ChemotherapyDrugsCisplatin resistanceMolecularTherapiesVitroPathwaysConfersTumorsProteinEndocrineAgentsAndrogen receptorMetastasisMechanisms of resistanceInhibitorsInsulin ResistanceTherapyTherapeuticSpeciesEGFRGefitinibMedicationsActivityCommonlyIntrinsicChemotherapeuticCellsBreastProteinsAgentMoleculesRoleDevelopmentResearchers
Chemotherapy9
- However, the results of gliomas chemotherapy are unsatisfactory, and resistance to platinum drugs is one of the important reasons. (eurekaselect.com)
- Multidrug resistance (MDR) is a significant obstacle to providing effective chemotherapy to many patients suffering from different types of cancer. (ac.rs)
- TY - JOUR AU - Erić, Slavica AU - Ilić, Katarina PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1431 AB - Multidrug resistance (MDR) is a significant obstacle to providing effective chemotherapy to many patients suffering from different types of cancer. (ac.rs)
- The generation of cellular models of drug resistance has been pivotal in unravelling the main effectors of resistance to traditional chemotherapy at the molecular level (i.e. intracellular drug inactivation, detoxifying systems, defects in DNA repair, apoptosis evasion, membrane transporters and cell adhesion). (nature.com)
- Since then, chemotherapy has been one of the main therapeutic strategies in cancer treatment, but, to paraphrase Paul Ehrlich, resistance has followed as a faithful shadow. (nature.com)
- Diazido Pt( IV ) complexes with a general formula [Pt(N 3 ) 2 (L)(L′)(OR)(OR′)] are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy. (rsc.org)
- 9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)
- Resistance to chemotherapy or metastasis is an important clinical problem in cancer. (scientistlive.com)
- Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy [electronic resource]. (who.int)
Drugs19
- Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. (news-medical.net)
- New findings by Fox Chase Cancer Center researchers identify one protein, Abcc10 (also known as Mrp7), as being intimately involved in resistance to certain drugs used to treat breast, ovarian, lung, and other cancers. (news-medical.net)
- The results suggest that blunting the activity of Abcc10 might help counter resistance and extend the effectiveness of these anticancer drugs. (news-medical.net)
- The researchers isolated cells from the knockout mice and tested the cells' reactions to taxanes and two other anticancer drugs, vincristine and Ara-C. Compared to cells from normal mice that still possessed the gene for Abcc10, the knockout mouse cells were much more sensitive to the drugs. (news-medical.net)
- The results provide the first evidence from living organisms that Abcc10 is a cell's built-in protection against the effects of powerful drugs, and raises the possibility of using Abcc10 inhibitors to break down that resistance and sensitize tumor cells to anticancer agents. (news-medical.net)
- The resistance of gliomas to platinum drugs is the result of a combination of influencing factors. (eurekaselect.com)
- miRNAs and lncRNAs control drug sensitivity and the development of tumor resistance towards platinum drugs. (eurekaselect.com)
- This mini-review summarizes the resistance mechanisms of gliomas to platinum drugs, as well as molecules and therapies that can improve the sensitivity of gliomas to platinum drugs. (eurekaselect.com)
- Although resistance to anticancer drugs may be developed by different mechanisms, one of the underlying mechanisms of classical MDR is cellular overexpression of P-glycoprotein (P-gp) which acts as an efflux pump for different substrates in cells, resulting in decreased concentration of anticancer drugs in cancer cells. (ac.rs)
- valspodar, biricodar) showed reduced toxicity but were confounded by unpredictable pharmacokinetic interactions with anticancer drugs as well as interactions with other transporter proteins. (ac.rs)
- Anticancer Drugs. (wikipedia.org)
- For example, we recently developed a technique in which engineered lentiviral cDNAs encoding activators of major oncogenic signaling pathways are introduced into cells and then profiled to identify those capable of conferring resistance to drugs. (duke.edu)
- Many anticancer drugs, such as platinum compounds, alkylating agents and nitrosoureas, cause direct damage to the structural integrity of the DNA, and resistance to these compounds results from activation of DNA repair systems. (nature.com)
