Researchers stem cells can differentiate. Medical search. Frequent questions

Once an embryonic stem cell begins to differentiate into an NPC, Tet3 becomes upregulated. (wikipedia.org)
While Tet3 is not important for the commitment of an embryonic stem cell to turn into an NPC, it is important for maintaining the cell as an NPC and eventually turning it into a mature neuron. (wikipedia.org)
Gene therapy and monoclonal antibodies didn't arrive with even a fraction of the hype surrounding embryonic stem cell research. (latimes.com)
Finding that a Polycomb target in an embryonic stem cell is 12 times more likely to become abnormally methylated in cancer is highly significant," says Peter Laird, Ph.D., one of the lead researchers and associate professor of surgery, biochemistry and molecular biology, and director of basic research for surgery at the Keck School of Medicine of USC. (sciencedaily.com)
The relatively few embryonic-stem-cell lines in existence have been well characterized by many scientists. (technologyreview.com)
Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. (hopkinsmedicine.org)
Without large T, cells form embryonic stem cell-like clusters in three to four weeks. (hopkinsmedicine.org)
Embryonic stem cell-like clusters were visible 14 days after they initiated reprogramming and from these clusters the researchers established three different cell lines that both look and behave like human embryonic stem cells. (hopkinsmedicine.org)
In my opinion there is no question but that the scientific information on stem cell research included in this science text book being used in Illinois schools incorporates some inaccurate scientific facts, and seems to be very partial to the use of human embryonic "stem cell" research. (lifeissues.net)
DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible. (sbir.gov)
Prof. Parmar and colleagues showed that following transplantation, the embryonic stem cell-derived dopaminergic neurons exhibited the functional characteristics of native dopaminergic neurons, including dopamine production as well as long distance extension and connection with target regions in the brain. (medgadget.com)

Fabricated by 3D laser lithography, the microrobots' porous structure facilitates the attachment, proliferation and differentiation of various stem cells. (physicsworld.com)
Fluorescent microscopy images of neural stem cells and their differentiation into astrocytes, oligodendrocytes and neurons on a lab dish, a helical microrobot and a spherical microrobot. (physicsworld.com)
Vascularization or vasculogenesis is defined as the differentiation of epithelial progenitor cells (EPCs) into mature epithelial cells to enable the formation of new blood vessels. (naturalnews.com)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)
C3H/10T1/2 is a clonal mouse embryo line used in the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. (naturalnews.com)
Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
Therefore, researchers have begun exploring combined therapies with biomaterials that promote cell growth and differentiation while localizing cells in the injured area. (karger.com)
This article reviews recent advancements in biomaterial strategies for the differentiation of neural stem cells into oligodendrocytes, and presents new data indicating appropriate properties for oligodendrocyte precursor cell growth. (karger.com)
Aizawa, Y., N.D. Leipzig, T. Zahira, M.S. Shoichet (2008) The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels. (karger.com)
The new technique targets the cytoskeleton - or inner "scaffolding" - of the hPSC to direct their differentiation into pancreatic cells. (medicalnewstoday.com)
This approach alters the grafts' response in the injury environment and confers enhanced neuronal differentiation capacity, survival, and integration, as well as reduced glial scar formation to provide a more effective stem cell therapy for severe traumatic SCI. (genengnews.com)
In early blood cells, called hematopoietic stem cells, the methylation patterns established by DNA methyltransferase 3 alpha promote maturation (differentiation) into different blood cell types. (medlineplus.gov)
As in cytogenetically normal acute myeloid leukemia (described above), the mutations disrupt the normal pattern of methylation in cells, which blocks differentiation. (medlineplus.gov)
Our research shows that the disease likely starts during the first trimester and involves accelerated cell divisions, excessive migration and premature differentiation of the neuroectodermal cells into neurons," he says. (scienceblog.com)
Aptamers are single-stranded pieces of DNA that bind to target proteins and are able to modulate signaling cascades during cell differentiation when a stem cell commits to a specific functional role or phenotype. (shinshu-u.ac.jp)
The team, led by Associate Professor Tomohide Takaya from the Department of Agricultural and Life Sciences at Shinshu University, recently discovered that an anti-nucleolin aptamer, myogenetic oligodeoxynucleotide iSN04, induced myocardial differentiation in embryonic stem cells (ESCs). (shinshu-u.ac.jp)
We had previously found that iSN04 promoted myogenic precursor cells (myoblasts) to differentiate into skeletal muscle cells and had hypothesized that the aptamer also enhanced differentiation of pluripotent stem cells. (shinshu-u.ac.jp)
Second, it results in the modulation of the Wnt signaling pathway that governs cell differentiation. (shinshu-u.ac.jp)
Ultimately, terminal cell differentiation commits to the cardiomyocyte lineage. (shinshu-u.ac.jp)
For this reason, our group has recently described and patented a method to obtain cardiac stem cells (CSCs) from small biopsies of myocardium and grow them through several generations in the laboratory without losing differentiation potential. (derstandard.at)
The researchers were able to use differentiation to treat an especially aggressive type of carcinoma called triple negative breast cancer. (unibas.ch)
A receptor of the same name plays a vital role, controlling the speed at which the cells multiply and monitoring the cell differentiation process. (uni-heidelberg.de)
Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
We now recognize that tumor suppressor genes regulate diverse cellular activities, including cell cycle checkpoint responses, detection and repair of DNA damage, protein ubiquitination and degradation, mitogenic signaling, cell specification, differentiation and migration, and tumor angiogenesis. (scienceopen.com)
For example, in the future, if you want to replace a failing liver, you could put the cells in a scaffold or microenvironment that strongly promotes liver cell differentiation and place the cell-seeded scaffold into the liver to let them differentiate in the optimal macroenvironment. (stanford.edu)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)
Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)

These cells are the progenitors of mature neurons and begin to develop shortly after a zygote is formed. (wikipedia.org)
The complete absence or knockout of Tet3 in mouse cells leads to increased apoptosis of neurons, demonstrating how important the gene is to neuronal development. (wikipedia.org)
Here, the stem cells are shown expressing various markers and differentiating into neurons. (livescience.com)
Reprogrammed cells could then develop into a multitude of cell types, including the neurons found in the brain and spinal cord. (livescience.com)
Scanning electron microscopy images of the microrobots (grey) and differentiated neurons (orange). (physicsworld.com)
Immunofluorescence staining showed that, after 72 hours, NSCs on the microrobots differentiated into astrocytes, oligodendrocytes and neurons. (physicsworld.com)
Scanning electron microscopy revealed that the differentiated neurons became attached to and entangled with the microrobot scaffolds. (physicsworld.com)
Such imaging is vital for mapping the brain and requires differentiating between the brain's cell types, including neurons, microglia, oligodendrocytes, and astrocytes. (acs.org)
Diminished myelin levels lead to further cell death in which unmyelinated neurons die. (karger.com)
The researchers showed that human pluripotent stem cell (hPSC)-derived neural stem cells engineered with reduced expression of a gene called SOX9 differentiate preferentially into spinal motor neurons. (genengnews.com)
When transplanted into a rat model of spinal cord injury (SCI) these neural stem cells generated mature neuronal subtypes, were able to integrate and grow axons that projected over long distances and connected with the recipient's neurons. (genengnews.com)
Spinal neurons around the scar cannot be restored due to the low intrinsic regenerative ability of undamaged neurons and the lack of neural stem cells in the adult spinal cord. (genengnews.com)
Transplantation of human NSCs (hNSCs) derived from human pluripotent stem cells at the SCI sites has been considered a promising therapeutic strategy to compensate for the loss of spinal neurons, and could feasibly enable their connectivity with host neurons, leading to spinal cord recovery. (genengnews.com)
They found that certain kinds of neural progenitor cells (which later become neurons) were abnormally distributed in the cortex of the mini-brains developed from patients. (scienceblog.com)
Researchers started at the molecular level, examining a system called store-operated calcium entry, which transports calcium into neurons to control processes important for growth and activity. (uoguelph.ca)
They then took a step back to examine the function and behaviour of neural progenitor cells, finding that these neurons replicate slower, but migrate more and have longer neurites - the connections between neurons - than those from healthy individuals. (uoguelph.ca)
Since studying brain cells in a dish can't show researchers how these neurons might organize themselves should they be allowed to grow in three dimensions, researchers turned to a newer research tool. (uoguelph.ca)
Thanks to the organoids, which mimic the early stages of brain development, researchers were able to see that the areas on the organoid where immature neurons differentiate and migrate were smaller and thinner than those made using stem cells from healthy individuals. (uoguelph.ca)
These include neurons and glial cells, which are known to be important for cell repair and cell replacement in different brain regions. (medica-tradefair.com)
In the brain of adult mammals neural stem cells ensure that new nerve cells, i.e. neurons, are constantly formed. (uni-heidelberg.de)
This new type of stem cell, and not the one previously known, is primarily involved in the production of new neurons in the olfactory bulb of adult mice. (uni-heidelberg.de)
They were once believed to form the precursor cells that then differentiate in the olfactory bulb of mice into interneurons, nerve cells that modulate stimuli transmission between interconnecting neurons. (uni-heidelberg.de)
At first, we thought that they could be astrocytes, helper cells that ensure that the neurons are able to do their work. (uni-heidelberg.de)
The researchers determined that the basal - and not the apical - stem cells are responsible for the formation of neurons in the olfactory bulb. (uni-heidelberg.de)
To prove this, they separately labelled both cell populations and then observed whether labelled neurons turned up in the olfactory bulb. (uni-heidelberg.de)
When only apical stem cells were labelled, no new labelled neurons could be detected in the olfactory bulb. (uni-heidelberg.de)
Researchers from Lund University in Sweden have published an article in Cell Stem Cell describing the generation of functional dopaminergic neurons from human embryonic stem cells. (medgadget.com)
Led by Prof. Malin Parmar, the team differentiated dopaminergic neurons from human embryonic stem cells in culture, then transplanted them into the brains of rats that were modeled to exhibit the symptoms of Parkinson's. (medgadget.com)
Unlike fetal stem cells, which have been previously used to create dopaminergic neurons, embryonic stem cells (from existing stem cell lines) offer an abundant, readily accessible supply of cells. (medgadget.com)
A research team led by Eri Hashino, Ph.D., Ruth C. Holton Professor of Otolaryngology at Indiana University School of Medicine, reported that by using a three-dimensional cell culture method, they were able to coax stem cells to develop into inner-ear sensory epithelia - containing hair cells, supporting cells and neurons - that detect sound, head movements and gravity. (iu.edu)
Moreover, neurons like those that normally link the inner-ear cells to the brain had also developed in the cell culture and were connected to the hair cells. (iu.edu)
for example, we study how immune system cells decide to mature or how skin cells can be directly reprogrammed into neurons or stem cells. (lu.se)

