Resistance genes encode. Medical search. Frequent questions

Sr60 is an exception that encodes a tandem kinase protein 10 . (nature.com)
Reduced heat resistance of mutant spores after cloning and mutagenesis of the Bacillus subtilis gene encoding penicillin-binding protein 5. (ox.ac.uk)
Part of the gene encoding penicillin-binding protein 5 from Bacillus subtilis 168 was cloned in Escherichia coli with a synthetic oligonucleotide as a hybridization probe. (ox.ac.uk)
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (nih.gov)
Hessian fly larvae are thought to inject secreted salivary gland protein (SSGP) effectors into wheat seedlings to help obtain nutrients and dampen the host resistance response. (usda.gov)
We will use changes in the gene expression levels of Mds-1 and the lipid transfer protein gene BT008922 as biomarkers to measure plant responses using RT-qPCR. (usda.gov)
Spinocerebellar ataxia type 35 (SCA35) is a rare, autosomal dominant neurodegenerative disorder associated with mutations in TGM6 gene that encode the protein transglutaminase 6 (TG6). (ataxia.org)
This focuses on the expression of the human tdp1 mutant gene in brain tissue of flies lacking the endogenous Gkt protein. (ataxia.org)
Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
This gene encodes the major vault protein which is a lung resistance-related protein. (thermofisher.com)
This protein mediates drug resistance, perhaps via a transport process. (thermofisher.com)
The protein overexpression is a potentially useful marker of clinical drug resistance. (thermofisher.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)
The ALMS1 gene provides instructions for making a protein whose function is unknown. (medlineplus.gov)
A loss of this protein in the pancreas may cause insulin resistance, a condition in which the body cannot use insulin properly. (medlineplus.gov)
Our work mapped the taxonomic distribution of protein sequences in the AA7 family and revealed a striking high proportion of sequences encoded by major plant pathogenic fungi and Oomycetes," said Maher Abou Hachem, Professor of Biotechnology and Biomedicine at the Technical University of Denmark (DTU). (lu.se)
The gene affected encodes a SH2D1A protein consisting only of a SH2 domain and a short C-terminal tail [Sayos et al. (lu.se)
ZAP-70 deficiency is a rare autosomal recessive form of severe combined immunodeficiency (SCID) caused by mutations in the gene coding for T cell receptor z-chain associated protein kinase [ Chan et al. (lu.se)
Noonan syndrome (NS) is caused by mutations in PTPN11 , a gene encoding the nonreceptor protein tyrosine phosphatase SHP2. (lu.se)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism. (medscape.com)

Mutational genomics and targeted exome capture identify Sr26 and Sr61 as separate single genes that encode unrelated (34.8%) nucleotide binding site leucine rich repeat proteins. (nature.com)
Next, we will generate recombinant proteins using the cloned genes that have shown a measurable plant response. (usda.gov)
The presence of cellulose synthesis genes and a large class of novel high-molecular-weight excreted proteins suggests potential traits for desiccation resistance, biofilm formation, and/or contribution to soil structure. (nih.gov)
Genes that encode a variety of novel proteins were also identified. (nih.gov)
The deletion involves two closely-related genes that encode proteins containing 800-900 amino acids with a signal peptide. (biorxiv.org)
Moreover, when these proteins were transiently expressed, they induced cell death in grapevines carrying Rpv3.1 resistance, confirming their avirulence nature. (biorxiv.org)
The significantly upregulated genes encode proteins involved in reactions of the energy-generating phosphotransferase system and transcription processing, which could be related to phage transcription. (lu.se)

