Residual patients antigen of tumor. Medical search. Frequent questions

Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
Patients with metastatic neuroblastoma have a poor survival rate, which has led to numerous efforts to develop prognostic markers. (nih.gov)
Despite high response rates to first-line systemic treatment, all patients with initially advanced or secondary metastatic disease relapse, develop platinum resistance, and eventually die from the disease [ 4 ]. (biomedcentral.com)
In clinical studies of patients with prostate cancer, Indium In 111 ProstaScint ® (capromab pendetide) localized to the prostate, and some known primary and metastatic tumor sites. (nih.gov)
Antigen-specific memory T cells (Tms) are essential in the immune surveillance of residual and metastatic tumors. (johnshopkins.edu)
Researchers have found the technique useful in patients with both metastatic and primary brain tumor who have been treated with chemotherapy and whose MRI scans show an increase in the residual abnormality (like necrotizing leukoencephalopathy). (cancer.org)
During the discussion, Kim and Bustamante examined the use of ctDNA for MRD detection in the context of the PREDATOR trial, which featured patients with metastatic CRC who underwent metastatic resection with curative intent. (cancernetwork.com)
A total of 112 patients with metastatic CRC who underwent metastatic resection were enrolled, with ctDNA drawn after surgery and at the time of radiologic evidence of progressive disease or last follow-up. (cancernetwork.com)
T lymphocytes and HLA expression on tumor cell both influence prognostic of localized colorectal cancer, but their role following chemotherapy in patients with liver metastatic colorectal cancer (mCRC) was not addressed. (biomedcentral.com)
Pharmacy SIG Literature Update: tumor-infiltrating lymphocytes for metastatic melanoma, post-transplant cyclophosphamide in pediatric allogeneic HCT, auto vs. allo first-line therapy in poor-risk T-NHL, and more! (astct.org)

Using EL4 cell-derived transfectants with differential expression levels of exogenous human CC chemokine receptor 4 or human CD20 as target cells, ADCC of fucose variants of chimeric IgG1 antibodies specific for these antigens were measured. (aacrjournals.org)
Chimeric antigen receptor (CAR) T cell therapy, Oncolytic viruses, Immune-checkpoint inhibitors, and Dendritic cells (DC) vaccination were the most encouraging areas in glioma therapy [ 2 , 3 ]. (aging-us.com)
To test the safety of giving T cells expressing a novel fully-human anti-cluster of differentiation 19 (CD19) chimeric antigen receptor (CAR) to people with advanced B-cell cancer. (nih.gov)
Donor-derived CD7-directed chimeric antigen receptor (CAR) T cells showed feasibility and early efficacy in patients with refractory or relapsed T-cell acute lymphoblastic leukemia (r/r T-ALL), in a previous phase I trial report, at a median follow-up of 6.3 months. (biomedcentral.com)
Following the development of a line of chimeric antigen receptor (CAR) T-cell therapies for B cell leukemias, there is growing interest in developing novel cell-based therapies for T-ALL [ 12 ]. (biomedcentral.com)
Alpha-beta T cell-based chimeric antigen receptor, or CAR-T therapies have shown remarkable results against some leukemias and myelomas. (atlasstory.com)
In addition to the studies below, forthcoming press releases will feature groundbreaking clinical studies on chimeric antigen receptor (CAR) T cell therapies for patients with lymphoma (Abstracts 2 , 93 , 739 ) and targeted therapies for patients with acute myeloid leukemia (Abstracts 371 , 691 , 794 ). (eurekalert.org)
The gene is called a chimeric antigen receptor, or CAR. (stbaldricks.org)
Prior treatment with chimeric antigen receptor (CAR) T-cell therapy. (moffitt.org)

1. [Minimal residual disease detection in acute leukemia patients by flow cytometric assay of cross-lineage antigen expression]. (nih.gov)
2. Flow cytometric follow-up of minimal residual disease in bone marrow gives prognostic information in children with acute lymphoblastic leukemia. (nih.gov)
3. [The clinical significance of detecting minimal residual disease in acute childhood B-cell lymphoblastic leukemia with flow cytometry]. (nih.gov)
4. High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study. (nih.gov)
5. [Prognosticating relapse risk based on multiparameter flow cytometric assessment of minimal residual disease in patients with acute myeloid leukemia]. (nih.gov)
7. Measurement of minimal residual disease before and after myeloablative hematopoietic cell transplantation for acute leukemia. (nih.gov)
8. The use of receiver operating characteristic analysis for detection of minimal residual disease using five-color multiparameter flow cytometry in acute myeloid leukemia identifies patients with high risk of relapse. (nih.gov)
9. [Dynamically monitoring minimal residual disease in acute leukemia after complete remission by multiparameter flow cytometry and its relation with prognosis]. (nih.gov)
10. [Detection of minimal residual disease in B lineage acute lymphoblastic leukemia by 4-color flow cytometry]. (nih.gov)
11. Prognostic impact of minimal residual disease analysis by flow cytometry in patients with acute myeloid leukemia before and after allogeneic hemopoietic stem cell transplantation. (nih.gov)
14. [Minimal residual disease analysis in acute lymphoblastic leukemia of childhood within the framework of COALL Study: results of an induction therapy without asparaginase]. (nih.gov)
15. Predictive factors of relapse and survival in childhood acute myeloid leukemia: role of minimal residual disease. (nih.gov)
16. [Clinical significance and prognostic detection of minimal residual disease in acute leukemias]. (nih.gov)
17. [Prognostic significance of minimal residual disease detected by multiparameter flow cytometry in acute myeloid leukemia]. (nih.gov)
Cancer/testis-specific antigens MAGE-A1 and MAGE-A3 genes were proposed as minimal residual disease (MRD) markers in neuroblastoma, but its usefulness for this purpose is rather limited. (nih.gov)
Circulating tumor DNA (ctDNA) detection following curative-intent surgery could directly reflect the presence of minimal residual disease, the ultimate cause of clinical recurrence. (biomedcentral.com)
Circulating tumor DNA (ctDNA) analysis, also known as "liquid biopsy," is an emerging and promising alternative strategy to directly evaluate the existence of minimal residual disease (MRD), the primary source of cancer recurrence. (biomedcentral.com)
These results are in line with another study from the Fred Hutchinson Cancer Research Center that demonstrated that, among AML patients in CR but with minimal residual disease at transplantation, those receiving CBT had at least as good overall survival (OS) than those given grafts from UD10/10, and better OS than those receiving grafts from HLA-mismatched UD 10 . (nature.com)
We hypothesized that, since CBT provides better outcome than UD in AML patients with minimal residual disease at transplantation, transplantation outcomes might be better with CBT than with UD in AML patients with active disease at transplantation. (nature.com)
Similarly, the efficacy of postoperative systemic treatment is currently limited for patients with stage IV CRC, and patients may benefit greatly from a reliable biomarker to identify minimal residual disease (MRD). (cancernetwork.com)
Of those patients, 70% had no evidence of minimal residual disease. (eurekalert.org)

Targeted T-cell therapy consisting of vaccination or the adoptive transfer of T-cells against defined tumor-associated antigens (TAA) is a reasonable extension of established treatment strategies. (biomedcentral.com)

Included were 34 patients at least 60 years of age, 32 patients at high risk of lymphoma relapse after disease recurrence following prior autologous transplantation, and 51 patients at high risk of developing GVHD due to lack of a fully human leukocyte antigen (HLA)-matched related donor. (stanfordhealthcare.org)