Cadavers can provide brain, heart and other tissues for study that researchers cannot safely obtain from living people. (livescience.com)
Studying how induced pluripotent stem cells develop into various tissues could also shed light on disorders that are due to malfunctions in development. (livescience.com)
These stem cells come from developed organs and tissues in the body. (healthline.com)
June 30, 2022 Researchers have created artificial Hox genes -- which plan and direct where cells go to develop tissues or organs -- using new synthetic DNA technology and genomic engineering in stem cells. (sciencedaily.com)
Stem cell therapy is an emerging method for restoring damaged tissues or treating a variety of diseases, from cancer to degenerative neural disorders like Alzheimer's disease. (physicsworld.com)
Together, she and Anderson designed a sealed, self-contained cell incubation system that is mobile and eliminates many of the problems with cultivating tissues in the fragile environment of the petri dish. (al.com)
Cells Tissues Organs (2016) 202 (1-2): 85-101. (karger.com)
In the developing embryo, Stachowiak explains, surface cells develop tissues and organs such as skin and brain structures. (scienceblog.com)
For a few weeks, the researchers fed the stem cells nutrients, glucose, acids and growth factors that enabled the development and formation of so-called embryoid bodies, which contain the first recognizable stage where tissues begin to differentiate. (scienceblog.com)
In adults, stem cells act as a repair system for the body, replenishing specialised cells, and maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues. (derstandard.at)
Through medical research, stem cells can now be grown and transformed into a variety of specialised cells with characteristics consistent with tissues such as muscles or nerves. (derstandard.at)
Several technologies have been described over the past 10 years to create functional heart tissue by using stem cells that have been isolated from other tissues such as bone marrow, skeletal muscle, and umbilical cord blood. (derstandard.at)
These new transplantation systems enhance the viability of cells and stimulate their outward migration so that they can populate and help regenerate injured tissues. (derstandard.at)
Beth Karlan, MD , a specialist in gynecologic oncology and the director of Cancer Population Genetics at UCLA Jonsson Comprehensive Cancer Center , co-led a study in which cancer researchers and stem cell scientists used cells from ovarian cancer patients who had a BRCA1 mutation to create tissues, called organoids, modeling tissues of fallopian tubes. (uclahealth.org)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
This research shows how satellite cells can maintain their populations within injured tissues," said Olwin. (phys.org)
The hydrogel confines the cells and doesn't allow them to communicate as they do in native tissues. (carbomer.com)
Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
Transplanting organs, tissues or cells from one person to another. (mayo.edu)
Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
BACKGROUND: In recent years, researchers discovered that menstrual blood-derived stem cells (MenSCs) have the potential to differentiate into a wide range of tissues including the chondrogenic lineage. (koreamed.org)
The three-dimensional culture allows the cells to self-organize into complex tissues using mechanical cues that are found during embryonic development," Koehler said. (iu.edu)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
We develop and analyse models of biological networks to improve our understanding of how living cells and tissues function. (lu.se)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)

The methylation marks from the parent cells must be removed so that certain genes can be accessed and transcribed for the zygote to mature into a fully grown organism. (wikipedia.org)
The researchers speculate that this occurs in order to demethylate genes associated with neuronal maturation so they can be transcribed. (wikipedia.org)
Epigenetic markers, especially ones that make the DNA more accessible, are important after cell damage because they can turn on genes that function in cell repair. (wikipedia.org)
Researchers at the University of Southern California found genes that are reversibly repressed in embryonic stem cells are over-represented among genes that are permanently silenced in cancers. (sciencedaily.com)
USC researchers uncovered this link after observing that of 177 genes repressed by Polycomb group (PcG) proteins, fully 77 showed evidence of cancer-associated enzymatic modification of DNA (known as methylation). (sciencedaily.com)
Laird and his colleagues discovered that some genes repressed by Polycomb in embryonic stem cells are essentially pre-marked to become permanently silenced by DNA methylation. (sciencedaily.com)
BOSTON - Researchers from the Center for Regenerative Medicine at Boston Medical Center and Boston University School of Medicine used variants of CRISPR to understand the functions of the genes that cause emphysema and chronic obstructive pulmonary disease (COPD). (bmc.org)
This is the first time that CRISPRi and CRISPRa have been applied in human induced pluripotent stem cells to understand the functional role of these genes," says Andrew Wilson, MD, a pulmonologist at Boston Medical Center and associate professor of medicine at Boston University School of Medicine. (bmc.org)
So by understanding how GWAS genes affect type 2 cells, researchers can start to understand how these might contribute to diseases that affect these cells, like emphysema. (bmc.org)
Once type 2 cells were generated, researchers then used CRISPRi to turn off expression of nine different GWAS genes and analyzed them to see how the cells were affected, especially their ability to proliferate, something that they need to be able to do in response to injury like that which occurs in emphysema. (bmc.org)
Researchers noticed that turning off one particular gene, desmoplakin (DSP), caused the cells to increase their proliferation and increased their expression of genes associated with cellular maturation. (bmc.org)
Researchers found that cells in which DSP expression was turned off before smoke exposure turned off expression of cell junction genes to a greater degree than in controls. (bmc.org)
In this study, single-cell RNA-sequencing analyses show that islet1 + -derived ECs express a set of genes that reflects their unique origin even as they become heterogeneous. (go.jp)
I remember it clearly, but I didn't feel the earthquake at the time: a youngish, earnest Japanese researcher named Shinya Yamanaka gave a talk at the annual meeting of the International Society for Stem Cell Research, reporting that he could make mouse skin cells look and act like embryonic stem cells just by adding a few genes. (technologyreview.com)
They were able to produce a cell line that turned off certain genes to generate functional platelets. (ibtimes.com)
They have discovered novel genes that control blood forming stem cells and uncovered new cell populations that produce platelets. (childrenshospital.org)
Using both fetal and adult human skin cells, the researchers introduced the four genes previously reported sufficient for cell reprogramming and compared the efficiency of reprogramming in the presence or absence of large T antigen. (hopkinsmedicine.org)
However, when these pluripotent stem cells were treated after experiencing differentiating conditions for five days, specific marker genes were upregulated, and the cells committed to forming beating cardiomyocytes. (shinshu-u.ac.jp)
By adding three genes, they converted those cells into induced pluripotent stem cells (iPSCs), which have the capability to differentiate into any cell types in the body. (scienceblog.com)
What's more, the process Xu used to create iPSCs involves genetic modification of human cells with genes encoding oncogenic proteins and so needs more refinement. (scienceblog.com)
But the cells can also form tumors if certain genes meant to stop out-of-control growth get turned off. (nbcnews.com)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
The models are mainly based on the interaction between different genes and proteins, for example in stem cells. (lu.se)
By triggering certain genes, researchers may be able to cause the stem cells to specialize and become the cells that need to be replaced. (msdmanuals.com)
One way to induce these cells is to inject them with material that affects their genes, a process called reprogramming. (msdmanuals.com)
The insulin-producing cells that we can make from these patients can then be used to understand the mechanisms by which these risk genes cause dysfunction of beta-cells. (lu.se)
MicroRNA are small molecules that are found in cells of the body and that are able to influence the genes. (lu.se)

