• But as countries roll-out the latest 2017 World Health Organization (WHO) treatment guidelines that call for all people living with HIV to be on treatment 1 HIV drug resistance (HIVDR) has the potential to become a significant barrier to reaching the UNAIDS Fast-Track goal of ending AIDS by 2030. (avert.org)
  • The AR Investment Map showcases CDC's critical activities in the United States and abroad to combat antibiotic resistance with investments in laboratory and epidemiological expertise and public health innovation. (cdc.gov)
  • While containment efforts to stop the spread of resistant parasites were underway, it was discovered that artemisinin resistance had emerged independently in multiple areas and that resistance to ACT partner drugs had also emerged, threatening the progress achieved in the region to date. (who.int)
  • Eliminating malaria requires beating artemisinin resistance. (slate.com)
  • Aung Pyae Phyo estimates that 85 percent of the malaria cases he sees at Wang Pha now show some level of artemisinin resistance, meaning treatment takes longer and longer and is gradually becoming less effective. (slate.com)
  • Researchers will now go on to look more closely at the genetic variations they identified to see which ones contribute towards artemisinin resistance. (www.nhs.uk)
  • Other diseases including tuberculosis (TB), gonorrhea, malaria, and childhood ear infections are increasingly more difficult to treat due to the emergence of resistance. (nih.gov)
  • Further extending basic malaria interventions, including vector control, will reduce the number of parasites exposed to a drug and the risk of resistance. (who.int)
  • Countries where resistance to artemisinins or to ACT partner drugs is reported need to intensify malaria control in order to reduce the burden of the disease, and delay or prevent the spread of resistance. (who.int)
  • In areas of low transmission where antimalarial drug resistance is present, countries should target rapid elimination of falciparum malaria to limit the risk of spread and minimize the impact of resistance in the region. (who.int)
  • The spread of resistance to India and beyond is probably inevitable if malaria isn't wiped out soon. (slate.com)
  • For reasons researchers still don't have a satisfying explanation for, resistance to anti-malaria drugs has repeatedly emerged first in western Cambodia before spreading elsewhere. (slate.com)
  • Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. (jci.org)
  • Drug resistance has been implicated in the regularly, as well as in areas where transmission has spread of malaria to new areas and re-emergence of been largely controlled or eliminated. (who.int)
  • Population movement has as the species of malaria parasites that occur in a introduced resistant parasites to areas previously free given area, their susceptibility to commonly used of drug resistance. (who.int)
  • Our armoury of malarial drugs is limited, so further resistance could lead to a world where malaria is practically incurable. (www.nhs.uk)
  • Three genetically different subpopulations showed resistance to artemisinin drugs, the medication that is the basis of current treatments for P. falciparum malaria. (www.nhs.uk)
  • Some strains of the P. falciparum parasite have evolved resistance to antimalarial drugs such as artemisinin, one of the main drugs used to treat this type of malaria. (www.nhs.uk)
  • A new technique pioneered at Liverpool School of Tropical Medicine (LSTM) is improving the detection and monitoring of insecticide resistance in field populations of an important malaria-carrying mosquito. (redorbit.com)
  • This will enable researchers to map the distribution of this resistance and allow the Ministry of Health to modify its vector control program, thereby increasing its effectiveness and helping to reduce the transmission of malaria. (redorbit.com)
  • They discovered what they describe as a "striking" difference in resistance to a representative antibiotic-rifampicin-in strains with and without Mfd. (phys.org)
  • Then, they combined this information with the resistance, cross-resistance, and cross-susceptibility data from some strains to make a simple linear model that did a very good job predicting the resistance and susceptibility patterns of the remaining strains. (eurekalert.org)
  • The researchers hope that these findings and subsequent research will help us better understand how resistance to antimalarial drugs develops, with the ultimate aim of being able to eliminate the resistant strains of the parasite. (www.nhs.uk)
  • Her research is focussed on the bacterial ecology in human-impacted environments, with particular emphasis on the spread of antibiotic resistance over the urban water cycle and water-soil interface. (rsc.org)
  • While FDA's limited sample size makes it impossible to estimate national resistance rates with statistical confidence, it does provide evidence that Sanderson Farms chicken is indeed part of the problem and is contributing to the spread of antibiotic resistance (in addition to spreading E. coli , which can be harmful). (nrdc.org)