Serum prostate-specific antigen (PSA) and a rectal examination may suggest whether or not radiotherapy has eradicated the entire prostate tumor. (medscape.com)
With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Patients are regarded at high risk if the prostate cancer is locally advanced or the Gleason score is 8 to 10 or a serum prostate-specific antigen is greater than 20 ng/mL [ 3 ]. (hindawi.com)
In 1997, at age 63, following a suspicious digital rectal exam of the prostate gland, the concentration of prostate-specific antigen in blood was measured for the first time. (hindawi.com)

The quantitative analysis revealed that fucose depletion could reduce the antigen amount on target cells required for constant degrees of ADCC induction by 10-fold for CC chemokine receptor 4 and 3-fold for CD20. (aacrjournals.org)
WALTHAM, Mass., July 11, 2022 (GLOBE NEWSWIRE) -- TScan Therapeutics, Inc. (Nasdaq: TCRX), a clinical-stage biopharmaceutical company focused on the development of T cell receptor (TCR) engineered T cell therapies (TCR-T) for the treatment of patients with cancer, today announced the publication of a peer-reviewed article titled, " Tissue-resident Memory and Circulating T cells are Early Responders to Pre-surgical Cancer Immunotherapy " in the journal Cell . (tscan.com)
TScan is a clinical-stage biopharmaceutical company focused on the development of T cell receptor (TCR) engineered T cell therapies (TCR-T) for the treatment of patients with cancer. (tscan.com)

Other sites are focusing on advancing PET's applications in brain tumor, which was the first clinical indication for fluorodeoxyglucose (FDG) in tumor imaging. (cancer.org)
This trial has recently initiated enrollment at leading brain tumor centers across the United States following clearance of a company-sponsored investigational new drug application, or IND, by the U.S. Food and Drug Administration, or FDA. (atlasstory.com)
Dr. Cooper's research interests involve brain tumor stem cells and the development of new antibodies to recognize glioma cells. (vumc.org)
The Cooper laboratory studies brain tumor cellular heterogeneity with respect to molecular pathways that drive glioma cell growth and adaptive responses to therapeutic modalities. (vumc.org)

The data highlight the ability of TScan's unbiased, genome-wide screening technology to identify novel target antigens and highly active TCRs for adoptive T cell cancer therapies, including the TCR that has now become the Company's therapeutic candidate TSC-204-C07 for MAGE-A1. (tscan.com)
Although reconstitution with allogeneic stem cells can provide effective antitumor immunity, the mechanisms whereby donor T cells exert this activity are unknown and the target antigens of this response have not been well defined. (niepokorny.org)

Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
PET has been approved by the FDA for characterization of solitary pulmonary nodules, lung cancer staging, evaluation of colorectal cancer in patients with rising levels of cardioembryonic antigen, and imaging of patients who have lymphoma and melanoma. (cancer.org)
However, ctDNA is not postoperatively detected in ≥ 50% of patients with stage I-III colorectal cancer (CRC) who ultimately recur. (biomedcentral.com)
Richard Kim, MD, and Lilliana Bustamante, MD, discuss the potnetial for using ctDNA to treat patients with oligometastatic colorectal cancer. (cancernetwork.com)
With approximately 50% of patients with oligometastatic colorectal cancer (CRC) relapsing following surgical resection, effective prognostic biomarkers that can identify residual disease are needed in this patient population. (cancernetwork.com)
Characteristics and Natural History of Patients with Colorectal Cancer Complicated by Infectious Endocarditis. (iiarjournals.org)
Patients and Methods: Two groups of five patients with colorectal cancer and either active endocarditis (CRC E+), or without endocarditis (CRC, n=20) were matched 1:4 for age, sex, and location of colorectal tumor. (iiarjournals.org)
In Europe, the 5-year survival rate of patients with colorectal cancer ranges from 50.5% to 58.8% ( 1 ). (iiarjournals.org)
In this case-control analysis, we compared oncological characteristics and survival rates of a group of patients with colorectal cancer associated with Streptococcus gallolyticus endocarditis to those of a group of patients with colorectal cancer alone. (iiarjournals.org)

However, a consistent increase in tumor marker levels, coupled with lack of clinical improvement, may indicate treatment failure. (aafp.org)
GSCA has four main functional modules for cancer GSA to explore, analyze and visualize expression, genomic variations, tumor immune infiltration, drug sensitivity and their associations with clinical outcomes. (bvsalud.org)
This publication details the characterization of tumor-infiltrating and circulating T cells in oral cancer patients treated with neoadjuvant anti-PD-1 or anti-PD-1/CTLA-4 in a Phase 2 open-label randomized clinical trial conducted by the Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School 1 . (tscan.com)
In December 2021, regulators in the Netherlands approved Frames clinical trial protocol to evaluate this approach based on a peptide vaccine in 15 patients with non-small cell lung cancer. (businessinsider.com)
Liau et al showed a clinical phase I trial of DC vaccines from patients' peripheral blood pulsed GBM antigen peptides successfully extended mean OS to 23.4 months [ 9 ]. (aging-us.com)
It is encouraging to see that the robust and durable immune response observed in a significant percentage of patients could translate into promising clinical outcome in the ROSALIE study. (klfy.com)
The study aims to assess the safety, tolerability, immunogenicity, and preliminary efficacy of the combination in 100 patients enrolled at 10 clinical sites in Europe and the US. (klfy.com)
This study establishes the feasibility of preparing and delivering off-the-shelf, SARS-CoV-2-directed, virus-specific T cells to patients with COVID-19 and supports the clinical use of these products outside of the profoundly immune compromised setting (ClinicalTrials.gov number, NCT04401410). (haematologica.org)
Despite significant progress in the field of NK cell-based immunotherapies, some factors including their short life span and the occurrence of a tumor-dependent functional exhaustion have limited their clinical efficacy so that strategies aimed at overcoming these limitations represent one of the main current challenges in the field. (hindawi.com)
Along with highlighting these issues, we speculate that memory NK cell-based adoptive immunotherapy settings would greatly take advantage from the combination with tumor-targeting therapeutic antibodies (mAbs), as a strategy to fully unleash their clinical efficacy. (hindawi.com)
Clinical tumor stage before treatment was assessed to be T2. (hindawi.com)
Specifically, the company is focused on using the immune system to eliminate residual tumors, and currently has two clinical programs focused on leukemia and on glioblastoma, the deadliest type of brain cancer. (atlasstory.com)
It was IN8bios co-founder, Dr. Lawrence Lamb, a clinical immunologist on a cancer ward treating patients with aggressive leukemias in the 1990s, who made the first observation that gamma-delta T cells are linked to greater survival in cancer patients. (atlasstory.com)
In a cohort of patients with liver metastasis of CRC, the Galon's group also observed that immunoscore is associated with a poor prognosis, thus suggesting that immune infiltrate in metastasis could also be a surrogate biomarker of clinical outcome [ 9 ]. (biomedcentral.com)
A Phase III Clinical Trial Evaluating DCVax®-L, Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen For The Treatment Of Glioblastoma Multiforme. (virtualtrials.org)
Clinical effects of administer leukemia-specific donor T cells to patients with AML/MDS after allogeneic transplant. (astct.org)
A new subgroup analysis reports results from the original clinical trial (across 4 stages) stratified by age and baseline disease involvement (skin only, systemic only, skin and systemic) in the 65 patients who received tagraxofusp as the first line of therapy for BPDCN. (eurekalert.org)
However, approximately 40% of patients relapse after initial treatment, so developing a first treatment with a long-lasting response remains an area of clinical unmet need. (eurekalert.org)
When a 23-year-old leukemia patient ran out of treatment options, she joined an immunotherapy clinical trial supported by the St. Baldrick's Foundation. (stbaldricks.org)
However, several clinical observations provide convincing evidence that donor immune elements also contribute to the elimination of residual leukemia after BMT. (niepokorny.org)
The close collaboration between clinical and basic science investigations fosters translational research and thus results in cutting edge patient care. (vumc.org)
Dr. Clark's research focuses on clinical trial development and translational work for tumors of the CNS including glioblastoma, anaplastic glioma, low-grade glioma, meningioma. (vumc.org)
This clinical trial included laboratory investigations of tumor DNA methylation patterns before and after treatment. (vumc.org)
Longer term goals of these preclinical studies are to design clinical trials of Hedgehog inhibitors based upon selecting patients with malignant glioma who might best respond to Hedgehog inhibitors, defining the mechanism of action of Hedgehog pathway inhibition on glioma cancer stem cells and avoiding potential mechanisms of drug resistance. (vumc.org)