- and 6) clinical prospects for future therapeutic use of Se in combination with anticancer drugs. (oncotarget.com)
- The conjugation of diazido Pt( IV ) complexes with anticancer drugs or cancer-targeting vectors is an effective strategy to optimise the design of these photoactive prodrugs. (rsc.org)
- July 11, 2019 Targeted drugs for breast and lung cancer could be used together to overcome resistance to treatment in several different tumour types, a new study shows. (sciencedaily.com)
- In this perspective article we update the status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials, and discuss the results in the context of where we believe the field will develop over the next decade. (rsc.org)
- This model can be a valuable tool for screening potential anticancer drugs and developing personalized cancer treatment strategies. (bvsalud.org)
- Current treatment involves either administration of antiobesity drugs or surgical procedures such as Roux-en-Y-gastric bypass or sleeve gastrectomy, both of which are associated with serious side effects and poor patient acceptance. (bvsalud.org)
Cisplatin resistance3
- Diazido Pt( IV ) complexes exhibit high dark stability and promising photocytotoxicity circumventing cisplatin resistance. (rsc.org)
- Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)
- This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)
Molecular4
- Molecular docking specifies the capability of a C60 fullerene to form van der Waals interactions with potential binding sites on P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP-1), and multidrug resistance protein 2 (MRP-2) molecules. (hereon.de)
- Mechanistically, resistance is highly specific to each cancer subtype and therapy, and most likely involves multiple molecular interactors. (lu.se)
- An understanding of the molecular mechanisms of resistance to anti-cancer therapy will facilitate the development of novel therapeutic regimens. (lu.se)
- Our research focuses on deciphering the molecular mechanisms of resistance to anti-cancer therapy in leukemia and ovarian cancer by targeting the RTK signaling axis. (lu.se)
Therapies4
- Our laboratory uses genomic, pharmacological, and biochemical approaches to define the pathways of resistance to targeted anticancer therapies. (duke.edu)
- In parallel, we have also developed analogous loss-of-function screening approaches based on CRISPR/Cas9 gene editing, and have used these approaches to map the pathways supporting intrinsic resistance to targeted therapies. (duke.edu)
- The development of targeted therapies has also been followed by resistance, reminiscent of an evolutionary arms race, as exemplified by imatinib and other BCR-ABL inhibitors for the treatment of chronic myelogenous leukaemia. (nature.com)
- Despite incredible progress in the treatment of cancer, the cure rate remains low due to the fact that almost all cancer patients develop resistance to anticancer therapies. (lu.se)
Vitro4
- We formulated and analyzed a novel nanoformulation of the anticancer drug cisplatin (Cis) with C60 fullerene (C60+Cis complex) and showed its higher toxicity toward tumor cell lines in vitro when compared to Cis alone. (hereon.de)
- In conclusion, the C60+Cis complex effectively induced tumor cell death in vitro and inhibited tumor growth in vivo, overcoming drug resistance likely by the potential of the C60 fullerene to interact with P-gp, MRP-1, and MRP-2 molecules. (hereon.de)
- The kinase inhibitor gefitinib inhibited the transporter function of BCRP and reversed BCRP-mediated drug resistance both in vitro and in vivo. (elsevierpure.com)
- In vitro anticancer activity of some plants used in Moroccan traditional medicine. (academicjournals.org)
Pathways3
- Drug analogues of DNA precursors such as 5-fluorouracil and cytosine arabinoside require metabolic activation, and resistance can arise from modification of these activation pathways. (nature.com)
- Upon irradiation, diazido Pt( IV ) complexes release anticancer active Pt( II ) species, azidyl radicals and ROS, which interact with biomolecules and therefore affect the cellular components and pathways. (rsc.org)
- State‑of‑the‑art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple‑negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. (spandidos-publications.com)
Confers2
- In earlier work, Elizabeth A. Hopper-Borge, Ph.D., an assistant professor at Fox Chase, showed that Abcc10 confers resistance to a number of anticancer agents, particularly taxanes, which include paclitaxel (Taxol) and docetaxel (Taxotere). (news-medical.net)
