• A review found that in persons with schizophrenia, reserpine and chlorpromazine had similar rates of adverse effects, but that reserpine was less effective than chlorpromazine for improving a person's global state. (wikipedia.org)
  • Study of the differential behavioral effects of reserpine, chlorpromazine and a combination of these drugs in chronic schizophrenics. (cambridge.org)
  • The use of reserpine as an antipsychotic drug had been nearly completely abandoned, but more recently it made a comeback as adjunctive treatment, in combination with other antipsychotics, so that more refractory patients get dopamine blockade from the other antipsychotic, and dopamine depletion from reserpine. (wikipedia.org)
  • The ability of bromocriptine (BRC), a selective dopamine D-2 receptor agonist, to induce yawning responses was studied in rats pretreated with reserpine and alpha-methyl-p-tyrosine (alpha-MPT). (baillement.com)
  • The effects of dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, were studied on dopamine-related behaviors induced by reserpine treatments. (unifesp.br)
  • Reserpine inhibits formation of biofilms by Staphylococcus aureus and inhibits the metabolic activity of bacteria present in biofilms. (wikipedia.org)
  • Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. (immunoportal.com)
  • It is concluded that the adrenal glands seem to be of no importance in the secretion of gastric mucus but reserpine inhibits mucus release and stimulates surface mucus gel breakdown via -adrenoceptor stimulation. (internationalscholarsjournals.com)
  • At least 20 days should elapse after stopping reserpine before starting deutetrabenazine. (medscape.com)
  • If your healthcare provider plans to switch you from taking reserpine to AUSTEDO XR or AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR or AUSTEDO. (nih.gov)
  • Reserpine, isolated in 1952, was the first of many Rauwolfia alkaloids found in the crude drug. (britannica.com)
  • Reserpine is in a class of medications called rauwolfia alkaloids. (safemedication.com)
  • It was appreciably lower at room temperature and almost negligible at 2 degrees C. . Only those rauwolfia alkaloids which exert reserpine-like pharmacological properties caused the release of 5- hydroxytryptamine. (erowid.org)
  • Reserpine irreversibly blocks the H+-coupled vesicular monoamine transporters, VMAT1 and VMAT2. (wikipedia.org)
  • Reserpine binds irreversibly to VMAT2 and the duration of its effect is several days. (medscape.com)
  • Derived from Rauwolfia serpentina (a plant that for centuries has been used in India for the treatment of mental illness, insomnia, and snake bites), reserpine was introduced in the West as a treatment for schizophrenia. (medscape.com)
  • The reserpine-hydrochlorothiazide combo pill was the 17th most commonly prescribed of the 43 combination antihypertensive pills available In 2012. (wikipedia.org)
  • The daily dose of reserpine in antihypertensive treatment is as low as 0.05 to 0.25 mg. (wikipedia.org)
  • In particular, combined treatment with reserpine (5 mg/kg) and BRC (10 and 20 mg/kg) elicited upright fighting and jumping behaviors which were inhibited by haloperidol (1 mg/kg IP), a non-selective D-1 and D-2 receptor antagonist, SCH23390 (0.05 mg/kg SC). (baillement.com)
  • In this study, N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced the head-twitch response induced by 5-hydroxytryptamine (5-HT) in reserpine-treated mice. (ewha.ac.kr)
  • tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (safemedication.com)
  • reserpine increases levels of berotralstat by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • Resistance to fluoroquinolones in S . pneu- with MIC 4-8 µg/mL) was caused by a reserpine-sensitive moniae can be acquired by point mutations, intraspecific efflux phenotype (n = 4) or single topoisomerase IV ( parC [n = 24] or parE [n = 1]) changes. (cdc.gov)
  • One isolate did not show recombination ( 3 ) or interspecific recombination with the reserpine-sensitive efflux or mutations. (cdc.gov)
  • Since reserpine increases gastrointestinal motility and secretion, it should be used cautiously in patients with a history of peptic ulcer , ulcerative colitis , or gallstones ( biliary colic may be precipitated). (wikidoc.org)
  • The present study was undertaken to assess the effect of acute bilateral adrenalectomy and reserpine on gastric mucus secretion and degradation in the pyloric ligated rats. (internationalscholarsjournals.com)
  • Reserpine diminished adherent mucus secretion and increased soluble glycoprotein in the gastric juice. (internationalscholarsjournals.com)
  • BRC cannot be considered a directly acting agonist like apomorphine, since reserpine and -MPT inhibit or completely abolish most of the behavioral effects induced by BRC (Johnson et al. (baillement.com)
  • In addition, the enhancement of 5-HT-induced head-twitch response was inhibited by apomorphine and NMDA as well as ritanserin in reserpine-treated mice. (ewha.ac.kr)
  • Various pharmacological agents were tested for their ability to block reserpine-induced (0.5 mg/kg) emesis in pigeons. (erowid.org)
  • We have described that GABA mimetic drugs present the ability to inhibit the expression of reserpine-induced oral movements. (unifesp.br)
  • LSD, d-amphetamine and desoxyephedrine exert an analeptic action in mice sedated with reserpine. (erowid.org)