Immunotherapy is based on the concept that immune cells or antibodies that can recognize and kill cancer cells can be produced in the laboratory and then given to patients to treat cancer. (lls.org)
The hope is that matching the right checkpoint inhibitor to a sarcoma subtype will enable those sarcoma patients to benefit from immunotherapy. (sarcomahelp.org)
With some patients on immunotherapy, the immune system continues to eradicate cancer in an ongoing way. (sarcomahelp.org)
This International Collaborative Grant will help to ensure that sarcoma patients are not left behind as immunotherapy science advances. (sarcomahelp.org)
This validates the founding principle of TScan - that we can use our technology to understand how T cells recognize and eliminate cancer cells in patients responding to immunotherapy, and then apply these learnings to design and develop novel TCR-engineered T cell therapies. (tscan.com)
Zeng Y , Chen X , . 90K predicts the prognosis of glioma patients and enhances tumor lysate-pulsed DC vaccine for immunotherapy of GBM in vitro . (aging-us.com)
To improve the tumor-killing efficiency, a combination of tumor-specific antigen and apoptotic GBM tumor cell lysate was pulsed DC to improve the effect of immunotherapy. (aging-us.com)
90K, also known as galectin 3 binding protein, LGALS3BP, Mac-2-binding protein, has recently been identified as a tumor-associated antigen and a promising immunotherapy target. (aging-us.com)
This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability. (hindawi.com)
REGULATory T-Cell Inhibition With Basiliximab (Simulect®) During Recovery From Therapeutic Temozolomide-induced Lymphopenia During Antitumor Immunotherapy Targeted Against Cytomegalovirus in Patients With Newly-Diagnosed Glioblastoma Multiforme. (virtualtrials.org)
malignancies and may be a target for antigen-specific immunotherapy. (niepokorny.org)

Resection of CRC metastases, using surgical techniques or local ablation using stereotaxic radiotherapy or radiofrequence could induce complete remission and cure patients. (biomedcentral.com)
Responsiveness is defined as a tumor demonstrating either a complete or partial remission. (aetna.com)
Partial remission (response) is defined as at least a 50% decrease in tumor burden. (aetna.com)
The high incidence of sustained remission among patients with active disease at time of transplantation suggests retained graft-versus-tumor reactions. (stanfordhealthcare.org)

During this procedure, doctors transfer lymphocytes (a type of white cell) from the original stem cell donor's blood to the patient. (lls.org)
To better characterize the antitumor effect LeptinR antibody of DLI we previously examined the reconstitution of T AZD0156 and B cell immunity in patients with chronic myelocytic leukemia (CML) who received infusions of CD4+ donor lymphocytes for treatment of relapse after allogeneic BMT (14). (niepokorny.org)

13. Leukemia-associated aberrant immunophenotype in patients with acute myeloid leukemia: changes at refractory disease or first relapse and clinicopathological findings. (nih.gov)
These tumor markers are most useful for monitoring response to therapy and detecting early relapse. (aafp.org)
Some blood cancer patients, especially those with chronic myeloid leukemia (CML), who have a relapse after stem cell transplantation or for whom transplantation isn't successful, may benefit from an immune cell treatment called donor lymphocyte infusion. (lls.org)
Transplantation of autologous hematopoietic cells has a reduced risk of complications, but residual tumor cells in the autograft may contribute to relapse. (nih.gov)
The Company's lead leukemia TCR-T therapy candidates, TSC-100 and TSC-101, are in development for the treatment of patients with hematologic malignancies to eliminate residual leukemia and prevent relapse after hematopoietic stem cell transplantation. (tscan.com)
We observed that, in comparison with patients given grafts from HLA-matched unrelated donor (UD 10/10), those receiving CBT had similar overall survival (OS) but better GVHD-free and relapse-free survival (GRFS). (nature.com)
Six patients experienced disease relapse with a median time-to-relapse of 6 (range, 4.0-10.9) months, and 4 of these 6 patients were found to have lost CD7 expression on tumor cells. (biomedcentral.com)
As a result, microscopic residual tumors that are resistant to therapy often remain and result in relapse because of the weakened immune system. (atlasstory.com)
These observations include the reduced risk of relapse after BMT in patients who develop graft-versus-host disease and the increased risk of relapse in patients who receive AZD0156 T cell-depleted donor marrow (3, 4). (niepokorny.org)
Phase III randomized study of SU101 versus procarbazine for patients with glioblastoma in first relapse (IN NEU 9805). (vumc.org)

After resection, 39.2% of patients received systemic therapy. (cancernetwork.com)
Throughout the field, efforts continue to optimize patient-specific management as we integrate surgery and systemic therapy for complex melanoma patients. (facs.org)
Research on chronic HIV infection has uncovered substantial information regarding oral and systemic effects of residual inflammation, immune activation, and microbial translocation in subjects treated with a combination of antiretroviral therapies. (nih.gov)
EO2401/nivolumab generated fast, strong, and durable systemic immune responses against the targeted tumor-associated antigens IL13Rα2, BIRC5/survivin, and FOXM1. (klfy.com)
Lymph node disease (N1) is associated with a high risk for systemic tumor progression and treatment failure. (hindawi.com)
4 patients (16%) developed cGVHD, but all were of mild severity and did not require systemic treatment. (astct.org)
Patients with both skin and systemic baseline disease had a 50% CR/CRc rate and a 76% ORR. (eurekalert.org)
To investigate whether a pre-modulation strategy using itacitinib in conjunction with axi-cel improves the 6-month progression-free survival (PFS) from 25% to 45% in patients who express high levels of systemic inflammation. (moffitt.org)

