• Insulin resistance increases your risk for developing prediabetes and type 2 diabetes . (healthline.com)
  • A diagnosis of insulin resistance is also an early warning sign. (healthline.com)
  • Saturated fats have also been associated with insulin resistance . (healthline.com)
  • Skip whole milk and full-fat yogurts because a high intake of saturated fat, found in animal fats, has been linked to insulin resistance. (healthline.com)
  • Whole-grain foods are fine for people with insulin resistance. (healthline.com)
  • They raise blood sugar levels slowly, which is a plus for people with insulin resistance. (healthline.com)
  • Insulin Resistance is a condition in which the body does not respond to insulin properly. (news-medical.net)
  • This groundbreaking nine-year study used advanced mass spectrometry to analyze lipid profiles in human plasma, revealing dynamic changes tied to aging, insulin resistance, and viral infections. (news-medical.net)
  • The effects of theabrownin (TB) from dark tea treatment on insulin resistance (IR). (news-medical.net)
  • More specifically, proinflammatory adipokines from visceral adipose tissue may initiate the development of insulin resistance, microvascular dysfunction, and endothelial dysfunction. (hindawi.com)
  • Insulin resistance and endothelial dysfunction have both been implicated in the pathogenesis of hypertension [ 3 - 7 ] and atherosclerosis [ 8 , 9 ]. (hindawi.com)
  • Microvascular dysfunction may affect both peripheral vascular resistance and insulin-mediated glucose disposal, thereby contributing to hypertension and insulin resistance, respectively [ 10 ]. (hindawi.com)
  • The study was designed to evaluate the role of inflammation markers in the development of insulin resistance, microvascular dysfunction, and endothelial dysfunction and eventually the progression to (pre)diabetes and (pre)hypertension. (hindawi.com)
  • Recent studies suggest an association between vitamin D status, metabolic syndrome, insulin resistance, and obesity among Canadians (12,13). (cdc.gov)
  • A new study by investigators from the Mass General Cancer Center, a member of the Mass General Brigham healthcare system, reveals how lung tumors may develop drug resistance over time, pointing to a protein, called APOBEC3A, that could be a promising target. (medicalxpress.com)
  • The authors found that the tumor cells surviving TKI treatment overexpress a type of APOBEC protein, APOBEC3A, which appears to cause drug resistance in two main ways. (medicalxpress.com)
  • In other cases, the cause of drug resistance is less direct, though the researchers hypothesize that APOBEC3A causes extensive DNA damage that helps push tumor cells into a "persister" state that is more resistant to treatment. (medicalxpress.com)
  • Going forward, the researchers hope to gain further insight into the mechanisms by which APOBEC causes drug resistance, which may shed more light on how to develop a drug to inhibit APOBEC expression or activity. (medicalxpress.com)
  • Furthermore, it is not yet clear whether APOBEC drives acquired drug resistance in other cancer types or with use of other targeted therapies. (medicalxpress.com)
  • Our research helps us understand the mechanisms that drive the process of drug resistance, which begin before the tumor becomes resistant. (medicalxpress.com)
  • This study will be of interest to scientists working on parasite biology as well as antimalarial drug resistance. (elifesciences.org)
  • In an attempt to identify new breast cancer drug resistance associated antigens, MAb 5C3 was generated using paraffin wax embedded formalin fixed archival breast tumour tissue from a biopsy showing no P-170 or MRP-1 expression, as an immunogen. (dcu.ie)
  • Chemotherapy is a treatment method commonly used for cancer and that patients showing low to no response to the treatment often developed drug resistance via multiple mechanisms. (jcancer.org)
  • Natural products have been shown to reduce tumor drug resistance. (jcancer.org)
  • 5 Although ovarian cancer in advanced stages initially appears to be chemotherapy sensitive as response rates to platinum-based therapy exceed 80%, long-term survival remains poor as a result of recurrence and emergence of drug resistance. (nature.com)
  • Furthermore, synthetic estrogens, tamoxifen derivatives and phytoestrogens/flavonoids have now been identified that can effectively circumvent BCRP-mediated drug resistance. (elsevierpure.com)
  • The kinase inhibitor gefitinib inhibited the transporter function of BCRP and reversed BCRP-mediated drug resistance both in vitro and in vivo. (elsevierpure.com)
  • The C421A (Q141K) polymorphism is also significant as Q141K-BCRP-transfected cells show markedly low protein expression levels and low-level drug resistance. (elsevierpure.com)
  • Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)
  • Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • A poor anticoagulant response to activated protein C (APC) in an activated partial thromboplastin time (aPTT) assay (APC resistance) was recently reported to be a cause of familial thrombophilia. (nih.gov)
  • 0.0001) between the results of this functional protein S assay and APC resistance (represented by the ratio (Rs value) of clotting time with and without addition of activated protein C) was observed. (nih.gov)
