• Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). (wikipedia.org)
  • Following reserpine treatment, glyoxylic acid-induced fluorescence or neutral red staining closely mirrored the HPLC-determined time course of amine depletion and recovery. (jneurosci.org)
  • The threshold concentration of reserpine necessary to produce amine depletion was approximately 1 microM. (jneurosci.org)
  • A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. (unboundmedicine.com)
  • The akinetic state, resulting from reserpine-induced dopamine depletion in the caudate nucleus and putamen, led Carlsson to speculate that PD was due to loss of dopamine neurotransmission. (guwsmedical.info)
  • The net depletion of these substances creates the calming and relaxing effects of RESERPINE INJECTION. (horsehealthcare.net)
  • N2 - Reserpine administration has been shown to increase striatal tissue levels of neurotensin with a time course similar to that for striatal dopamine depletion. (paperkilledrock.com)
  • We show that depletion of endogenous DA stores with reserpine was accompanied in PC12 cells by a long-lasting, significant increase in GSH content the extent of which appeared to be inversely related to the rate of GSH synthesis. (jneurosci.org)
  • Chronic reserpine administration produces persistent oral dyskinesia accompanied by severe dopamine depletion in the caudate-putamen. (elsevier.com)
  • Reserpine also produced a 74% depletion of dopamine in the caudate-putamen relative to vehicle treatment at 3 days post-injection, but did not significantly alter dopamine in the caudate-putamen at 84 days post-injection. (elsevier.com)
  • U'Prichard, DC & Snyder, SH 1978, ' 3H-catecholamine binding to α-receptors in rat brain: Enhancement by reserpine ', European Journal of Pharmacology , vol. 51, no. 2, pp. 145-155. (elsevier.com)
  • Manara, L & Garattini, S 1967, ' Time course of 3H-reserpine levels in brains of normal and tetrabenazine-pretreated rats ', European Journal of Pharmacology , vol. 2, no. 2, pp. 139-141. (elsevier.com)
  • Animal studies have revealed evidence of teratogenicity after doses of reserpine 125 to 250 times the maximum recommended human dose (MRHD, on a per kg basis) were given to rats. (drugs.com)
  • The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. (frontiersin.org)
  • Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. (unboundmedicine.com)
  • Previous studies showed that chronic administration of the monoamine depleting agent reserpine in low doses promotes progressive cognitive and motor impairments in rats, and this protocol has been used as a pharmacological progressive model of Parkinson's disease . (omicsonline.org)
  • We aimed to verify the effects of the concomitant treatment with the antioxidant agent alpha-tocopherol on the motor and cognitive deficits induced by chronic reserpine in rats. (omicsonline.org)
  • Rats were repeatedly treated with 0.1 mg/kg reserpine with or without a concomitant treatment with 40 mg/kg alpha-tocopherol. (omicsonline.org)
  • In detail, 90 Sprague Dawley rats were randomly treated with reserpine, to reproduce the pathogenic process of fibromyalgia and thereafter they received melatonin. (mdpi.com)
  • Measurements of reserpine in the brain of normal and tetrabenazine-pretreated rats supply direct evidence in favor of the view that these drugs compete at the level of a common target. (elsevier.com)
  • We demonstrate that, opposite to normotensive Wistar rats (NWR), spontaneously hypertensive rats (SHR) do not develop aging- or reserpine-OD. (unifesp.br)
  • Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats', Iranian Journal of Pharmaceutical Research , 15(Special Issue), pp. 125-137. (ac.ir)
  • Compared to control, amitriptyline (10, 20 mg/kg) and dexamethasone significantly decreased weight of colon and ulcer index in normal and reserpine-induced depressed rats. (ac.ir)
  • If you become pregnant while taking reserpine, call your doctor. (medlineplus.gov)
  • Tell your doctor if you are pregnant or plan to become pregnant while taking reserpine. (cigna.com)
  • Reserpine is one of the few antihypertensive medications that have been shown in randomized controlled trials to reduce mortality: The Hypertension Detection and Follow-up Program, the Veterans Administration Cooperative Study Group in Anti-hypertensive Agents, and the Systolic Hypertension in the Elderly Program. (wikipedia.org)
  • Reserpine is rarely used in the management of hypertension today. (wikipedia.org)
  • In some countries reserpine is still available as part of combination drugs for the treatment of hypertension, in most cases they contain also a diuretic and/or a vasodilator like hydralazine. (wikipedia.org)
  • Reserpine is a catecholamine -depleting sympatholytic that is FDA approved for the {{{indicationType}}} of mild essential hypertension . (wikidoc.org)