Vaccines that treat existing cancer are known as therapeutic cancer vaccines or tumor antigen vaccines. (wikipedia.org)
Some of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient. (wikipedia.org)
Tumor antigen vaccines work the same way that viral vaccines work, by training the immune system to attack cells that contain the antigens in the vaccine. (wikipedia.org)
The difference is that the antigens for viral vaccines are derived from viruses or cells infected with virus, while the antigens for tumor antigen vaccines are derived from cancer cells. (wikipedia.org)
Similarly, cancer vaccines can be designed to target common antigens before cancer evolves if an individual has appropriate risk factors. (wikipedia.org)
Therapeutic vaccines focus on killing existing tumors. (wikipedia.org)
Since tumors often evolve mechanisms to suppress the immune system, immune checkpoint blockade has recently received a lot of attention as a potential treatment to be combined with vaccines. (wikipedia.org)
For therapeutic vaccines, combined therapies can be more aggressive, but greater care to ensure the safety of relatively healthy patients is needed for combinations involving preventive vaccines. (wikipedia.org)
Cell-based vaccines include tumor cells or tumor cell lysates. (wikipedia.org)
Activation of Tms requires designing vaccines based on tumor rejection antigens, which are often not available to cancer patients. (johnshopkins.edu)
Although these genetic changes are highly specific to individuals, the resulting neoantigenic proteins may be shared among many patients, potentially enabling development of more broadly applicable cancer vaccines. (businessinsider.com)
An additional application of Frames technology is the development of personalized cancer vaccines, thereby leveraging the full antigenic potential of a tumor. (businessinsider.com)

This enhances the anti-tumor immune response to tumor antigens released following viral lysis and provides a patient-specific vaccine. (wikipedia.org)
The first-in-human Phase I/II AUGMENT 101 study, led by Ghayas Issa, M.D. , evaluated the safety and anti-tumor activity of SNDX-5613 - an oral small-molecule inhibitor of the menin-MLL interaction - for children and adults with advanced MLLr and NPM1m acute myeloid or lymphoid leukemias. (eurekalert.org)

Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
We report a series of 13 patients who had ophthalmic symptoms after DF or DHF, and describe the course, spectrum of manifestations, and prognosis and treatment of these new and emergent complications. (cdc.gov)
If you look at the correlation between a one-time baseline blood draw and try to [connect] that with [survival outcomes], there's a clear correlation between positive circulating tumor DNA and the worst prognosis in terms of the disease-free survival and overall survival. (cancernetwork.com)
The relationship between the 90K expression and the tumor grade as well as the prognosis of patients was further analyzed by mining TCGA and CGGA database. (aging-us.com)
Conclusion: 90K was a useful biomarker for glioma malignancy and patient prognosis. (aging-us.com)
Subsequently, it was recognized as a novel circulating antigen with poor prognosis in breast cancer and non-Hodgkin's-lymphoma [ 16 , 17 ]. (aging-us.com)
Conclusion: This is the first case-control study demonstrating that during the first two years of follow-up, occurrence of endocarditis did not alter the prognosis of patients with CRC. (iiarjournals.org)
So biomarker to better define patient's prognosis and to better classify patients are needed. (biomedcentral.com)

In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
Here, we report that activation of antigen-specific Tms could be achieved by the administration of agonistic anti-CD137 monoclonal antibody without additional tumor vaccination, leading to the prevention of recurrence and metastases after surgical resection of primary tumors in mouse models. (johnshopkins.edu)
Our findings implicate a potential new approach to prevent recurrence and metastases in cancer patients. (johnshopkins.edu)
After curative-intent surgery, the risk of cancer recurrence is estimated via a careful histological examination of the resected specimen, which subsequently determines whether patients should receive adjuvant chemotherapy (ACT). (biomedcentral.com)
So far, efforts to refine recurrence risk for nonmetastatic CRC have mainly focused on examinations of the resected tumor to identify potential biomarkers with prognostic significance. (biomedcentral.com)
ROSALIE (EOGBM1-18) is a multicenter, open-label, first-in-human, Phase 1/2 study of EO2401 in combination with an immune checkpoint inhibitor (nivolumab, Opdivo®) +/- bevacizumab for the treatment of patients with first progression/recurrence of glioblastoma. (klfy.com)
However despite optimal therapy many patients develop recurrence. (biomedcentral.com)

Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
Monoclonal antibody (mAb) technol- part, which binds and activates, complements ogy allows production of large amounts of and/or interacts with receptors on antigen- pure antibodies which are potentially more presenting cells. (who.int)
Diffuse large B-cell lymphoma (DLBCL) patients must have received at least two prior chemotherapy-containing regimens at least one of which must have contained doxorubicin and a monoclonal antibody. (nih.gov)

The volume of residual disease at the completion of surgery represents one of the most powerful prognostic factors. (medscape.com)
Now we're trying to figure out the prognostic role of the circulating tumor DNA in this setting, which is a very novel idea. (cancernetwork.com)