  • Assessment of protein S activity with a second protein S clotting assay using factor Va as substrate confirmed only 47% of the decreased levels of the thromboplastin-based protein S clotting assay. (nih.gov)
  • However, because of the unknown binding affinity of antibody to MRP2/Mrp2 protein across species and lack of purified MRP2/Mrp2 proteins for calibration, the immunoblotting assay was excluded from the absolute quantification of MRP2/Mrp2 protein for multiple species. (aspetjournals.org)
  • The activated protein C resistance assay is a screening test for the presence of factor V Leiden. (msdmanuals.com)
  • Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/775507/all/activated_protein_C_resistance_ratio_assay. (unboundmedicine.com)
  • ZEB1 achieves this unfortunate result through a complex chain of events that permit a gene known as ATM to stabilize the protein Chk1 that plays an important role in DNA damage response. (mdanderson.org)
  • APOBEC3A can directly cause mutations that are known to result in tumor resistance, such as mutations in the ALK gene. (medicalxpress.com)
  • A previous study had reported pineapple sweet orange plants transformed with a hairpin construct from the CPsV coat protein gene ( ihpCP ). (isaaa.org)
  • Artemisinin-resistant parasites contain mutations in the gene encoding the Kelch 13 protein (K13). (elifesciences.org)
  • The gene CPLCG5 encodes a cuticle protein that plays an important role in pyrethroid resistance. (biomedcentral.com)
  • The gene encoding ArsR/methyltransferase fusion protein, arsR M , was amplified and expressed in Escherichia coli BL21 (DE3), and this strain showed resistance to arsenic in the present of 0.25-6 mM As(III), aresenate, or pentavalent roxarsone. (biomedcentral.com)
  • By transformation of the susceptible variety Nipponbare, we show that one of 14 nucleotide-binding, leucine-rich repeat (NLR) protein genes at the locus, with a zinc finger BED domain, is the Xo1 gene. (uea.ac.uk)
  • Analyses of published transcriptomes revealed that the Xo1-mediated response is more similar to those mediated by two other NLR resistance genes than it is to the response associated with TALE-specific transcriptional activation of the executor resistance gene Xa23 and that a truncTALE dampens or abolishes activation of defense-associated genes by Xo1. (uea.ac.uk)
  • The ABCC6 gene provides instructions for making a protein called multidrug resistance-associated protein 6 (MRP6, also known as the ABCC6 protein). (medlineplus.gov)
  • The ABCC6 gene mutations involved in this condition lead to an absence of MRP6 protein or an altered protein that does not function properly. (medlineplus.gov)
  • Therefore, differences in the magnitude and pattern of these primary signals generated by endurance and resistance exercise will result in the activation of different signaling pathways and different gene-expression and protein-synthesis responses in skeletal muscle. (humankinetics.com)
  • The purpose of this study is to identify uncharacterized proteins that were found in a prior RNA- Seq experiment to measure gene expression in larvae that survived treatment of ivermectin at three different levels along with untreated controls. (udel.edu)
  • In summary, both modulators of BCRP and functional single nucleotide polymorphisms within the BCRP gene affect the transporter function of the protein and thus can modulate drug sensitivity and substrate pharmacokinetics and pharmacodynamics in affected cells and individuals. (elsevierpure.com)
  • Given that both Sirt6 gene activation and rapamycin treatment extend fly lifespan by blocking protein synthesis, perhaps these avenues can be explored therapeutically individually or in tandem. (nad.com)
  • IGF-I deficiency can be the result of GH resistance or insensitivity due to genetic disorders of the GH receptor causing GH receptor deficiency (growth hormone receptor deficiency [GHRD], Laron syndrome) or postreceptor defects, including the principal transduction agent STAT5b, the IGF-I/IGFBP3 stabilizer acid labile subunit (ALS), the IGF-I gene, or the IGF-I receptor. (medscape.com)
  • The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)
  • The E. coli AcrB protein is a transporter that is energized by proton-motive force and that shows the widest substrate specificity among all known multidrug pumps, ranging from most of the currently used antibiotics, disinfectants, dyes, and detergents to simple solvents. (wikipedia.org)
  • One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport (efflux) drugs out of the tumor cells. (muni.cz)
  • However, whether ascites drives multidrug resistance in ovarian cancer cells awaits elucidation. (muni.cz)
  • Collectively, our findings identify a novel activity for ascites in promoting ovarian cancer multidrug resistance. (muni.cz)
  • The presence of plasma membrane multidrug resistance protein P-glycoprotein (P-gp) is favorable for tumor cells to elicit chemotherapeutic resistance. (jcancer.org)
  • We previously reported that hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) is considered to be the major cause of the interspecies differences detected by efflux of fluorescent substrates in isolated hepatocytes. (aspetjournals.org)