  • The World Health Organization (WHO) call antibiotic resistance "one of the biggest threats to global health, food security, and development today. (medicalnewstoday.com)
  • Global prevalence of HIV drug resistance (HIVDR) is rising, mainly due to resistance to non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs - which make up the backbone of World Health Organization (WHO) first-line antiretroviral treatment regimes. (avert.org)
  • What dose of medication is best to prevent the evolution of drug resistance? (psu.edu)
  • A new model shows that the standard practice of treating infections with the highest tolerable dose of anti-microbial medications may not be best for preventing the evolution of drug resistance in all cases. (psu.edu)
  • There is nothing in evolutionary theory that says that the dogma of hitting infections hard with high doses of medication should be the best rule of thumb to prevent drug resistance," said Andrew Read, Evan Pugh Professor of Biology and Entomology and Eberly Professor in Biotechnology at Penn State University. (psu.edu)
  • Read, and colleague Troy Day, professor of mathematics, statistics, and biology at Queen's University in Ontario, Canada, developed a very general mathematical model that quantifies the two main evolutionary forces at work in the evolution of drug resistance in disease-causing microbes. (psu.edu)
  • Killing all of the infecting microbes obviously stops any further evolution of drug resistance, but we can't do this in every case. (psu.edu)
  • If a small number of microbes are already resistant to treatment, or if drug resistance arises by chance, high doses of medication may allow resistant microbes to survive and spread by the very act of killing off drug-sensitive microbes. (psu.edu)
  • Day and Read showed that the optimal approach to combatting the evolution of drug resistance will be either to use the highest dose that is safe or to use the lowest dose that is effective. (psu.edu)
  • Research findings of NIH and NIH-supported scientists are yielding insights into how TB develops resistance to specific drugs and whether specific factors predispose some patients to develop multiple drug resistance. (nih.gov)
  • it's an epigenetic mode of drug resistance. (vanderbilt.edu)
  • Coffey and his colleagues are using the 3-D culture system to explore mechanisms of drug resistance in other colon cancer cell lines. (vanderbilt.edu)
  • Because the drug is so specific, any mutation in these molecules will interfere with or negate its destructive effect, resulting in antibiotic resistance. (wikipedia.org)
  • Without alternative strategies, the acquisition of drug resistance by pathogenic microorganisms looms as possibly one of the most significant public health threats facing humanity in the 21st century. (wikipedia.org)
  • Drug, toxin, or chemical resistance is a consequence of evolution and is a response to pressures imposed on any living organism. (wikipedia.org)
  • Unless the drug used makes sexual reproduction or cell-division or horizontal gene transfer impossible in the entire target population, resistance to the drug will inevitably follow. (wikipedia.org)
  • Drug resistance develops naturally, but careless practices in drug supply and use are hastening it unnecessarily. (wikipedia.org)
  • Clopidogrel resistance is a condition in which the drug clopidogrel is less effective than normal in people who are treated with it. (medlineplus.gov)
  • Clopidogrel resistance does not appear to cause any health problems other than those associated with clopidogrel drug treatment. (medlineplus.gov)
  • Some people with clopidogrel resistance have a reduced ability to convert the drug to its active form because of a polymorphism in one copy of the CYP2C19 gene that results in decreased enzyme activity. (medlineplus.gov)
  • Other individuals with clopidogrel resistance convert very little or none of the drug to its active form because of polymorphisms in both copies of the CYP2C19 gene, which results in a lack of enzyme activity. (medlineplus.gov)
  • The Greater Mekong Subregion has long been the epicentre of antimalarial drug resistance. (who.int)
  • The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. (liebertpub.com)
  • Microbial Drug Resistance is under the editorial leadership of Editor Alexander Tomasz, PhD , The Rockefeller University, Laboratory of Microbiology, and other leading investigators. (liebertpub.com)
  • Hypoxia and drug resistance. (nih.gov)
  • Hypoxia can result in drug resistance indirectly if under this condition cells more effectively detoxify the drug molecules. (nih.gov)
  • Finally, the use of hypoxic cell selective cytotoxic agents as a means of addressing hypoxic 'drug resistance' is discussed. (nih.gov)