Surgery is often the initial treatment of choice for ovarian cancer, provided patients are medically fit. (medscape.com)
According to the National Comprehensive Cancer Network (NCCN) ovarian cancer guidelines, in newly diagnosed invasive epithelial ovarian cancer that involves the pelvis and upper abdomen, residual disease of less than 1 cm is evidence of optimal cytoreduction, although the greatest possible effort should be made to remove all obvious disease. (medscape.com)
One approach to cancer vaccination is to separate proteins from cancer cells and immunize patients against those proteins as antigens, in the hope of stimulating the immune system to kill the cancer cells. (wikipedia.org)
Since tumor antigens are antigens found in cancer cells but not normal cells, vaccinations containing tumor antigens should train the immune system to target cancer cells not healthy cells. (wikipedia.org)
Cancer-specific tumor antigens include peptides from proteins that are not typically found in normal cells but are activated in cancer cells or peptides containing cancer-specific mutations. (wikipedia.org)
Using a combination of established cancer cell lines that resemble the patient's tumor can overcome these barriers, but this approach has yet to be effective. (wikipedia.org)
The early published literature on post-radiation therapy pathology in patients with prostate cancer was based on treatment with external beam radiation. (medscape.com)
In this matched set of photomicrographs from the same patient, compared with pretreatment grade 3 cancer (left), the main posttreatment change is atrophy (right). (medscape.com)
The residual neoplasm loses architectural differentiation while retaining the cytologic features of cancer. (medscape.com)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
Instead, cancer cells are altered versions (mutations) of normal cells and don't produce a unique feature like an antigen that will trigger an immune response. (lls.org)
Manmade antibodies are able to attach to antigens on the cancer cell, using samples of tumors. (lls.org)
It's designed to react with or attach to antigens - foreign substances such as bacteria, viruses, fungi and allergens - on the surface of cancer cells. (lls.org)
Dr. Blay states that the overall goal of the research is 'to understand how immune cells, white blood cells, contribute to tumor progression and can be manipulated to eradicate cancer. (sarcomahelp.org)
The transcriptional profile of tumor-educated platelets (TEPs) is skewed and therefore practicable for cancer detection. (bvsalud.org)
In general, PSMA expression by prostate cancer cells is either unchanged or increased in patients treated with hormonal therapy (see PRECAUTIONS, Drug Interactions ). (nih.gov)
One of our primary research goals is to improve the noninvasive staging of tumors for better surgical management, and we're looking at specific circumstances, such as esophageal cancer, to validate PET as a diagnostic tool," Larson said. (cancer.org)
In one responding patient, two different T cell clones recognized the same novel C*07:02-restricted epitope on the cancer/testis antigen MAGE-A1, and both TCRs exhibited strong anti-cancer activity. (tscan.com)
As of right now, the only biomarker that we typically use in the setting is CEA [carcinoembryonic antigen], which we typically check before and after surgery," explained Kim, who is service chief of Medical Gastrointestinal Oncology and senior member in the Gastrointestinal Oncology Department at the Moffitt Cancer Center in Tampa, Florida. (cancernetwork.com)
Circulating tumor DNA is something that we can easily get that could help guide us in knowing how the patient is going to do and hopefully guide our treatments going forward," Bustamante, a hematologist and medical oncologist at Florida Cancer Specialists in Fort Myers, Florida, added. (cancernetwork.com)
1 The Elecsys CA 125 II assay is further indicated for serial measurement of CA 125 to aid in the management of cancer patients. (mylabtest.net)
Despite the recent move to board certification in complex surgical oncology, general surgeons still perform most cancer operations in the U.S., particularly for the more common tumors of the breast, skin, and lower gastrointestinal tract. (facs.org)
The purpose of this review is to update surgeons on the latest advances in our understanding of tumor biology as it pertains to the surgical care of cancer patients. (facs.org)
However, indications for neoadjuvant therapy are expanding, and genomic assays can be used to identify additional breast cancer patients who might be appropriate candidates. (facs.org)
We are very enthusiastic about the great synergies between our content-driven approach in antigen discovery and validation and CureVacs extensive experience with mRNA vaccine development, said Ronald Plasterk, Founder and CEO of Frame Cancer Therapeutics. (businessinsider.com)
Inflammation-driven phenotypic plasticity and its effects on the immune landscape of oral tumors cells is yet to be understood, resulting in cancer progression and metastasis. (nih.gov)
OncoMimics ™ immunotherapies are designed to activate pre-existing effector memory T cells that target bacterial (non-self) peptides, which are strongly cross-reactive against selected Tumor-Associated Antigens (TAAs), or B cell markers expressed on tumoral cells, resulting in a rapid, targeted cytotoxic response against cancer. (klfy.com)
This process, when used to focus on more broadly indicated tumor antigens such as for example WT-1 and extra Cancer-Testis antigens will improve the range and feasibility of adoptive T cell therapy. (epf2013.org)
Locally advanced prostate cancer can be defined by the categories T3a, T3b, T4, or by the category N1 associated with any T of the Tumor-Node-Metastasis (TNM) staging system [ 2 ] if combined with an absence of distant metastasis (M0). (hindawi.com)
The tumor type presented in this paper has extended through the prostate capsule into the seminal vesicles (T3b N0 M0) and is therefore categorized as a very high-risk locally advanced prostate cancer (T3b N0 M0, T4 N0 M0, or any T N1 M0). (hindawi.com)
Radical prostatectomy (RP) can be a reasonable first step treating very high-risk locally advanced prostate cancer in selected patients [ 3 ]. (hindawi.com)
IN8bio set out on a mission that it calls Cancer Zero, which co-founder and CEO William Ho describes as the goal of pursuing the safe eradication of all tumor cells in patients fighting cancer. (atlasstory.com)
Study to evaluate the efficacy and safety of Durvalumab (MEDI4736) in combination with intravesical BCG for the treatment of patients diagnosed with early stage bladder cancer (non-muscle invasive) compare to the standard therapy of intravesical BCG alone. (clinicaltrialsregister.eu)
To exert their cytotoxic effect CD8 T cells required that, cancer cells present tumor peptide via Human Leucocyte Antigen (HLA) class I molecule [ 11 ]. (biomedcentral.com)
Taking Care of Your Health features cancer-related information, health tips, patient stories and more. (moffitt.org)
When considering bladder cancer screening, the key question to be answered is if early detection of bladder cancer may have any impact on cure rates and, subsequently, on patient survival. (healthybladderclub.com)
Since improved survival of screened patients was not demonstrated in a randomized fashion, but only in comparison with a cancer register, this study presents interesting information however, it cannot serve to provide a final decision on the benefit of hematuria screening. (healthybladderclub.com)

Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)
When antigens are ingested or come into contact with the skin or mucous membranes, they stimulate an immune response: White cells produce antibodies that "coat" the antigens, marking them as targets for other white cells or inactivating the antigens. (lls.org)
In this report, we investigated the relationship between enhanced ADCC and antigen density on target cells using IgG1 antibodies with reduced fucose. (aacrjournals.org)
Seroepidemiologic studies have demonstrated that 80-90% of patients with World Health Organization (WHO) type 2 NPC and WHO type 3 NPC have elevated levels of immunoglobulin A (IgA) antibodies to viral capsid antigen (VCA) and early antigen (EA). (medscape.com)

Nevertheless, there is still an unmet need for therapeutic modalities that can contribute to more sustainable tumor control without constant exposure to treatment-related toxicity. (biomedcentral.com)
Our hope is now that the improvement in survival associated with the combination regimen of EO2401 with nivolumab and bevacizumab will convert into meaningful therapeutic benefit for patients with brain tumors in large scale studies. (klfy.com)
Further, NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) is a main immune-dependent mechanism by which tumor-targeting therapeutic mAbs mediate tumor cell killing [ 6 - 8 ]. (hindawi.com)
Initial reports using these approaches are encouraging and provide evidence that the therapeutic effects of DLI can be extended to provide effective immunity against solid tumors as well as hematopoietic malignancies (13). (niepokorny.org)

RAS status but not immune cell infiltrate was associated with HLA expression on tumor cells. (biomedcentral.com)

Besides the so-called neoantigens, which are generated by somatic mutations in the neoplastic cells (e.g., p53) and are usually patient-specific, the targetable TAAs in EOC are usually self-antigens, which are non-mutated proteins aberrantly expressed by the tumor. (biomedcentral.com)
More than 20 self-antigens have been described in EOC, including several membrane-bound proteins with limited processing and presentation (e.g. (biomedcentral.com)
Emerging antigen-specific immunotherapies, novel vaccination strategies with autoantigens, and new approaches for inducing immune tolerance to specific self-antigens are being successfully tested in animal models. (nih.gov)

In patients with BCRA mutations, maintenance therapy with olaparib, with or without bevacizumab, after surgery and/or chemotherapy may significantly improve survival. (medscape.com)
To date, no tumor marker has demonstrated a survival benefit in randomized controlled trials of screening in the general population. (aafp.org)
We studied the MAGE-A1 and MAGE-A3 expressions, and the MAGE-A1 expression showed significant association with tumor stage, absence of bone marrow infiltration and survival. (nih.gov)
FIGO stage, grading, age, macroscopic residual tumor after debulking, and peritoneal carcinomatosis / distant metastasis had no impact on TTP or overall survival (OS). (biomedcentral.com)
Higher 90K expression was observed in IDH wildtype glioma than IDH mutant and predicted worse overall survival for glioma patients. (aging-us.com)
While effective at shrinking a tumor and prolonging survival, they also kill white blood cells. (atlasstory.com)
By targeting compartments of residual tumor cells, IN8bios DRI approach may achieve deeper tumor responses that can prolong survival. (atlasstory.com)
About half of the patients diagnosed with CRC will eventually develop liver metastases and only 10-20% of these patients will be resectable resulting in five-year survival rates of up to 60% depending on the tumor characteristics, extent of the disease and resection margin [ 2 ]. (biomedcentral.com)

In addition to ctDNA status, the univariate Cox model identified pathologic stage, lymphovascular invasion, nerve invasion, and preoperative carcinoembryonic antigen level associated with RFS. (biomedcentral.com)