This new technique may help researchers avoid the controversies that come with the use of human embryos to produce human embryonic stem cells for research purposes. (sciencedaily.com)
In the laboratory of Prof. Jacob Hanna at the Weizmann Institute of Science , researchers created complete models of human embryos from stem cells cultured in a lab grew them up to day 14. (israel21c.org)
Embryonic stem cells come from human embryos that are three to five days old. (healthline.com)
The following year, both Yamanaka and Rudolf Jaenisch, a well-respected stem-cell researcher from MIT, reported that these induced pluripotent stem cells (known as iPS cells) passed the litmus test for pluripotency, or the ability to differentiate into all types of cells: when mouse iPS cells were injected into mouse embryos, the cells were incorporated into the developing mice. (technologyreview.com)
Like embryonic stem cells, iPS cells can give rise to different types of tissue, but they offer a way to avoid both the ethical and practical hurdles of dealing with human embryos. (technologyreview.com)
A type of undifferentiated stem cell found in embryos. (mayo.edu)
Stem cells can be obtained from the embryos that are not used. (msdmanuals.com)
Because the embryos then lose the ability to grow into a complete human being, the use of stem cells from embryos is controversial. (msdmanuals.com)
Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)

The researchers examined hippocampal neural stem cells (NSCs) grown on the microrobots. (physicsworld.com)
however, stem cell injection alone has been unsuccessful in many areas of neural regeneration. (karger.com)
The regrowth of myelinating oligodendrocytes from neural stem cells through a biomaterials approach may prove to be a beneficial strategy following the onset of demyelination. (karger.com)
Bakshi, A., C.A. Keck, V.S. Koshkin, D.G. LeBold, R. Siman, E.Y. Snyder, T.K. McIntosh (2005) Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. (karger.com)
Bible, E., D.Y. Chau, M.R. Alexander, J. Price, K.M. Shakesheff, M. Modo (2009) The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles. (karger.com)
Researchers at the University of Hong Kong (HKUMed) LKS Faculty of Medicine, and at City University of Hong Kong (CityU) have generated human neural stem cells (hNSCs) that exhibit what they claim is "powerful therapeutic potential" for the treatment of spinal cord injury. (genengnews.com)
The researchers reported on their developments in Advanced Science , in a paper titled, " Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury ," in which they concluded, "Our findings represent a new paradigm in generating genetically modified hNSCs for the treatment of SCI. (genengnews.com)
A research team from HKUMed has generated human neural stem cells with powerful therapeutic potential for the treatment of spinal cord injury that paves the way for new therapeutic opportunities. (genengnews.com)
For this study, U of G researchers from Dr. Jasmin Lalonde 's lab started earlier, analyzing differences in neural progenitor cells, which are early-stage cells that can differentiate themselves into many other types of neural cells. (uoguelph.ca)
They found that this system was dysfunctional in the neural progenitor cells derived from donors with bipolar disorder, compared to those from healthy individuals. (uoguelph.ca)
We believe these cells, called neural progenitor cells, are present in the optic nerve tissue at birth and remain for decades, helping to nourish the nerve fibers that form the optic nerve," said study leader Steven Bernstein, MD, PhD, Professor and Vice Chair of the Department of Ophthalmology and Visual Sciences at the University of Maryland School of Medicine. (medica-tradefair.com)
This is the first time that neural progenitor cells have been discovered in the optic nerve. (medica-tradefair.com)
The presence of neural stem/progenitor cells opens the door to new treatments to repair damage to the optic nerve, which is very exciting news. (medica-tradefair.com)
Eventually the research team found the stem cells could be coaxed into differentiating into several different types of neural cells. (medica-tradefair.com)
Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods of time. (disabled-world.com)
Though the content may have been edited for style, clarity, or length, the article "Spinal Cord Neural Stem Cells Show Diverse Promise for SCI" was originally written by University of California - San Diego, and published by Disabled-World.com on 2018/08/14 (Updated: 2018/08/16). (disabled-world.com)
These neural stem cells are located in the subventricular zone near the lateral cerebral ventricle. (uni-heidelberg.de)
They used genetically modified animals whose neural stem cells were dyed green using a dye active in the cell nucleus. (uni-heidelberg.de)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)
To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. (lu.se)

In this reprogramming technique, somatic cells are converted into induced pluripotent stem cells (iPSCs). (sciencedaily.com)
These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
Researchers devised a system using variants of CRISPR to either turn off expression of a gene of interest using CRISPR interference (CRISPRi) or overexpress a gene of interest using CRISPR activation (CRISPRa) in induced pluripotent stem cells (iPSCs). (bmc.org)
The mini-brain structures were reprogrammed into induced pluripotent stem cells (iPSCs) using skin cells removed from three controls and four patients with schizophrenia as described in earlier publications by the UB researchers and Kristen J. Brennand of the Icahn School of Medicine at Mt. Sinai. (scienceblog.com)
Guiding iPSCs toward a target cell line has garnered much attention, but the process remains challenging. (shinshu-u.ac.jp)
Self-renewal and pluripotency-the capacity to form any cell lineage-are inherent characteristics of induced pluripotent stem cells (iPSCs). (shinshu-u.ac.jp)
Using various assays like RNA sequencing, cell staining and imaging, and molecular interaction and pathway analysis, the researchers investigated iSN04's effect on murine ESCs and iPSCs. (shinshu-u.ac.jp)
The team grew retinal pigment cells from induced pluripotent stem cells (iPSCs) and transplanted them into the damaged retina of a human participant. (neurosciencenews.com)
In order to avoid tissue rejection, they used autologous iPSCs-iPSCs that were created from the recipient's own skin cells. (neurosciencenews.com)
To test whether MHC matching is a viable method, the team used retinal pigment cells that were grown from monkey iPSCs in the iPS cell bank at the Center for iPS Cell Research and Application, Kyoto University. (neurosciencenews.com)
In a separate study published in the same issue of Stem Cell Reports , the researchers saw similar results when they repeated this last experiment with human T cells and HLA-matched or unmatched retinal pigment cells grown from IPSCs. (neurosciencenews.com)
Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells. (scienceblog.com)
In the Xu study, the team's protocol succeeded in turning over 25% of the iPSCs into epithelial stem cells in 18 days. (scienceblog.com)

As such, this work could help lead to novel stem cell therapies and shed light on a variety of mental disorders, such as schizophrenia , autism and bipolar disorder, which may stem from problems with development, researchers say. (livescience.com)
Cells from corpses might play a key role in developing future stem cell therapies . (livescience.com)
It may also give researchers a method of studying disease processes at the cellular level, yielding insights that could contribute to the development of other therapies. (latimes.com)
Publishing online in Stem Cells on May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies. (hopkinsmedicine.org)
Stem cell therapies already exist in medical practice. (derstandard.at)
Understanding the cellular and molecular mechanisms that define cancer and how these mechanisms differ from normal cells is crucial for developing new innovative therapies," says Bentires-Alj. (unibas.ch)
If this work can be replicated using human stem cells, the researchers said, it could be a key step toward the development of stem cell-based therapies that restore sensation in people who have lost feeling in parts of their body due to spinal cord injuries. (ucla.edu)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