  • Erowid.org: Erowid Reference 1551 : The analeptic action of lysergic acid diethylamide on reserpine-sedated mice. (erowid.org)
  • The reserpine-induced prolongation of pentobarbital anesthesia in mice is reversed by LSD and d-amphetamine, but not by BOL. (erowid.org)
  • The results showed that DSS treatment significantly antagonized reserpine-induced ptosis in mice. (hindawi.com)
  • Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. (wikipedia.org)
  • Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension. (wikipedia.org)
  • Although the use of reserpine as a solo drug has declined since it was first approved by the FDA in 1955, the combined use of reserpine and a thiazide diuretic or vasodilator is still recommended in patients who do not achieve adequate lowering of blood pressure with first-line drug treatment alone. (wikipedia.org)
  • Reserpine is sometimes used in treating hypertension, though newer antihypertensive drugs with fewer central nervous system side effects are the preferred treatment . (britannica.com)
  • If you are currently taking reserpine, you should call your doctor to discuss switching to another treatment. (safemedication.com)
  • Reserpine is infrequently used alone for the treatment of hypertension due to possible side effects. (syrianclinic.com)
  • Reserpine has been reported as potentially beneficial for treatment of COVID-19. (c19early.org)
  • RESERPINE INJECTION produces a prolonged calming effect without sedation, drowsiness, or loss of coordination while vicious or dangerously anxious horses will become relaxed, sociable and co-operative with continued treatment. (kihorsemed.com)
  • Groups of Wistar rats of mixed sexes were adrenalectomized or administered with 5 mg/kg reserpine intraperitoneally or given both treatment followed by pyloric ligation. (internationalscholarsjournals.com)
  • His manic symptoms improved markedly with the addition of reserpine to the treatment regimen. (sajp.org.za)
  • Reserpine used in conjunction with other psychotropic medication may be considered in the treatment of refractory mania, but controlled trials are necessary to support our finding more generally. (sajp.org.za)
  • Reserpine is recommended as an alternative drug for treating hypertension by the JNC 8. (wikipedia.org)
  • The reserpine - thiazide diuretic combination is one of the few drug treatments shown to reduce mortality in randomized controlled trials: The Hypertension Detection and Follow-up Program, the Veterans Administration Cooperative Study Group in Anti-hypertensive Agents, and the Systolic Hypertension in the Elderly Program. (wikipedia.org)
  • Reserpine is a catecholamine -depleting sympatholytic that is FDA approved for the {{{indicationType}}} of mild essential hypertension . (wikidoc.org)
  • A 2016 Cochrane review found reserpine to be as effective as other first-line antihypertensive drugs for lowering of blood pressure. (wikipedia.org)
  • Reserpine can cause: nasal congestion, nausea, vomiting, weight gain, gastric intolerance, gastric ulceration (due to increased cholinergic activity in gastric tissue and impaired mucosal quality), stomach cramps and diarrhea. (wikipedia.org)
  • At doses of less than 0.2 mg/day, reserpine has few adverse effects, the most common of which is nasal congestion. (wikipedia.org)
  • According to the literature, most of the effective drugs antagonize other effects of reserpine. (erowid.org)
  • Recently we have described the antidyskinetic property of the GABA mimetic drugs valproic acid and topiramate on reserpine-induced oral dyskinesia. (unifesp.br)
  • AOAC 976.34-1978, Reserpine in drugs. (aoacofficialmethod.org)
  • Title:Reserpine in drugs. (aoacofficialmethod.org)
  • Spoiler alert: Brodie's work showed that a new psychiatric drug known as reserpine was capable of fully depleting the brain's stores of serotonin and ― of greatest significance, as it turned out - mimicking the neuromuscular symptoms typical of Parkinson's disease. (medscape.com)
  • ACTION:- RESERPINE INJECTION causes a rapid release of the nerve system transmitters serotonin and norepinephrine from bound stores in the brain, subjecting them to rapid destruction by the body's own enzyme, monoamine oxidase (MOA). (kihorsemed.com)
  • High dose studies in rodents found reserpine to cause fibroadenoma of the breast and malignant tumors of the seminal vesicles among others. (wikipedia.org)
  • Reserpine is used as a long-acting tranquilizer to subdue excitable or difficult horses and has been used illicitly for the sedation of show horses, for-sale horses, and in other circumstances where a "quieter" horse might be desired. (wikipedia.org)
  • acrivastine and reserpine both increase sedation. (medscape.com)
  • asenapine transdermal and reserpine both increase sedation. (medscape.com)
  • benzhydrocodone/acetaminophen and reserpine both increase sedation. (medscape.com)
  • brivaracetam and reserpine both increase sedation. (medscape.com)
  • buprenorphine subdermal implant and reserpine both increase sedation. (medscape.com)
  • buprenorphine, long-acting injection and reserpine both increase sedation. (medscape.com)
  • reserpine and ganaxolone both increase sedation. (medscape.com)
  • reserpine , drug derived from the roots of certain species of the tropical plant Rauwolfia . (britannica.com)
