-resistant depression. (prnewswire.com)
This study is intended for the patients who have been diagnosed with Epithelial Ovarian Cancer that either came back or did not improve after platinum treatments (platinum resistant). (survivornet.com)
The purpose of this study is to test the safety of using a new treatment called Integrated Circuit T (ICT) cells (AB-1015 cells) in patients with ovarian cancer . (survivornet.com)
CDC has confirmed the presence of tecovirimat-resistant viruses in two patients. (cdc.gov)
Variant hairy cell patients are resistant to the standard treatments, which include the use of purine analogues and interferon alfa. (medscape.com)
Extended follow-up of patients with hairy cell leukemia after treatment with cladribine. (medscape.com)
Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. (medscape.com)

JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)

Isolates from the other 11 cases were sensitive to tecovirimat in cell culture. (cdc.gov)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)

Most importantly this defense response was more prompt in the resistant than the susceptible host indicating that a resistant host makes different choices from a susceptible host during infection which ultimately influences the severity of the disease. (nature.com)
The cells were thawed and resus- disease control measures in ACL [5]. (who.int)

However, the expression of resistant genes was acquired by subsequent reprogramming as a result of chemotherapy. (medindia.net)

extended the analysis of this resistant Tennessee cluster and identified a novel clone termed TN 23F -4 with MIC values of third-generation cephalosporins as high as 32 μg/mL ( 8 , 9 ). (cdc.gov)

Double immunofluorescence analysis showed co-expression of LUM and COL3A1 as well as the presence of extracellular COL3A1 in the TOP-resistant cell line. (oncotarget.com)

Purification of the dihydrofolate reductases overproduced by 16 independently-derived antifolate-resistant sublines of Chinese hamster lung cells and their drug-sensitive parental cell line, DC-3F, has confirmed our original observation that two molecular weight classes of this enzyme, viz. (researchwithrutgers.com)

It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)
T cells are part of the immune system that protect the body from infection and may help fight cancer. (survivornet.com)
These logic-gated T cells may help the body's immune system identify and kill cancer cells while sparing normal healthy tissues from toxicity. (survivornet.com)

Sandflies were refractory or resistant to oral infection (4,5). (cdc.gov)

Importantly, manipulation of the recycling pathway influenced the response of drug-sensitive cells to doxorubicin treatment. (up.pt)

It has good ozone/UV resistance making it weather resistant and suitable for outdoor use. (reglinrubber.com.au)

NRTX-1001 is an inhibitory neuron cell therapy derived from human embryonic stem cells. (ca.gov)
NRTX-1001 is an inhibitory neuron cell therapy derived from human embryonic stem cells (hESCs) for the prospective treatment of drug-resistant focal epilepsy (MTLE). (ca.gov)

Yan is putting together a strategy to change that and enable death by iron for treatment-resistant prostate cancer through a cell-death process called ferroptosis. (genengnews.com)
OAKLAND, Calif. , June 30, 2021 /PRNewswire/ -- Aditum Bio, the biotech investment firm co-founded in 2019 by former Novartis CEO Joe Jimenez and former President of the Novartis Institutes for BioMedical Research (NIBR) Dr. Mark Fishman , today announced the formation of Ancora Bio, a portfolio company developing a new therapy for treatment-resistant depression. (prnewswire.com)

The most abundant LUM expression was observed in TOP-resistant cell line. (oncotarget.com)

The risk for fatal infection increases if the patient is colonized with antimicrobial drug-resistant pneumococci. (cdc.gov)
Neuraminidase are the proteins that allow flu viruses to escape infected cells, and for that reason, antiviral drugs that block neuraminidase proteins, like oseltamivir, help to limit further infection. (cdc.gov)

Here, we show that IFN-β sensitizes glioma cells that harbor the unmethylated MGMT promoter and are resistant to temozolomide. (aacrjournals.org)
Pterostilbene treatment suppressed glioma stem cell development via negatively modulating GRP78 signaling. (greenmedinfo.com)

The metal that is key to red blood cells carrying oxygen and other body fundamentals also is known to be lethal to cells in big doses, but prostate cancer cells are essentially impervious to it, says Chunhong Yan, PhD, molecular biologist at the Georgia Cancer Center and the department of biochemistry and molecular biology at the Medical College of Georgia (MCG). (genengnews.com)
It provides us tools to manipulate and then break chemo-resistance in cancer cells," said Marcus Smolka, interim director of the Weill Institute for Cell and Molecular Biology and professor of molecular biology and genetics in the College of Agriculture and Life Sciences. (technologynetworks.com)