  • A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4/ABCC4) mediates cellular export of dimethylarsinic acid (DMAV) and the diglutathione conjugate of monomethylarsonous acid (MMAIII). (bvsalud.org)
  • Human multidrug resistance protein 1 (MRP1/ABCC1) and MRP2 (ABCC2) are established arsenic efflux pumps , but unlike the related MRP4 (ABCC4) are not present at the basolateral membrane of hepatocytes . (bvsalud.org)
  • The Xo1 locus in the heirloom rice variety Carolina Gold Select confers resistance to bacterial leaf streak and bacterial blight, caused by Xanthomonas oryzae pv. (uea.ac.uk)
  • Evidence is presented for PI3P-dependent signalling in which transgenic expression of an additional kinase confers resistance. (nature.com)
  • We determined myofibrillar and mitochondrial protein fractional synthesis rates (FSR), intramuscular signaling protein phosphorylation, and mRNA expression responses after isolated bouts of resistance exercise (RE), aerobic exercise (AE), or in combination [termed concurrent exercise (CE)] in sedentary middle-aged men. (roehampton.ac.uk)
  • These data suggest that CE-induced acute stimulation of myofibrillar and mitochondrial FSR, protein signaling, and mRNA expression are equivalent to either isolate mode (RE or AE). (roehampton.ac.uk)
  • These results occurred without an interference effect on muscle protein subfractional synthesis rates, protein signaling, or mRNA expression. (roehampton.ac.uk)
  • Additionally, in order to significantly increase in size or hypertrophy, muscles have to add more nuclei, since a nucleus is only able to supply mRNA for new protein synthesis to a limited amount of cytoplasm in its vicinity. (humankinetics.com)
  • Physiological concentrations of estrogens (10-100 pM) reduced BCRP protein expression without affecting its mRNA levels. (elsevierpure.com)
  • To further characterize the manner in which Sirt6 extends lifespan, Taylor and colleagues analyzed protein levels of genes involved in protein synthesis and ribosome - vital proteins involved in translating mRNA to new proteins - generation. (nad.com)
  • The protein expression levels of phosph-protein kinase B (P-AKT), phosph-mammalian targets of rapamycin (P-mTOR), and phosph-p70 ribosomal s6 kinase (P-p70s6K) in tumor cells were likewise reduced after hinokitiol treatment. (jcancer.org)
  • Rapid and transient activation of myelin basic protein kinase in tobacco leaves treated with hairpin from Erwinia amylovora . (springer.com)
  • SEPT9-ABL1 has the same ABL1 region as seen in BCR-ABL1 but no point mutation in its kinase domain, which is one of the main mechanisms underlying TKI resistance in the leukemic cells harboring BCR-ABL1. (elsevierpure.com)
  • The intact receptor lacks tyrosine kinase activity, but binding of GH and dimerization results in association with JAK2, a member of the Janus kinase family, which results in self-phosphorylation of the JAK2 and a cascade of phosphorylation of cellular proteins. (medscape.com)
  • This study further examined the time course for elevated muscle protein synthesis by examining its rate at 36 hrs following a training session. (researchgate.net)
  • Several proteins, including factors II (prothrombin), VII, IX and X, protein C and protein S, are subjected to vitamin K-dependent g-carboxylation of glutamic acid residues during their synthesis in the liver. (apcresistance.com)
  • Provision of dietary amino acids increases skeletal muscle protein synthesis (MPS), an effect that is enhanced by prior resistance exercise. (biomedcentral.com)
  • MPB assists in maintenance of intracellular amino acid levels, and likely plays a role in maintaining muscle protein quality by removing damaged proteins and allowing their constituent amino acids to be used for the synthesis of new functional muscle proteins. (biomedcentral.com)
  • A number of studies have shown that resistance exercise results in increased rates of muscle-protein synthesis, about two- to fivefold after exercise for periods up to 48 h before declining to baseline values. (humankinetics.com)
  • This means that chronic resistance training, but not endurance training, increases the rate of muscle-protein synthesis to levels above the rate of protein degradation. (humankinetics.com)
  • These new satellite cells will then fuse with the existing muscle fibers and add their nuclei to the cells to support greater protein synthesis and increase muscle hypertrophy or repair. (humankinetics.com)
  • Sirt6 lowers expression of genes that participate in making proteins, corroborating with research showing that inhibiting protein synthesis extends lifespan. (nad.com)
  • Studies show that reduced protein synthesis and ribosome generation are linked to longevity in yeast, worms, flies, and even humans . (nad.com)
  • The results showed that Sirt6 overexpression diminished both protein synthesis and ribosome generation in male and female flies, as evidenced by the decreased levels in protein synthesis and ribosome genes. (nad.com)
  • Interestingly, other researchers have achieved decreased protein synthesis in flies by inhibiting mTOR - a protein known to be involved in nutrient sensing and aging - with rapamycin treatment. (nad.com)