b) Isolate plasmids encoding multiple antibiotic resistance genes from swine manure, analyze the conjugative mobility, and detect plasmid-specific sequences in the soil following manure application using PCR method. (uregina.ca)
c) Characterize antibiotic resistance plasmids and bacterial communities isolated from a municipal wastewater treatment plant environment using comparative genomics approach and denaturing gradient gel electrophoresis (DGGE) microbial profiling method. (uregina.ca)
d) Analyze the functions of the plasmids replication, conjugative mobility and maintenance genes by in vitro techniques, detect and quantify the plasmid-associated resistance determinants in the environment upstream and downstream of the wastewater treatment plant (WWTP) using molecular methods. (uregina.ca)
I have also isolated and characterized five plasmids from swine manure and WWTP environments, these plasmids carry multiple resistance genes to clinically relevant antibiotics (macrolides, tetracyclines, beta-lactams, chloramphenicol, sulfonamides, aminoglycosides, trimethoprim), quaternary ammonium compounds and heavy metals (mercury, chromium and zinc). (uregina.ca)
AMR, through acquired genes located on transposons or conjugative plasmids, is the horizontal transmission of genes required for a given bacteria to withstand antibiotics. (mdpi.com)
Expression of ESBL is often associated with multidrug resistance and dissemination by resistance plasmids. (scielo.br)
Most of these plasmids were detected to carry both TEM- and SHV-derived genes by PCR, and confirmed by localizing each gene by hybridization assay. (scielo.br)
Plasmids confer genes encoding clinically relevant antibiotic resistance. (bham.ac.uk)
RNAsequencing showed both plasmids affected a different set of genes related to metabolism. (bham.ac.uk)
The understanding of the factor(s) contributing to the persistence and dissemination of successful plasmids may help to control antibiotic resistance. (bham.ac.uk)
The ESBLs are encoded by large plasmids that can confer the information between strains as well as different species of organisms. (vin.com)
The bla NDM-1 gene was encoded on plasmids that were easily transferable. (who.int)

A population-level investigation uncovers deep population differentiation for local adaptation, multiple target-site herbicide resistance mutations of barnyard grasses, and limited domestication of barnyard millets. (nature.com)
Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 2 , 3 ] Heterozygous loss-of-function mutations of the gene encoding FGFR1 have also been described in individuals with idiopathic hypogonadotropic hypogonadism, normal smell sense, and normal MRI of the olfactory system. (medscape.com)
Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
More than 80 mutations in the ALMS1 gene have been identified in people with Alström syndrome. (medlineplus.gov)
X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the gene coding for Bruton's tyrosine kinase (BTK) [Väliaho et al. (lu.se)
Mutations in the PIK3R1 gene encoding phosphatidylinositol 3-kinase (PI3-kinase) have been found to cause severe insulin resistance [Baynes et al. (lu.se)
1997]. Mutations in the STAT1 gene cause complete STAT1 deficiency. (lu.se)
Mutations of the DAX1 gene, which encodes a nuclear transcription factor, lead to X-linked idiopathic hypogonadotropic hypogonadism associated with adrenal hypoplasia congenita (AHC). (medscape.com)
[ 10 ] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)
[ 11 ] Several loss-of-function mutations of the GnRH receptor gene leading to GnRH resistance and autosomally transmitted hypogonadotropic hypogonadism have been described. (medscape.com)
[ 12 ] . In addition, autosomal recessive mutations of the GnRH gene may underlie hypogonadotropic hypogonadism. (medscape.com)
Rarely, hypogonadotropic hypogonadism occurs as a result of isolated follicle-stimulating hormone (FSH) deficiency due to homozygous mutations in the FSH beta subunit gene. (medscape.com)
Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells. (who.int)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

The continued emergence and spread of antibiotic resistance genes (ARGs) among different bacteria in clinical and non-clinical environments is cause for concern. (uregina.ca)
Zoonotic resistant bacteria and resistance genes could be transferred not only to people with occupational livestock exposure but also other persons in the community through direct contact with animals, via the food chain or by environment [ 9 , 10 ]. (hindawi.com)
Because of the continued nontherapeutic use of antimicrobial drugs as feed additives for food animals, releases from industrial food animal production operations contain antimicrobial drugs, antimicrobial-resistant bacteria, and genetic resistance determinants. (confex.com)
In terms of framing research and evaluating pathways of exposure and human health risks, we can consider these releases of antimicrobials, the drug-resistant bacteria, and genes for resistance collectively as pollutants. (confex.com)
At the molecular level, antimicrobial resistance is often transferred among bacteria in genetic exchange communities through plasmid-mediated cassettes of multiple resistance genes. (confex.com)
The ability of bacteria to quickly develop resistance to commonly used antibiotics is a huge hurdle in the path of disease treatment. (kenyon.edu)
Whether these phenotype and resistances that had no fitness cost to the bacterium could significantly affect the virulence of the bacteria in vivo remains to be investigated. (scirp.org)
Comammox bacteria obtain the genes encoding the AMO and HAO enzymes via a horizontal gene transfer from AOB. (databasefootball.com)