  • There is limited information regarding Clinical Trial Experience of Reserpine in the drug label. (wikidoc.org)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51659/all/reserpine. (unboundmedicine.com)
  • There is limited information regarding Off-Label Guideline-Supported Use of Reserpine in adult patients. (wikidoc.org)
  • There is limited information regarding Off-Label Non-Guideline-Supported Use of Reserpine in adult patients. (wikidoc.org)
  • reserpine increases toxicity of deutetrabenazine by pharmacodynamic synergism. (medscape.com)
  • The net depletion of these substances creates the calming and relaxing effects of RESERPINE INJECTION. (kihorsemed.com)
  • Reserpine has also been used for relief of psychotic symptoms. (wikipedia.org)
  • Reserpine controls high blood pressure or symptoms of agitation, but does not cure them. (safemedication.com)
  • The symptoms reserpine caused in the laboratory animals were reminiscent of symptoms experienced by patients suffering from Parkinson's disease. (lu.se)
  • Do not take medicines that contain reserpine with AUSTEDO XR or AUSTEDO. (nih.gov)
  • The antihypertensive actions of reserpine are largely due to its antinoradrenergic effects, which are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. (wikipedia.org)
  • If you suddenly stop taking reserpine you may develop high blood pressure and experience unwanted side effects. (safemedication.com)
  • Potential advantages for hydroflumethiazide and reserpine combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects. (syrianclinic.com)
  • The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. (unifesp.br)
  • It has been suggested that reserpine-induced oral dyskinesia in rats may provide a new animal model of tardive dyskinesia. (unifesp.br)
  • Reserpine, a catecholaminergic blocking agent, reduces the pituitary and serum activities of angiotensin-converting enzyme and activates soluble carboxypeptidase H in the pituitary and striatum and membrane-bound carboxypeptidase in the hypothalamus and striatum. (msk.ru)
  • Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. (immunoportal.com)
  • INDICATION: RESERPINE INJECTION is particularly indicated where a prolonged effect to reduce anxiety and/or to calm horses is required, especially in the handling and management of dangerously anxious horses. (kihorsemed.com)
  • RESERPINE INJECTION is useful as an aid when unfamiliar surroundings and/or unaccustomed stress create anxiety in horses and also as a calming agent to aid in the training and education of stressed young horses. (kihorsemed.com)
  • RESERPINE INJECTION is indicated in any situation where stress or anxiety in horses is difficult to manage. (kihorsemed.com)
  • Moreover, reserpine was included as a secondary antihypertensive option for patients who did not achieve blood pressure lowering targets in the ALLHAT study. (wikipedia.org)
  • Les étudiants en année de doctorat affectés dans le service de médecine interne étaient responsables de la gestion quotidienne du CTE sous la supervision des spécialistes en médecine interne Ce service était subdivisé en deux parties: le CTE qui prenait en charge les cas de Covid -19 et le reste du service qui devait continuer à accueillir les patients atteints d'autres affections ou qui y étaient régulièrement suivies. (bvsalud.org)
  • Conclusion: La mise en place du CTE au niveau du service de Médecine interne , a permis une adaptation efficiente dans la prise en charge des patients concernés mais aussi de ceux qui étaient suivis pour des pathologies chroniques comme les urgences médicales reçues durant la période. (bvsalud.org)
  • Effect of reserpine (RSP) on LCA10 patient retinal organoids. (elifesciences.org)
  • Gengin M.T., Vernigora A.N., Nikishin N.N., Makeeva N.V. (1995) Effect of captopril and reserpine on the activity of certain neuropeptide metabolism enzymes. (msk.ru)
  • The effect of reserpine on the conditioned emotional response in the guinea pig. (bvsalud.org)
  • Pretreatment with reserpine (1 and 5 mg/kg SC), alpha-MPT (100 and 300 mg/kg IP) and reserpine (1 mg/kg) plus alpha-MPT (100 mg/kg) was able to significantly reduce BRC-induced yawning. (baillement.com)
  • RESERPINE INJECTION (Compare to the active ingredients of Nature Vet Rakelin®) is a long-acting non-sedating injectable calmative agent. (kihorsemed.com)
  • D ) Chemical structure depiction of the selected lead compound reserpine. (elifesciences.org)
  • Stallions which have been treated with RESERPINE INJECTION (Compare to the active ingredients of Nature Vet Rakelin®) should not be used to service mares for at least fourteen days following injection. (kihorsemed.com)
  • Brodie observed that when reserpine was injected, animals became completely immobile. (medscape.com)
  • Adrenalectomized animals (40%, n = 5) developed haemorrhagic lesions as compared to 100% (n = 5) in animals treated with reserpine. (internationalscholarsjournals.com)
  • Adrenalectomy or propranolol did not protect the animals against the reserpine induced injury. (internationalscholarsjournals.com)
  • When he gave reserpine to laboratory animals, they lost their capacity for spontaneous movement. (lu.se)
  • Reserpine incubated at 37degrees C with platelet-enriched plasma caused the release of 5-hydroxytryptamine from the platelets. (erowid.org)
  • WARNING: RESERPINE INJECTION may produce penile relaxation. (kihorsemed.com)