• The PREOPANC-2 trial investigates whether neoadjuvant FOLFIRINOX improves OS compared with neoadjuvant gemcitabine-based chemoradiotherapy and adjuvant gemcitabine in resectable and borderline resectable pancreatic cancer patients. (nih.gov)
  • This nationwide multicenter phase III randomized controlled trial includes patients with pathologically confirmed resectable and borderline resectable pancreatic cancer with a WHO performance score of 0 or 1. (nih.gov)
  • borderline resectable pancreatic cancer is defined as ≤90 degrees arterial and ≤ 270 degrees venous involvement without occlusion. (nih.gov)
  • The PREOPANC-2 trial directly compares two neoadjuvant regimens for patients with resectable and borderline resectable pancreatic cancer. (nih.gov)
  • Our study will provide evidence on the neoadjuvant treatment of choice for patients with resectable and borderline resectable pancreatic cancer. (nih.gov)
  • Results of a phase II study on the use of neoadjuvant chemotherapy (FOLFIRINOX or GEM/nab-PTX) for borderline-resectable pancreatic cancer (NUPAT-01). (springermedizin.at)
  • Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis. (springermedizin.at)
  • Comprehensive multimodal management of borderline resectable pancreatic cancer: Current status and progress. (bvsalud.org)
  • Borderline resectable pancreatic cancer (BRPC) is a complex clinical entity with specific biological features. (bvsalud.org)
  • The rationale for neoadjuvant chemoradiation therapy (Neo-CRT) and the definition of borderline resectable pancreatic cancer (BRPC) are still controversial. (elsevierpure.com)
  • On October 16, 2023, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) with platinum-containing chemotherapy as neoadjuvant treatment, and with continuation of single-agent pembrolizumab as post-surgical adjuvant treatment for resectable (tumors ≥4 cm or node positive) non-small cell lung cancer (NSCLC). (fda.gov)
  • Efficacy was evaluated in KEYNOTE-671 (NCT03425643), a multicenter, randomized, double-blind, placebo-controlled trial in 797 patients with previously untreated and resectable Stage II, IIIA, or IIIB (N2) NSCLC by AJCC 8th edition. (fda.gov)
  • As reported in The New England Journal of Medicine by John V. Heymach, MD, PhD , and colleagues, the phase III AEGEAN trial has shown that perioperative durvalumab improved event-free survival and pathologic complete response (pCR) rate in patients with resectable non-small cell lung cancer (NSCLC). (ascopost.com)
  • The investigators concluded, "In patients with resectable NSCLC, perioperative durvalumab plus neoadjuvant chemotherapy was associated with significantly greater event-free survival and pCR than neoadjuvant chemotherapy alone, with a safety profile that was consistent with the individual agents. (ascopost.com)
  • To improve knowledge of current standards and future candidates of perioperative therapy to promote better outcome in patients with resectable NSCLC. (iaslc.org)
  • OPDIVO ® (nivolumab), in combination with platinum-doublet chemotherapy, is indicated as neoadjuvant treatment of adult patients with resectable (tumors ≥4 cm or node positive) non-small cell lung cancer (NSCLC). (opdivohcp.com)
  • Discussant Valerie W. Rusch, MD, FACS, of Memorial Sloan Kettering Cancer Center, said the study results inform the future management of patients with NSCLC and definitely establishes the standard of care for early-stage resectable NSCLC. (ilcn.org)
  • Patients with resectable stage I-IIIB NSCLC who underwent thoracic surgery from January 1, 2009, to December 31, 2018, from the Taiwan Cancer Registry were included. (appliedradiationoncology.com)
  • From the abstract: 'Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). (cdc.gov)
  • Background: The aim of this study was to assess the implications of positive peritoneal washing cytology for management of patients with potentially resectable pancreatic cancer. (elsevierpure.com)
  • Methods: The study population consisted of patients with potentially resectable pancreatic cancer treated on a phase II trial of neoadjuvant chemotherapy and chemoradiation. (psu.edu)
  • Discussion: These data suggest that body composition analysis of standard CT images may provide clinically relevant information for patients with potentially resectable pancreatic cancer who receive neoadjuvant therapy. (psu.edu)
  • Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. (biomedcentral.com)