Using molecular PCR tools, I have also detected and quantified the plasmid sequences and resistance determinants in manure-amended soil and effluent influenced water ecosystems. (uregina.ca)
The data suggest that the mucoid phenotype could be associated with extrachromsomal element(s) carrying resistance genes to antibiotics and that these extrachromosomal elements may not harbour resistance determinants to chloramphenicol. (scirp.org)
lactamase encoding genes ( bla ) including bla NDM-1 and plasmid-mediated quinolone and aminoglycoside resistance determinants. (who.int)

However, the subsequent appearance of new, diverse virulent isolates means that most of these cloned Sr genes have been overcome by at least one Pgt race within and/or beyond the Ug99 lineage. (nature.com)
The presence of 16S rRNA, nuc , mec A, mec C, Panton-Valentine leukocidin (PVL), and the toxic shock syndrome toxin 1 (TSST-1) genes were detected by PCR analysis for all isolates. (hindawi.com)
ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
This study in a tertiary care hospital in Egypt used real-time PCR assay to test ertapenem-nonsusceptible isolates of K. pneumoniae for the presence of the blaKPC gene and compared the results with modified Hodge test. (who.int)
The blaKPC gene was confirmed in 14/20 (70.0%) of these isolates. (who.int)
The high prevalence of ertapenem nonsusceptibility at a tertiary care hospital in Egypt was predominantly attributed to K. pneumoniae carbapenemase-mediated resistance mechanisms in K. pneumoniae isolates. (who.int)
Exposure to antimicrobials may facilitate survival of isolates that have either spontaneously mutated or acquired resistance through other means. (vin.com)
Umar, U. , Anagor, S. , Aliyu, A. and Suleiman, A. (2016) Hypermucoviscosity in Clinical Isolates of Klebsiella pneumoniae Correlates with High Multiple Antibiotic Resistance (MAR) Index. (scirp.org)
We compared spa types, genetic markers (mecA, scn), and antibiotic resistance profiles of 10 S. aureus isolates recovered from a single nasal swab for each of 19 participants (190 isolates total) selected from a cohort of industrial hog operation workers and their household members. (cdc.gov)

To develop strategies for more effective, durable resistance, the molecular foundations of the plant-insect interactions need to be better understood. (usda.gov)
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
Molecular testing detects the resistance mechanism whereas phenotypic tests detect the in-vitro activity of carbapenemase enzyme. (clickpress.com)
Molecular analysis of anthocyanin biosynthesis-related genes reveal BoTT8 associated with purple hypocotyl of broccoli ( Brassica oleracea var. (bvsalud.org)

Enterococci have both an intrinsic and acquired resistance to antibiotics, making them important nosocomial pathogens. (medscape.com)
Because of this, there is an ever-present need to develop new antibiotics that are use novel mechanisms to overcome multidrug-resistance and prevent microbial growth. (kenyon.edu)
Microbial biofilms contribute to virulence and resistance to antibiotics by shielding microbial cells from host defenses and antimicrobial drugs, respectively. (who.int)
A few enterobacteriaceaea have gained resistance to these antibiotics. (clickpress.com)

This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. (nih.gov)
Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)
It also reviews the way drug resistance develops and spreads, methods used to assess the presence and level of drug resistance, and the extent to which chloroquine and sulfadoxine/pyrimethamine (SP)-the two most widely used antimalarial drugs in the world today-have now lost efficacy. (nationalacademies.org)
Escherichia coli rapidly develops resistance, particularly that associated with multiple drug resistance (MDR) when exposed to selected antimicrobials. (vin.com)
In an attempt to identify new breast cancer drug resistance associated antigens, MAb 5C3 was generated using paraffin wax embedded formalin fixed archival breast tumour tissue from a biopsy showing no P-170 or MRP-1 expression, as an immunogen. (dcu.ie)
The report also includes a summary on the status of drug resistance for TB, HIV and malaria. (who.int)