This will enable us to begin in 2023 to execute on our strategy to develop multiplexed TCR-T cell therapy for a wide range of solid tumor malignancies. (tscan.com)
Although the highest CA 125 values occur in patients suffering from ovarian carcinoma, clearly elevated values are also observed in malignancies of the endometrium, breast, gastrointestinal tract, and various other malignancies. (mylabtest.net)
Patients with the following malignancies are potentially eligible: any B-cell lymphoma, and chronic lymphocytic leukemia (CLL). (nih.gov)
Patients with indolent malignancies that have transformed to diffuse large B-cell lymphoma are eligible. (nih.gov)
One hundred eleven patients with lymphoid (64) and myeloid (47) malignancies received RIC using total lymphoid irradiation (TLI) and antithymocyte globulin (ATG) followed by the infusion of granulocyte colony-stimulating factor-mobilized grafts. (stanfordhealthcare.org)

This article describes the use of common tumor markers in primary care practice. (aafp.org)
Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
1 CA 125 belongs to the family of hybridoma-defined tumor markers. (mylabtest.net)

Non-antigen-dependent localization, suspected to be secondary to catabolism, has been observed in the liver, spleen, and bone marrow. (nih.gov)
Participants may samples taken of spinal fluid, bone marrow, and tumors. (nih.gov)

This is called a graft versus tumor (GVT) effect. (lls.org)

The patients who are negative for circulating tumor DNA at baseline tend to do much better," Kim said. (cancernetwork.com)

Overexpression of 90K correlated with tumor distant metastasis and advanced stage [ 18 - 20 ]. (aging-us.com)

It may also be a helpful treatment for patients with relapsed myeloma after allogeneic stem cell transplantation. (lls.org)

CA 125 is found in a high percentage of nonmucinous ovarian tumors of epithelial origin 4 and can be detected in serum. (mylabtest.net)
Patients must have a serum ferritin level above 400 mg/mL and C-reactive protein level above 2 mg/dL (20 mg/L) at screening. (moffitt.org)

1 - 14 CA 27.29 also can be found in patients with benign disorders of the breast, liver, and kidney, and in patients with ovarian cysts. (aafp.org)
Early Detection: Since PET images biochemical activity, it can accurately predict whether a tumor is benign or malignant, thereby avoiding surgical biopsy when the PET scan is negative. (cancer.org)
JNA is a histologically benign but highly vascular tumor, with an invasive and destructive growth, that causes significant morbidity. (springeropen.com)
The diagnostic sensitivity and specificity of the Elecsys CA 125 II test was calculated by comparing ovarian carcinoma patients at primary diagnosis (FIGO stage I to IV) with patients suffering from benign gynecologic diseases. (mylabtest.net)

A rare tumor, nasopharyngeal carcinoma (NPC) develops from the epithelium of the nasopharynx. (medscape.com)

Some recurrent mutations in CSMD3 were only in responders or non-responders, indicating their diverse impacts on patient response. (bvsalud.org)
Morphologically, it's impossible to distinguish radiation change (like radiation necrosis) from recurrent tumor," Segall said. (cancer.org)
1 The Elecsys CA 125 II assay is indicated for use as an aid in the detection of residual or recurrent ovarian carcinoma in patients who have undergone first-line therapy and would be considered for second-look procedures. (mylabtest.net)
EO2401 in combination with nivolumab and bevacizumab, as administered to 26 patients with recurrent glioblastoma comprising Cohort 3 of the ROSALIE study, was well tolerated with a safety profile consistent with the profile of nivolumab and bevacizumab, with the addition of local administration site reaction. (klfy.com)
In the detection of residual and/or recurrent NPC following radiation treatment, function-based modalities, such as 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scanning, are not affected by the anatomic distortion resulting from radiation-induced scarring, fibrosis, and edema of the nasopharyngeal tissue. (medscape.com)
In 1988, Fee and Tu published results of salvage nasopharyngectomy in a series of patients with recurrent NPC who failed previous treatment with radiation. (medscape.com)
[ 4 ] and inspired other investigators to start using surgery in the treatment of patients with recurrent NPC. (medscape.com)
He leads ongoing trials for recurrent anaplastic astrocytoma, IDH mutated gliomas, and progressive plexiform neurofibromas in patient with NF1 . (vumc.org)

This approach was used in the drug talimogene laherparepvec, a variant of herpes simplex virus engineered to selectively replicate in tumor tissue and to express the immune stimulatory protein GM-CSF. (wikipedia.org)
The tumor mass had bilaterally invaded into the surrounding soft tissue, the seminal gland, and the seminal tract. (hindawi.com)
the other group receives the DCVax-L vaccine, in which the patients' dendritic cells are trained to recognize tumor antigens by co-culture with tissue from the patients' tumor. (virtualtrials.org)
Towards these goals, the laboratory utilizes a patient tissue repository to identify the specific glioma subtypes in which the Hedgehog signaling pathway is operational and activated. (vumc.org)

For patients with no disease visible outside the ovaries, adequate surgical staging is essential because the incidence of microscopic metastases is significant. (medscape.com)
Microscopic metastases may be present but not yet detectable and there is a considerable risk of incomplete tumor removal. (hindawi.com)

This novel purging strategy may offer a new approach to improving the effectiveness of autologous transplantation in imatinib-refractory CML patients. (nih.gov)
The role of umbilical cord blood transplantation (CBT) in acute myeloid leukemia (AML) patients with active disease at allogeneic hematopoietic cell transplantation (allo-HCT) remains poorly investigated. (nature.com)
In this study, we compared transplantation outcomes of 2963 patients with primary refractory or relapsed AML given CBT, 10/10 HLA-matched UD, or 9/10 HLA-matched UD allo-HCT from 2004 to 2015 at EBMT-affiliated centers. (nature.com)
In summary, these data suggest that in AML patients with active disease at transplantation, allo-HCT with UD results in better transplantation outcomes than CBT. (nature.com)
More than half of the patients achieving CR/CRc (median age 63 years) went on to receive hematopoietic stem cell transplantation. (eurekalert.org)
A hematopoietic cell transplantation regimen was adapted from a preclinical model that used reduced-intensity conditioning (RIC) and protected against graft-versus-host disease (GVHD) by skewing residual host T-cell subsets to favor regulatory natural killer T cells. (stanfordhealthcare.org)
BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. (cdc.gov)

Antigen-presenting cells (APCs) such as dendritic cells take up antigens from the vaccine, process them into epitopes, and present the epitopes to T-cells via Major Histocompatibility Complex proteins. (wikipedia.org)
Another cell-based vaccine strategy involves autologous dendritic cells (dendritic cells derived from the patient) to which tumor antigens are added. (wikipedia.org)
In this strategy, the antigen-presenting dendritic cells directly stimulate T-cells rather than relying on processing of the antigens by native APCs after the vaccine is delivered. (wikipedia.org)
Currently, the most widely used DC vaccine loading antigens include 1. (aging-us.com)
Patients joining this trial must have sufficient tumor material available from surgery to create the vaccine, and must undergo standard radiochemotherapy. (virtualtrials.org)

Dendritic cells are the most robust antigen-presenting cells. (aging-us.com)
Tagraxofusp-erzs, an anti-CD123 targeted therapy, is the first and only approved targeted therapy for treatment of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare, but highly aggressive hematologic malignancy. (eurekalert.org)