Liu X, Li S, Zhang X. An experimental study on the malignant characteristics of gemcitabine resistant cells by Transferring MiRNA-222-3p via exosomes. (minervamedica.it)

ATF3 in turn induces expression of HMOX1, an enzyme and known antioxidant which basically cuts iron loose from places like hemoglobin so more can accumulate inside cells, which is lethal. (genengnews.com)
The research describes for the first time how a type of enzyme - previously known for its roles in DNA repair - prevents DNA damage in cancer cells, making them tolerant to chemotherapy drugs. (technologynetworks.com)
Of the 16 drug-resistant sublines analyzed, 12 overproduce the 21,000-dalton enzyme, while 4 overproduce the 20,000-dalton enzyme. (researchwithrutgers.com)
Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5), is a glycosylated monomeric metalloprotein enzyme expressed in mammals. (wikipedia.org)

Prolonged exposure to venetoclax led to the development of resistance to it in all three sensitive cell lines. (lu.se)
After exposure to 1 microM 5-Aza-C for 40 hr, methylation patterns of newly synthesized DNA reverted in HL-60/Ara-C cells to a clevage pattern similar to that in HL-60 wild-type cells. (aspetjournals.org)
While naturally circulating tecovirimat-resistant monkeypox viruses have not been observed, previous cell culture experiments performed during drug development and independent studies performed prior to the current outbreak have demonstrated induction of resistance following tecovirimat exposure. (cdc.gov)
Flu viruses are constantly undergoing genetic changes and the changes that make a virus resistant can occur without exposure to an antiviral drug. (cdc.gov)

We hypothesized that the combination of pyrotinib and 5-FU would show synergistic antitumor activity, and pyrotinib could reverse 5-FU resistance in HER2+ breast cancer cells in vitro and in vivo. (techscience.com)

In a cell culture, Yan's team has watched increased ATF3 expression sensitize human prostate cancer cells to death by iron, and the new DOD funded studies are enabling the next steps: studying the induction in a mouse with human prostate cancer, called a humanized mouse model, to see whether ATF3-induced bortezomib paired with JKE-1674 again induces ferroptosis in advanced, typically lethal prostate cancer. (genengnews.com)
These cell lines displayed differential BCL2 and BCL2L1 expression. (lu.se)
In conclusion, our findings suggest that pyrotinib could restore sensitivity of 5-FU-resistant HER2+ breast cancer cells to 5-FU through downregulating the expression levels of TS and ABCG2. (techscience.com)
The aim of the present study is to determine the expression of LUM in drug-resistant ovarian cancer cell lines. (oncotarget.com)
The expression of LUM in cytostatic-resistant cell lines suggests its role in drug resistance. (oncotarget.com)
Furthermore, we observed that JNK signaling may control the expression of both snail and twist1 in KB/VCR cells, indicating that both snail and twist1 are involved in controlling the mesenchymal characteristics of KB/VCR cells by JNK signaling. (biomedcentral.com)

These features are characteristic of highly mobile cells, and enable cancerous cells to metastasize rapidly around the body. (genengnews.com)
With basal cancer, cells in this layer are the ones that become cancerous. (medlineplus.gov)

Our results showed that MDR cells released more EVs than their drug-sensitive counterparts and also that the drug-sensitive cells captured more EVs than their MDR counterparts. (up.pt)