It is, for example, the same mechanism that causes the spread of antibiotic resistance. (databasefootball.com)

Twenty ESBL producing strains (15%) including Escherichia coli (n = 9), Klebsiella pneumoniae (n = 7), Klebsiella oxytoca (n = 2) and Enterobacter aerogenes (n = 2) were detected and further analyzed for their resistance transfer features, plasmid profile and nature of the resistance genes. (scielo.br)
Foram detectadas vinte cepas produtoras de ESBL, entre as quais Escherichia coli (n=9), Klebsiella pneumoniae (n=7), Klebsiella oxytoca (n=2) e Enterobacter aerogenes (n=2), que foram posteriormente analisadas quanto a suas características de transferência de resistência, perfil plasmidial e natureza dos genes de resistência. (scielo.br)
A pCb plasmid encoding a beta-lactamase from Haemophilus ducreyi was transferred to Escherichia coli, purified, and characterized. (lu.se)
To identify Escherichia coli genes potentially regulated by filamentous phage infection, we used oligonucleotide microarrays. (lu.se)

Preventive and containment measures should be implemented in order to limit the dissemination of resistance genes through the food chain and to reduce their increased rate. (hindawi.com)
In this example, mercury exposure can drive plasmid dissemination of antimicrobial resistance. (confex.com)

Disease Resistance Conferred by the Expression of a Gene Encoding a Sy" by Kanniah Rajasekaran, Jeffrey W. Cary et al. (kennesaw.edu)
A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance. (springer.com)
Myeloid malignancy patients lacking one copy of this gene showed levels of MYBL2 expression that were less than 50% of those in healthy individuals. (elifesciences.org)
This suggests that additional mechanisms must be acting to reduce expression of their remaining copy of the gene. (elifesciences.org)
Hence, this finding reveals a more general role for MYBL2 as it indicates that more patients are likely to be affected by altered expression of this gene. (elifesciences.org)
used gene silencing techniques to reduce the expression of MYBL2 in mice and showed that this induced symptoms of myeloid malignancies in the animals. (elifesciences.org)
. 2006 ). In order to enhance blight-tolerance in the American chestnut tree, we are studying several gene products, regulatory regions of genes to control expression (promoters), and the possibility of combining two or more genes (called stacking or pyramiding) for better and more sustainable resistance. (esf.edu)
Expression varies depending on the nature of the gene. (origene.com)
The exact significance of this expression and the contribution, if any, of MDR-3 Pgp in the resistance of breast cancer or other solid cancers further investigation. (dcu.ie)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)

Twenty genes form the basis of a bacterial CCM. (elifesciences.org)

The rtN236T mutation, a blunder protected through codon 236 in the change transcriptase place regarding HBV Genetic make-up, was used because style gene goal. (g418inhibitor.com)
The genetic alteration causative of SCAN-1 is a mutation altering the function of a gene called tdp1 (tyrosyl- DNA phosphodiesterase 1). (ataxia.org)
But in 2019, a woman was discovered who, as well as carrying the harmful mutation, also has two copies of a second rare variant, called Christchurch, of a different gene , which gave partial protection against what otherwise would have been her genetic fate of early-onset Alzheimer's. (newscientist.com)
Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alstrom syndrome. (medlineplus.gov)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
A second patient had a different homozygous mutation in the LH beta subunit gene that prevented LH heterodimerization and secretion. (medscape.com)

Several genes encoding putative Hessian fly effector family 31 members have been cloned previously. (usda.gov)

Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APT 3' II. (g418inhibitor.com)

Amino acid sequencing of some beta-lactamases has shown that substitution of only a few amino acids in the bla gene leads to high-level resistance against specific cephalosporins. (lu.se)

Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid. (pacb.com)

The gene, which leads to an inability to reduce minimum inhibitory concentration (MIC) of the active nitro- group in metronidazole the antimicrobials was also determined. (who.int)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)