  • Arrington AK, Nelson R, Patel SS, Luu C, Ko M, Garcia-Aguilar J, Kim J. Timing of chemotherapy and survival in patients with resectable gastric adenocarcinoma. (wjgnet.com)
  • oxaliplatin, irinotecan, leucovorin, fluorouracil) vs mFOLFIRINOX plus hypofractionated radiotherapy in patients with borderline resectable pancreatic ductal adenocarcinoma. (ascopost.com)
  • As stated by the investigators, "National guidelines endorse treatment with neoadjuvant therapy for borderline resectable pancreatic ductal adenocarcinoma, but the optimal strategy remains unclear. (ascopost.com)
  • A randomised phase II study evaluated the clinical efficacy of the combination of trastuzumab and pertuzumab with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT regimen) as perioperative treatment for patients with resectable, locally-advanced HER2-positive oesophagogastric adenocarcinoma. (ogkologos.com)
  • Findings from the randomised phase III studies in the first-line metastatic setting of HER2-positive breast cancer and in adjuvant treatment for patients with lymph node positive HER2-positive early breast cancer provide a strong rationale to evaluate the efficacy and safety of trastuzumab and pertuzumab in combination with FLOT in the perioperative setting in patients with resectable, HER2-positive oesophagogastric adenocarcinoma. (ogkologos.com)
  • In PETRARCA, the multicentre, randomised phase II/III study, patients with HER2-positive, resectable oesophagogastric adenocarcinoma were assigned to 4 pre- and post-operative cycles of either FLOT alone (arm A) or combined with trastuzumab and pertuzumab, followed by 9 cycles of trastuzumab/pertuzumab (arm B). The study primary endpoint for the phase II part was the pCR rate. (ogkologos.com)
  • Background: The impact of neoadjuvant stereotactic body radiation therapy on postoperative complications for patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma remains unclear. (johnshopkins.edu)
  • A retrospective study was performed to determine if perioperative complications were different among patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma receiving neoadjuvant stereotactic body radiation therapy or chemoradiation therapy. (johnshopkins.edu)
  • Methods: Patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma who underwent neoadjuvant chemotherapy with stereotactic body radiation therapy or chemoradiation therapy followed by pancreatectomy at the Johns Hopkins Hospital between 2008 and 2015 were included. (johnshopkins.edu)
  • Results: A total of 168 patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma underwent neoadjuvant chemotherapy and RT followed by pancreatectomy. (johnshopkins.edu)
  • Conclusion: Compared with chemoradiation therapy, neoadjuvant stereotactic body radiation therapy appears to offer equivalent rates of perioperative complications in patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma despite a greater percentage of locally advanced disease and more complex operative treatment. (johnshopkins.edu)
  • METHODS: Eighty-four patients with resectable esophageal adenocarcinoma, who completed the planned preoperative chemoradiation and underwent a potentially curative esophageal resection were retrospectively evaluated. (who.int)
  • In this article, we review the data surrounding the use of chemotherapy (CT) and chemoradiotherapy (CRT) in patients with resectable pancreatic cancer. (cancernetwork.com)
  • In this report, the FPR was evaluated in patients with resectable pancreatic cancer. (tokushima-u.ac.jp)
  • One of the take-home questions, if not clear messages, is that these patients in the upper register of what we would consider maybe resectable are now increasingly being considered, if not strongly favored, to go on neoadjuvant approaches with chemoimmunotherapy. (medscape.com)
  • The important point is that in all of these studies, patients were defined to be resectable up front. (medscape.com)
  • There's a real risk in extending these trial data to the borderline-resectable patients who really weren't the topic of study here in these trials. (medscape.com)
  • The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. (cancernetwork.com)
  • Further therapeutic advances and prospective trials are needed to better define the optimal role of adjuvant and neoadjuvant treatment in patients with resectable pancreatic cancer. (cancernetwork.com)
