Resistance to carbapenems in klebsiella pneumoniae. Medical search. Frequent questions

In this work, we studied the antimicrobial resistance and performed a comparative genomics analysis of ten CR- Kp isolates from the Chilean surveillance of carbapenem-resistant Enterobacteriaceae . (biorxiv.org)
High resistance to most of the antibiotics tested was observed among the isolates, five ST25, three ST11, one ST45, and one ST505, which harbored a total of 44 plasmids, many of them predicted to be conjugative and carrying genes conferring resistance to a variety of antibiotic, metals, and disinfectants. (biorxiv.org)
Escherichia coli and Klebsiella pneumoniae isolates were obtained from the Canadian Ward Surveillance Study (CANWARD) and underwent in vitro susceptibility testing to determine prevalence and antimicrobial resistance patterns. (umanitoba.ca)
Porin alteration was found to be a factor leading to carbapenem reduced susceptibility among isolates. (umanitoba.ca)
During the next 4 months, an additional 21 CRE isolates were identified from facility patients, resulting in a total of 23 isolates, including 17 K. pneumoniae, five Escherichia coli , and one Enterobacter cloacae isolate. (cdc.gov)
As of June 2010[update], there were three reported cases of Enterobacteriaceae isolates bearing this newly described resistance mechanism in the US, the Centers for Disease Control and Prevention (CDC) stated that "All three U.S. isolates were from patients having received recent medical care in India. (wikipedia.org)
Carbapenemases are a class of enzymes that can confer resistance to carbapenems and other Beta-lactam antibiotic drugs, but not all carbapenemase-producing isolates are carbapenem-resistant. (cdc.gov)
So far, the isolates with mcr-1 haven't carried resistance to all other antibiotic classes. (scienceblogs.com)
All laboratories participating in ELR must report antimicrobial resistance testing results for all Acinetobacter baumannii, Citrobater species, Enterococcus species, Enterobacter species, Escherichia coli , Klebsiella species, Pseudomonas aeruginosa, Serratia species, and S. aureus isolates from normally sterile sites. (floridahealth.gov)
We examined the clinical data from patients with CPE infections and their outcomes, concentrating on Klebsiella pneumoniae isolates. (biomedcentral.com)
Whole genome sequences of these isolates were determined and analysed to compute bacterial multilocus sequence types and plasmid replicon types, infer phylogenetic relationships, and identify antimicrobial resistance and virulence genes. (biomedcentral.com)
Altogether, 88.9% (40/45) of the CPE isolates were K. pneumoniae . (biomedcentral.com)
The most abundant carbapenemase gene family in the K. pneumoniae isolates (33/39) was bla OXA-232 , with bla NDM-1 additionally identified in 19 of them. (biomedcentral.com)
This study has revealed the genomic features of colonising CPE isolates, focusing on antimicrobial resistance and virulence determinants. (biomedcentral.com)
Detection of NDM-1 and VIM Genes in Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Health-Care Center in Kathmandu, Nepal. (tropmedres.ac)
All K. pneumoniae isolates were processed for antimicrobial susceptibility testing (AST) using the disk diffusion method. (tropmedres.ac)
Thus, confirmed carbapenemase-producing isolates were further screened for the production of blaNDM-1 and blaVIM using conventional polymerase chain reaction (PCR).ResultsAmong the clinical isolates tested, culture positivity was 38.29% (224/585), and the prevalence of K. pneumoniae was 25.89% (58/224). (tropmedres.ac)
Overall, AST detected 60.34% (35/58) carbapenem-resistant isolates, while the MHT phenotypically confirmed 51.72% (30/58) isolates as carbapenemase-producers and 48.28% (28/58) as carbapenemase nonproducers. (tropmedres.ac)
In the same assay among 28 carbapenem nonproducing isolates, 9 (32.14%) isolates were positive for blaNDM-1 gene while none of them were tested positive for blaVIM gene.ConclusionsMolecular detection of resistant genes provides greater specificity and sensitivity than those with conventional techniques, thus aiding in accurate identification of antimicrobial resistance and clinical management of the disease. (tropmedres.ac)
ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
This study in a tertiary care hospital in Egypt used real-time PCR assay to test ertapenem-nonsusceptible isolates of K. pneumoniae for the presence of the blaKPC gene and compared the results with modified Hodge test. (who.int)
From the 45 non-duplicate isolates of K. pneumoniae recovered from different clinical specimens, a high prevalence of ertapenem-nonsusceptible isolates (44.4%) was reported using the new lower CLSI breakpoints. (who.int)
The high prevalence of ertapenem nonsusceptibility at a tertiary care hospital in Egypt was predominantly attributed to K. pneumoniae carbapenemase-mediated resistance mechanisms in K. pneumoniae isolates. (who.int)
Herein, we analyse the MGEs in three extensively drug-resistant (XDR) Klebsiella pneumoniae isolates from Germany. (uni-frankfurt.de)
40,000 S. aureus isolates identified from inpatient and outpatient settings in a large children's hospital demonstrated resistance to clindamycin and TMP-SMX increased among outpatient isolates between 2005-2014. (pids.org)
Moreover, hypervirulent K. pneumoniae (hvKp) isolates, first identified in Southeast Asia, have emerged globally and are able to cause infections in healthy people. (bvsalud.org)
Alarmingly, isolates displaying a convergence phenotype of carbapenem resistance and hypervirulence have been detected in several countries, representing a serious threat to public health. (bvsalud.org)
A search of the computerized database at the National Taiwan University Hospital was made for cefotaxime-resistant and cefmetazole-susceptible isolates of Escherichia coli and Klebsiella pneumoniae (which may be extended-spectrum β-lactamase-producing strains) in pediatric wards and intensive care units between 1999 and 2001. (ntu.edu.tw)
To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. (cdc.gov)
The aim of this study was to characterise the molecular mechanism of resistance in the clinical isolates of Enterobacteriaceae causing bacteremia and showing resistance to β-lactams, including carbapenems. (omicsonline.org)
Isolates of E.coli (n=42) and K. pneumoniae (n=134) from blood culture collected during 2013-2015 were screened for carbapenemase production by using carba NP test and the presence of carbapenem resistant genes (KPC, IMP, VIM, NDM and OXA- 48 like). (omicsonline.org)
Methods Six hundred and forty-seven K. pneumoniae isolates (2008-2017) with reduced susceptibility to carbapenems were screened for blaBKC-1. (cardiff.ac.uk)
In this study, we determined the fitness effects of the major antibiotic resistance plasmid pOXA-48_K8 in wild-type, ecologically compatible enterobacterial isolates from the human gut microbiota. (nature.com)
Here, we used a combination of long- and short-read sequence data of Klebsiella pneumoniae isolates (n = 1,717) from a European survey to perform an integrated, continent-wide study of chromosomal and plasmid diversity. (ox.ac.uk)
We sequenced the whole genomes of 176 P. aeruginosa isolates collected in 2013-2014 by the Antimicrobial Resistance Surveillance Program. (who.int)
The multi-locus sequence type, presence of antimicrobial resistance (AMR) determinants, and relatedness between the isolates were derived from the sequence data. (who.int)
Many of the isolates also proved resistant to other drugs as well as colistin, although there was little evidence of extensive carbapenem coresistance. (medscape.com)
mrc-1 positivity also was found in 13 isolates of Klebsiella pneumoniae , and 1 isolate each of Enterobacter cloacae and Enterobacter aerogenes . (medscape.com)
The finding of multiple-drug resistance in MCRPEC isolates suggests these organisms were able to recruit other resistance genes, "which could raise difficulties in the treatment of patients with clinical infection due to MCRPEC," the authors write. (medscape.com)
A study of 89 carbapenem nonsusceptible Enterobacteriaceae isolates from China showed that polymyxin B was much more active than tigecycline. (medscape.com)
Extended-spectrum beta-lactamase produc- ing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. (who.int)

