ApoptosisCytotoxicRadiotherapyAutophagyExternal stimuliInflammationPathwaysMechanismsDiabetes-inducedGeneCisplatinInsulinAntimicrobialChemoresistanceInhibitionTumorNauseaRecurrenceClinicalAbnormalDysfunctionFindingsTherapeuticInhibitorAnticancer drugsRadiationResponsesCompoundsTumorsAcuteDrugChronicInvolvesCellsAcidCancerMethodsImprovesBoneDrugsLoss
Apoptosis7
- In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
- Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours. (oncotarget.com)
- Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
- Downregulation of UCA1 enhanced the radiosensitivity of CCL244 cells via inhibition of the colony formation, proliferation and promotion of radiation-induced apoptosis and G2/M arrest. (bvsalud.org)
- The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
- This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
- Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
Cytotoxic2
- The Warburg phenotype provides tumors an enhanced resistance against cytotoxic insults. (springer.com)
- Studies have shown that xanthine dehydrogenase (XDH)-derived reactive oxygen species (ROS) accelerates tumor growth, and also induces mutations or produces cytotoxic effects concurrently. (medsci.org)
Radiotherapy2
- With the support of various diagnosis technologies including positron emission tomography (PET), magnetic resonance imaging (MRI), and computed tomography (CT), surgery, radiotherapy, chemotherapy, and hormone therapy are generally applied to treat patients with cancer, including those three deadliest carcinomas. (frontiersin.org)
- Traditional chemotherapy and radiotherapy have limited effect in RCC, and molecular biomarkers are more targetable to guide treatment decisions. (medsci.org)
Autophagy5
- During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)
- Out of the seven tested recombinant human RNases, we have identified two members, RNase3 and RNase6, which were highly effective against Mycobacterium aurum extra- and intracellularly and induced an autophagy process. (frontiersin.org)
- Both autophagy inhibitor chloroquine and extracellular vesicles (EVs) release inhibitor GW4869 enhanced doxorubicin activity and counteracted doxorubicin resistance. (preprints.org)
- Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism. (babraham.ac.uk)
- Here, we review the diverse, and still expanding, collection of stimuli and processes now known to harness the noncanonical autophagy pathway, including engulfment processes, drug treatments, TRPML1 and STING signaling, viral infection, and other pathogenic factors. (babraham.ac.uk)
External stimuli1
- In this review, we discuss how the properties of the tumor microenvironment promote chemoresistance in cancer cells, and the interplay between these external stimuli. (peoplebeatingcancer.org)
Inflammation5
- Although leukocyte count and serum C-reactive protein did not suggest inflammation, empiric antimicrobial chemotherapy with ceftriaxone, ampicillin, gentamicin, and acyclovir was started immediately. (cdc.gov)
- In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
- Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
- Together our results reveal the potential ability of gefitinib to initiate sterile inflammation via two distinct mechanisms, and identified IL-1β and HMGB1 as key determinants of gefitinib-induced inflammation that may provide insights into gefitinib-induced interstitial pneumonitis. (nature.com)
- Collectively, they may help limit tissue injury, enhance host resistance to infection, and promote tissue repair and resolution of inflammation. (msdmanuals.com)
Pathways3
- With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
- One key malignant phenotype of cancer cells is their ability to resist chemotherapeutics, and elements of the ECM can promote chemoresistance in cancer cells through a variety of signaling pathways, inducing changes in gene expression and protein activity that allow resistance. (peoplebeatingcancer.org)
- Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. (biomedcentral.com)
Mechanisms5
- Our focus is translational research that advances the understanding of cancer treatment resistance mechanisms through the development of novel targeted therapies in order to improve patient survival. (massgeneral.org)
- Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
- Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
- Previously it was thought that they act by targeting angiogenesis, but recently additional mechanisms have been discovered which has established metronomic chemotherapy as a type of multi-targeted therapy. (peoplebeatingcancer.org)
- Treatment of patients with advanced and metastatic LC presents a significant challenge as malignant cells use different mechanisms to resist chemotherapy. (preprints.org)
Diabetes-induced2
- The prevention of diabetes-induced mtDNA deletions may be a potential mechanism of the neuroprotective effects of EQ in diabetic neuropathy. (nature.com)