Colored scanning electron micrograph of the surface of prostate cancer cells. (genengnews.com)
A research team believes that one way to kill resistant prostate cancer cells will be with use of a lot of iron. (genengnews.com)
But the MCG research team has found that the gene, ATF3, a regulator of cell stress which they have shown also can suppress prostate cancer, can make prostate cancer cells more vulnerable to a newer compound, JKE-1674, that can help induce ferroptosis. (genengnews.com)
Basically, if you reduce prostate cancer cells' ability to ignore stress, they will die, notes Yan. (genengnews.com)
One way JKE-1674 works is by inhibiting GPX4, which has the added advantage of repairing some of the damage to the lipids that makes prostate cancer cells insensitive to death by ferroptosis. (genengnews.com)
However, whether pyrotinib sensitizes 5-FU-resistant breast cancer cells to 5-FU is unknown. (techscience.com)
After TS or ABCG2 in 5-FU-resistant breast cancer cells was knocked down, the sensitivity of SKBR-3/ FU and MDA-MB-453/FU cells to 5-FU was restored. (techscience.com)
Many anti-cancer drugs work by creating blocks on the DNA of cancer cells as they replicate. (technologynetworks.com)
But cancer cells have a way of slowing down these forks, which allows them to avoid such collisions and protect their DNA, leading to drug tolerance. (technologynetworks.com)
In addition to possess cross drug resistance characteristic, emerging evidences have shown that multiple-drug resistance (MDR) cancer cells exhibit aberrant metastatic capacity when compared to parental cells. (biomedcentral.com)
This process shares many similarities with epithelial-mesenchymal transition (EMT), which has been proposed as one of critical mechanisms for the acquisition of metastatic capacity by epithelial cancer cells [ 7 ]. (biomedcentral.com)
Basal cell cancer is the most common form of cancer in the United States. (medlineplus.gov)
Basal cell cancer is almost always slow-growing. (medlineplus.gov)
Basal cell cancer usually grows slowly and is often painless. (medlineplus.gov)
Basal cell skin cancer almost never spreads beyond the original location. (medlineplus.gov)
It seems reversible changes to the DNA scaffold might underlie drug resistance in some cancer cells. (newscientist.com)
Jeffrey Settleman of the Massachusetts General Hospital Cancer Center in Charlestown and his colleagues treated tumour cells with cancer drugs. (newscientist.com)
Stem cells: their role in breast cancer development and resistance to treatment. (greenmedinfo.com)
2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant breast cancer cells through multiple mechanisms. (greenmedinfo.com)
Recurrent, advanced, platinum resistant ovarian, fallopian tube, and primary peritoneal cancer and must have a histological diagnosis of a high-grade serous histology. (survivornet.com)
Surgical staging is the first step in the management of ovarian germ cell cancer . (medscape.com)
Available at http://www.cancer.gov/cancertopics/pdq/treatment/hairy-cell-leukemia/HealthProfessional. (medscape.com)

Proposed functions of TRAP include osteopontin /bone sialoprotein dephosphorylation, the generation of reactive oxygen species (ROS), iron transport, and as a cell growth and differentiation factor. (wikipedia.org)

Taking advantage of experimental strategies including pharmacological tool and gene knockdown, we showed here that interference with JNK signaling pathway by targeting JNK1/2 or c-Jun reversed the mesenchymal properties of KB/VCR cells to epithelial phenotypes and suppressed the motile capacity of KB/VCR cells, such as migration and invasion. (biomedcentral.com)

These observations support a critical role of JNK signaling in maintaining the mesenchymal properties of KB/VCR cells. (biomedcentral.com)
and JNK signaling may maintain the mesenchymal characteristics of KB/VCR cells potentially through snail and twist1. (biomedcentral.com)

The 2009 pandemic H1N1 viruses that are resistant to oseltamivir have a genetic change that changes their neuraminidase. (cdc.gov)
However, when identified, the resistant pandemic viruses have the same genetic change we saw in the resistant seasonal H1N1 viruses: the H275Y substitution. (cdc.gov)

Anatomy16

Organisms7

Diseases24

Chemicals and Drugs129

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes57

Information Science3

Methicillin-resist1

Acute lymphobl1

Multidrug5

Tumor12

Strains6

Prevalence of colonization1

Sickle cell di9

Ovarian cancer cells3

Chemotherapy resistant1

Dihydrofolate reductase2

Stem cell transplant6

MRNA5

Bacteria9

Hairy cell leuk2

Aureus4

Protein7

Increased cell viability1

Cancers8

Hematopoietic stem1

Transplantation3

Cellular9

Drug resistant cells1

Pathways2

Fecal samples1

Antibiotic1

Tumors3

Extensively1

Resistance to chemotherapy1

Vincristine2

Gene expression4

Platinum resistant disease2

Patients22

Inhibitors1

Isolates2

Disease2

Genes1

Identified a novel1

Extracellular1

Parental cell line1

Immune3

Refractory1

Doxorubicin1

Weather resistant1

Embryonic2

Treatment-resistant2

Abundant1

Infection2

Glioma2

Molecular Biology2

Malignant1

Enzyme4

Exposure4

Vivo1

Expression6

Cancerous2

Sensitive cells1

Cancer22

TRAP1

Phenotypes1

Mesenchymal2

Genetic2