Carbapenems are last-resort antibiotics for treating severe infections caused by MDR Enterobacteriaceae [ 3 ]. (biorxiv.org)
Multicenter clinical and molecular epidemiological analysis of bacteremia due to carbapenem-resistant Enterobacteriaceae (CRE) in the CRE epicenter of the United States. (ijmedicine.com)
Carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) express plasmid-encoded carbapenemases, enzymes that inactivate carbapenem antibiotics. (cdc.gov)
Concern has arisen in recent years over increasing rates of resistance to carbapenems, as there are few therapeutic options for treating infections caused by carbapenem-resistant bacteria (such as Klebsiella pneumoniae and other carbapenem-resistant Enterobacteriaceae). (wikipedia.org)
The carbapenems imipenem and meropenem are recommended by the American Thoracic Society and the Infectious Disease Society of America as one of several first-line therapy options for people with late-onset hospital-acquired or ventilator-associated pneumonia, especially when Pseudomonas, Acinetobacter, or extended spectrum beta-lactamase producing Enterobacteriaceae are suspected pathogens. (wikipedia.org)
The North American Emerging Infections Network reported that about 80 percent of responding infectious disease physicians had treated a UTI caused by the most resistant bacteria, carbapenem-resistant Enterobacteriaceae (CRE). (prnewswire.com)
Carbapenem-resistant strains have emerged among species belonging to the Enterobacteriaceae family. (cdc.gov)
Several outbreaks caused by carbapenem-resistant Enterobacteriaceae , or CRE, have been recorded in health care facilities around the world, and in some places, CRE have become endemic. (cdc.gov)
For example, some Enterobacteriaceae can produce enzymes called carbapenemases that break down antibiotics including carbapenems, making the drugs ineffective. (floridahealth.gov)
Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) is defined as E. coli , Klebsiella spp. (cdc.gov)
Carbapenem antibiotics are often used as the last line of treatment for infections caused by highly resistant bacteria, including those in the Enterobacteriaceae family. (cdc.gov)
For example, countries with high quality health systems were associated with low levels of antibiotic resistance among all the gram-negative bacteria 1 investigated, while high temperatures were associated with high levels of antibiotic resistance in Enterobacteriaceae. (pasteur.fr)
High temperatures were associated with high levels of antibiotic resistance, but only for Enterobacteriaceae ( Escherichia coli and Klebsiella pneumoniae ). (pasteur.fr)
OXA-427, a new plasmid-borne carbapenem-hydrolysing class D β-lactamase in Enterobacteriaceae. (cdc.gov)
In 2006, Paterson published a good review of resistance among various Enterobacteriaceae. (medscape.com)
Carbapenem-resistant gram-negative bacteria, namely, carbapenem-resistant Enterobacteriaceae (CRE) (for example, Klebsiella pneumoniae, Escherichia coli), Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPsA), are a matter of national and international concern as they are an emerging cause of. (bvsalud.org)