More than half of the strains (54%) were resistant to penicillin, 29.4% to tetracycline, 23.5% to erythromycin, and 17% showed resistance to ciprofloxacin. (hindawi.com)
A British study on antimicrobial resistance (AMR) estimated that 700,000 persons are dying each year worldwide due to antibiotic-resistant infections [ 4 ]. (hindawi.com)
Several genes isolated from resistant enterococci ( agg, gelE, ace, cylLLS, esp, cpd, fsrB ) encode virulence factors such as the production of gelatinase and hemolysin, adherence to caco-2 and hep-2 cells, and capacity for biofilm formation. (medscape.com)
Penicillin-resistant Streptococcus pneumoniae , methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis , and vancomycin-resistant Enterococcus species are several examples of species that have developed an antibiotic resistance but are still affected by tigecycline (Greer 2006). (kenyon.edu)
We recently showed that some of these early lines feature enhanced blight resistance to levels intermediate between susceptible American chestnut and resistant Chinese chestnut (Newhouse et al. (esf.edu)
While genetically resistant varieties are becoming more accessible, populations of P. viticola are demonstrating rapid adaptability, successfully over-coming these resistances. (biorxiv.org)
Growing awareness about prevention of Carbapenem resistance and increased efforts by governments through the implementation of infection prevention and control measures might hinder the growth of the Carbapenem-resistant enterobacteriaceae testing market during the forecast period. (clickpress.com)
However, resistance zole-resistant strains of H. pylori . (who.int)
The patients were diag- resistance is believed to result from clonal nosed with ulcer (9), oesophagitis (18), Bar- selection of resistant variants rather than rett's oesophagus (15) and gastritis (28). (who.int)

The first gene being tested in transgenic American chestnut encodes an enzyme called oxalate oxidase . (esf.edu)
These early trees contain the wheat oxalate oxidase gene controlled by a vascular promoter, meaning the enzyme is predominantly present in the stem tissues where infections occur. (esf.edu)
Third, there is a very simple enzyme assay that can detect the presence of this gene in any chestnut tree, and thereby making blight tolerant trees easy to identify and follow in a restoration program. (esf.edu)
The product of this gene is an enzyme that plays a key role in DNA repair processes whose defective activity causes failure to reseal broken DNA strands causing neurodegeneration. (ataxia.org)
The gene encodes an enzyme involved in making amyloid and people with one copy of the risky variant were thought to inevitably develop Alzheimer's in their 40s. (newscientist.com)
It confirmed that the enzyme belonged to a class A beta-lactamase which had 99% identity to the ampicillin resistance transposon Tn3 of pBR322. (lu.se)

These genes encode molecules essential for insulin signaling in target tissues. (lu.se)

The gene was designated dacA by analogy with E. coli. (ox.ac.uk)
In human medicine, E. coli has developed resistance to the fluorinated quinolones, beta-lactams, or both: it is among the gram-negative organisms that secrete extended-spectrum beta-lactamases (ESBL). (vin.com)
Two nucleotides were different between the E. coli (Tn3) and H. ducreyi (pCb) genes that affected the amino-acid sequence. (lu.se)
The analysis revealed altered transcription levels of 12 E. coli genes in response to phage infection, and the observed regulation of phage genes correlated with the known in vivo pattern of M13 mRNA species. (lu.se)
No genes belonging to any known E. coli stress response pathways were scored as upregulated. (lu.se)

It was hypothesised that the AcrAB-TolC multidrug resistance efflux pump was required for clinically relevant levels of carbapenem resistance. (bham.ac.uk)

E2F site in the essential promoter region does not confer S phase-specific transcription of the ABCC10 gene in human prostate cancer cells. (nih.gov)

Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)
The two protective gene variants affect tau in different ways. (newscientist.com)
Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. (cancerindex.org)

The genomes encode low-specificity major facilitator superfamily transporters and high-affinity ABC transporters for sugars, suggesting that they are best suited to low-nutrient conditions. (nih.gov)
The genomes contained numerous genes that encode siderophore receptors, but no evidence of siderophore production was found, suggesting that they may obtain iron via interaction with other microorganisms. (nih.gov)