  • As the man who discovered the first antibiotic almost 70 years ago predicted, drug resistance is starting to become commonplace. (medicalnewstoday.com)
  • In each case, resistance to the drug has spread worldwide, most disastrously to Africa. (slate.com)
  • Drug resistance has also played a significant and clinical manifestation in different parts of the role in the occurrence and severity of epidemics in world. (who.int)
  • When the drug is used on mixed populations of the parasite, some of which have resistance, the resistant parasites are more likely to survive than the non-resistant parasites. (www.nhs.uk)
  • The researchers report that successive waves of this drug resistance originated in western Cambodia. (www.nhs.uk)
  • The researchers also looked at resistance of these parasite samples to the drug artemisinin. (www.nhs.uk)
  • Is Drug Resistance in Humans Coming From Chickens? (wired.com)
  • The Netherlands has one of the lowest rates of human antibiotic resistance in the world, thanks to especially stringent infection control and drug-conservation policies. (wired.com)
  • As a result, when something starts to move into humans, it is easier to distinguish, because there is no 'background noise' of high rates of hospital and community drug resistance such as there are in the US. (wired.com)
  • Since 1928, there have been more than 100 compounds unearthed, but no new class had been discovered since 1987, until earlier this month when prototype antibiotic Teixobactin was hailed as a major breakthrough in the fight against an ever-increasing drug-resistance . (prweb.com)
  • The researchers noted, "Generating hypermutation may offer an adaptive strategy to evolve high-level antibiotic resistance, and Mfd might promote this phenomenon. (phys.org)
  • The finding that Mfd is critical to the development of antibiotic resistance in mycobacterium TB could have potential clinical implications, the researchers noted. (phys.org)
  • The researchers also examined tumor samples from patients with colorectal cancer who received cetuximab therapy and developed resistance to it. (vanderbilt.edu)
  • In Antiviral Resistance in Plants: Methods and Protocols , expert researchers in the field detail many of the methods which are now commonly used to study the phenomenon of RNA silencing in relation to viral infections of plants. (springer.com)
  • Researchers analyzed data from 16 previously published studies with a total of 922 participants who were randomly assigned to do resistance training or be inactive. (reuters.com)
  • The researchers reasoned that similar alterations in gene expression might be one cause of cross-resistance. (eurekalert.org)
  • Researchers don't fully understand what causes insulin resistance and prediabetes, but they think excess weight and lack of physical activity are major factors. (nih.gov)
  • Researchers at LSTM, led by Dr Charles Wondji have developed a new technique which encourages the female Anopheles funestus mosquitoes to lay eggs which are then reared into adult mosquitoes to provide sufficient numbers to determine levels of insecticide resistance and to characterize the underlying mechanisms. (redorbit.com)
  • those who inherit a mutated gene from just one parent will end up with greater resistance against HIV than other people, but they won't be immune. (wired.com)
  • Besides the Northern Europeans and Central Asians with the CCR5 receptor gene mutation, new research shows that members of several ethnic groups have another, less-powerful kind of AIDS resistance. (wired.com)
  • In the Science study released this week, a large team of investigators report that people who have more copies of a specific gene end up with greater resistance to AIDS, in some cases significantly changing how they handle getting infected. (wired.com)
  • The CYP2C19 gene is particularly important for the activation of clopidogrel, and certain common variations (polymorphisms) in this gene have been associated with clopidogrel resistance. (medlineplus.gov)
  • The two most common CYP2C19 gene polymorphisms associated with clopidogrel resistance (known as CYP2C19*2 and CYP2C19*3 ) result in the production of a nonfunctional CYP2C19 enzyme that cannot convert clopidogrel to its active form. (medlineplus.gov)
  • Studies related to pathogen-mediated virus resistance in plants were instrumental in providing some of the historical observations which ultimately led to the vital discovery of double-stranded RNA (dsRNA)-induced gene silencing or RNA interference (RNAi), which has since revolutionized research on plant-virus interactions. (springer.com)
  • Plant Scientist Tom Clemente, head of the university's Plant Transformation Core Facility, helped the team insert this gene into a plant's chromosomes, successfully transferring dicamba resistance to the plant. (newswise.com)
  • But the potential impact of increasing antimalarial resistance could be devastating. (www.nhs.uk)