However, many of these CAR-T treatments have faced challenges against more difficult-to-treat leukemias, such as acute myeloid leukemia (AML) and solid tumor cancers. (atlasstory.com)

If T-cells recognize the epitope as foreign, the adaptive immune system is activated and target cells that express the antigens. (wikipedia.org)
Tumor cells from the patient are predicted to contain the greatest spectrum of relevant antigens, but this approach is expensive and often requires too many tumor cells from the patient to be effective. (wikipedia.org)
Neuroblastoma is an embryonal tumor of neuroectodermal cells. (nih.gov)
Considering the epigenetic regulation of MAGE-A1, we analyzed its methylation profile, and found a significant association with its expression in tumor cells. (nih.gov)
It includes a network of cells and organs that help defend the body from "antigens" - foreign substances such as bacteria, viruses, fungi, harmful toxins and allergens. (lls.org)
The other white cells then attack and destroy the antigens. (lls.org)
Immune cells from the patient or a transplant donor are used to attack residual leukemia, lymphoma or myeloma cells that remain after chemotherapy. (lls.org)
The patient cells are removed through apheresis and modified in a laboratory so they can be reprogrammed to target tumor cells through a gene modification technique. (lls.org)
The cells are then returned to the patient following chemotherapy. (lls.org)
We further investigated IgG1 binding to natural killer (NK) cells and NK cell activation during ADCC induction to elucidate the mechanism by which low-fucose IgG1 induces ADCC upon target cells with low antigen expression. (aacrjournals.org)
IgG1 binding to NK cells was increased by ligating IgG1 with clustered antigen, especially for low-fucose IgG1. (aacrjournals.org)
Our data showed that fucose removal from IgG1 could reduce the antigen amount required for ADCC induction via efficient recruitment and activation of NK cells. (aacrjournals.org)
Development of methods for purging tumor cells that do not compromise the engraftment potential of the normal hematopoietic cells in the autograft has been a long-standing goal. (nih.gov)
Treatment with 1.0 microM imatinib, 60 microg/ml mafosfamide and 14 days of culture with cytokines eliminated BCR-ABL(+) cells from chronic phase CML patient aphereses, while preserving normal progenitors. (nih.gov)
Single cell analysis revealed that tumor-infiltrating CD8 T cells that expanded upon treatment with checkpoint blockade exhibited specific and identifiable gene expression signatures. (tscan.com)
It enhances the recognition of GBM cells by the patient's immune system, activates a broad, effective, and persistent immune response, and eliminates tumor cells. (aging-us.com)
This employs a fusion and intended to bind to and neutralize foreign of murine B cells derived from the spleen of antigens and pathogens. (who.int)
In Cohort 3, 23 patients (92% of tested, 88% of total) had a specific CD8 + T cell response against EO2401 and all of those patients (100%) had CD8 + T cells cross-reactive with the targeted TAAs, i.e., recognizing IL13Rα2, BIRC5/survivin, and/or FOXM1. (klfy.com)
T cells can destroy tumors. (nih.gov)
Researchers want to try to manipulate the immune system to better recognize and kill tumor cells. (nih.gov)
Lentinan To determine whether passionate extremely, oligoclonal NY-ESO-1 particular Compact disc8+ T cells knowing NY-ESO-1 positive tumor cell lines could Lentinan possibly be regularly isolated from individuals who might reap the benefits of NY-ESO-1 targeted therapy, we centered on individuals with synovial sarcoma (SS) and myxoid/rounded cell liposarcoma (MRCL) because these tumors homogenously communicate NY-ESO-1, with high strength [20 frequently,21]. (epf2013.org)
Outcomes Patient features and leukapheresis produce Isolation and enlargement of NY-ESO-1 particular T cells from leukapheresis items was attempted in six individuals with SS (n? (epf2013.org)
109 mononuclear cells was obtained by leukapheresis from each one of the six patients. (epf2013.org)
109). Lentinan Desk 1 Leukapheresis produce in advanced sarcoma individuals priming offers previously been proven to enrich to get a population of Compact disc8+ T cells with high affinity reputation of tumor antigen, effector function, and manifestation of co-stimulatory substances such as Compact disc28 [18,19]. (epf2013.org)
The target dose was 1 × 10 6 (± 30%) CAR T cells per kg of patient weight. (biomedcentral.com)
NK cell functional response to tumor cells encounter is triggered by a variety of activating receptors, some of which (e.g. (hindawi.com)
The first demonstration of antigen-specific recall responses by NK cells was in the setting of hapten-induced contact hypersensitivity, where CXCR6 + liver-derived murine NK cells could mediate antigen-specific contact hypersensitivity independently from B and T cells [ 13 , 14 ]. (hindawi.com)
Protection in these models is mediated by Ly49H + NK cells, which upon recognition of m157 viral antigen (Ly49H ligand) proliferate and persist in lymphoid and nonlymphoid organs. (hindawi.com)
The company has the capability to utilize autologous (from the patient), allogeneic (from a donor or off-the-shelf) and induced pluripotent stem cell (iPSC)-derived gamma-delta T cells. (atlasstory.com)
IN8bios DRI approach allows the simultaneous combination of chemotherapy with an immune therapy that may create synergies that allow the DRI gamma-delta T cells to recognize and eliminate the residual tumor cells while leaving healthy tissues alone. (atlasstory.com)
In comparison to untreated patients, neoadjuvant chemotherapy induced CD8+ cells recruitment and increased PD-L1 staining in immune infiltrates only for WT RAS patients. (biomedcentral.com)
What we do is reprogram the T cells so the tumor cells can no longer escape immune surveillance," she explained. (stbaldricks.org)
We know that before Lynsie got her transplant, we couldn't find any leukemia cells, and we looked really hard and used tests that can detect very small amounts of residual leukemia," Dr. Gardner explained. (stbaldricks.org)
Total RNA was prepared from AZD0156 cultured tumor cell lines, patient CML cells, and normal human PBMC by using RNAzole (Tel-Test, Friendswood, TX). (niepokorny.org)

In acute myeloid leukemia, it acts as a leukemia-associated antigen. (biomedcentral.com)
All other lymphoma and leukemia patients must have had at least 1 prior chemotherapy-containing regimen. (nih.gov)
As a postdoctoral fellow, I identified and characterized several chromosomal rearrangements involving the SCL gene, which is activated by chromosomal rearrangements in approximately 30 percent of patients with T-cell acute lymphoblastic leukemia. (nih.gov)
Over the past several years, my lab has cloned and characterized several chromosomal translocations that are seen in patients with acute myelogenous leukemia and produce NUP98 fusion genes. (nih.gov)
This special edition features presentations at the 2021 American Society of Hematology (ASH) Annual Meeting on innovative targeted therapies, new combination approaches, and novel cellular therapies to improve treatments for patients with leukemia, lymphoma and other hematologic cancers. (eurekalert.org)
Early data suggest that SNDX-5613 may be an effective and novel oral targeted therapy for patients with an acute leukemia caused by these genetic alterations. (eurekalert.org)

Many tumors also express these proteins and their expression can help identify the origin of a neoplasm. (thermofisher.com)

In total, 82 patients experienced disease progression. (cancernetwork.com)
The median age of patients was 60.1 years, and disease progression was observed in 73.2% of patients ( TABLE ). (cancernetwork.com)