This study aimed to assess the nasopharyngeal carriage of S. aureus in poultry and to investigate antimicrobial susceptibility and virulence-associated genes. (hindawi.com)

Some of the genes involved in the pathogenesis of Kallmann syndrome and idiopathic hypogonadotropic hypogonadism have been identified. (medscape.com)

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)

The combined effects of overeating and insulin resistance impair the body's ability to handle excess glucose, leading to diabetes and obesity (two common features of Alström syndrome). (medlineplus.gov)
Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. (medlineplus.gov)

Here, we isolate from wheat, Sr26 and Sr61 , with both genes independently introduced as alien chromosome introgressions from tall wheat grass ( Thinopyrum ponticum ). (nature.com)
derived Sr gene, Sr61 (previously designated SrB ), was identified in South African wheat accession W3757, which carries a 6Ae#3 (6D) chromosome substitution 16 . (nature.com)
Resistance in W3757 was located on chromosome 6Ae#3, making it possible that Sr26 and Sr61 are alleles or related paralogues 18 . (nature.com)
A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. (elifesciences.org)
Many individuals affected by these disorders possess a shortened form of chromosome 20 that lacks a number of genes. (elifesciences.org)
This deletion is only ever seen in one of their two copies of the chromosome-suggesting that at least some of these genes are essential for survival-but the identity of the gene(s) that are associated with the increased risk of myeloid malignancies is unknown. (elifesciences.org)
have uncovered a key tumor suppressor among those genes frequently lost on chromosome 20. (elifesciences.org)

The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)

Furthermore, the extrachromosomal elements bearing the mucoid phenotype and the resistance elements in the mucoid strains do not significantly impact on the fitness of the cognate strain. (scirp.org)

These results suggest that surveillance studies that rely on testing one S. aureus isolate are likely to identify predominant spa types but may not fully capture more variable characteristics of S. aureus, including antibiotic resistance. (cdc.gov)

Lum 1 is characterized by the presence of mecA gene, which codes for resistance to methicillin, and a spa type t128 found in the CA-MRSA strain lineage CMRSA 7/US400. (uregina.ca)
Less similarity was observed for genes encoded on mobile genetic elements (mecA, scn) and antibiotic resistance profiles. (cdc.gov)

Although extensive data has described the key role of salicylic acid (SA) in signaling pathogen-induced disease resistance, its function in physiological processes related to cell death is still poorly understood. (springer.com)
We also confirm the role of ethylene in resistance to NCLB and contribute to the growing body of literature on ethylene and disease resistance in monocots. (frontiersin.org)

Moreover, these releases have cumulative impacts through expanding the microbial resistome, which is defined as the collective resources of resistance genes available to microbes in a community (microbiome) linked by efficient mechanisms of horizontal gene transfer. (confex.com)
Horizontal gene transfer (HGT) is the transfer of genes between unicellular organisms without reproduction. (databasefootball.com)

Since genetic dissection of genes within alien segments in wheat was not possible due to lack of recombination, the question arose as to whether the apparent durability of such resistances might be due to multiple genes rather than a single gene. (nature.com)
While the genetic architecture of NCLB has been well characterized, the pathogen is known to overcome currently deployed resistance genes, and the role of hormones in resistance to NCLB is an area of active research. (frontiersin.org)
The first description of candidate effectors of P. viticola involved in the interaction with resistance gene provides valuable insights into the genetic mechanisms that enable P. viticola to adapt to grapevine resistance, laying a foundation for developing strategies to manage this damaging crop pathogen. (biorxiv.org)

The objectives of the study were (i) to identify significant markers associated with resistance to NCLB, (ii) to identify metabolic pathways associated with NCLB resistance, and (iii) to examine role of ethylene in resistance to NCLB. (frontiersin.org)
We conducted a greenhouse assay in which we inhibited ethylene to examine the role of ethylene in resistance to NCLB. (frontiersin.org)
Abscisic acid and ethylene biosynthesis-related genes are associated with anthocyanin accumulation in purple ornamental cabbage ( Brassica oleracea var. (bvsalud.org)