  • One hundred nine patients with moderately severe hypertension and 12 patients with severe hypertension received the combination of 50 mg. of chlorthalidone plus 0.25 mg. of reserpine combined in a single tablet (Regroton) administered once daily for an average duration of 2 years. (ahajournals.org)
  • The ease of administration (one tablet daily), the effectiveness (78-per cent good response), the lack of development of drug resistance over a 2-year period, and the small incidence of side effects would seem to make the combination of 50 mg. of chlorthalidone plus 0.25 mg. of reserpine the ideal treatment for most patients with hypertension. (ahajournals.org)
  • Reserpine, a Rauvolfia alkaloid with centrally acting anti-adrenergic properties, was previously widely used as a first-line drug in the treatment of mild to moderate hypertension, but has largely been replaced by other antihypertensives owing to its side-effect profile. (scielo.org.za)
  • Finally, cotransfer experiments indicated that the effect of reserpine on the transfer of CS was not due to activation of suppressor cells. (rupress.org)
  • Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. (wikipedia.org)
  • What other drugs will affect reserpine? (cigna.com)
  • Do not take chlorothiazide and reserpine if you have an allergy to sulfa-based drugs such as sulfa antibiotics. (drugster.info)
  • The daily dose of reserpine in antihypertensive treatment is as low as 0.1 to 0.25 mg. (wikipedia.org)
  • Reserpine (0.25 mg/kg s.c. per day for 3 weeks) causes 25 and 46% increases in the numbers of (±)- 3 H-epinephrine and 3 H-WB-4101 α-receptor binding sites respectively, and a 51% increase in the number of 3 H-dihydroalprenolol β-receptor sites, in rat forebrain. (elsevier.com)
  • Reserpine (0.25 mg/kg s.c. per day for 3 weeks) causes 25 and 46{\%} increases in the numbers of (±)-3H-epinephrine and 3H-WB-4101 α-receptor binding sites respectively, and a 51{\%} increase in the number of 3H-dihydroalprenolol β-receptor sites, in rat forebrain. (elsevier.com)
  • Kalueff, A. V. Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish. (alfa.com)
  • Reserpine precludes the storage of monoamines through the blockage of the synaptic vesicles transporters [ 1 ]. (omicsonline.org)
  • Besides its classical mechanism of action (i.e. blockage of the vesicular transport of monoamines), there is clear evidence that reserpine also causes an increase in cellular oxidative stress, possibly potentiated by the rise in the levels of dopamine in the cytoplasm, which undergoes oxidative metabolism [ 10 ]. (omicsonline.org)
  • Reserpine acts at the membrane of intraneuronal granules which store monoamines (NA, 5-HT, DA) and irreversibly inhibits the active amine transporters so the monoamines are gradually depleted and degraded by MAO. (medicineport.com)
  • Reserpine is a catecholamine-depleting agent that blocks vesicular storage of monoamines. (guwsmedical.info)
  • Reserpine (Lannett's Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms. (godowell.net)
  • Reserpine is an indole alkaloid isolated in 1952 from the extract of Rauwolfia sepentina or 'Indian snake root', a popular plant in traditional Indian medicine used as a sedative and antipyretic, and reportedly taken by Mahatma Gandhi himself. (brsmblog.com)
  • Reserpine, an indole alkaloid and antipsychotic drug, is used to control high blood pressure and to relieve psychotic symptoms. (spectrumchemical.com)
  • Serpalan etc. (reserpine) is an anti-adrenergic medication used to treat high blood pressure (hypotension). (rightpet.com)
  • The animals treated with reserpine showed moderate alterations at hind limb skeletal muscles level and had difficulty in moving, together with significant morphological and ultrastructural alterations and expression of inflammatory and oxidative stress markers in the gastrocnemius muscle. (mdpi.com)
  • In the biochemical level, the ability of astaxanthin to mitigate reserpine-induced oxidative stress was evaluated by the measurement of malondialdehyde (MDA) and nitric oxide (NO) in brain, liver and plasma samples. (eurekaselect.com)
  • Conclusion: This study suggests that astaxanthin reduces reserpine-induced oxidative stress and therefore might be effective in treating oxidative stress associated depression. (eurekaselect.com)
  • in order to investigate a possible role of nigrostriatal dopaminergic supersensitivity and of oxidative stress in aging- and reserpine-induced OD, the stereotyped behavior induced by dopaminergic agonists, a functional index of dopaminergic striatal activity, as well as the striatal antioxidant enzymes glutathione peroxidase and catalase were assessed. (unifesp.br)
  • You should not use reserpine if you have a stomach ulcer, ulcerative colitis, a history of depression or suicidal thoughts, or if you are being treated with electroconvulsive therapy. (cigna.com)
  • Since reserpine increases gastrointestinal motility and secretion, it should be used cautiously in patients with a history of peptic ulcer , ulcerative colitis , or gallstones ( biliary colic may be precipitated). (wikidoc.org)