He is also interim president of the state's new stem cell agency, the California Institute for Regenerative Research. (latimes.com)
Oct. 10, 2023 Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (sciencedaily.com)
Findings from the USC study also can be applied to stem cell research funded by the California Institute for Regenerative Medicine (CIRM), which was created through passage of California Proposition 71 in 2004. (sciencedaily.com)
By demonstrating the generation of cardiomyocytes from murine pluripotent stem cells, their concept shows promise as a regenerative therapy. (shinshu-u.ac.jp)
Unfortunately, regenerative medicine is not yet feasible outside a laboratory setting as available protocols to generate target cells are complicated and expensive. (shinshu-u.ac.jp)
Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind roadmap detailing how stem cells become sensory interneurons - the cells that enable sensations like touch, pain and itch. (ucla.edu)
From "adult stem cells" to "xenotransplantation," learn about common and specialized regenerative medicine terms. (mayo.edu)
A type of stem cell found in organs of the body that can be used for regenerative interventions. (mayo.edu)
UniStem Day is the largest educational outreach initiative on stem cells and regenerative medicine in Europe. (lu.se)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)

Now scientists have harvested such cells from the scalps and brain linings of human corpses and reprogrammed them into stem cells. (livescience.com)
Now scientists have taken fibroblasts from the scalps and the brain linings of 146 human brain donors and grown induced pluripotent stem cells from them as well. (livescience.com)
This may allow scientists to culture healthy tissue cells in the lab to replace damaged ones in the human body. (latimes.com)
Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
Scientists are hoping that the cells can be made from someone's own skin to treat a disease. (healthline.com)
AMSBIO , a provider of cutting-edge products and services for accelerating stem cell research, has sponsored two aspiring life scientists to attend and present posters at the recent ISSCR 2023 conference in Boston, USA. (onenucleus.com)
For over 20 years - AMSBIO has aimed to help advance stem cell discovery by supplying research scientists with the necessary tools and reagents needed to work more efficiently and obtain reliable results faster. (onenucleus.com)
Chang's goal is a rainbow of probes that would provide researchers with different ways to image a target of choice, even allowing scientists to detect multiple targets at the same time. (acs.org)
Scientists have made human iPS cells from skin and hair follicles, as well as from tissue harvested from people with various ailments. (technologyreview.com)
IPS cells and embryonic stem cells must be compared, directly, by a lot of scientists in a lot of ways before we can think seriously about what cells to use for medical applications. (technologyreview.com)
Reuters) - Scientists have for the first time created blood platelet cells by reprogramming stem cells derived from adult cells, offering the potential for a renewable supply of the fragile blood component. (ibtimes.com)
Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
The problem was that scientists could never reach critical cell density for the heart muscle cells to actually function. (techbriefs.com)
The Heidelberg scientists also found out that both stem cell types and precursor cells in the mouse brain communicate with one another via so-called notch interactions. (uni-heidelberg.de)
While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells. (ucla.edu)
Gupta and Butler also identified unique markers on the cell surface of each of the six subtypes, which will allow scientists to isolate pure populations of these different sensory interneurons, whether derived from stem cells or obtained from the body. (ucla.edu)
INDIANAPOLIS - Indiana University scientists have transformed mouse embryonic stem cells into key structures of the inner ear. (iu.edu)
Bringing together Universities and high school students, UniStem Day is an opportunity to foster learning, discovery and debate in the field of stem cell research - inspiring the scientists of tomorrow. (lu.se)
These and many more questions will be answered by PhD students, postdoctoral fellows, and senior scientists from Lund Stem Cell Center during UniStem Day 2024. (lu.se)
Scientists are developing ways of enabling (inducing) other cells (such as a blood or skin cell) to act as stem cells. (msdmanuals.com)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)

First, it was tested whether patient‑derived ADSCs could differentiate into chondrogenic and osteogenic lineages. (spandidos-publications.com)
C3H/10T1/2 cells can be induced to differentiate into multiple stem cell lineages. (naturalnews.com)
HSPCs are multipotent cells that can self-renew and differentiate to give rise to all blood cell lineages. (go.jp)

An experiment done by several researchers on mice showed that Tet3 is most active in NPC or Neuronal Progenitor Cells. (wikipedia.org)
In response to lesion healing, the scar can prevent inflammation from spreading and causing further damage," the researchers pointed out, but this barrier-like structure also prevents neuronal regeneration. (genengnews.com)
However, using this approach it takes a long time for hNSCs to mature, and there are "less amount of differentiated neuronal subtypes," which limits the degree of functional recovery in SCI models. (genengnews.com)
The researchers were able to confirm the presence of these stem cells by using antibodies and genetically modified animals that identified the specific protein markers on neuronal stem cells. (medica-tradefair.com)
We established a scalable source of human spinal cord NSCs that includes all spinal cord neuronal progenitor cell types," said Kumamaru. (disabled-world.com)
A nerve fiber that transmits signals away from the neuronal cell body and to the next nerve synapse. (mayo.edu)

In other words, dead people can yield living cells that can be converted into any cell or tissue in the body. (livescience.com)
Mature cells can be made or induced to become immature cells, known as pluripotent stem cells , which have the ability to become any tissue in the body and potentially can replace cells destroyed by disease or injury. (livescience.com)
Fibroblasts are the most common cells of connective tissue in animals, and they synthesize the extracellular matrix, the complex scaffolding between cells. (livescience.com)
Embryonic stem cells are intriguing because they can differentiate into any of the specialized tissue cells of the body. (latimes.com)
The MDC researchers found that in contrast to the original cells, the new pluripotent cells derived from mouse connective tissue contained E-cadherin. (sciencedaily.com)
This means they can potentially produce new cells for any organ or tissue. (healthline.com)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
It will allow us, as researchers, to not live in the lab and control our tissue culture conditions, including the sensitive cultures including those like adult stem cells. (al.com)
Finally, the researchers reported that the mRNA levels of endothelial markers - namely, the platelet endothelial adhesive factor-1 (CD31), the endothelial cell-specific molecule-1 (ESM-1), and the vascular von Willebrand factor (vWF) in mouse 4T1 mammary tumor tissue - significantly increased after epimedin C treatment. (naturalnews.com)
They also serve as specialized vascular niches that provide instructive signals to tissue-specific stem cells or parenchymal cells for tissue formation and repair. (go.jp)
A realistic hope of modern medicine is to replace damaged tissue with healthy cells grown in the lab. (neurosciencenews.com)
There are many genetic variations of MHCs, and after transplantation, if the MHCs of the transplanted cells are not recognized by the T cells of the host immune system, there is an immune response and the tissue is rejected. (neurosciencenews.com)
This means that CSCs represent a logical source for cardiac regeneration therapy because, unlike other adult stem cells, they are intrinsically programmed to generate cardiac tissue in the lab and thus increase cardiac tissue viability in humans. (derstandard.at)
After injecting these cells into the hearts of animals with damaged myocardial tissue, my colleagues and I have observed an improvement in physiological functions. (derstandard.at)
So we decided to use these stem cells in association with an artificial, netlike matrix to support formation of functional tissue-like structures that can be used in a new therapeutic approach to repair the heart. (derstandard.at)
Using a hybrid therapy that incorporates tissue engineering, we seeded a biodegradable mesh with cardiac stem cells. (derstandard.at)
The mesh acted as a scaffold on which the stems cells were grown into morphologically recognizable cardiac tissue. (derstandard.at)
We then joined the cardiac tissue built from the mesh scaffold onto the diseased structure of the heart to stimulate the regeneration of the optimal cell types for that particular portion of the heart. (derstandard.at)
Using this technique in animals, the researchers have observed an increase in physiological functions such as the cardiac ejection fraction - a measure of the efficacy of the heart's contraction - and an improvement of cardiac chamber volumes following the placement of these tissue structures on the surface of the animal's damaged hearts. (derstandard.at)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
A University of Colorado at Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice, which could have important implications in the treatment of injured, diseased or aging muscle tissue in humans, including the ravages of muscular dystrophy. (phys.org)
The newly identified stem cells are found within populations of satellite cells located between muscle fibers and the surrounding connective tissue that are responsible for the repair and maintenance of skeletal muscles, said Professor Bradley Olwin of CU-Boulder's molecular, cellular and developmental biology department. (phys.org)
The stem cell population identified by the CU team within the satellite cells -- dubbed "satellite-SP" cells -- were shown to renew the satellite cell population after injection into injured muscle cells, contributing to recovery of muscle tissue in the laboratory mice. (phys.org)
In healthy skeletal muscle tissue, the population of satellite cells is constantly maintained, leading the CU-Boulder team to believe that at least some of the satellite cell population in the mouse study included stem cells. (phys.org)
For the study, the researchers injected 2,500 satellite-SP cells into a population of satellite cells within injured mouse muscle tissue. (phys.org)
They found that 75 percent of the satellite cells that reproduced were derived from the previous satellite-SP cells injected into the tissue. (phys.org)
Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. (carbomer.com)
Previous attempts at growing cartilage began with cells embedded in a hydrogel-a substance composed of polymer chains and about 90 percent water-that is used as a scaffold to grow the tissue. (carbomer.com)
The researchers put the patch in nutrient media to allow it to further integrate into a single piece of tissue. (carbomer.com)
Once we identify the key proteins and signals coaching the tissue within the body, we can try to mimic them when we use the stem cells," said Longaker. (stanford.edu)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)

Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)

May 20, 2020 In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (sciencedaily.com)
The Japanese researchers set out to create an immortalized cell line with a large number of high-quality megakaryocytes -- precursor cells that develop into platelets -- from stem cells that can be grown indefinitely and differentiate into a variety of cell types in the body. (ibtimes.com)

Researchers from South Korea and Switzerland have developed magnetically actuated microrobots and used them for precise stem cell delivery and transplantation in vitro , ex vivo and in vivo . (physicsworld.com)
Precise delivery of stem cells to the desired target is, however, crucial for the success of transplantation. (physicsworld.com)
They cultured mesenchymal stem cells derived from the human nose on spherical microrobots for transplantation in the mouse, and showed that an externally applied magnetic field could manipulate the cell-loaded microrobots within the animal's hollow abdominal cavity. (physicsworld.com)
These results confirm the feasibility of using microrobots for targeted stem cell transportation and transplantation in various physiological fluidic environments. (physicsworld.com)
Transplantation of monkey iPS-RPE cells into the subretinal space in a control monkey (MHC mismatched) was performed without immunosuppression. (neurosciencenews.com)
B) Transplantation of monkey iPS-RPE cells into the subretinal space in an MHC-matched monkey. (neurosciencenews.com)
Now that we have established the lack of immune response in monkeys and in human cells in vitro," explains Sugita, "using the iPS cell bank appears to be a viable solution, at least in the case of retinal pigment epithelial cell transplantation. (neurosciencenews.com)
The clinical data after the transplantation will allow us to see if the iPS cell bank is truly useful or not. (neurosciencenews.com)
But we realized that cell transplantation may not always be suitable for catastrophic events, such as a heart attack in which there is major myocardial damage. (derstandard.at)
Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)
But researchers think that these stem cells have the most potential for producing different kinds of cells and for surviving after transplantation. (msdmanuals.com)
These stem cells are most often used for transplantation. (msdmanuals.com)

For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)
In this study, we developed the disc-type bio-cartilage reconstruction strategies for transplantable hyaline cartilage for reconstructive surgery using 3D-cell sheet culture of human bone marrow stromal cells and human costal. (koreamed.org)
Blood is preferred to bone marrow as a source because the procedure is less invasive and the number (count) of blood cells returns to normal more quickly. (msdmanuals.com)
The bone marrow and blood of children and adults contain stem cells. (msdmanuals.com)

this link lends support to the increasingly discussed theory that cancer is rooted in small populations of stem cells. (sciencedaily.com)
Such systems biology models can, for example, describe how whole populations interact with their environment, how individual cells choose to differentiate into different cell types, or how multicellular systems form patterns and grow new organs in two or three dimensions. (lu.se)

Researchers produced pluripotent stem cells from the fibroblast cells in the brain lining of human corpses. (livescience.com)
Next, the MDC researchers want to find out to what extent E-cadherin also regulates human embryonic stem cells. (sciencedaily.com)
Understanding the molecular relationships is essential for using human somatic cells to develop stem cell therapy for diseases such as heart attack, Alzheimer's or Parkinson's disease or diabetes," Dr. Besser said. (sciencedaily.com)
The embryo models, created from adult human skin cells and cultivated stem cells, could improve fertility research. (israel21c.org)
While previous studies of cellular aggregates derived from human stem cells could not be considered accurate human embryo models because they lacked many of the defining characteristics of a post-implementation embryo, the Weizmann synthetic embryo models had all the structures characteristic of this stage, such as the placenta and yolk sac. (israel21c.org)
Our stem cell-derived human embryo model offers an ethical and accessible way of peering into this box. (israel21c.org)
The researchers started out with human pluripotent stem cells, which can differentiate into various cell types. (israel21c.org)
Some of these were derived from reprogrammed adult skin cells and others were the progeny of lab-cultured human stem-cell lines. (israel21c.org)
The researchers reprogrammed the pluripotent stem cells to an earlier (naïve) stage corresponding to day 7 of a natural human embryo, around the time it implants itself in the womb. (israel21c.org)
A stem cell-derived human embryo model equivalent to a day-14 embryo has all the compartments that define this stage: the yolk sac (yellow) and the part that will become the embryo itself, topped by the amnion (blue) - all enveloped by cells that will become the placenta (pink). (israel21c.org)
However, in recent years, there has been controversy surrounding the way human embryonic stem cells are obtained. (healthline.com)
Next, Jeon and colleagues established the feasibility of targeted cell delivery using microrobots loaded with human colon cancer cells in a body-on-a-chip microfluidic cell culture platform that mimics parts of a liver tumour network. (physicsworld.com)
Stem cells, particularly human embryonic stem cells, are a notoriously labile cell type. (onenucleus.com)
New research uses an innovative technique to convert human stem cells into insulin-producing beta cells much more effectively. (medicalnewstoday.com)
Human stem cells, shown here, can turn into insulin-producing beta cells. (medicalnewstoday.com)
Previous research has pointed to human pluripotent stem cells (hPSCs) as a potential therapeutic avenue for type 1 diabetes. (medicalnewstoday.com)
He says, "A common problem when you're trying to transform a human stem cell into an insulin-producing beta cell - or a neuron or a heart cell - is that you also produce other cells that you don't want. (medicalnewstoday.com)
the most recent development, as of this writing, is the transformation of human skin cells into iPS cells using proteins rather than the currently most common approach of genetic engineering. (technologyreview.com)
Given the rapid successes of iPS-cell research, some have argued that we should abandon human embryonic stem cells. (technologyreview.com)
Researchers at the Center for iPS Cell Research and Application at Kyoto University in Japan presented data at a meeting of the American Society of Hematology showing they were able to create the cells in the laboratory and confirm they had the same life span as normal human platelets when infused in mice. (ibtimes.com)
Induced pluripotent stem cells, or iPS cells, are produced by manipulating ordinary human skin or blood cells back to a state in which they are able to differentiate into a number of different cell types. (ibtimes.com)
The human body is derived from a single cell. (childrenshospital.org)
If comprehensive whole-organism family trees could be assembled, researchers would learn a lot about human fetal development, genetic diseases and more. (childrenshospital.org)
The functioning human heart pump provides a model to track and trace what happens at the cell and molecular levels in the pump structure. (techbriefs.com)
In the past, researchers have tried to 3D-print cardiomyocytes, or heart muscle cells, that were derived from pluripotent human stem cells. (techbriefs.com)
Researchers have optimized specialized ink made from extracellular matrix proteins, combined the ink with human stem cells, and used the ink-plus-cells to 3D-print the chambered structure. (techbriefs.com)
The researchers achieved the goal of high cell density within less than a month to allow the cells to beat together, just like a human heart. (techbriefs.com)
The 3D-printed structure is a model to track and trace what is happening at the cell and molecular level in pump structure that begins to approximate the human heart. (techbriefs.com)
Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. (hopkinsmedicine.org)
We mimic this process in the laboratory with stem cells, focused specifically on developing the cerebral organoids that resemble the developing human brain in its earliest stages of growth," he says. (scienceblog.com)
A new study suggests that the stem cells located in human ovaries might be able to produce new eggs. (scitechdaily.com)
Researchers have announced that a wirelessly-programmed implant, which has been successfully tested in human trials, could save patients the pain of daily injections. (scitechdaily.com)
Today, the regrowth of Prometheus' liver has become a symbol to medical researchers for the possible renewal of damaged human organs through the use of human stem cells. (derstandard.at)
The question for us at University of Rome "Sapienza" in Italy is: Why not use stem cells to repair the human heart? (derstandard.at)
Derived from human pluripotent stem cells, these diverse cells advance disease modeling and may provide new, scalable source of replacement cells for spinal cord injuries (SCI). (disabled-world.com)
Scanning electron micrograph image of cultured human neuron from induced pluripotent stem cell - Image Credit: Mark Ellisman and Thomas Deerinck, National Center for Microscopy and Imaging Research, UC San Diego. (disabled-world.com)
Tuszynski said that, although more work needs to be done, these newly generated cells will constitute source cells for advancement to human clinical trials on a time frame of three to five years. (disabled-world.com)
It still needs to be determined that the cells are safe over long time periods in rodent and non-human primate studies, and that their efficacy can be replicated. (disabled-world.com)
The human brain has similar stem cells that are involved in the formation of brain tumours. (uni-heidelberg.de)
The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people. (scienceblog.com)
Xu and his team, which includes researchers from Penn's departments of Dermatology and Biology, as well as the New Jersey Institute of Technology, started with human skin cells called dermal fibroblasts. (scienceblog.com)
Comparison of the gene expression patterns of the human iPSC-derived epithelial stem cells with epithelial stem cells obtained from human hair follicles showed that the team had succeeded in producing the cells they set out to make in the first place. (scienceblog.com)
When they mixed those cells with mouse follicular inductive dermal cells and grafted them onto the skin of immunodeficient mice, they produced functional human epidermis (the outermost layers of skin cells) and follicles structurally similar to human hair follicles. (scienceblog.com)
That said, iPSC-derived epithelial stem cells are not yet ready for use in human subjects, Xu adds. (scienceblog.com)
The human body is made up of about 220 different kinds of specialized cells such as nerve cells, muscle cells, fat cells and skin cells. (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
In 2018, Butler's laboratory became the first group to create sensory interneurons from human embryonic and induced pluripotent stem cells. (ucla.edu)
So when I was recently contacted by an earnest and amiable member of a local school board who was concerned about the questionable manner in which the issue of "stem cell" research - both human embryonic and adult - was presented to the high school students in his district in a currently-used science textbook, I agreed to evaluate that section in the text for him. (lifeissues.net)
Researchers have been working on ways to grow healthy organs outside the human body, and one particular method called blastocyst complementation has produced promising results. (earth.com)
In the future, this approach could be used to generate human stem cell-derived organs in livestock, potentially extending the lifespan and improving the quality of life of millions of people worldwide. (earth.com)
Additional research is needed to determine how inner-ear cells involved in auditory sensing might be developed, as well as how these processes can be applied to develop human inner-ear cells, the researchers said. (iu.edu)
To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. (lu.se)
Knowing the hepatocyte cell of origin, and their subsequent dynamics and trajectory within the human liver will provide an important basis to understand disease-associated dysregulation. (bvsalud.org)
IMPACT AND IMPLICATIONS: The liver is mainly composed of hepatocytes, but we know little regarding the source of these cells or how they multiply over time within the disease-free human liver. (bvsalud.org)
Researchers at Lund University have discovered that a specific group of genetic elements in our DNA influence the development of the human brain, their study was published in Science Advances. (lu.se)
Researchers at Lund University offer new insights in their latest study, published in Science Advances, detailing how a specific group of genetic elements have influenced the development of the human brain over time. (lu.se)
In Lund, researchers are investigating these repetitive regions of our DNA to understand the role transposable elements play in human brain development and evolution. (lu.se)
Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)
The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
Yet, for almost 50 years, the lack of a reproducible cell culture system impaired the direct assessment of human norovirus infectivity in environmental conditions. (cdc.gov)
We compared the stability in seawater of 2 human norovirus strains, GII.4 (TCH11-64) and GII.3 (TCH04-577), obtained from human stool filtrates as described previously ( 12 ), and 1 TuV strain (M33) produced in simian LLC-MK2 cells ( 10 ). (cdc.gov)
Ethics approval for collection of virus-containing fecal samples and human intestinal cells was obtained from the Baylor College of Medicine Institutional Review Board. (cdc.gov)