- Finally, diabetes induced by drugs and chemicals (such as steroids used in chemotherapy and organ transplant therapy). (sajbl.org.za)
Gene1
- In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
Cisplatin2
- We previously identified ethoxyquin (EQ) as a potent neuroprotective compound through a phenotypic screen against three neurotoxic drugs and demonstrated that it prevents development of peripheral neuropathy in paclitaxel and cisplatin models of chemotherapy-induced peripheral neuropathy (CIPN). (nature.com)
- Cisplatin-based chemotherapy has been the best option for decades, but only 50% of patients benefit in the form of objective responses, and just 13-25% experience a complete response [ 1 ]. (iospress.com)
Insulin3
- Puzzlingly, rapamycin can induce insulin sensitivity, but may also induce insulin resistance or glucose. (rapamycin.news)
- Being overweight, obese, sedentary, and poor eating habits generate insulin resistance, preventing insulin from working properly, which means that glucose cannot enter the cell and remains circulating in the blood. (sajbl.org.za)
- This hyperglycemia in turn generates a new stimulus to the pancreas that makes it secrete more insulin than necessary, so that over time the pancreatic reserves of insulin are depleted. (sajbl.org.za)
Antimicrobial1
- Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)
Chemoresistance1
- "Toxic effects and chemoresistance are major hurdles in chemotherapy and to avoid these problems caused by traditional chemotherapeutic regimens, a new modality of drug administration called "metronomic chemotherapy" has emerged. (peoplebeatingcancer.org)
Inhibition2
- The efficacy of SPNs in inducing cancer cell death by inhibition of kinase signaling and imaging the response was evaluated in murine BRAFV 600E melanoma (D4M) and triple-negative breast cancer (4T1) cell lines. (ntno.org)
- The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
Tumor3
- Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. (bbrc.in)
- Recently, it has been reported by many workers that the potential functions of exosomes contributed to various aspects of hematological tumorigenesis, particularly with a focus on the exosome-mediated tumor progression, metastasis, drug resistance and immune escape by altering the function of receiver cells via diverse exosomal cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs) (Whiteside and Boyiadzis, (2017). (bbrc.in)
- These attributes enhance the delivery of multiple therapeutic agents directly to the tumor microenvironment (TME), resulting in reversal of LC resistance to anticancer treatment. (preprints.org)
Nausea4
- This compound has several uses in a variety of health conditions, and it may be useful in combating nausea and vomiting caused by chemotherapy. (cbdcontent.org)
- It may be useful in treating chemotherapy-induced nausea, among other conditions. (cbdcontent.org)
- CBDA inhibits vomiting induced by movement or toxins, and it also delays the onset of nausea. (cbdcontent.org)
- CBDA also inhibited nausea caused by anticipatory stimuli, including sights, sounds, and the smell of chemotherapy. (cbdcontent.org)
Recurrence1
- Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
Clinical5
- Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
- In clinical conditions, parietal cell dysfunction can be induced by antiparietal cell antibodies. (medscape.com)
- The knowledge gained from the preclinical studies of metronomic chemotherapy, along with clinical experience, will help to design better therapeutic protocols against cancer. (peoplebeatingcancer.org)
- and discusses the future directions for clinical application of nanomedicine in management of LC resistance. (preprints.org)
- Classical Hodgkin lymphoma (cHL) is a highly curable disease (70-80%), even though long-term toxicities, drug resistance, and predicting clinical responses to therapy are major challenges in cHL treatment. (preprints.org)
Abnormal1
- Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an injury or disease of the somatosensory nervous system, which induces abnormal painful sensations including allodynia and hyperalgesia. (researchgate.net)
Dysfunction1
- Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells. (mpg.de)
Findings1
- Obese children with leukemia have higher rates of chemotherapy resistance and higher relapse rates than thinner kids, according to recent findings published online in Cancer Research, a journal of the American Association for Cancer Research. (dotmed.com)
Therapeutic3
- Our investigations are ongoing in biomarkers of resistance and potential new targets for therapeutic intervention in colorectal cancer, melanoma and Merkel cell carcinoma. (massgeneral.org)
- Although general therapeutic strategies and existent nanomedicine have been applied in relating cancer treatments, the side effects and potential damage induced by the off-target effect greatly lower the therapeutic efficiency. (frontiersin.org)