  • The results show a preventive role of alpha-tocopherol on behavioral alterations induced by repeated reserpine treatment. (omicsonline.org)
  • Method: On the behavioral level, antidepressant property of astaxanthin (50 mg/kg, orally) on reserpine (2 mg/kg, subcutaneously) induced depressed mice was evaluated by forced swim test (FST) and tail suspension test (TST). (eurekaselect.com)
  • The present study examined whether these behavioral and neurochemical effects would persist following acute reserpine administration. (elsevier.com)
  • Acute exposure of isolated ganglia to 10 microM reserpine for periods up to 6 hr produced a 20-30% reduction of serotonin and dopamine content. (jneurosci.org)
  • To rapidly restore amine levels in reserpine-treated animals, we bathed intact leeches in pond water containing serotonin, dopamine, or octopamine. (jneurosci.org)
  • It has been suggested that reserpine blocks expression of delayed hypersensitivity (DH) by depleting tissue mast cells of serotonin (5-HT), thereby preventing a T cell-dependent release of mast cell 5-HT necessary to localize and to amplify the DH response. (rupress.org)
  • Reserpine is an oral prescription medication used to treat high blood pressure and agitation affiliated with mental problems such as schizophrenia, and it works by decreasing the amounts of norepinephrine and serotonin in the brain. (rxgo.com)
  • The increase in enzyme activity of rat ganglia and adrenals was dose-dependent up to 5 mg/kg and persisted for at least four days after reserpine was given. (aspetjournals.org)
  • The acute administration of a high dose of reserpine (above 1.0 mg/kg) leads to severe motor impairment [ 4 ]. (omicsonline.org)
  • You may require a lower dose or special monitoring during therapy with chlorothiazide and reserpine if you have any of the conditions listed above. (drugster.info)
  • What is the most important information I should know about chlorothiazide and reserpine?Stand up slowly from a sitting or lying position. (drugster.info)
  • Reserpine may also be used for purposes not listed in this medication guide. (cigna.com)
  • Reserpine used in conjunction with other psychotropic medication may be considered in the treatment of refractory mania, but controlled trials are necessary to support our finding more generally. (scielo.org.za)
  • The Medication Coupons.com Drug Savings card saves you up to 85% or more on Reserpine and Chlorthalidone . (medicationcoupons.com)
  • Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian snakeroot), which had been known as Sarpagandha and had been used for centuries in India for the treatment of insanity, as well as fever and snakebites - Mahatma Gandhi used it as a tranquilizer. (wikipedia.org)
  • reserpine rĕsûr´pēn [ key ] , alkaloid isolated from the root of the snakeroot plant ( Rauwolfia serpentina ), a small evergreen climbing shrub of the dogbane family native to the Indian subcontinent. (infoplease.com)
  • Although there is no specific information comparing use of reserpine, hydralazine, and hydrochlorothiazide combination in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (mayoclinic.org)
  • The relative contributions of serum esterases versus hepatic metabolism in the biotransformation of reserpine in vivo are not known. (aspetjournals.org)
  • We therefore decided to reevaluate the mechanism by which reserpine abrogates expression of cellular immunity, and investigated whether the drug might interfere with T cell activity in vitro or in vivo. (rupress.org)
  • Our findings strongly suggest that whatever effects reserpine might have on immunologically nonspecific host cells, the drug's effects on sensitized T cells are sufficient to explain its ability to block cell-mediated immune responses in vivo. (rupress.org)
  • Reserpine controls high blood pressure or symptoms of agitation, but does not cure them. (medlineplus.gov)
  • His manic symptoms improved markedly with the addition of reserpine to the treatment regimen. (scielo.org.za)
  • Reserpine is a kind of drug that is being used for the control of high blood pressure and for the relief of psychotic symptoms. (eanswers.net)
  • The first demonstration of an animal model for PD was reported by Carlsson in the 1950s using rabbits treated with reserpine. (guwsmedical.info)
  • Ferdous Khan, Syed Abdul Kuddus, Md. Hasanuzzaman Shohag, Hasan Mahmud Reza and Murad Hossain*, "Astaxanthin, the Natural Antioxidant, Reduces Reserpine Induced Depression in Mice", Current Bioactive Compounds (2020) 16: 1. (eurekaselect.com)
  • tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (medlineplus.gov)
  • If you are currently taking reserpine, you should call your doctor to discuss switching to another treatment. (medlineplus.gov)
  • Neither the total group nor subgroups of congenital anomalies indicated a significant increase associated with reserpine treatment during pregnancy. (drugs.com)
  • The purpose of this study is to assess the efficacy and safety of reserpine for the treatment of cocaine dependence. (clinicaltrials.gov)