  • Many agents are expected to be introduced into the perioperative treatment of resectable Stage IB to Stage III, but the balance of efficacy and adverse events varies for each subset of patients. (iaslc.org)
  • The FFCD 9102 trial randomized 444 patients with resectable esophageal cancer (majority squamous histology) to induction CRT consisting of either 46 Gy in 23 fractions with concurrent cisplatin and 5-FU or split course 30 Gy in 10 fractions RT given over 4 weeks (5 days on, 10 days off, 5 days on). (appliedradiationoncology.com)
  • The records of 217 patients with proven non-resectable gastric cancer were studied at Yonsei University Hospital over the 4 years period from January 1990, to December 1993 to clarify Quality of life of gastric cancer patients who could not be resected. (e-crt.org)
  • In conclusion, we could confirm the bad limited survival and quality of life of non-resectable gastric cancer patients. (e-crt.org)
  • We suggest a new therapeutic approach to improve the survival and QOL of non-resectable gastric cancer patients. (e-crt.org)
  • 5 According to a meta-analysis review of clinical trials examining the use of neoadjuvant FOLFIRINOX therapy for patients with pancreatic cancer, an estimated 68% of patients with borderline resectable disease will successfully undergo resection after 4 to 9 cycles of neoadjuvant FOLFIRINOX, with each cycle administered every 14 days. (jhoponline.com)
  • Neoadjuvant chemotherapy followed by chemoradiation and surgery with and without cetuximab in patients with resectable esophageal cancer: a randomized, open-label, phase III trial (SAKK 75/08). (agmt.at)
  • Conclusions : The FPR might be a prognostic factor for patients with resectable pancreatic cancer. (tokushima-u.ac.jp)
  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
  • Neoadjuvant or adjuvant therapy for resectable gastric cancer. (blogspot.com)
  • Earle CC, Maroun J, Zuraw L. Neoadjuvant or adjuvant therapy for resectable gastric cancer [full report]. (blogspot.com)
  • The fibrinogen-platelet ratio (FPR) was reported as a prognostic factor of resectable gastric cancer. (tokushima-u.ac.jp)
  • T4b tumors involving pericardium, pleura, diaphragm are also potentially resectable. (medscape.com)
  • Pancreatic tumors that are considered to be borderline resectable may warrant neoadjuvant therapy to shrink the tumor for surgical intervention, with the goal of cure. (jhoponline.com)
  • Potentially, some of these are not de novo upfront great resection candidates, but something we might consider as "aspirationally resectable," like if they have a good response - they're not great now but maybe they'll be better. (medscape.com)
  • Short-course neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer: A multicenter randomized phase-II trial (NORPACT-1). (springermedizin.at)
  • The study investigates the effect of neoadjuvant chemoradiation in locally resectable or probably resectable cancer of the pancreatic head without distant metastasis on median overall survival time compared to primary surgery. (biomedcentral.com)
  • Stage I, II, and III esophageal cancers are all potentially resectable. (medscape.com)
  • What are your thoughts about the implications of this in terms of what we consider to be resectable disease now? (medscape.com)
  • We focus in particular on primary resectable as well as advanced or metastatic disease. (springermedizin.at)
  • The authors detailed the treatment this patient received at their institution, noting that the tumor was evaluated as potentially resectable N2, and he was a candidate to receive systemic neoadjuvant chemotherapy, which is currently ongoing (as of June 2022). (medpagetoday.com)
  • It speaks to the challenge we've had for a long time of defining what it means to be resectable in stage III lung cancer, which varies from surgeon to surgeon and from center to center. (medscape.com)
  • Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. (sci-hub.se)
  • The management of resectable rectal cancer continues to be guided by clinical trials and advances in technique. (biomedcentral.com)
  • It's very tempting to extend these data to the borderline resectable or the unresectable, hoping to convert. (medscape.com)
  • Background: Non-randomized studies have investigated multi-agent gemcitabinebased neo-adjuvant therapies (GEM-NAT) in borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC). (eur.nl)
  • A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer. (nih.gov)