- In patients with cancer, MDSC are associated with adverse oncologic outcomes and therapeutic resistance. (iospress.com)
Inhibitor1
- Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion. (mpg.de)
Anticancer drugs1
- Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. (mdpi.com)
Radiation1
- It protects from trauma, insect penetration, and electromagnetic radiation and insulates against heat loss and heat gain. (naturalmedicinejournal.com)
Responses2
- In addition, they modify the body's immune responses to diverse stimuli. (nih.gov)
- Low calcium levels decrease the threshold of excitation of neurons, causing them to have repetitive responses to a single stimulus. (medscape.com)
Compounds2
- Metallothionein biosynthesis can also be induced by certain hormones, pharmaceuticals, alcohols, and other compounds. (wikipedia.org)
- Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
Tumors1
- Such regimen involves the frequent administration of conventional chemotherapeutic agents at very low doses to target activated endothelial cells in tumors, the advantages of which include minimal adverse effects and a rare chance of developing acquired drug resistance. (peoplebeatingcancer.org)
Acute1
- Intensive detecton (one), Procedures in case of suspected acute leukemia publish-inducton chemotherapy for all patents is 2 This article is available from: dx. (ehd.org)
Drug9
- Relapse of neuroblastoma commonly occurs in hypoxic tissues, and is associated with an acquired and sustained high-level drug resistance, often due to p53 loss of function. (aacrjournals.org)
- Abrogating p53 function with HPV 16 E6 transduction in drug-sensitive neuroblastoma cell lines caused high-level drug resistance. (aacrjournals.org)
- In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
- Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. (nih.gov)
- Conclusion Multi-drug resistance tuberculosis is very prevalent in Pakistan, which may increase burden on health care system and may lead to various complications of tuberculosis. (preprints.org)
- Drug resistance (DR) is a complex process that occurs due to a variety of genetic and acquired factors. (preprints.org)
- Both HDLM-2 and HDLM-2dx cells had an intrinsic resistance to BV but not to the drug MMAE. (preprints.org)
- Upon V0-V1 binding, V-ATPase recruits ATG16L1, via K490, during LC3-associated phagocytosis (LAP), STING- and drug-induced CASM, indicating a common mechanism. (babraham.ac.uk)
- As well as the enzyme complexes directly responsible for LC3 lipidation in all contexts, we show the RALGAP complex is important for M2-induced, but not ionophore drug-induced, LC3 lipidation. (babraham.ac.uk)
Chronic1
- Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
Involves1
- First, the Roux-en-Y gastric bypass surgery involves formation of a 15- to 30-mL fundal pouch. (medscape.com)
Cells2
- A high peak concentration may affect neurons, protected by the blood brain barrier, and stem cells in their niches. (rapamycin.news)
- To solve these problems, we characterized two cHL cell lines with acquired resistance to doxorubicin, KM-H2dx and HDLM-2dx (HRSdx), generated from KM-H2 and HDLM-2 cells, respectively. (preprints.org)
Acid2
- First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women. (medscape.com)
- Fluoride allows the formation of an enamel layer less sensitive to acid attacks that induce cavities. (sinaftin.fr)
Cancer2
- Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
- KEGG pathway term mTOR signaling pathway is observed to be meliorated in this tricluster and has been reported to be associated Inhibitors,Modulators,Libraries with estrogen induced breast cancer cell. (ampk-signal.com)
Methods1
- Methods: ICH was induced by collagenase injection into the striatum of wild type (C57BL/6J) anticoagulated mice (warfarin or rivaroxaban) and Mmp10 -/- mice. (unav.edu)
Improves1
- Fluor promotes the remineralization of enamel and improves its resistance to acidity (acidity caused by bacteria and responsible for the demineralization of enamel). (sinaftin.fr)
Bone1
- Estrogen and testosterone help to maintain bone mass and strength and may protect the cardiovascular system . (encyclopedia.com)
Drugs2
- Ethoxyquin (EQ), a quinolone-based antioxidant, has demonstrated neuroprotective properties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in animal models of chemotherapy-induced peripheral neuropathy. (nature.com)
- Due to various factors including socioeconomic factors, compliance is poor to anti-tuberculosis drugs, leading to resistance. (preprints.org)
Loss2
- Analysis revealed that Buffy acted to rescue the associated loss of locomotor ability observed in the alpha-synuclein-induced model of PD, while Buffy RNA interference resulted in an enhanced alpha-synuclein-induced loss of climbing ability. (sdbonline.org)
- Subject self-assessment determined that the product was effective in reducing hair loss as well as improving the strength/resistance and volume of hair. (naturalmedicinejournal.com)