This permanent silencing," Laird explains, "prevents embryonic stem cells from differentiating, and they thus become the seeds of cancer development later in life. (sciencedaily.com)
While implanting these unnecessary - or "off-target" - cells does not cause any harm, Millman further explains that creating more of them offsets the number of therapeutically useful cells. (medicalnewstoday.com)
However, the researcher also explains that there are a few more steps to follow before the research can help humans. (medicalnewstoday.com)
Not only did T speed up reprogramming, we also found that it increases the total number of reprogrammed cells, which is great because often in reprogramming, not all cells go all the way," says Cheng, who explains that rigorous follow-up tests are required to determine if the reprogrammed cells really behave like pluripotent embryonic stem cells. (hopkinsmedicine.org)
They were long considered to be the only stem cell population in the adult mouse brain as well as the main driver of nerve cell formation," explains Dr Ciccolini. (uni-heidelberg.de)
The notch activity decides, as it were, whether a stem cell remains a stem cell or develops into a nerve cell," explains Katja Baur, a doctoral researcher in Francesca Ciccolini's working group. (uni-heidelberg.de)
This approach helped us to address these highly repetitive sequences, usually masked in standard bioinformatics pipelines, allowing us to accurately measure LINE-1 expression in each cell type found in our samples," explains Raquel Garza, co-first author of the study. (lu.se)

So when St. Francis Memorial Hospital in San Francisco announced that the topic of his speech there last week would be "Stem Cell Research: Hope or Hype? (latimes.com)
Skepticism about the potential of stem cell research was wholly absent from the campaign for Proposition 71. (latimes.com)
However, more research is needed to help understand the potential uses of amniotic fluid stem cells. (healthline.com)
Since our research shows that cancer is rooted in stem cells, it would be very important to screen for the epigenetic abnormalities that we uncovered, so as to prevent people from receiving potentially cancer-prone cells. (sciencedaily.com)
Fellow travel grand award winner Kerstin Filippi from Dr Michael Hesse's group was impressed by "How many important people in the field of stem cell research were there. (onenucleus.com)
For further information please visit https://www.amsbio.com/research-areas/stem-cells or contact AMSBIO on +31-72-8080244 / +44-1235-828200 / +1-617-945-5033 / [email protected] . (onenucleus.com)
It was in Toronto, in the summer of 2006, that stem-cell research was turned upside down. (technologyreview.com)
Since then, research based on iPS cells has exploded (see " Medicine's New Toolbox ") . (technologyreview.com)
This critical advance in heart research shows how the researchers were able to 3D-print heart muscle cells in a way that the cells could organize and work together. (techbriefs.com)
Compared to other research in the past, the new discovery creates a structure that is like a closed sac with a fluid inlet and fluid outlet, where researchers can measure how a heart moves blood within the body. (techbriefs.com)
The research team first sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells and can differentiate into many different cell types. (hopkinsmedicine.org)
The research was funded by the National Institutes of Health and the Johns Hopkins Institute for Cell Engineering. (hopkinsmedicine.org)
The research builds on previous work by Stachowiak and his colleagues showing that although hundreds of different genetic mutations may be responsible for schizophrenia in different patients, they all converge in a single faulty genomic pathway called the Integrative Nuclear FGFR 1 Signaling (INFS) pathway, which the UB researchers reported on earlier this year. (scienceblog.com)
Since bipolar symptoms most often appear in late adolescence or early adulthood, past research has focused on studying mature or post-mortem brain cells from donors, but this approach missed changes very early in the brain's formation. (uoguelph.ca)
But medical researchers hope to be able to use technologies derived from stem cell research to treat a much wider variety of diseases. (derstandard.at)
The study supports recent research suggesting that ovarian cancer most frequently originates from the cells lining the fallopian tubes. (uclahealth.org)
The achievement, described in the August 6 online issue of Nature Methods , advances not only basic research like biomedical applications of in vitro disease modeling, but may constitute an improved, clinically translatable cell source for replacement strategies in spinal cord injuries and disorders. (disabled-world.com)
A research team led by Dr Francesca Ciccolini at the Interdisciplinary Center for Neurosciences (IZN) of Heidelberg University recently discovered a second stem cell population in the mouse brain. (uni-heidelberg.de)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Previous research suggested that prostate cancer originates from basal stem cells, and that during cancer formation these cells differentiate into luminal cells," Shen said in a statement. (nbcnews.com)
In the video above, Michael Longaker , MD, a Stanford stem cell scientist and pediatric plastic and reconstructive surgeon, discusses fascinating new research appearing today in the Proceedings of the National Academy of Science . (stanford.edu)
For many years, my lab's research has focused on helping people who have experienced spinal cord injuries feel again," said the study's senior author, Samantha Butler, a professor of neurobiology and member of the Broad Stem Cell Research Center. (ucla.edu)
My edited analysis of the section on "stem cell research" in this science textbook is copied below. (lifeissues.net)
A type of research study in which researchers learn if a new test or treatment works and is safe. (mayo.edu)
Over the course of the day, researchers from the Center will showcase their cutting-edge research, provide insights into their daily work, and explain the mechanisms behind scientific breakthroughs by offering lessons, group discussions, practical workshops, and laboratory visits. (lu.se)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
This interdisciplinary research is conducted in close collaboration with researchers in medicine and biology. (lu.se)
This paper outlines the debates prompted through a reproduction mechanism involv- by progress in cloning research, with special ing male and female germ cells. (who.int)