- In addition, we identify an operon that confers TDA resistance to the producing marine bacteria. (princeton.edu)
Tumors1
- Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
Protein2
- Breast cancer resistance protein (BCRP) is a half-molecule ATP-binding cassette transporter that forms a functional homodimer and pumps out various anticancer agents, such as 7-ethyl-10-hydroxycamptothecin, topotecan, mitoxantrone and flavopiridol, from cells. (elsevierpure.com)
- The C421A (Q141K) polymorphism is also significant as Q141K-BCRP-transfected cells show markedly low protein expression levels and low-level drug resistance. (elsevierpure.com)
Endocrine1
- Resistance to prior adjuvant endocrine therapy (ET). (who.int)
Agents8
- It is therefore critical to determine the mechanisms of resistance against agents and the prognostic value of acquired resistance-related molecules to EGFR-TKI. (iiarjournals.org)
- Hence, individuals with C376T or C421A polymorphisms may express low levels of BCRP or none at all, resulting in hypersensitivity of normal cells to BCRP-substrate anticancer agents. (elsevierpure.com)
- Based on similarities to polyether anticancer agents we have further examined TDA's cytotoxicity and find it to exhibit potent, broad-spectrum anticancer activities. (princeton.edu)
- systematic analysis of patterns of cross resistance between anticancer agents and treating drug resistant malignancy. (novapublishers.com)
- Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
- Mechanisms for resistance to anticancer agents and the reversal of the resistance]. (nih.gov)
- however, the duration of response to these agents is limited due to the development of treatment resistance. (renalandurologynews.com)
- Both agents also increased androgen receptor (AR) and AR variant AR-V7, which is involved in the development of resistance to abiraterone and enzalutamide. (renalandurologynews.com)
Androgen receptor1
- Three main mechanisms of resistance to androgen deprivation therapy related to androgen receptor (AR) are depicted. (endocrinology-journals.org)
Metastasis1
- Selenium (Se)-containing molecules exert antioxidant properties and modulate targets associated with tumor growth, metastasis, angiogenesis, and drug resistance. (oncotarget.com)
Mechanisms of resistance3
- Understanding the mechanisms of resistance to treatment can provide a method for overcoming such resistance. (iiarjournals.org)
- Mechanisms of resistance to androgen deprivation therapy. (endocrinology-journals.org)
- Other mechanisms of resistance have been described, such as androgen-independent activation of AR mediated by oncogenic signaling (see text and Wadosky & Koochekpour 2016). (endocrinology-journals.org)
Inhibitors1
- Furthermore, the emergence of resistance to neuraminidase inhibitors may limit the utility of prophylaxis in this population ( 7 - 12 ). (cdc.gov)
Insulin Resistance2
- Kefir has a beneficial effect in decreasing insulin resistance. (greenmedinfo.com)
- Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin resistance women. (greenmedinfo.com)
Therapy4
- Oseltamivir resistance in 4 (13.3%) of 30 patients who were administered oseltamivir highlights the need for ongoing surveillance of such resistance and further research on optimal antiviral therapy in the immunocompromised. (cdc.gov)
- Consequently, identification of the factors that drive the development of therapy resistance is a pressing issue in the field. (lu.se)
- Several RTKs are mutated or overexpressed in cancer, and many of them cooperate to mediate therapy resistance. (lu.se)
- Deciphering the role of RTKs in anticancer therapy resistance will improve the general understanding of basic biology of receptor regulation and, in the long term, inform the development of more effective therapeutic regimens. (lu.se)
Therapeutic1
- In this talk, I will describe our large-scale application of these methods, as well as how the results of these studies have highlighted examples of "convergent" therapeutic resistance. (duke.edu)
Species1
- L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)
EGFR5
- A retrospective multi-institutional study analyzed the correlation between patients' survival and acquired resistance-related molecules in non-small cell lung cancer (NSCLC) samples, that possessed sensitive EGFR mutations (7 cases: exon 19 deletion, and 12 cases: exon 21 point mutation). (iiarjournals.org)
- The current patients' selection might be changed by discrimination of acquired resistance-related molecules in patients with NSCLC treated with an EGFR-TKI. (iiarjournals.org)