  • Taken together, the study's findings demonstrate Sirt6's effectiveness in prolonging fly lifespan through means of oxidative stress-resistance and altered expression of genes that regulate protein synthesis. (nad.com)
  • Left) Sirt6 blocks the activity of Myc, known to modulate protein synthesis genes. (nad.com)
  • Sirt6 overexpression also induces epigenetic changes to the H3K9ac protein, which functions as another blocker of protein synthesis genes. (nad.com)
  • The Escherichia coli Acriflavine resistance (acrA and acrB genes) encode a multi-drug efflux system that is believed to protect the bacterium against hydrophobic inhibitors. (wikipedia.org)
  • They further suggest that effector coimmunoprecipitation may be effective for identifying or characterizing other resistance genes. (uea.ac.uk)
  • Moreover, a significant loss of Mrp2 protein in the membrane fraction of rat cryopreserved hepatocytes was observed. (aspetjournals.org)
  • The proteins that were of most interest were membrane transporters and cytoskeleton structure and organization proteins. (udel.edu)
  • These proteins also were found in hosts such as humans, mouse and rat. (sciencedaily.com)
  • It has been shown that muscle protein synthetic rate (MPS) is elevated in humans by 50% at 4 hrs following a bout of heavy resistance training, and by 109% at 24 hrs following training. (researchgate.net)
  • Although the overall sequence of the orthologs is highly similar, the study identifies a protein domain carrying distinct amino acid variations present in the different organisms. (sciencedaily.com)
  • This unique amino acid modification allows the proteins to bind calcium ions necessary for phospholipid binding and thereby to participate efficiently in multimolecular complexes in the coagulation cascade. (apcresistance.com)
  • Such factors include timing of protein intake, dietary protein type, the role of leucine as a key anabolic amino acid, and the impact of other macronutrients (i.e. carbohydrate) on the regulation of MPS after resistance exercise. (biomedcentral.com)
  • It combines insights from nutritional ecology, ecological sciences, and nutritional geometry, suggesting that protein deficiency and amino acid imbalances could drive increased food intake and contribute to obesity. (news-medical.net)
  • This project will link to industry partners in assessing metabolic pathway expression in wheat tissues to develop protein markers for industry and learn about metabolic pathway responses linked to real world problems in improving grain production. (edu.au)
  • During the course of this thesis the expression of a panel of MDR associated proteins was correlated with patient and tumour characteristics and relapse and overall survival in a series of invasive breast carcinomas. (dcu.ie)
  • In order to address the multifactorial nature o f this disease, expression of individual proteins was analysed in relation to other markers. (dcu.ie)
  • The results presented show that MRP-1 protein at diagnosis is an independent prognostic factor for overall survival in node positive breast cancer patients treated with CMF based chemotherapy, absence o f MRP-1 expression at diagnosis was significantly associated with increased overall survival. (dcu.ie)
  • The exact significance of this expression and the contribution, if any, of MDR-3 Pgp in the resistance of breast cancer or other solid cancers further investigation. (dcu.ie)
  • Expression of ArsR M in E. coli increased its arsenite resistance to 1.5 mM. (biomedcentral.com)
  • Hydrogen peroxide does not function downstream of salicylic acid in the induction of PR protein expression. (springer.com)
  • A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance. (springer.com)
  • Isolated lung macrophages from TLR2 knockout mice demonstrated reduced TNF-a, IL-6, keratinocyte chemoattractant/CXCL1, but not macrophage inflammatory protein-2/CXCL2 expression, after DE stimulation ex vivo. (cdc.gov)
  • Deadly bacteria may be evolving antibiotic resistance by mimicking human proteins, according to a new study. (sciencedaily.com)
  • Is Antibiotic Resistance Evidence for Darwinian Evolution? (discovery.org)
  • Antibiotic resistance is an example of natural selection acting on random mutation and is often referred to as one of the hallmark pieces of evidence for Darwin's theory of evolution. (discovery.org)
  • Streptococcus pneumoniae and Neisseria meningitidis selection pressure borne by these bacteria, as young children have very similar mechanisms of resistance to penicillin G. are treated more frequently than young adults. (cdc.gov)
  • Streptococcus pneumoniae and Neisseria meningitidis have is specific to the mechanism of resistance to penicillin G com- very similar mechanisms of resistance to penicillin G, which mon to S. pneumoniae and N. meningitidis and mediated by the are mediated by the decreased affinity of penicillin-binding decrease in affinity of their PBPs. (cdc.gov)
  • By identifying these uncharacterized proteins by finding potential matches in other nematode species, we can understand possible mechanisms of resistance in these cyathostomins. (udel.edu)