Similar to penicillins and cephalosporins, carbapenems are members of the beta-lactam antibiotics drug class, which kill bacteria by binding to penicillin-binding proteins, thus inhibiting bacterial cell wall synthesis. (wikipedia.org)
medical citation needed] Carbapenem antibiotics were originally developed at Merck & Co. from the carbapenem thienamycin, a naturally derived product of Streptomyces cattleya. (wikipedia.org)
Antibiotics are the current standard of care for UTI patients, but repeated antibiotic use in this population contributes to the development of antibiotic resistance. (prnewswire.com)
These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections. (wikipedia.org)
Carbapenems are a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one of their cell wall layers. (wikipedia.org)
However, the blaNDM-1 gene produces NDM-1, which is a carbapenemase beta-lactamase - an enzyme that hydrolyzes and inactivates these carbapenem antibiotics. (wikipedia.org)
citation needed] Carbapenemases are particularly dangerous resistance mechanisms, since they can inactivate a wide range of different antibiotics. (wikipedia.org)
Apart from empirical treatment, the antibiotics used for treatment might be less effective against carbapenem-resistant infections as well. (cdc.gov)
We have a high-performance medicine in which we have to use antibiotics over and over again, and so resistance will carry on developing. (medscape.com)
The most important measure to avoid antibiotic resistance is to use antibiotics as sparingly as possible. (medscape.com)
Carbapenem antibiotics are typically reserved to treat multidrug-resistant bacterial infections, so when bacteria develop resistance to them, treatment options can be extremely limited. (floridahealth.gov)
A carbapenemase is an enzyme that breaks down carbapenem antibiotics and can be transferred between organisms. (floridahealth.gov)
For example, Escherichia coliurinary tract infections, and respiratory infections by Streptococcus pneumoniae or Haemophilus influenzae may not respond to antibiotics commonly used and require the use of more complex and expensive treatments. (paho.org)
In more than 30% of infections, the isolate will be resistant to one or more clinically useful antibiotics (CDC, Antibiotic Resistance Threat Report , 2019. (pids.org)
While Streptococcus pyogenes remains highly susceptible to beta-lactam antibiotics, over the past decade increasing prevalence of clindamycin and macrolide resistance are being reported worldwide. (pids.org)
These enzymes promote an important mechanism of resistance to antibiotics in an increasingly variety of Gram-negative bacteria. (uc.pt)
Due to differences in the molecular epidemiology of resistance and availability of specific antibiotics internationally, treatment recommendations are geared toward antimicrobial resistant infections in the United States. (idsociety.org)
Certain strains of Klebsiella pneumoniae are resistant to the carbapenem antibiotics that can be the last resort in treating infections. (first4lawyers.com)
Dr David and her colleagues identified a small number of genes that can cause resistance to carbapenem antibiotics. (first4lawyers.com)
This pathogen is characterized by its notorious resistance to last-line antibiotics, such as carbapenems. (bvsalud.org)
Methods: K-B assay was used to determine the susceptibility of Klebsiella pneumoniae strains to antibiotics. (biomedres.info)
Carbapenemases are a versatile group of Ã�-lactamases that are characterised by their resistance to virtually all Ã�-lactam antibiotics including cephalosporins and carbapenems, complicating therapy and limiting treatment options. (omicsonline.org)
KPCs) are Ambler class A plasmid- gene by polymerase chain reaction cin, imipenem, ertapenem, meropenem, encoded enzymes that are capable of (PCR) assay provides laboratories trimethoprim/sulfamethoxazole, piper- hydrolyzing all beta-lactam antibiotics, with a means to quickly identify the acillin, piperacillin/tazobactam and including monobactams, extended- presence of this important resistance tobramycin (Oxoid). (who.int)
Some of the most clinically relevant resistance genes, such those encoding carbapenemases (ß-lactamase enzymes able to degrade carbapenem antibiotics), are carried on conjugative plasmids that spread across high-risk bacterial clones 5 , 6 . (nature.com)
Using the ATLAS antimicrobial resistance surveillance database, the model revealed significant differences in trends and associated factors depending on bacterial species and resistance to certain antibiotics. (pasteur.fr)
It is a natural phenomenon, but improper use of antibiotics is contributing to it by selecting resistance and complicating bacterial infection-control strategies. (pasteur.fr)
In recent years, increasing resistance rates to antibiotics such as carbapenems and extended-spectrum cephalosporins have been reported, as well as multi-drug resistant and possible extremely drug-resistant rates of approximately 21% and 15%, respectively. (who.int)
The concordance between phenotypic and genotypic resistance was 93.27% overall for 6 antibiotics in 3 classes, but varied widely between aminoglycosides. (who.int)
With few exceptions, the major classes of antibiotics used to manage infections with these bacteria include the beta-lactams, carbapenems, the fluoroquinolones, the aminoglycosides, and TMP-SMZ. (medscape.com)

Functional characterization of KPC-109 was performed investigating the impact of KPC-109 production on the β-lactam resistance phenotype of various Escherichia coli and Klebsiella pneumoniae strains, including derivatives of K. pneumoniae with OmpK35 and OmpK36 porin alterations. (imperial.ac.uk)
The most common bacteria that make this enzyme are gram-negative such as Escherichia coli and Klebsiella pneumoniae, but the gene for NDM-1 can spread from one strain of bacteria to another by horizontal gene transfer. (wikipedia.org)

Carbapenems are less commonly used in the treatment of community-acquired pneumonia, as community-acquired strains of the most common responsible pathogens (Streptococcus pneumoniae, Haemophilus influenazae, atypical bacteria, and Enterobactericeace) are typically susceptible to narrower spectrum and/or orally administered agents such as fluoroquinolones, amoxicillin, or azithromycin. (wikipedia.org)
Chimeric oligosaccharide conjugate induces opsonic antibodies against Streptococcus pneumoniae serotypes 19A and 19F. (mpg.de)
Sequential linkage of carbohydrate antigens to mimic capsular polysaccharides: towards semisynthetic glycoconjugate vaccine candidates against Streptococcus pneumoniae serotype 14. (mpg.de)
2018. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae , 2018. (pids.org)