There are several types of stem cells that can be used for different purposes. (healthline.com)
But the benefits using these types of stem cells have ranged from marginal, to transient, to nil. (derstandard.at)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)

In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
Pluripotent stem cells are an attractive option for researchers from a therapeutic standpoint because they can self-renew in lab cultures and can differentiate into a variety of cell types. (medicalnewstoday.com)
a hostile microenvironment and deficiency of growth factors in the injured spinal cord limited the therapeutic effects of grafted NSCs that are largely determined by their survival, neurogenic potency, integration capacity, and axial identity," the researchers continued. (genengnews.com)
It also enables researchers to test therapeutic interventions on organoids that recapitulate ovarian cancer. (uclahealth.org)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)

Feb. 21, 2022 Embryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body. (sciencedaily.com)
The cytoskeleton is a structure that helps cells keep their shape and offers the mechanical support that allows cells to move, divide, and multiply. (medicalnewstoday.com)
The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)
To find new ways to treat triple-negative breast cancer, researchers have differentiated cancer cells to convert them into less harmful cells that no longer divide. (unibas.ch)
When muscle fibers are stressed or traumatized, satellite cells divide to make more specialized muscle cells and repair the muscle, said Olwin. (phys.org)
Stem cells divide, producing more stem cells, until they are triggered to specialize. (msdmanuals.com)
Then as they continue to divide, they become more and more specialized until they lose the ability to be anything but one kind of cell. (msdmanuals.com)

Researchers identify the origin of endothelial cells that constitute the vascular niche for hematopoietic stem and progenitor cells in zebrafish. (go.jp)
Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. (go.jp)
Researchers speculate that the altered gene activity prevents hematopoietic stem cells from differentiating normally, which leads to the overproduction of abnormal, immature white blood cells characteristic of acute myeloid leukemia. (medlineplus.gov)

Cord blood stem cells are harvested from the umbilical cord after childbirth. (healthline.com)
One challenge to studying blood diseases like sickle cell anemia is that blood stem cells can't be kept alive for very long in the lab, so researchers need to keep returning to patients for more cells to study," says Cheng. (hopkinsmedicine.org)
How do blood stem cells look in the microscope? (lu.se)

Cancer occurs when cells grow uncontrollably and spread to other organs in the body. (unibas.ch)

Successfully reprogramming induced pluripotent stem cells so they behave like the cells they are meant to replace means that samples of the mimicked cells must be present for comparison. (livescience.com)

Asmani, M.N., J. Ai, G. Amoabediny, A. Noroozi, M. Azami, S. Ebrahimi-Barough, M. Navaei-Nigjeh, A. Ai, M. Jafarabadi (2013) Three-dimensional culture of differentiated endometrial stromal cells to oligodendrocyte progenitor cells (OPCs) in fibrin hydrogel. (karger.com)

At that time, their study identified how to produce only some subtypes of these critical cells. (ucla.edu)
This new paper expands on that work by presenting detailed protocols that can be used to direct stem cells to differentiate into each of the six sensory interneuron subtypes. (ucla.edu)
Any cell therapy used to treat spinal cord injuries and restore sensation will need to contain all of these subtypes, and the subtypes need to resemble real interneurons as closely as possible. (ucla.edu)
We showed that IAPP is expressed in several islet cell subtypes, as well as in the gastrointestinal tract and the sensory nervous system. (lu.se)

The cell type studied is called the type 2 alveolar epithelial cell, a progenitor cell for the alveolus - the alveolus is the part of the lung where gas exchange occurs and is the structure that is damaged in emphysema. (bmc.org)

E-Cadherin is necessary for maintaining pluripotent stem cells and also for inducing the pluripotent state in the reprogramming of somatic cells," Dr. Besser said. (sciencedaily.com)

Published in Science Advances , researchers discovered functional consequences by turning off the expression of the gene that contributes to the pathogenesis of these diseases. (bmc.org)
The limitation in using stem cells to produce platelets has been the ability to find a method that creates a large number of high-quality, functional platelets. (ibtimes.com)
In a groundbreaking new study, experts have managed to grow functional mouse kidneys inside rats by using just a few stem cells. (earth.com)
Electrophysiology testing further proved that those hair cells generated from stem cells were functional, and were the type that sense gravity and motion. (iu.edu)

In vitro, the team saw that T cells failed to respond to the iPSC-derived retinal pigment cells if they were from an MHC-matched monkey. (neurosciencenews.com)

Without careful attention, these cells tend to spontaneously differentiate and undergo genomic rearrangements in culture. (onenucleus.com)
In fact, the Science list of six Areas to Watch in 2012 puts genomic epidemiology fourth-right after the Higgs boson, faster-than-light neutrinos, and stem-cell metabolism. (cdc.gov)

Cadaver-collected fibroblasts can be reprogrammed into induced pluripotent stem cells using chemicals known as growth factors that are linked with stem cell activity. (livescience.com)

One potential approach to reversing hair loss uses stem cells to regenerate the missing or dying hair follicles. (scienceblog.com)

This was foiled by tumour cell plasticity, a phenomenon whereby a non-CSC spontaneously de-differentiates into a CSC. (scienceopen.com)

Researchers grew these cells in a dish and differentiated them to generate cells that reside in the lung. (bmc.org)
They are now utilizing barcoding technologies to generate family trees of cancer and aging models to understand the ancestry and the function of the cells involved in these diseases. (childrenshospital.org)
But it hasn't been possible to generate sufficient number of hair-follicle-generating stem cells - until now. (scienceblog.com)
Xu and his team mixed iPSC-derived EpSCs and mouse dermal cells to generate hair follicles to achieve the growth of the follicles. (scienceblog.com)

Differentiated cells express typical glial markers and show a marked decrease in their proliferative state. (lu.se)

In this characteristic, they resemble stem cells or cells in an early stage of maturation. (unibas.ch)