  • Recently, several cases overseas and in the United States were reported of S. aureus developing resistance to vancomycin, a very powerful antibiotic prescribed for the most intractable bacterial infections. (nih.gov)
  • Regions for which there is evidence of resistance should consider adding more sentinel sites to facilitate early detection of new resistance foci. (who.int)
  • In short, the lack of concerted effort by governments and the pharmaceutical industry, together with the innate capacity of microbes to develop resistance at a rate that outpaces development of new drugs, suggests that existing strategies for developing viable, long-term anti-microbial therapies are ultimately doomed to failure. (wikipedia.org)
  • What we found is that there is another form of resistance. (vanderbilt.edu)
  • One form of resistance exercise that has drawn attention is superslow resistance training. (unm.edu)
  • Genetically engineered cotton and corn produce a toxin that kills caterpillar larvae and other pests, but a new study shows that resistance to this toxin could be spreading among one species of caterpillar. (sciencenews.org)
  • Antibiotic resistance (AR), when germs do not respond to the drugs designed to kill them, threatens to return us to the time when simple infections were often fatal. (cdc.gov)
  • Superslow training, originated in 1982 by Ken Hutchins, was developed in an osteoporosis study with older women because of the need to utilize a safer speed for subjects to perform the resistance exercises. (unm.edu)
  • A well-rounded and well-balanced athlete will incorporate resistance exercises, aerobic conditioning, and flexibility exercises into an overall training program. (encyclopedia.com)
  • Any resistance exercise training program must be accompanied by a comprehensive stretching and flexibility routine, both as a part of the warm up/cool down aspect to a particular workout, as well as those stretching exercises conducted on a daily basis. (encyclopedia.com)
  • Resistance training, especially those exercises involving free weights, will emphasize a complete range of motion to obtain the maximum resistance benefit. (encyclopedia.com)
  • Like any form of training, resistance exercises develop greater muscular strength, endurance, and power by virtue of their progressive nature. (encyclopedia.com)
  • In the current analysis, people did resistance exercises on two to five days per week for an average of 11 weeks. (reuters.com)
  • Adequate calcium and vitamin D consumption paired with sufficient physical activity, specifically resistance training and weight-bearing exercises, can help prevent osteoporosis, reduce severity of the disease or stop its progression. (eatright.org)
  • Aside from medication, changing certain lifestyle factors can improve insulin resistance. (news-medical.net)
  • RET (resistance exercise training) significantly reduced anxiety in both healthy participants and those with a physical or mental illness, and the effect size of these reductions is comparable to that of frontline treatments such as medication and psychotherapy," Gordon said by email. (reuters.com)
  • The Institute's Prof. Yosef Yarden's recent research provides a vital piece for the puzzle of resistance - how cancer cells, especially those in recurring cancers, stop responding to chemotherapy. (scienceblogs.com)
  • In other words, this mechanism of chemotherapy resistance is likely to be present in many cancers, suggesting that more than a few more pieces of the puzzle might now be within reach. (scienceblogs.com)
  • Therefore, we suppose that the lemon detox program reduces body fat and insulin resistance through caloric restriction and might have a potential beneficial effect on risk factors for cardiovascular disease related to circulating hs-CRP reduction without hematological changes. (nih.gov)
  • Resistance workouts were associated with a reduction in anxiety symptoms regardless of whether or not participants had a mental health disorder, though the effect was more pronounced in healthy people who didn't report any physical or psychological problems. (reuters.com)
  • The Program will conduct research that will deliver key evidence that is required to enhance the success of antibiotic resistance reduction strategies in China. (bath.ac.uk)
  • This protein factor, DNA translocase Mfd, seems to speed resistance in diverse species toward every antibiotic that was tested. (phys.org)
  • We are interested in one such protein family known as the Resistance-Nodulation-cell Division (RND) family. (google.com)
  • Resistance training at least twice a week and consuming an adequate amount of high-quality sources of protein may help to slow or partially reverse the effects of natural, gradual sarcopenia. (eatright.org)
  • Takiar, also a member of the UC Cancer Institute, says the study will use Reverse Phase Protein Arrays (RPPA), a protein microarray tool, to strategically identify and compare treatment combinations that could target various molecular pathways and combat therapy resistance. (uc.edu)