Carbapenems exhibit broad spectrum activity against gram-negative bacteria and somewhat narrower activity against gram-positive bacteria. (wikipedia.org)
The spectrum of activity of the carbapenems against gram-positive bacteria is fairly broad, but not as exceptionally so as in the case of gram-negative bacteria. (wikipedia.org)
The resistance conferred by this gene (blaNDM-1), therefore, aids the expansion of bacteria that carry it throughout a human host, since they will face less opposition/competition from populations of antibiotic-sensitive bacteria, which will be diminished by the original antibacterial treatment. (wikipedia.org)
In March 2010, a study in a hospital in Mumbai found that most carbapenem-resistant bacteria isolated from patients carried the blaNDM-1 gene. (wikipedia.org)
This plasmid mobility makes it easier for bacteria to acquire resistance to multiple drugs. (scienceblogs.com)
So the Italian discovery signals two things that medicine has feared: that MCR has landed in bacteria that are already good at spreading through healthcare, and that it has begun the process of stacking up in bacteria, alongside other resistance DNA, on the way to creating what could be a truly untreatable bug. (scienceblogs.com)
Antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. (paho.org)
Their continued use in farming increases the chance bacteria will develop resistance to them, leaving them useless when treating patients. (thebureauinvestigates.com)
Recent estimates of the burden of antimicrobial resistance suggest that there are approximately 700,000 deaths worldwide every year due to infections with antimicrobial resistant bacteria, with nearly 50,000 of these deaths occurring in the United States and Europe (CDC. (pids.org)
Some of the most worrisome antibiotic-resistant bacteria are MDR Enterobacterales , which includes species like E. coli and Klebsiella pneumoniae . (pids.org)
The morbidity and mortality associated with infections caused by carbapenemases-producing bacteria, namely the Klebsiella pneumoniae carbapenemases (KPCs), are at very high levels, aggravated by the emerging global dissemination in the last 15 years. (uc.pt)
Once carbapenems are no longer effective against bacteria, there are few options left for treating them. (first4lawyers.com)
Klebsiella pneumoniae is a form of bacteria that lives normally in our intestines. (first4lawyers.com)
The antimicrobial resistance (AMR) and/or virulence determinants possessed by the associated bacteria are generally found on mobile genetic elements (MGEs) that transmit between K . pneumoniae cells via horizontal gene transfer (HGT) [ 4 ]. (biomedcentral.com)
All classes of microbes are capable of developing a resistance to drugs: bacteria can develop antibiotic resistance, viruses can develop antiviral resistance, fungi can develop an antifungal resistance and protozoan can develop an antiprotozoal resistance. (scalarlight.com)
Surprisingly, national antibiotic consumption levels were not correlated with resistance for the majority of the bacteria tested. (pasteur.fr)
The results suggest that antibiotic resistance control measures need to be adapted to the local context and to targeted bacteria-antibiotic combinations. (pasteur.fr)
Research teams study how antibiotic resistance emerges in a bacterium in a Petri dish or in an individual, but we are currently lacking a population-level, global overview that can be used to investigate links between resistance and specific factors like national health system quality for different species of pathogenic bacteria. (pasteur.fr)
The study also demonstrated that the dynamics and factors associated with antibiotic resistance depend on bacteria-antibiotic combinations. (pasteur.fr)
Surprisingly, however, national antibiotic consumption was not significantly associated with resistance for the majority of bacteria tested (except for quinolone consumption for fluoroquinolone-resistant Escherichia coli and Pseudomonas aeruginosa and carbapenem consumption for carbapenem-resistant Acinetobacter baumannii ). (pasteur.fr)
Conversely, high health system quality was associated with low levels of antibiotic resistance in all the gram-negative bacteria 1 tested. (pasteur.fr)
The therapeutic use of bacteriophages, viruses that infect and kill bacteria, is well suited to be part of the multidimensional strategies to combat antibiotic resistance. (asm.org)
Many multidrug-resistant hospital-acquired bacteria are sensitive only to carbapenems. (msdmanuals.com)
The bacteria designated by the acronym SERMOR-PROVENF (SER = Serratia, MOR = Morganella, PROV = Providencia, EN = Enterobacter, F = freundii for Citrobacter freundii ) have similar, although not identical, chromosomal beta-lactamase genes that are inducible. (medscape.com)
Resistance is expressed in vitro only with bacteria that are in a state of stable derepression (mutant hyperproducers of beta-lactamases). (medscape.com)
Age 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with in- creased in-hospital mortality. (who.int)
Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. (who.int)

Multidrug and carbapenem-resistant K. pneumoniae (CR- Kp ) are considered critical threats to global health and key traffickers of resistance genes to other pathogens. (biorxiv.org)
Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes. (ijmedicine.com)
The main objective of this study was to detect the carbapenem-resistant genes blaNDM-1 and blaVIM in K. pneumoniae isolated from different clinical specimens.MethodsA total of 585 clinical specimens (urine, pus, sputum, blood, catheter tips, and others) from human subjects attended at Annapurna Neurological Institute and Allied Sciences, Kathmandu were obtained in the period between July 2018 and January 2019. (tropmedres.ac)
Twenty ESBL producing strains (15%) including Escherichia coli (n = 9), Klebsiella pneumoniae (n = 7), Klebsiella oxytoca (n = 2) and Enterobacter aerogenes (n = 2) were detected and further analyzed for their resistance transfer features, plasmid profile and nature of the resistance genes. (scielo.br)
Foram detectadas vinte cepas produtoras de ESBL, entre as quais Escherichia coli (n=9), Klebsiella pneumoniae (n=7), Klebsiella oxytoca (n=2) e Enterobacter aerogenes (n=2), que foram posteriormente analisadas quanto a suas características de transferência de resistência, perfil plasmidial e natureza dos genes de resistência. (scielo.br)
Polymerase chain reaction results for carbapenem resistance genes detection showed strain SCM96 carried blaNDM-19. (pacb.com)
In addition to the 4 antibiotic resistance genes located in the chromosome, pSCM96-1 carried a complex resistance region containing 17 resistance genes and several mobile genetic elements (MGEs) like ?Tn6029, In4-like integron, and Tn3, and pSCM96-2 had only 1 blaNDM-19 gene. (pacb.com)
Strikingly, K-2157 displayed a resistome composed of ß-lactam resistance genes (blaSHV-190, blaTEM-1, blaOXA-9, and blaKPC-2), the fosfomycin resistance gene fosA, and the fluoroquinolones resistance genes oqxA and oqxB. (bvsalud.org)
In addition, K-2157 harbored two plasmids: one of 113,644 bp (KPC+) and another of 230,602 bp, containing virulence genes, in addition to an integrative and conjugative element (ICE) embedded on its chromosome, revealing that the presence of these mobile genetic elements mediates the convergence between virulence and antibiotic resistance. (bvsalud.org)
Susceptibility profiles were determined by broth microdilution, and additional antimicrobial resistance genes (ARGs) were investigated by polymerase chain reaction. (cardiff.ac.uk)
By contrast, plasmids are usually excluded or analyzed with low-resolution techniques, despite being the primary vectors of antibiotic resistance genes across many key pathogens. (ox.ac.uk)
This revealed three contrasting modes of dissemination used by carbapenemase genes, which confer resistance to last-line carbapenems. (ox.ac.uk)
The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5). (ub.edu)
This was further supported by long-read sequencing of one representative XDR isolate, which revealed the presence of an integron carrying multiple resistance genes, including bla VIM-2 , with differences in gene composition and synteny to other P. aeruginosa class 1 integrons described before. (who.int)
En nuestro país, durante el primer cuatrimestre del año, se observó un aumento inusual en el número de aislamiento de gérmenes multirresistentes, sobre todo de bacilos gramnegativos, los cuales fueron remitidos al laboratorio de referencia con el objetivo de caracterizar los genes de resistencia a los carbapenemes. (bvsalud.org)
During the first quarter of the year, an unusual increase in the number of isolation multi-resistant germs, especially gram-negative bacilli was observed, specially of Gram-negative bacilli which were referred to the reference laboratory in order to characterize the carbapenems resistance genes. (bvsalud.org)
Many carbapenemases are encoded on plasmids, facilitating the spread of resistance genes among organisms of the same species or even different bacterial species. (msdmanuals.com)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