The ability of organisms to develop resistance to an antimicrobial varies with the species and strain. (vin.com)

This is important because it removes the selective pressure on the fungus to overcome this tolerance-enhancing gene. (esf.edu)

Cell-autonomous recognition of the rust pathogen determines Rpl-specified resistance in maize. (springer.com)
We screened 252 lines from the exotic-derived double haploid BGEM maize population for resistance to NCLB in both field and greenhouse environments. (frontiersin.org)
Both qualitative resistance, conferred by a single gene, and quantitative resistance, conferred by multiple genes, have been characterized in maize. (frontiersin.org)

These gram-negative pathogens can be mediated and treated by transferable carbapenemase-encoding genes. (clickpress.com)

These downregulated genes are normally part of the host stress response mechanisms that protect the bacterium during conditions of acid stress and stationary phase transition. (lu.se)

Emergence of extended-spectrum beta-lactamases (ESBL) is an example of the relentless adaptive nature of microbes toward designer drugs intended to preclude the advent of resistance. (vin.com)

Grass species related to wheat carry sources of resistance that can be transferred to wheat. (nature.com)
This particular gene comes from wheat, and it is also found in many grass species. (esf.edu)

The co-location of these genes on a small non-recombinogenic segment simplifies their deployment as a gene stack and potentially enhances their resistance durability. (nature.com)
Resistance may be easily conferred to other potentially more virulent organisms. (vin.com)

resistance associated with clinical treatment failure has been reported previously in only one person, who probably acquired the infection in the Philippines (3-5). (cdc.gov)

The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
Both glutathione S-transferase pi ( GSTpi ) (80%, 24/30 in tumor and 56.7%, 17/30 in the paired non-cancerous tissues) and cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) ( CFTR ) (77%, 23/30 in tumor and 50%, 15/30 in the paired non-cancerous tissues) genes were prevalently hypermethylated in HCC as well as their neighboring non-cancerous tissues. (wjgnet.com)

The region that contains Hdic will be compared between wild-type WGRC42 and its gene-edited, susceptible mutants. (usda.gov)

The oxalate oxidase gene is also being tested by several other researchers to enhance pathogen tolerance in plant systems such as peanut , soybean , sunflower , and oilseed rape and also to possibly increase salt tolerance in tomato . (esf.edu)

Consequently, there is an ongoing need to expand resistance resources and to enhance gene stewardship through co-deployment of multiple resitance (R) genes, rather than single genes, to increase resistance durability. (nature.com)
The Multiple Antibiotic Resistance (MAR) index shows the themucoid strains with a high MAR index range of 0.7 - 1.0 with a median MAR index of 0.8, while the non-mucoid strains had a MAR index of 0.2 - 0.8 with a median MAR index of 0.35. (scirp.org)

More disconcerting, resistance is easily conferred to more pathogenic organisms. (vin.com)
The acquisition of vancomycin resistance by enterococci has seriously affected the treatment and infection control of these organisms. (medscape.com)

Anatomy7

Organisms54

Diseases11

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes84

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture10

Information Science4

Health Care5

Protein22

Proteins7

Plasmids12

Mutations16

Bacteria8

Determinants3

Isolates9

Molecular4

Antibiotics4

Drug-resistance7

Spread of antibiotic resistance1

Escherichia4

Dissemination2

Expression11

Bacterial1

Mutation6

Putative1

Aminoglycoside1

Amino acids1

Conjugative1

Antimicrobials1

Sequences1

Resistant9

Enzyme6

Molecules1

Coli5

Clinically relevant1

Confer1

Variants3

Genomes2

Virulence1

Idiopathic hypogonadotropic hypogonadism1

Superfamily1

Insulin resistance2

Chromosome7

Transcription factor1

Phenotype1

Isolate1

MecA2

Disease resistance2

Horizontal2

Genetic3

Ethylene3

Strain1

Overcome1

Maize3

Transferable1

Mechanisms1

Microbes1

Species2

Potentially2

Clinical1

Tissues2

Susceptible1

Pathogen1

Multiple2

Organisms2