  • These results point to specific mechanisms enabling survival of cyathostomins, which could be developed into more effective drug targets to reduce resistance. (udel.edu)
  • Despite its importance, cuticle resistance is an under-studied area, and exploring the detailed molecular basis of resistance is critical for implementing suitable resistance management strategies. (biomedcentral.com)
  • The results suggest CPLCG5 participates in pyrethroid resistance by forming a rigid matrix and increasing the thickness of the cuticle. (biomedcentral.com)
  • 2 cuticle proteins were up-regulated which indicates the structural component of the cuticle was enriched to prevent ivermectin stimulation. (udel.edu)
  • ARTs are administered in combination with other antimalarials (ART combination therapies, ACTs) due to artemisinin's short in vivo half-life and to impede development of resistance ( WHO, 2021 ). (elifesciences.org)
  • How K13 mutations result in artemisinin resistance is unclear. (elifesciences.org)
  • Our results suggest that artemisinin resistance is due to a decrease in artemisinin activation brought about by a decrease in efficiency of haemoglobin uptake and consequently reduced production of haem. (elifesciences.org)
  • In resistant clinical strains, increased PfPI3K was associated with the C580Y mutation in P. falciparum Kelch13 (PfKelch13), a primary marker of artemisinin resistance. (nature.com)
  • We find PI3P levels to be predictive of artemisinin resistance in both clinical and engineered laboratory parasites as well as across non-isogenic strains. (nature.com)
  • Elevated PI3P induced artemisinin resistance in absence of PfKelch13 mutations, but remained responsive to regulation by PfKelch13. (nature.com)
  • Together these data present PI3P as the key mediator of artemisinin resistance and the sole PfPI3K as an important target for malaria elimination. (nature.com)
  • Figure 3: Elevated PI3P and artemisinin-resistance in presence and absence of PfKelch13 mutations. (nature.com)
  • Artemisinin resistance in Plasmodium falciparum malaria. (nature.com)
  • A major genome region underlying artemisinin resistance in malaria. (nature.com)
  • However, ovarian cancers often acquire chemotherapeutic resistance to this agent. (nature.com)
  • Mutations in the parasite's Kelch 13 (K13) protein compromise the efficacy of this drug. (elifesciences.org)
  • Resistance of Plasmodium falciparum to artemisinin, which has become a threat to malaria control, has been linked to mutations in the parasite protein K13. (elifesciences.org)
  • Mutations of factor V make it resistant to its normal cleavage and inactivation by activated protein C, and they also predispose to venous thrombosis. (msdmanuals.com)
  • These mutations lead to an absent or nonfunctional MRP6 protein. (medlineplus.gov)
  • NEW & NOTEWORTHY Our research evaluates the efficacy of higher in comparison with moderate animal-based protein intake on resistance exercise training-induced muscle strength, clinical biomarkers, and gut microbiota in middle-aged adults through a dietary counseling-controlled intervention. (nih.gov)
  • Upon infection, bacterial pathogens dump more than 200 proteins into human macrophage cells called 'effector proteins. (sciencedaily.com)
  • In a new meta analysis which included over 80 clinical trials and almost 4000 subjects, researchers found muscle strength increased significantly only when protein consumption was coupled with resistance training. (theproof.com)
  • As illustrated in the image above (by the red lines), this level of protein intake can support significant improvements in muscle strength, providing people are subjecting their body to resistance exercise. (theproof.com)
  • Resistance training is the work necessary to turn protein from food into the muscle and strength you need to feel better for longer. (theproof.com)
  • A plant-based diet protects your heart and provides the protein you need to build muscle with resistance training. (theproof.com)
  • As a fundamentally necessary process in the enhancement of muscle mass, strategies to enhance rates of MPS would be beneficial in the development of interventions aimed at increasing skeletal muscle mass particularly when combined with chronic resistance exercise. (biomedcentral.com)
  • The purpose of this review article is to provide an update on current findings regarding the nutritional regulation of MPS and highlight nutrition based strategies that may serve to maximize skeletal muscle protein anabolism with resistance exercise. (biomedcentral.com)
  • Consuming dietary amino acids after resistance exercise stimulates an increase in MPS and is necessary to shift net protein balance (defined as MPS minus muscle protein breakdown (MPB)) from negative (net protein loss) to positive (net protein gain) [ 3 ]. (biomedcentral.com)
  • In healthy individuals, feeding-induced changes in MPS are ~3-5 times greater over the course of any given day than measurable changes in MPB, demonstrating that MPS is highly responsive, regulated, and represents the primary driver of changes in muscle net protein balance. (biomedcentral.com)
  • As such, it would follow that for chronic elevations in net muscle protein balance to result in gains in muscle mass, changes in MPS are highly relevant. (biomedcentral.com)