Activity is maintained against most strains of E. coli and K. pneumoniae that are resistant to cephalosporins due to the production of extended spectrum beta-lactamases. (wikipedia.org)
Serious concurrent conditions and prior use of fluoroquinolones, carbapenems, or broad-spectrum cephalosporins have been independently associated with acquisition of infections caused by CRE. (cdc.gov)
Carbapenem-resistant Klebsiella pneumoniae makes up under 1%, and E coli with a combined resistance against third-generation cephalosporins, fluoroquinolones, and aminoglycosides is around 3%, following a decline in the last 3-4 years. (medscape.com)

They have the potential for epidemic spread through person-to-person transmission and horizontal transfer of resistance mechanisms ( 1 , 2 ). (cdc.gov)
To further improve surveillance and awareness of CRE, FDOH's Bureau of Public Health Laboratories (BPHL) expanded CRE testing capabilities to identify types of resistance mechanisms used by organisms. (floridahealth.gov)
New resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases, resulting in prolonged illness, disability, and death. (paho.org)
Although brief descriptions of notable clinical trials, resistance mechanisms, and antimicrobial susceptibility testing (AST) methods are included, the document does not provide a comprehensive review of these topics. (idsociety.org)
Xpert Carba-R) for all known resistance mechanisms (e.g. (cdc.gov)
Synthesis of acquired siderophores contributes to K . pneumoniae virulence via multiple mechanisms. (biomedcentral.com)
this reinforces the need for correct and rapid identification of antimicrobial resistance mechanisms in hospitals. (cardiff.ac.uk)
We discuss conventional approaches as well as novel strategies, including the use of phage-antibiotic combinations, phage-derived enzymes, exploitation of phage resistance mechanisms, and phage bioengineering. (asm.org)
CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain. (ub.edu)
The molecular studies about colistin resistance indicated two main mechanisms: modifications in lipid A structure and complete loss of LPS (3). (idcmjournal.org)
The cellular effects of colistin use were mimicked in laboratory conditions to understand the relationship between the clinical features and molecular resistance mechanisms. (idcmjournal.org)
Pseudomonas aeruginosa is an opportunistic pathogen often causing nosocomial infections that are resilient to treatment due to an extensive repertoire of intrinsic and acquired resistance mechanisms. (who.int)

Acinetobacter species with a combined resistance against fluoroquinolones, aminoglycosides, and carbapenems make up 4% of the total in Germany. (medscape.com)
In the present document, guidance is provided on the treatment of infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), AmpC β-lactamase-producing Enterobacterales (AmpC-E), carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa), carbapenem-resistant Acinetobacter baumannii species (CRAB), and Stenotrophomonas maltophilia. (idsociety.org)
Acinetobacter baumannii (100%) and Klebsiella pneumoniae (88.88%) also showed multi-drug resistance. (farmaciajournal.com)
The increase of colistin resistance in Acinetobacter baumannii is a great concern in various regions of the world such as Asia, Europe, and North and South America (1). (idcmjournal.org)

A positive Modified Hodge Test (MHT) can be used to confirm CP-CRE for Klebsiella spp and E. coli but not Enterobacter spp. (cdc.gov)
Because most Enterobacter species are either very resistant to many agents or can develop resistance during antimicrobial therapy, the choice of appropriate antimicrobial agents is complicated. (medscape.com)

Multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae , particularly carbapenem-resistant strains (CR- Kp ) causing high mortality and morbidity, are critical concerns[ 1 ]. (biorxiv.org)
A new bacterial threat, the carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), is rapidly spreading in clinical environments in China, posing a significant public health challenge. (phys.org)
The aim of this study was to investigate the genomic features of a carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) isolate (K-2157) collected in Chile. (bvsalud.org)
A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. (cdc.gov)

Carbapenems are a class of very effective antibiotic agents most commonly used for the treatment of severe bacterial infections. (wikipedia.org)
The penicillinase-resistant, or second-generation, penicillins are semisynthetic modifications of natural penicillins that are resistant to bacterial enzyme beta-lactamase, which accounts for typical penicillin resistance. (medscape.com)
The carbapenems were developed to overcome antibiotic resistance mediated by bacterial beta-lactamase enzymes. (wikipedia.org)
Carbapenems are used as the last resort for the treatment of multidrug resistant Gram-negative bacterial infections. (tropmedres.ac)
Antibiotic resistance varies considerably depending on the bacterial species, but a recent study 2 estimated that in 2019, 1.27 million deaths worldwide were attributable globally to ABR and ABR was associated with 4.95 million deaths. (pasteur.fr)

Combination therapy, typically with an aminoglycoside, is recommended for Pseudomonas infections to avoid resistance development during treatment. (wikipedia.org)
Aside from the vancomycin-resistant Enterococcus faecum and the carbapenem-resistant Pseudomonas aeruginosa , nothing is on the rise," said Eckmanns. (medscape.com)