  • Can a CT-based nomogram predict recurrence in resectable pancreatic body and tail adenocarcinoma? (qxmd.com)
  • Borderline resectable pancreatic cancer (BRPC) is a new diagnosis that blurs the line between resectable and locally progressed pancreatic cancer. (cancerworld.info)
  • In general, pancreatic cancer that is borderline resectable is neither clearly resectable nor definitely unresectable, but rather suggests a higher risk of incomplete resection in the case of early surgery. (cancerworld.info)
  • Numerous associations offer definitions for borderline resectable pancreatic cancer, however, there is currently no commonly accepted classification. (cancerworld.info)
  • Sometimes, doctors state that pancreatic cancer is "borderline resectable. (cancerworld.info)
  • Approximately 15 to 20% of pancreatic cancers are resectable. (cancerworld.info)
  • Patients who initially appear with resectable tumors get a better chance of surviving for a longer period if they get multimodal treatment for their pancreatic cancer. (cancerworld.info)
  • Comprehensive multimodal management of borderline resectable pancreatic cancer: Current status and progress. (bvsalud.org)
  • Borderline resectable pancreatic cancer (BRPC) is a complex clinical entity with specific biological features. (bvsalud.org)
  • Very interesting study which gives more support for preoperatory therapy in the setting of borderline resectable pancreatic cancer. (fcshemoncreview.com)
  • The benefit of neoadjuvant chemoradiotherapy in resectable and borderline resectable pancreatic cancer remains controversial. (fcshemoncreview.com)
  • In this multicenter, phase III trial, patients with resectable and borderline resectable pancreatic cancer were randomly assigned (1:1) to neoadjuvant chemoradiotherapy or upfront surgery in 16 Dutch centers. (fcshemoncreview.com)
  • The effect of neoadjuvant chemoradiotherapy was consistent across the prespecified subgroups, including resectable and borderline resectable pancreatic cancer. (fcshemoncreview.com)
  • Neoadjuvant gemcitabine-based chemoradiotherapy followed by surgery and adjuvant gemcitabine improves OS compared with upfront surgery and adjuvant gemcitabine in resectable and borderline resectable pancreatic cancer. (fcshemoncreview.com)
  • The effectiveness of neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer (BRPC) remains debated. (wustl.edu)
  • There are no reliable biomarkers to guide treatment for patients with borderline resectable pancreatic cancer (BRPC) in the neoadjuvant setting. (e-crt.org)
  • Detection of DDR gene mutations from plasma ctDNA at baseline was associated with better survival outcomes of patients with borderline resectable pancreatic ductal adenocarcinoma treated with neoadjuvant mFOLFIRINOX and may be a prognostic biomarker. (e-crt.org)
  • For patients with borderline resectable pancreatic cancer (BRPC), neoadjuvant therapy followed by surgical resection is the standard treatment [ 4 ]. (e-crt.org)
  • METHODS: Patients with resectable pancreatic adenocarcinoma of the body or tail treated with either upfront pancreatectomy or NAC followed by surgery were identified in the 2006-2014 National Cancer Database. (providence.org)
  • Patients must have stage III or IV pancreatic cancer (Cohort 1) or locally advanced pancreas cancer (LAPC), either borderline resectable pancreas cancer or locally advanced, unresectable pancreas cancer (Cohorts 2 and 3). (nih.gov)
  • Background Neoadjuvant PD-1 blockade produces major pathological responses (MPR) in ~30% of patients (pts) with high-risk resectable melanoma (MEL) with durable relapse-free benefit, and increased circulating activated CD8+ T cells. (bmj.com)
  • 14. Intensive preoperative chemotherapy with colony-stimulating factor for resectable adenocarcinoma of the esophagus or gastroesophageal junction. (nih.gov)
  • Health Canada approved nivolumab in combination with platinum-doublet chemotherapy for the neoadjuvant treatment of patients with resectable non-small cell lung cancer prior to surgery. (cancernetwork.com)
  • Nivolumab (Opdivo) plus platinum-doublet chemotherapy has been approved by Health Canada for the treatment of certain patients with resectable non-small cell lung cancer, according to Bristol Meyers Squibb. (cancernetwork.com)