  • Consequently, we propose that nutritional interventions that enhance MPS may be of great scientific and clinical interest as a strategy to promote positive muscle protein balance and eventual muscle protein accrual. (biomedcentral.com)
  • For example, endurance exercise likely results in extended periods of moderately elevated [Ca 2+ ] , while resistance exercise would generate short cycles of significantly higher intracellular [Ca 2+ ] in skeletal muscle (Chin 2010). (humankinetics.com)
  • Although acute resistance and endurance-type exercise result in a similar global anabolic response in untrained skeletal muscle, increases in muscle mass (i.e., hypertrophy) and strength are significantly greater following chronic resistance training compared with chronic endurance training. (humankinetics.com)
  • Activation and differentiation of muscle satellite cells into new muscle cells that fuse with existing muscle fibers can also contribute significantly to the hypertrophic response to resistance exercise. (humankinetics.com)
  • When stimulated by resistance training or by exercise-induced muscle damage, these specialized cells will be activated and induced to create daughter cells or proliferate. (humankinetics.com)
  • It is well known that the primary factor determining the hypertrophic response to contractile activity is the load across the muscle or the mechanical stretch/strain imposed on the muscle fibers, which is higher in resistance exercise than in endurance exercise. (humankinetics.com)
  • For several years, researchers have focused on the role of insulin-like growth factor (IGF)-1 as a primary signaling molecule that mediates skeletal-muscle growth in response to resistance exercise, given that resistance exercise stimulates the secretion of IGF-1. (humankinetics.com)
  • This supports prior hypotheses suggesting that up-regulation of transporter proteins, such as ABC transporters, contribute to ivermectin efflux out of the parasite, therefore limiting the time the drug has to act in the parasite. (udel.edu)
  • The loss of strength and physical ability seen in western countries today is primarily due to a sedentary lifestyle, not protein deficiency. (theproof.com)
  • Moreover, specific proteins important for this process and the cellular structures involved have not been unambiguously identified. (elifesciences.org)
  • These longevity-linked proteins maintain cellular health and are known to participate in DNA repair and stability. (nad.com)
  • In conclusion, higher protein intake above moderate amounts does not potentiate resistance training adaptations in previously untrained middle-aged adults. (nih.gov)
  • Higher protein intake did not potentiate training adaptations, nor did the intervention effect disease biomarkers. (nih.gov)
  • Collectively, moderate amounts of high-quality, animal-based protein is sufficient to promote resistance exercise adaptations at the onset of aging. (nih.gov)
  • The factors that influenced the time course of resistance-type exercise training (RET) adaptations remained unknown. (physiciansweekly.com)
  • One protein with the even more out-there name of ZEB1 (zinc finger E-box binding homeobox 1), is now thought to keep breast cancer cells from being successfully treated with radiation therapy, according to a study at The University of Texas MD Anderson Cancer Center in Houston. (mdanderson.org)
  • The aim of this study was to examine the role of stemness proteins in breast cancer cell lines and anti-hormonal therapy resistance. (lincoln.ac.uk)
  • Conclusion: Stemness" proteins are highly expressed in breast cancer cells resistant to tamoxifen therapy. (lincoln.ac.uk)
  • Breast cancer resistance protein (BCRP) is a half-molecule ATP-binding cassette transporter that forms a functional homodimer and pumps out various anticancer agents, such as 7-ethyl-10-hydroxycamptothecin, topotecan, mitoxantrone and flavopiridol, from cells. (elsevierpure.com)
  • The model suggests that simple differences in the impact of antibiotic exposure does not differ according to the natural history of colonization, interhuman contact, and expo- mechanism of resistance and do not consider the particular nat- sure to -lactam antibiotics explain major differences in the epi- ural history of the colonization of the bacterial species. (cdc.gov)
  • In both S. pneumoniae and N. meningi- establishing whether meningococcal resistance could increase tidis , the main mechanism of penicillin G resistance is mediat- are important. (cdc.gov)
  • Altogether, evidence suggests a role of the Francisella tularensis protein in a mechanism of molecular mimicry. (sciencedaily.com)
  • The purpose of this study was to reveal the mechanism underlying TKI resistance induced by SEPT9-ABL1. (elsevierpure.com)
  • Similar methyltransferase proteins are found in other highly infectious bacteria, including the pathogen Mycobacterium tuberculosis that causes Tuberculosis, a disease that results in more than 1 million deaths annually. (sciencedaily.com)
  • Because these proteins are so similar to the human proteins, it mimics them and enables them to interfere with the body's immunity response, thereby protecting the pathogen,'' Dr. Champion said. (sciencedaily.com)