  • Unexpectedly, reserpine treatment increased rather than reduced the duration of stimulus-evoked swimming activity. (jneurosci.org)
  • Importantly, these detrimental outcomes due to reserpine treatment were prevented by concomitant daily administration of the antioxidant agent alpha-tocopherol. (omicsonline.org)
  • Furthermore, treatment of I-LNC with reserpine (20 microM) for 1 h in vitro virtually abolished the ability of these cells to transfer CS to naive mice. (rupress.org)
  • To determine whether reserpine treatment may increase striatal neurotensin synthesis we have examined striatal neurotensin mRNA levels using in situ hybridization histochemistry. (paperkilledrock.com)
  • Reserpine is used to treat high blood pressure. (medlineplus.gov)
  • If you suddenly stop taking reserpine you may develop high blood pressure and experience unwanted side effects. (medlineplus.gov)
  • Rauvolfia (family Apocynaceae ) A genus of shrubs or small trees, some species of which, especially R. serpentina , produce the alkaloid reserpine, used to counteract high blood pressure. (encyclopedia.com)
  • Together, chlorthalidone and reserpine are used to lower high blood pressure. (drugster.info)
  • Orally administered reserpine is readily absorbed from the GI tract. (aspetjournals.org)
  • There is a report of galactorrhea associated with reserpine. (drugs.com)
  • Reserpine has reportedly caused galactorrhea and has been used to increase breastmilk production, although it is obsolete for this use. (anikamd.com)
  • Click a link below to do a Google powered SiteComber search for CHLOROTHIAZIDE RESERPINE within any of the sites below. (sitecomber.com)
  • You instead may execute your own search for CHLOROTHIAZIDE RESERPINE using the search box above. (sitecomber.com)
  • Or, if you prefer, do you own search for HYDROFLUMETHIAZIDE AND RESERPINE using the search box above. (sitecomber.com)
  • Because an important loss of dopaminergic neurons is the core feature of Parkinson´s disease (PD) [ 2 ], reserpine administration to rodents is a valid approach to study this disease in animal models [ 3 - 5 ]. (omicsonline.org)
  • Jacobsen, E. N. Enantioselective Total Synthesis of (+)-Reserpine. (alfa.com)
  • The Michigan Medicaid surveillance study showed no association between reserpine or thiazide diuretics and congenital defects (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). (drugs.com)
  • Some reserpine molecules do seem to escape metabolism, however, since significant amounts of intact reserpine have been found in fecal samples taken from both experimental animals and human beings after either oral or parenteral drug administration. (aspetjournals.org)
  • Such a small specific binding would not be detectable for at least 18 hr after reserpine administration, i.e., until most of the reversibly bound alkaloid had been metabolized and/or excreted. (aspetjournals.org)
  • Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). (aspetjournals.org)
  • The effect of systemic administration of these agents on the muscular hyperalgesia that develops in the reserpine-induced myalgia (RIM) rat, a putative animal model of fibromyalgia, was investigated. (ovid.com)
  • The number of striatal cells expressing neurotensin mRNA was increased 6 h, but not 1 h, after reserpine administration. (paperkilledrock.com)
  • In addition the results of the present drug interaction study underline the relevance of the long-lasting concentrations of reserpine in the brain for explaining the functional modifications induced by its administration. (elsevier.com)
  • The reserpine-induced depression is considered by some researchers to be a myth, while others claim that teas made out of the plant roots containing reserpine have a calming, sedative action that can actually be considered antidepressant. (wikipedia.org)
  • Reserpine was also highly influential in promoting the thought of a biogenic amine hypothesis of depression - see Everett & Tolman, 1959. (wikipedia.org)
  • Some people taking reserpine have developed depression. (cigna.com)
  • Reserpine may cause mental depression . (wikidoc.org)
  • Objective: The objective of this study was to evaluate the ability of astaxanthin, a potential antioxidant, to reduce reserpine-induced depression of BALB/c mice (Mus musculus). (eurekaselect.com)
  • Despite initially positive results, Reserpine use steadily decreased as more patients experienced a number of side effects, including reduced blood pressure, diarrhea, and depression. (discoveriesinmedicine.com)
  • CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion - induced by reserpine. (frontiersin.org)
  • The finding that reserpine-induced oral dyskinesia persisted despite repletion of dopamine in the caudate-putamen suggests that the persistent neuropathological change underlying this behavior occurs in a neural pathway other than the dopaminergic nigrostriatal pathway. (elsevier.com)