Only 1 of each KPC-producing E. coli and K. pneumoniae was found. (umanitoba.ca)
Genetic relatedness of CRS/CIR E. coli and K. pneumoniae was determined using pulsed-field gel electrophoresis. (umanitoba.ca)
Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. (ijmedicine.com)
Comparison of predictors and mortality between bloodstream infections caused by ESBL-producing Escherichia coli and ESBL-Producing Klebsiella pneumoniae . (escmid.org)
E. coli , Klebsiella spp. (cdc.gov)
Dipòsit Digital de la Universitat de Barcelona: CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3. (ub.edu)
CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3. (ub.edu)
In the second article , Jingjing Quan, MS , from the Department of Infectious Diseases at Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China, and colleagues conducted a multicenter, longitudinal study of the prevalence of mrc-1 -positive E coli and K pneumoniae isolated from 2066 patients with bloodstream infections at 28 hospitals throughout China. (medscape.com)

established the presence of previously undetected tickborne pathogens Polymyxin B Resistance in in rural dogs and associated ticks in Uganda. (cdc.gov)
These high-risk pathogens have developed mainly by acquiring different mobile genetic elements (MGEs), including plasmids and genomic islands (GIs) encoding an array of virulence and antibiotic resistance factors[ 2 ]. (biorxiv.org)
It is ideal for mammalian bite wounds, but it is not ideal for nosocomial pathogens because of increasing rates of resistance of gram-negative organisms. (medscape.com)
In the United States, antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 deaths annually from 2012 through 2017, according to the Centers for Disease Control and Prevention (CDC) Antibiotic Resistance Threats in the United States Report[2]. (idsociety.org)
Conclusion: We thought that the key factor of the resistance mechanism to carbapenem for Klebsiella pneumoniae maybe these pathogens contain blaKPC-2 gene. (biomedres.info)
We adapted the Ross-Macdonald model to describe hospital cross-transmission dynamics of carbapenem resistant Klebsiella pneumoniae (CRKP), considering healthcare workers as the vectors transmitting susceptible and resistant pathogens among admitted patients. (univr.it)
The objective of the current ering new classes of antimicrobials and the increasing study was, therefore, to assess the bacteriologic pro- emergence and reemergence of resistant pathogens, file, resistance pattern, and patient's outcome in Lan- mortality from infectious disease is increasing [1]. (who.int)

The most concerning carbapenem resistance mechanism corresponds to carbapenem-inactivating beta-lactamases, especially the K. pneumoniae carbapenemase (KPC) distributed worldwide, showing the highest prevalence. (biorxiv.org)
However, a survey from the National Antimicrobial Resistance Surveillance, Thailand from 2008 to 2016 revealed that carbapenemase-producing Klebsiella pneumoniae (CPKP) had increased in prevalence from 0.4% in 2008 to 5.4% in 2016 [ 3 ]. (biomedcentral.com)

NDM-1 β-lactamase was also found in an K. pneumoniae isolate from Croatia, and the patient arrived from Bosnia and Herzegovina. (wikipedia.org)
Our report is the first genomic characterization of a hypervirulent and highly resistant K. pneumoniae isolate in Chile, which was collected during the coronavirus disease 2019 (COVID-19) pandemic. (bvsalud.org)
In this work, we analyzed the genomic characteristics of a carbapenem-resistant hvKp isolate recovered in 2022 from a patient with COVID-19 in Chile, representing the first analysis of this type in the country. (bvsalud.org)

In Chile, although a sustained increase in CR- Kp infections has been observed, few strains have been described at the genomic level, lacking molecular details of their resistance and virulence determinants and the mobile elements mediating their dissemination. (biorxiv.org)
These results provide baseline knowledge for the detailed understanding of molecular and genetic determinants behind antibiotic resistance and virulence of K. pneumoniae in Chile and South America. (biorxiv.org)
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. (ijmedicine.com)
The resistance mechanism for CPE is attributed to the following Ambler molecular classes of carbapenem-hydrolysing beta-lactamases: class A (KPC), class B (IMP, NDM, VIM), and class D (OXA-48) [ 5 ]. (biomedcentral.com)
Regardless of the level of drug-resistance that a pathogen has achieved, scalar light is a divine, fundamental force in nature that controls the molecular bonds of that infectious agent. (scalarlight.com)
Caracterización molecular de carbapenemasas en bacilos gramnegativos circulantes en hospi. (bvsalud.org)

The carbapenem ertapenem is one of several first-line agents recommended by the Infectious Disease Society of America for the empiric treatment of community-acquired intra-abdominal infections of mild-to-moderate severity. (wikipedia.org)

Colistin MIC values were determined by BMD, broth microdilution based commercial kit (Sensititre, ThermoFisher, USA), Vitek2 (bioMerieux, France) and gradient test (Bioanalyse, Turkey) in 128 carbapenem resistant K. pneumonaie strains isolated from various clinical samples sent from July 2018 to July 2019 to the microbiology laboratory. (ijmedicine.com)
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. (ijmedicine.com)
However, in the presence of porin alterations commonly encountered in high-risk clonal lineages of K. pneumoniae, KPC-109 was able to confer clinical-level resistance to carbapenems as well. (imperial.ac.uk)
Level B data: the data provide an indication of the resistance patterns present in clinical settings in the country, but the proportion of resistance should be interpreted with care. (who.int)
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a major cause of nosocomial infections and posed challenges on clinical treatments. (pacb.com)
These MGEs, most typically plasmids and integrative and conjugative elements (ICEs), are therefore important constituents of the accessory genome that imbue K . pneumoniae organisms with their distinct HA or CA clinical profiles. (biomedcentral.com)
45 isolats non-dupliqués de K. pneumoniae prélevés à partir de différents échantillons cliniques, une prévalence élevée d'isolats non sensibles à l'ertapénème (44,4 %) a été rapportée selon les nouveaux seuils plus bas du Clinical and Laboratory Standards Institute . (who.int)

Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. (ijmedicine.com)
External validation of the INCREMENT-CPE mortality score in a carbapenem-resistant Klebsiella pneumoniae bacteraemia cohort: the prognostic significance of colistin resistance. (escmid.org)
Colistin resistance is an emerging threat. (idcmjournal.org)
Here, we presented the development of colistin resistance in A. baumannii after colistin use on a disease course of a patient. (idcmjournal.org)
In conclusion, the duration of colistin exposure is critical for the development of colistin resistance. (idcmjournal.org)
Colistin resistance in A.baumannii is induced during colistin therapy. (idcmjournal.org)
The gene that confers colistin resistance is called mcr-1 . (medscape.com)

96 fueron miembros de Enterobacterales, siendo prevalente Klebsiella pneumoniae (81). (bvsalud.org)
Los genotipos NDM (92%) y KPC (8%) fueron confirmados en Enterobacterales. (bvsalud.org)
96 were Enterobacterales, being Klebsiella pneumoniae (81) the most prevalent. (bvsalud.org)

Carbapenemase production is a resistance mechanism of concern. (floridahealth.gov)
Although QACs may play an important role in the propagation of antibiotic resistance gene (ARGs), the potential contribution and mechanism remains unclear. (bvsalud.org)
Positive for known carbapenemase resistance mechanism (e.g. (cdc.gov)
Background: To investigate the resistance mechanism of Klebsiella pneumoniae (Kpn) resistant to carbapenems. (biomedres.info)

Antibiotic-resistant strains of the superbug Klebsiella pneumoniae, a pathogen that can cause respiratory and bloodstream infections in humans, are spreading throughout European hospitals. (first4lawyers.com)
IMPORTANCE Klebsiella pneumoniae is a resistant pathogen involved primarily in hospital-acquired infections. (bvsalud.org)

Ten plasmids encoding either KPC-2, NDM-1, or NDM-7 carbapenemases were characterized, including novel plasmids with increased resistance gene load and a novel genetic environment for bla KPC-2 gene. (biorxiv.org)
This analysis does not include mutations that may result in antibiotic resistance or resistance determinants added to newer versions of used database or other antimicrobial resistance gene databases. (cdc.gov)
The infection was identified as a carbapenem-resistant Klebsiella pneumoniae strain bearing the novel gene blaNDM-1. (wikipedia.org)
In particular, gene clusters encoding the biosynthesis of siderophores aerobactin ( iuc ) and salmochelin ( iro ) are associated with invasive disease and are common amongst hypervirulent K . pneumoniae clones that cause severe community-associated infections such as liver abscess and pneumonia. (biomedcentral.com)
It has been demonstrated that even a low-level dosage of an antibiotic is sufficient to elicit a horizontal gene transfer thereby ensuring antimicrobial resistance. (scalarlight.com)
Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae. (ox.ac.uk)

This development is concerning because carbapenems are often the last resort for treating multidrug-resistant gram-negative organisms, particularly those that produce AmpC and extended-spectrum beta-lactamases, which destroy most beta-lactams except for carbapenems. (msdmanuals.com)

Furthermore, carbapenems are typically unaffected by emerging antibiotic resistance, even to other beta-lactams. (wikipedia.org)

Another example is the proportion of K pneumoniae , which are resistant to carbapenems. (medscape.com)
Six isolated strains were identified and collected, which were resistant to carbapenems using modified Hodge test. (biomedres.info)

Results: Fifty (26.7%) of the 187 Klebsiellae studied were EPK comprising of 37(26.8%) Klebsiella pneumoniae and 13(26.5%) Klebsiella oxytoca. (bvsalud.org)

What accelerates the emergence and spread of antimicrobial resistance? (paho.org)
This study provides a framework for identifying and tracking these important virulence loci, which will be important for genomic surveillance efforts including monitoring for the emergence of hypervirulent MDR K . pneumoniae strains. (biomedcentral.com)

As of 2018, CDC is tracking carbapenemase enzymes in CRE using data generated by the Antibiotic Resistance Laboratory Network (AR Lab Network) and CDC laboratories. (floridahealth.gov)

Due to their global dissemination and public health impact, genomic surveillance of the spread of convergent high-risk K1-ST23 K. pneumoniae clones should be highly prioritized. (bvsalud.org)

The analysis of global data for the period 2006-2019 initially revealed an increase in resistance to carbapenems for several species, although global trends were stable for other resistances. (pasteur.fr)

Expression of ESBL is often associated with multidrug resistance and dissemination by resistance plasmids. (scielo.br)
Mobile genetic elements (MGEs), especially multidrug-resistance plasmids, are major vehicles for the dissemination of antimicrobial resistance determinants. (uni-frankfurt.de)
Characterization of an NDM-19-producing Klebsiella pneumoniae strain harboring 2 resistance plasmids from China. (pacb.com)
These dominant types also carry hypermucoidy ( rmpA ) determinants and include all previously described virulence plasmids of K . pneumoniae . (biomedcentral.com)

In 2016, 490 000 people developed multi-drug resistant TB globally, and drug resistance is starting to complicate the fight against HIV and malaria, as well. (paho.org)
In order to address antimicrobial drug-resistance, the scalar light pathogenic cleanse has been developed to disassemble and eradicate superbugs. (scalarlight.com)
The ability of microbes to develop a drug-resistance is normal and can not be avoided. (scalarlight.com)
The report also includes a summary on the status of drug resistance for TB, HIV and malaria. (who.int)

The ECDC data show that from 2016 to 2020, the number of infections and deaths due to almost all antibiotic resistances had increased. (medscape.com)

Positive on a phenotypic test for carbapenemase production (e.g., metallo-β-lactamase test, modified Hodge test, Carba NP, Carbapenem Inactivation Method [CIM], or modified CIM). (cdc.gov)

To understand the main determinants behind worldwide antibiotic resistance dynamics, scientists from the Institut Pasteur, Inserm, Université de Versailles Saint-Quentin-en-Yvelines and Université Paris-Saclay developed a statistical model based on a large-scale spatial-temporal analysis. (pasteur.fr)
The scientists analyzed the data by testing a large number of determinants to reveal the main factors of antibiotic resistance and understand how they relate to the dynamics observed worldwide. (pasteur.fr)