  • Identifying small differences between the pathogen and human proteins through Next Generation genome-wide datasets could help develop molecular targets in the development of new drug treatments, she said. (sciencedaily.com)
  • Resistance is triggered by pathogen-delivered transcription activator-like effectors (TALEs) independent of their ability to activate transcription and is suppressed by truncated variants called truncTALEs, common among Asian strains. (uea.ac.uk)
  • Although extensive data has described the key role of salicylic acid (SA) in signaling pathogen-induced disease resistance, its function in physiological processes related to cell death is still poorly understood. (springer.com)
  • Cell-autonomous recognition of the rust pathogen determines Rpl-specified resistance in maize. (springer.com)
  • This enables the building of specific mass spectrometry assays for different sets of proteins of interest that can be quantified in wheat tissues. (edu.au)
  • Proteins and other biomedia are prone to adsorbing or fouling on stainless steel surfaces, leading to inaccuracies in clinical assays and detrimental downtime of the analytical system. (medicaldevice-network.com)
  • I am a protein biochemist focused on plant biology in the School of Molecular Sciences. (edu.au)
  • What are the wheat proteins that define wheat quality, enable disease resistance and tolerate harsh environmental conditions? (edu.au)
  • However, the development of resistance to tamoxifen as a primary therapy and disease reoccurrence limits its clinical benefit. (lincoln.ac.uk)
  • These results suggest that MET inhibitors administered concurrently with PTX could prevent the development of resistance to PTX. (nature.com)
  • We describe a mathematical model of the emergence and diffusion of bacterial resistance in the community. (cdc.gov)
  • Emergence and spread of resistance to them 2 , 3 , 4 raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global level. (nature.com)
  • However, due to the emergence of primary and acquired resistance, efficacy is compromised in clinical or preclinical settings. (lu.se)
  • The data enables dissection of tissue-specific proteomes, correlation of transcript and protein data for different wheat tissues and protein functional classes, and identification of constitutive and differential proteome markers for a variety of applications. (edu.au)
  • Our findings suggest that hamsters may lack functional TLR11, which has recently been shown to recognize a profilin-like protein homologous to rEA from the protozoan Toxoplasma gondii. (usu.edu)
  • Functional prediction analyses suggested that ArsR M is a difunctional protein with transcriptional regulation and methyltransferase activities. (biomedcentral.com)
  • Thus, depending on the size of poly(ADP-ribose) attached to nuclear proteins, these modified proteins might display different degrees of resistance to proteolysis. (oregonstate.edu)
  • The main results of the team are the lack of cross-reactivity between allergens with strong sequence homologies, the relationship between the structure, resistance to proteolysis and allergenicity and the effect of technological processes and composition of the matrix on digestibility and allergenicity. (cea.fr)
  • Allergenicity of food proteins has been correlated to their structural conformation and their resistance to proteolysis. (cea.fr)
  • A correct folding of Ara h 6 is then required for its proteolysis resistance and its elicitation potency. (cea.fr)
  • Therefore, pharmacological inhibition of this family of proteins is becoming a prevalent treatment method. (lu.se)
  • Using genomic sequencing, the spelling out of billions of genetic instructions stored in DNA, the study identified several methyltransferase protein families that are very similar in otherwise very distantly related human bacterial pathogens. (sciencedaily.com)
  • This was a marked increase over a short period of time, and the resistance was conferred by a specific genetic change called H275Y substitution. (cdc.gov)
  • Specifically, protein supplementation after resistance exercise and nightly are strategies to maximize utilization of protein intake above the RDA in healthy adults. (nih.gov)
  • Western cultures tend to place a lot of emphasis on eating protein, but the truth is, protein won't get you very far if you aren't challenging your muscles with resistance. (theproof.com)
  • Both pathways involve a number of plasma proteins as listed in Table 1. (apcresistance.com)
  • It is concluded that following a bout of heavy resistance training, MPS increases rapidly, is more than double at 24 hrs, and thereafter declines rapidly so that at 36 hrs it has almost returned to baseline. (researchgate.net)
  • The importance of early post-exercise protein ingestion relates to the fact that exercise-mediated increases in rates of MPS are greatest immediately after exercise (~100 - 150% above basal rates) [ 2 ], and thus the synergistic effects of exercise and feeding on MPS are likely greatest during this time-period. (biomedcentral.com)