  • The approval of nivolumab plus platinum-doublet chemotherapy in the neoadjuvant setting represents a pivotal transformation in the way we can help patients with resectable non-small cell lung cancer," Jonathan D. Spicer, MD, PhD, associate professor of surgery in the Department of Surgery (Thoracic and Upper GI Surgery) at McGill University, said in an interview. (cancernetwork.com)
  • Health Canada approves Opdivo (nivolumab) with chemotherapy as neoadjuvant treatment for adult patients with resectable non-small cell lung cancer. (cancernetwork.com)
  • A retrospective comparative study included patients with newly diagnosed and operated resectable RC. (karger.com)
  • The third question they asked me was, for stage III patients who are resectable and potential candidates for either surgical resection or definitive concurrent chemotherapy and radiation, like in the durvalumab trial , how do you choose among them? (medscape.com)
  • Objectives: To evaluate the safety and efficiency of the conversion therapy : chemotherapy plus anti-epidermal growth factor Receptor (EGFR) or anti-vascular endothelial growth factor receptor (VEGFR) monoclonal antibodies (MoAbs) with different rat sarcoma (RAS) status in patients with potentially resectable colorectal liver metastases (CRLM). (oncotarget.com)
  • Conclusion: We noted that the addition of MoAbs (anti-EGFR or anti-VEGFR) to standard chemotherapy could improve conversion efficiency for patients with potentially resectable CRLM patients, and anti-EGFR therapies maybe more effective than anti-VEGFR therapies. (oncotarget.com)
  • Bristol Myers Squibb Receives Positive CHMP Opinion Recommending Approval for Opdivo (nivolumab) with Chemotherapy as Neoadjuvant Treatment of Resectable Non-Small Cell Lung Cancer at High Risk of Recurrence in Patients with Tumor Cell PD-L1 Expre. (wapakdailynews.com)
  • CheckMate -816 is a Phase 3 randomized, open label, multi-center trial evaluating Opdivo with chemotherapy compared to chemotherapy alone as neoadjuvant treatment in patients with resectable stage IB to IIIA non-small cell lung cancer (per the 7th edition American Joint Committee on Cancer/Union for International Cancer Control staging criteria). (wapakdailynews.com)
  • PURPOSE: This randomized phase III trial is studying radiation therapy and either capecitabine or fluorouracil with or without oxaliplatin and comparing them to see how well they work when given before surgery in treating patients with resectable rectal cancer. (stanford.edu)
  • The resectability criteria suggested by the National Comprehensive Cancer Network (NCCN) are widely accepted, and only a few patients are diagnosed with initially resectable disease and may undergo upfront surgery [ 3 , 4 ]. (e-crt.org)
  • TFPI/TNC-FN III-C migration signature adds statistically significantly to CA 19-9's predictive power to detect early-stage PDAC and may have clinical utility for early detection of surgically resectable PDAC, as well as for enhanced survival from this routinely lethal cancer. (nih.gov)
  • Detection and localization of surgically resectable cancers with a multi-analyte blood test. (nih.gov)
  • Stage I, II, and III esophageal cancers are all potentially resectable. (medscape.com)
  • The international EORTC survey showed there is no consensus, although respondents were more likely to consider some stage III TNM combinations to be potentially resectable. (ascopost.com)
  • Conclusion We present an analysis of a large multi-center series of the role of neo-adjuvant chemotherapy in resectable CLM and demonstrate no survival advantage in this setting. (eur.nl)
  • These cases are a major challenge because surgery is often something to consider, because they often grow locally more than speading to the rest of the body, but surgery can be a special challenge because the vertebrae are generally not considered to be resectable. (cancergrace.org)
  • Resectable Distal Pancreas Cancer: Time to Reconsider the Role of Upfront Surgery. (providence.org)
  • Tend to be resectable (removable with surgery). (ohsu.edu)
  • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. (nih.gov)
  • Resectable Distal Pancreas Cancer: Time to Reconsider the Role of Upfr" by Daniel W Nelson, Shu-Ching Chang et al. (providence.org)
  • Background and objectives The use of neo-adjuvant chemotherapy in resectable synchronous liver metastasis is ill defined. (eur.nl)
  • In stage I-IIIA, the treatment of choice is complete resection, if resectable. (e-trd.org)
  • Further study of this combination in high-risk resectable MEL is planned. (bmj.com)