Central Asian and Eastern European surveillance of antimicrobial resistance: annual report 2017. (ijmedicine.com)
A long-lasting effort is necessary to keep the [antibiotic-resistance] situation at a good level," said Tim Eckmanns, MD, head of the Department for Nosocomial Infections, Surveillance of Antibiotic Resistance and Usage at the Robert Koch Institute (RKI) in Berlin, Germany. (medscape.com)
Eckmanns's department at the RKI has published the recent data on antibiotic resistance surveillance (ARS) in Germany up until 2021. (medscape.com)
Resistance results are process electronically in the state's reportable disease surveillance system. (floridahealth.gov)
We evaluated the One Health-ness (OH-ness) of the surveillance system for antimicrobial resistance (AMR) in Norway by using the recently developed "Evaluation tool for One Health epidemiological surveillance capacities and capabilities" (OH-EpiCap tool). (mdpi.com)
This data set describes antimicrobial resistance (AMR) data from the WHO European Region gathered through the Central Asian and Eastern European Surveillance of Antimicrobial Resistance (CAESAR) network and the European Centre for Disease Prevention and Control (ECDC) European Antimicrobial Resistance Surveillance Network (EARS-Net). (who.int)
Data from the European Antimicrobial Resistance Surveillance Network (EARS-Net). (who.int)
Here, we examined the genetic diversity, distribution and mobilisation of iuc and iro loci amongst 2503 K . pneumoniae genomes using comparative genomics approaches and developed tools for tracking them via genomic surveillance. (biomedcentral.com)
The SENTRY antimicrobial surveillance programme on antimicrobial resistance was conducted across India. (omicsonline.org)
Worldwide surveillance of antibiotic resistance, especially under the aegis of WHO has been set up, and several databases have been created to record ABR worldwide, with the long-term aim of improving understanding of the causes to help tackle the phenomenon. (pasteur.fr)
Our study provides a framework for the much needed incorporation of plasmid data into genomic surveillance systems, an essential step toward a more comprehensive understanding of resistance spread. (ox.ac.uk)

Novel, broadly reactive anticapsular antibodies against carbapenem-resistant Klebsiella pneumoniae protect from infection. (mpg.de)
Poor infection control, inadequate sanitary conditions, and inappropriate food-handling encourage the spread of antimicrobial resistance. (paho.org)
Antibiotic treatment for a single outpatient infection has been shown to influence resistance patterns of future infections. (pids.org)
If you have suffered a superbug infection in a hospital - from MRSA to Klebsiella pneumoniae - you may be able to get justice for the suffering you have experienced. (first4lawyers.com)

Infections that develop with resistant Klebsiella pneumoniae have been associated with high morbidity and mortality. (ijmedicine.com)
https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf) A 2014 UK government report projected that the number of annual deaths attributable to antimicrobial resistance would surpass 10 million by the year 2050 if no meaningful interventions occur, possibly surpassing cancer as the number-one cause of mortality worldwide. (pids.org)
Concerningly, iuc has also been reported in MDR strains in the hospital setting, where it was associated with increased mortality, highlighting the need to understand, detect and track the mobility of these virulence loci in the K . pneumoniae population. (biomedcentral.com)
We believe that expanding the focus of humanitarian interventions in unstable and fragile contexts to include antimicrobial stewardship in primary care will strengthen the global response to antimicrobial resistance and will decrease its burden where it is posing the highest toll in terms of mortality. (bvsalud.org)

For resistance determinant detection, 99-100% sequence identity and 100% sequence coverage from GAMMA and SRST2 was used. (cdc.gov)

The differences in estimates highlight the need for a unified methodology to estimate the burden of antimicrobial resistance in order to accurately advise health policy makers and prioritize resources expenditure. (biomedcentral.com)
Fragile and conflict-affected settings bear a disproportionate burden of antimicrobial resistance, due to the compounding effects of weak health policies, disrupted medical supply chains, and lack of knowledge and awareness about antibiotic stewardship both among health care providers and health service users. (bvsalud.org)

For bloodstream infections known to be due to extended spectrum beta-lactamase producing Enterobacteriaceace, carbapenems are superior to alternative treatments. (wikipedia.org)

BackgroundKlebsiella pneumoniae is one of the leading causes of nosocomial infections. (tropmedres.ac)

KPC-109 production mediated resistance/decreased susceptibility to avibactam-based combinations (with ceftazidime, cefepime and aztreonam) and cefiderocol, with a trade-off on carbapenem resistance. (imperial.ac.uk)

however, the broad spectrum antimicrobial resistance corresponds to the main problem of the current public health. (uc.pt)
Because of its weak hydrolytic acivity against broad spectrum cephalosporin and carbapenems, these may go undetected in routine screening. (omicsonline.org)
Antimicrobial resistance (AMR) represents a serious problem due to the indiscriminate use of broad-spectrum antimicrobials. (bvsalud.org)

Carbapenems are active synergistically with aminoglycosides against P. aeruginosa . (msdmanuals.com)

Anatomy6

Organisms27

Diseases29

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes43

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care8

Geographicals3

Isolates41

Enterobacteriaceae16

Antibiotics29

Escherichia coli and Klebsiella2

Streptococcus4

Bacteria27

Genes19

Cephalosporins3

Mechanisms12

Acinetobacter4

Enterobacter2

Hypervirulent Klebsiella pneumoniae4

Bacterial5

Pseudomonas2

Coli8

Pathogens7

Prevalence2

Isolate3

Molecular6

Ertapenem1

Clinical7

Colistin resistance7

Enterobacterales3

Mechanism4

Pathogen2

Gene6

Multidrug-resistant1

Beta-lactams1

Resistant to carbapenems2

Oxytoca1

Emergence2

Enzymes1

Clones1

Species1

Plasmids4

Drug resistance4

20161

Modified Hodge test1

Determinants2

Surveillance11

Infection4

Mortality4

Detection1

Burden of antimicrobial resistance2

Bloodstream infections1

Nosocomial1

Cefepime1

Spectrum3

Aminoglycosides1