In women who present with peritoneal carcinomatosis but without an obvious pelvic mass, an extensive search often fails to identify a primary tumor. (medscape.com)
These patients can be presumed to have ovarian carcinoma or primary peritoneal carcinoma and can be treated with cytoreductive surgery and platinum-based chemotherapy. (medscape.com)
We studied 47 primary neuroblastoma tumors. (nih.gov)
In order to challenge this hypothesis, we performed a large registry study comparing CBT with UD 10/10 or 1-antigen HLA-mismatched UD (UD 9/10) in patients with primary refractory or untreated/refractory relapsed AML. (nature.com)
Glioma is the most common primary central nervous system tumor, accounting for 50% of the brain tumors. (aging-us.com)
Diffuse leptomeningeal oligodendrogliomatosis is a rare disorder characterized by widespread invasion of the CSF-containing spaces by tumor without evidence of a primary intraparenchymal focus (1) . (ajnr.org)
Research in the Neuro-Oncology division focuses on the treatment of primary brain tumors. (vumc.org)
Dr. Moots' research activities focus on chemotherapy trials for patients with primary CNS neoplasms. (vumc.org)

Follicular lymphoma patients must have received at least 2 prior regimens including at least 1 regimen with chemotherapy. (nih.gov)
All patients with CLL or small lymphocytic lymphoma must have had prior treatment with ibrutinib or another signal transduction inhibitor. (nih.gov)
For two decades, standard-of-care therapy for newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL) has been the combination of the antibody rituximab plus chemotherapy drugs cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). (eurekalert.org)
Secondary Objectives: -To investigate the effect of pre-modulation with itacitinib on the lymphoma tumor microenvironment. (moffitt.org)
Patients must be ineligible for stem cell transplant at screening on the basis of active lymphoma. (moffitt.org)

and that tumors form when the immune system fails to destroy them. (wikipedia.org)
The investigators aim to learn how the immune system reacts to sarcomas and how the tumors manage to evade the immune system and continue growing. (sarcomahelp.org)
Based on this new knowledge, the investigators can recommend treatment strategies that should help the immune system kill the tumors. (sarcomahelp.org)

FINDINGS: Surveillance identified 377 patients from 45 US jurisdictions with hepatitis of unknown aetiology with onset from Oct 1, 2021, to Sept 30, 2022. (cdc.gov)

Results: All 25 patients were male, with a median age of 63 (range: 53-85) years. (iiarjournals.org)
The median age of patients was 2·8 years (IQR 1·2-5·0) and 192 (51%) were male, 184 (49%) were female, and one patient had sex unknown. (cdc.gov)

In this 2-year follow-up analysis, donor-derived CD7 CAR T-cell treatment demonstrated durable efficacy in a subset of patients with r/r T-ALL. (biomedcentral.com)
Cumulative probabilities of acute GVHD (grades II-IV) were 2 and 10% of patients receiving related and unrelated donor grafts. (stanfordhealthcare.org)

Although immune checkpoint blockade (ICB) therapies have achieved great progress, the patient response varies among cancers. (bvsalud.org)
The expectation is that new knowledge derived from this research will facilitate development of novel, personalized immunomodulatory-based therapies that skew the balance between damaging and reparative effects toward the desirable state specific for any given patient. (nih.gov)

Proportions of patients who had acute liver failure, received a liver transplant, and died were similar between those who tested positive for adenovirus compared with those who tested negative. (cdc.gov)

Furthermore, the urethra was also involved with tumor infiltration. (hindawi.com)

IRIS can complicate virtually any opportunistic infection and even tumors but is usually self-limited or responds to brief regimens of corticosteroids. (infectiontalk.net)

Patients who are not candidates for optimal debulking should be considered for neoadjuvant chemotherapy followed by interval debulking surgery and further chemotherapy. (medscape.com)
Patients who are not fit for surgery may be given chemotherapy and considered for surgery later, or treated primarily with chemotherapy. (medscape.com)
He says, 'When patients are treated with standard chemotherapy, the cancers have a tendency to come back after treatment ends. (sarcomahelp.org)
Confirmation of advanced metastases allows the physician and patient to more accurately decide on how to proceed, especially if the patient is against extraordinary measures or decides not to undergo the rigors of chemotherapy in the time they have remaining. (cancer.org)
The level of tumor metabolism is compared on PET scans taken before and after chemotherapy. (cancer.org)
Neoadjuvant chemotherapy traditionally has been employed to downstage large or inoperable tumors to allow for breast conservation therapy. (facs.org)
Previous work by our group underlined in preclinical models that chemotherapy could favor CD8 recruitment and activation thus enhancing efficacy of checkpoint inhibitor in preclinical model of MSS (microsatellite stability) colon tumors [ 10 ]. (biomedcentral.com)

If macroscopic disease is visible outside of the ovary, all visible tumor should be removed. (medscape.com)

According to Dr. Thomas, the most extraordinary aspect of immunotherapies in other cancers has been the duration of the patients' responses. (sarcomahelp.org)

We used case studies of three gene sets: (i) seven cell cycle genes, (ii) tumor suppressor genes of PI3K pathway and (iii) oncogenes of PI3K pathway to prove the advantage of GSCA over single gene analysis. (bvsalud.org)
In the discovery cohort, somatic variations in tumor tissues and plasmas were determined via a 733-gene and 127-gene next-generation sequencing panel, respectively. (biomedcentral.com)
3. transfecting tumor cell-associated antigen-encoding gene into DC [ 10 - 13 ]. (aging-us.com)
In each full case, the NY-ESO-1 particular CTL lines had been also verified to lyse a SS tumor range (SYO-1) and a MRCL tumor range (402) which had been transfected with the gene for A*0201 (Additional file 1: Number S5). (epf2013.org)

In the discovery cohort, 17 of 108 (15.7%) patients had detectable ctDNA. (biomedcentral.com)
Patients with MRD positivity characterized 54.4% of the total cohort, or 61 patients. (cancernetwork.com)
Dialysis patients were included in their own cohort (n=46). (astct.org)

Anatomy16

Organisms10

Diseases57

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes38

Disciplines and Occupations1

Information Science4

Health Care9

Metastatic10

Chimeric9

Minimal residua21

Defined tumor-associated antigens1

Human leukocy1

Prostate-specifi4

Receptor3

Brain tumor4

Target antigens2

Colorectal cancer9

Clinical24

Immunotherapy11

Remission4

Lymphocytes2

Relapse10

Systemic8

Vaccines12

Anti-tumor2

Prognosis8

Recurrence7

Monoclonal antibody3

Prognostic2

Cancer37

Antibodies4

Therapeutic4

Expression on tumor cells1

Self-antigens3

Survival8

Carcinoembryonic antigen1

Malignancies5

Markers3

Bone marrow2

Graft versus tumor1

Circulating tumor DNA1

Distant metastasis1

Allogeneic stem cell trans1

Serum2

Benign4

Rare tumor1

Recurrent8

Tissue4

Microscopic2

Transplantation7

Vaccine5

Dendritic2

Solid tumor1

Cells34

Leukemia6

Proteins1

Progression2

Primary8

Lymphoma5

Immune system3

20211

Median age2

Donor2

Therapies2

Acute1

Infiltration1

Opportunistic infection1

Chemotherapy7

Macroscopic1

Immunotherapies1

Gene4

Cohort3