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  • molecule
  • Emerging evidence shows that palmitic acid (PA), a common fatty acid in the human diet, serves as a signaling molecule regulating the progression and development of many diseases at the molecular level. (springer.com)
  • phenotype
  • Preclinical studies have indicated that resistance to topo-IIalpha drugs depends on topo-IIalpha content and/or activity, the altered-topo-II multidrug resistance phenotype (at-MDR) and/or one of two different drug efflux pumps, P-glycoprotein (P-gp) and the multidrug resistance protein (MRP). (paperity.org)
  • While essential to normal developmental processes such as gastrulation, EMT is associated with metastasis, the cancer stem cell phenotype, and the regulation of chemo and immune resistance in cancer. (biomedcentral.com)
  • Epithelial-to-mesenchymal transition (EMT) is the process by which epithelial cells lose their apical polarity and adopt a mesenchymal phenotype, thereby, increasing migratory properties, invasiveness and apoptotic resistance. (biomedcentral.com)
  • vimentin
  • Commonly used molecular markers for EMT include increased expression of N-cadherin and vimentin, nuclear localization of β-catenin, and increased production of the transcription factors such as Snail1 (Snail), Snail2 (Slug), Twist, EF1/ZEB1, SIP1/ZEB2, and/or E47 that inhibit E-cadherin production. (rupress.org)
  • Arabidopsis
  • March 1991: Pollinations for a half-diallel cross of fourteen Arabidopsis accessions was initiated to provide germplasm for investigating the inheritance of resistance to Peronospora. (bio.net)
  • Analysis of infections by a series of mutant viruses with single amino acid substitutions near the N-terminus of the CP implicated TIP binding ability of the CP with modulation of the host resistance response in both susceptible (Col-0) and resistant (Di-17) ecotypes of Arabidopsis. (unl.edu)
  • A genetic screen for components involved in resistance (R) protein-mediated immunity in Arabidopsis led to isolation of crt1 (compromised recognition of TCV). (utoronto.ca)
  • kinase
  • I compared three pairs of human colorectal 5-FU-sensitive and -resistant cell lines, and investigated whether there was a direct role for E-cadherin and/or the Src family kinase, c- Yes (which is co-amplified with thymidylate synthase) in promoting resistance to 5-FU. (gla.ac.uk)
  • Furthermore, the resistant cells displayed a greater dependence on signalling via the PI3- kinase/Akt pathway for their survival. (gla.ac.uk)
  • metastasis
  • The significance of Snail1 as a prognostic indicator, its involvement in the regulation of EMT and metastasis, and its roles in both drug and immune resistance point out that Snail1 is an attractive target for tumor growth inhibition and a target for sensitization to cytotoxic drugs. (biomedcentral.com)
  • loci
  • July 1991: A simple hypothetical model involving three resistance loci was proposed to explain differential interactions between six accessions from the half-diallel cross and four isolates of Peronospora. (bio.net)
  • Two additional loci for resistance were predicted to explain new differences observed from microscopic examinations of the interactions, tests made with new isolates, and a partial F2 analysis of the half- diallel cross. (bio.net)
  • RFLP mapping of loci for resistance to Peronospora was started by a postdoctoral researcher Mahmut Tor in Jim Beynon's lab. (bio.net)
  • The hypothetical genetic model now requires at least eight resistance loci to explain interactions observed between six accessions and six isolates of Peronospora. (bio.net)
  • potent
  • In mononuclear cells/monocytes, saturated FFAs are potent activators of TLR4 signaling, whereas unsaturated FFAs do not stimulate this pathway ( 10 ). (diabetesjournals.org)
  • sensitivity
  • We evaluated nine recurrent BRCA1 -mutated ovarian cancers previously treated with platinum compounds, including five with acquired platinum resistance, one with primary platinum resistance, and three with platinum sensitivity. (aacrjournals.org)
  • biotic
  • We are also testing whether trans-generational genomic instability facilitates development of novel alleles that enhance plant resistance to biotic stress. (utoronto.ca)
  • axis
  • Conclusion: This is the first report on an integrin/wnt signalling activation axis addressing the consequences for chemotherapy sensitiveness of melanoma cells, which thus offers novel therapeutic targets for approaches to interfere with chemoresistance. (mdpi.com)
  • ANKRD6 encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. (antikoerper-online.de)
  • interacts
  • The combined findings that CRT1 i) is an endonuclease, ii) physically interacts with several components of DNA repair and recombination (R/R) pathway, iii) is localized to heterochromatin, and iv) is implicated in epigenetic regulation, including suppression of heterochromatic transposable elements (TEs), suggest that CRT1 has an important nuclear function(s). (utoronto.ca)
  • molecular
  • Our previous study has developed an effective algorithm to predict nuclear import activity, in which molecular interaction energy components (MIECs) were used to characterize NLS-import receptor interaction, and a support vector regression machine(SVR) was used to learn the relationship between the characterized NLS-import receptor interaction and the corresponding nuclear import activity . (ommegaonline.org)
  • cancer
  • Resistance to these agents is a major obstacle to effective cancer therapy. (aacrjournals.org)
  • Androgen receptor (AR) variant AR-V7 is a ligand-independent transcription factor that promotes prostate cancer resistance to AR-targeted therapies. (aacrjournals.org)
  • As resistance to current therapies remains one of the major hurdles to the successful treatment of advanced colorectal cancer, we need to understand the mechanisms by which cancer cells evade therapy-induced cell death. (gla.ac.uk)
  • promoter
  • It was found that OSU-03012 blocked YB-1 nuclear translocation and binding to the -1 kb promoter of EGFR. (ubc.ca)
  • The objective of this study was to determine the effects (through over-expressing and using the CaMV 35S promoter) of Pikh on MR219 resistance because it is a rice variety that is susceptible to the blast fungus pathotype P7.2. (frontiersin.org)
  • therapies
  • The purpose of this study was to understand whether other AR variants may be coexpressed with AR-V7 and promote resistance to AR-targeted therapies. (aacrjournals.org)
  • enzyme
  • SCLC tumours are initially sensitive to drugs such as etoposide, which acts on the nuclear enzyme DNA topoisomerase Ila (topo-IlIa) by freezing an enzyme-DNA cleavable complex and thereby creating DNA breaks, eventually leading to cell death. (paperity.org)
  • glucose
  • Previous studies identified a pancreatic β-cell-restricted factor, called the RIPE3b1 activator, that is enriched in response to glucose in pancreatic β-cell nuclear extracts. (asm.org)
  • activity
  • They alter nuclear import and export steps, modify the DNA binding affinity, and alter the pattern of transcriptional activity for specific target. (hindawi.com)
  • responses
  • It has been established that, in addition to its structural role, TCV coat protein (CP) has multiple roles in virus - host interactions both as a silencing suppressor as well as a modulator of the host anti-viral resistance responses. (unl.edu)
  • Together, my studies permitted the formulation of a refined model for the involvement of both CP and TIP in both the basal and ETI resistance responses to TCV infection. (unl.edu)
  • secondary
  • Intriguingly, the case with primary platinum resistance showed back mutation of BRCA1 in the primary tumor and showed another secondary mutation in the recurrent tumor. (aacrjournals.org)