- Explanations for the resistance to EGFR-TKI include the T790M mutation in exon 20 of the EGFR, MET amplification, overexpression of HGF, changes in the EMT status, and others ( 4 - 8 ). (iiarjournals.org)
- However, few studies have investigated resistance-related genes in EGFR-TKI-resistant specimens from a translational viewpoint, because of the clinical difficulty of re-biopsy. (iiarjournals.org)
- This research revealed a number of new changes that EGFR can undergo that leads to resistance and also found ways to conquer this next generation of mutants. (sciencedaily.com)
Gefitinib2
- Summary of patients exhibiting acquired resistance to gefitinib. (iiarjournals.org)
- BCRP-transduced human epidermoid carcinoma A431 (A431/BCRP) and BCRP-transduced human non-small cell lung cancer PC-9 (PC-9/BCRP) cells showed gefitinib resistance. (elsevierpure.com)
Medications3
- Purpose The introduction of resistance against anticancer medications is a persistent clinical issue for the treating locally advanced malignancies in the top and throat mucosal derived squamous cell carcinoma (HNSCC). (healthdisparitiesks.org)
- Using a new second-generation of Tarceva-like medications, researchers can overcome the drug resistance. (sciencedaily.com)
- The research team developed compounds to overcome the resistance with innovative combinations of medications. (sciencedaily.com)
Activity2
- SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
- The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)
Commonly2
- Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation. (nature.com)
- Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
Intrinsic1
- Unfortunately its continued use is greatly limited by severe dose limiting side effects and intrinsic or acquired drug resistance. (rsc.org)
Chemotherapeutic1
- Resistance to cancer chemotherapeutic treatment is a common phenomenon, especially in progressive disease. (nature.com)
Cells4
- We discovered that the action of the C60+Cis complex is associated with overcoming the drug resistance of the tumor cell lines through observing an increased number of apoptotic cells in the Annexin V/PI assay. (hereon.de)
- Although traditionally associated with the last stages of the disease, recent findings with minimally transformed pretumorigenic primary human cells indicate that the ability to generate drug resistance arises early during the tumorigenic process, before the full transformation. (nature.com)
- The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
- Cancer treatment induces specific genetic and epigenetic changes in cancer cells and in the microenvironment in which cancer cells reside, contributing to resistance. (lu.se)
Breast2
- The present review mainly focused on the latest updates on RUNX2 in BCSCs and their roles in breast cancer progression and drug resistance, providing insight that may aid the development of RUNX2‑based diagnostics and treatments for breast cancer in clinical practice. (spandidos-publications.com)
- Taken together, these studies indicated the involvement of RUNX2 in BCSCs and its roles in breast cancer diagnosis and drug resistance, revealing its promising prospective clinical application and utility as an antitumor drug target in the future. (spandidos-publications.com)
Proteins1
- 1992. Resistance of ADP-ribosylated histones and HMG proteins to proteases. . (oregonstate.edu)
Agent1
- Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment. (nature.com)
Molecules1
- This is the first comprehensive analysis of prognostic markers for molecules related to the acquired resistance in such pre- and post-treatment specimens, in order to elucidate their prognostic value. (iiarjournals.org)
Role1
- The cytochrome P 450 enzymes, a multigene family of constitutive and inducible haem-containing oxidative enzymes from the liver, play an important role in the metabolism of a diverse range of xenobiotics and are often overexpressed in a variety of solid tumours in which they can contribute to drug resistance. (nature.com)
Development2
- Two main groups of factors contribute to the development of drug resistance. (nature.com)
- However, the use of paclitaxel is limited by undesirable side effects as well as the development of drug resistance. (lu.se)
Researchers1
- Medical researchers would like to find ways of counteracting such resistance, but first they must understand why and how it happens. (news-medical.net)