  • Elevated sirtuin - enzymes that promote longevity -activity, specifically Sirt6 (Sirtuin 6) increases lifespan by 33% in male flies and 38% in female flies and strengthens resistance to oxidative stress. (nad.com)
  • Protein intake above the recommended dietary allowance (RDA) and resistance training are known anabolic stimuli to support healthy aging. (nih.gov)
  • In all, 50 middle-aged adults (age: 50 ± 8 yr, BMI: 27.2 ± 4.1 kg/m 2 ) were randomized to either MOD or HIGH protein intake during a 10-wk resistance training program (3 × wk). (nih.gov)
  • What's interesting in this study is the level of protein intake that best enhances the effects of resistance training. (theproof.com)
  • Now, resistance training is a critical component of strength, but that doesn't mean you don't need to have your eye on protein intake too. (theproof.com)
  • In just this blog post we've covered how strength training is linked to protein intake which influences heart disease risk which impacts longevity. (theproof.com)
  • The research paper presents an integrative approach to understanding obesity, focusing on the protein leverage hypothesis (PLH) to examine how protein intake affects energy imbalance. (news-medical.net)
  • In 1963, an investigation conducted on house flies to determine the causes of insecticide resistance revealed that penetration in the resistant (DR) strain was slower than in the sensitive (DS) strain, indicating resistance to both DDT and pyrethroids [ 17 ]. (biomedcentral.com)
  • In patients with homozygous or heterozygous factor V Leiden resistance , the prolongation of the clotting time is significantly reduced because their factor V is resistant to cleavage by activated protein C. (msdmanuals.com)
  • To identify miRNAs that potentially cause the resistance to taxanes, such as PTX, we performed microarray analysis of miRNAs in KFr13 and PTX-resistant KFr13Tx cells. (nature.com)
  • Aaron Storms] So, the first concept is that flu viruses can become resistant to antiviral medications, and antiviral resistance means that a virus has changed in such a way that the antiviral drug isn't effective or is less effective. (cdc.gov)
  • And in the lab test, if oseltamivir doesn't inhibit the function of the neuraminidase protein, we call the virus oseltamivir-resistant. (cdc.gov)
  • Rice and almond milk are also alternative milk options, but they have very little protein or nutritional value. (healthline.com)
  • The purpose of this review is to discuss the nutritional regulation of human MPS and provide an update on nutritional strategies that may serve to maximize MPS with feeding and resistance exercise. (biomedcentral.com)
  • Immunohistochemical analysis with this novel MAb of pre and post treatment tumours however, did not reveal any apparent association with resistance for the antigen recognised by antibody 5C3. (dcu.ie)
  • A protein antigen from an Eimeria protozoan has recently been reported to induce antitumor activity in mice. (usu.edu)
  • The IGFBPs are a family of 6 structurally related proteins with a high affinity for binding IGF. (medscape.com)
  • The cross-reactions of MRP2/Mrp2 protein of different species with anti-human MRP2 polyclonal antibody were found by Western blotting. (aspetjournals.org)
  • Freshly isolated hepatocytes conserved MRP2/Mrp2 protein levels that are comparable with those in the liver tissues. (aspetjournals.org)
  • this period may vary examine treatment protocols for resistance prevention (12), and from 10 to 30 years. (cdc.gov)
  • A thorough understanding of insecticide metabolism may help us to generate countermeasures to insecticide resistance that may be critical for effective mosquito control. (biomedcentral.com)
  • The table below compares the clinical and biochemical features associated with these various causes of GH resistance. (medscape.com)
  • The methyltransferase protein also was found to have an ortholog, or similar counterpart, in human DNA. (sciencedaily.com)
  • Spontaneous central vein thrombosis in a patient with activated protein C resistance and dengue infection: An association or causation? (medscape.com)
  • Specifically, it works by blocking proteins called "neuraminidase," which are located on the surface of flu viruses and play an important role in how these viruses cause infection. (cdc.gov)
  • Neuraminidase are the proteins that allow flu viruses to escape infected cells, and for that reason, antiviral drugs that block neuraminidase proteins, like oseltamivir, help to limit further infection. (cdc.gov)
  • The hope is that new approaches to addressing radiation resistance may be developed through gaining better insight into how this signaling pathway keeps tumor cells growing despite being bombarded with toxic radiation treatments. (mdanderson.org)
  • They may sound like words in a children's nursery rhyme, but they are actually the exotic names given to proteins that can generate cells with stem cell-like properties that have the ability to form diverse types of tissue. (mdanderson.org)
  • To learn more about resistance training I highly recommend listening to Episode 223 of The Proof Podcast with exercise physiologist Drew Harrisberg where we talk about creating the optimal workout plan that includes resistance training for adding strength. (theproof.com)