The researchers found fibroblasts taken from the brain lining, or dura mater, were 16 times more likely to grow successfully than those from the scalp. (livescience.com)
Adult stem cells have a misleading name, because they are also found in infants and children. (healthline.com)
Stem cells have also been found in amniotic fluid. (healthline.com)
We found that cancer arises in cells that have already undergone epigenetic alterations," he adds, "which points to epigenetic events preceding genetic events in cancer development. (sciencedaily.com)
In a recent study published in The American Journal of Chinese Medicine , researchers from Zhejiang Chinese Medical University examined the effects of epimedin C, a compound found in a Chinese medicinal herb, on vasculogenesis. (naturalnews.com)
The researchers found that epimedin C treatment significantly increased the bone weight and blood perfusion of mice in the BMP2-induced ectopic osteogenesis model. (naturalnews.com)
They found that islet1 -expressing cells are the progenitors of the venous ECs that constitute the majority of the HSPC niche (Figure 1A). (go.jp)
DNMT3A gene mutations that cause DNMT3A overgrowth syndrome are found in all of the body's cells and lead to a decrease in normal enzyme function. (medlineplus.gov)
they are typically found in a small percentage of cells and the mutations are not inherited. (medlineplus.gov)
Somatic DNMT3A gene mutations are also found relatively frequently in another form of blood cancer called T-cell acute lymphoblastic leukemia. (medlineplus.gov)
Major histocompatibility complexes (MHCs) are a sets of cell-surface proteins found in all cells that function in the immune system. (neurosciencenews.com)
The researchers found that these transplanted cells survived without rejection for at least 6 months in MHC-matched monkeys, without using any of the usually necessary immunosuppressant drugs. (neurosciencenews.com)
In grafts, these cells could be found throughout the spinal cord, dorsal to ventral. (disabled-world.com)
They found that the compounds showing the most promising results were inhibitors of an essential cell cycle protein called polo-like kinase 1 (PLK1). (unibas.ch)
Researchers have found a stem cell, a kind of master cell, that may cause at least some types of prostate cancer. (nbcnews.com)
Their findings are only experimental - the stem cells were found in mice - but could explain at least some types of prostate cancer and eventually offer new ways to treat it, they reported on Wednesday in the journal Nature. (nbcnews.com)
An insulin-producing cell type found in the islets of Langerhans in the pancreas. (mayo.edu)
But, Dr. Hashino said, the team determined that the cells needed to be suspended as aggregates in a specialized culture medium, which provided an environment more like that found in the body during early development. (iu.edu)
Our initial goal was to make inner-ear precursors in culture, but when we did testing we found thousands of hair cells in a culture dish. (iu.edu)
In contrast, only in the past 20 years has the ototoxicity of chemicals found in the environment from contaminants in air, food or water, and in the workplace become a concern for researchers, toxicologists, audiologists, and other healthcare professionals. (cdc.gov)

Researchers would reprogram these stem cells to heart muscle cells and then use specialized 3D printers to print them within a three-dimensional structure, called an extracellular matrix. (techbriefs.com)
We procure skin biopsies from patients, reprogram fibroblasts from these into stem cells, i.e., iPSC, which are then differentiated into insulin-producing beta-like cells. (lu.se)

Lund Stem Cell Center will host UniStem Day 2024 on Friday, 22 March, 2024, with high school students from all over Skåne. (lu.se)

Because the cells were differentiating right next to each other, it is more similar to how the stem cells would grow in the body and then undergo specification to heart muscle cells. (techbriefs.com)
Treated cells undergo a remarkable shift in structure, acquiring an. (lu.se)
Treated cells undergo a remarkable shift in structure, acquiring an astrocyte-like morphology with star-shaped bodies and radial branched processes. (lu.se)

Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development. (sciencedaily.com)
USC researchers made these observations in relation to breast, colorectal, lung, and ovarian cancer. (sciencedaily.com)
Not only does the USC study provide empirical evidence for a stem cell origin of cancer, but, according to Laird, "It also supports a very early involvement of epigenetics in cancer. (sciencedaily.com)
Since the researchers already knew that vasculogenesis plays a pivotal role in bone formation, they used a bone morphogenetic protein 2 (BMP2)-induced ectopic bone formation model and mice 4T1 breast cancer cells co-implanted with luciferase-labeled C3H/10T1/2 cells (4T1 + C3H/10T1/2-Luc) model for their study. (naturalnews.com)
We then created conditions for those cells to differentiate into organoids that recapitulate the serous fallopian tube cells that are the origin of ovarian cancer. (uclahealth.org)
Cancer cells resemble stem cells in being extremely adaptable. (unibas.ch)
University of Basel researchers have identified compounds that artificially mature breast cancer cells of the highly aggressive triple negative subtype and convert them to a state that resembles normal cells. (unibas.ch)
Cancer cells differ from normal cells in many ways. (unibas.ch)
Researchers at the University of Basel and the University Hospital Basel have tested the possibility of artificially maturing (or more precisely, differentiating) breast cancer cells as an approach to turn them into a more normal type of cell. (unibas.ch)
We show here that we can convert breast cancer cells to less harmful cells that stop growing," says Bentires-Alj who is a group leader at the Department of Biomedicine. (unibas.ch)
To the researchers' surprise, this did not just convert the triple-negative breast cancer cells to a more manageable type of cancer cells. (unibas.ch)
The compounds used in this study are already in clinical trials to treat other cancer types, including blood-borne, lung, and pancreatic cancer," the researcher continues. (unibas.ch)
The role of stem cells in the development of prostate cancer has been a focus of speculation for many years," Dr. Helen Rippon of Britain's Prostate Cancer Charity said in a statement. (nbcnews.com)
The clonal evolution and cancer stem cell theories of cancer formation, have been used to explain tumour heterogeneity. (scienceopen.com)
Data supporting the cancer stem cell theory is accumulating. (scienceopen.com)
Cell plasticity and heterogeneity in cancer. (scienceopen.com)
and the cancer stem cells phenotype can vary substantially between patients. (scienceopen.com)
Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy. (scienceopen.com)
Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. (lu.se)
In addition, miR-145 is already interesting in other cancer-related contexts, because other researchers have linked it to functions of importance for tumour formation, such as division and growth of cancer cells and control of stem cells and blood vessels. (lu.se)

However, bacteria and fungi on the skin can wreak havoc on the culturing processes used to grow cells in labs, making the process tricky to successfully carry out. (livescience.com)
These cells have been successfully used to treat children with blood cancers, such as leukemia, and certain genetic blood disorders. (healthline.com)
Summary: Researchers report they have successfully transplanted retinal pigment cells derived from stem cells without rejection or the need of immunosuppressant drugs. (neurosciencenews.com)
Researchers at the RIKEN Center for Developmental Biology (CDB) have successfully transplanted retinal pigment cells derived from stem cells of one monkey into the eyes of other monkeys without rejection and without the need for immunosuppressant drugs. (neurosciencenews.com)
It took 52 trials to successfully grow the lamina progenitor cells in a culture," said Bernstein, "so this was a challenging process. (medica-tradefair.com)
The researchers then reversed their strategy by transferring mouse stem cells into rat blastocysts, which successfully formed the basic structures of a kidney. (earth.com)
Using advanced sequencing technologies and a set of specialized bioinformatics tools, created by PhD student Raquel Garza, the researchers successfully detected the activity of LINE-1 elements and were able to dig into their functions and epigenetic profiles. (lu.se)

Millman and team transplanted "islet-sized aggregates" of beta cells differentiated from hPSC into mice with type 1 diabetes. (medicalnewstoday.com)
In recent years, much work has been done exploring the potential of using hPSC-derived stem cells to create new spinal cord cells needed to repair damaged or diseased spinal cords. (disabled-world.com)

These islet1 -expressing cells surprisingly originate not from the mesoderm, the germ layer classically defined to give rise to ECs, but from the endoderm. (go.jp)
C) We have identified that islet1 + endothelial progenitors originate from endoderm and finally differentiate into posterior venous ECs in a process dependent on Bmp-Smad signaling, requiring Npas4l-Etsrp function. (go.jp)
All specialized cells originate from stem cells. (benthamscience.com)

For their study, the researchers extracted epimedin C from Herba Epimedii (yin yang huo), the dried leaves of a traditional Chinese medicinal herb used to treat bone diseases and gonadal dysfunction. (naturalnews.com)
We should continue, and even intensify, the study of these stem-cell lines. (technologyreview.com)
A new study by researchers from University of Guelph's Department of Molecular and Cellular Biology provides a new perspective on bipolar disorder, a poorly understood and under-researched mental health disorder affecting about 1-2 per cent of Canadians, or about 400,000 people. (uoguelph.ca)
The study was completed over seven years, with support from researchers across the university, including PhD, master's and undergraduate students, a postdoctoral fellow, Dr. Lalonde and Dr. Nina Jones from MCB and Dr. Melissa Perreault from the Ontario Veterinary College. (uoguelph.ca)
Published in Stem Cell Reports , the study shows that this procedure is possible as long as a set of cells called the MHC are genetically matched between the host monkey and the new retinal cells. (neurosciencenews.com)
In the study he and his colleagues showed that stem cells can be directed by the body to form bone in laboratory mice, and, under the appropriate guidance, are much less likely to become dangerous tumors called teratomas. (stanford.edu)
The study, conducted using embryonic stem cells from mice, also identified a method for producing all types of sensory interneurons in the laboratory. (ucla.edu)
Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)

First, a hair follicle contains epithelial cells - a cell type that lines the body's vessels and cavities - as well as a specific kind of adult stem cell called dermal papillae. (scienceblog.com)

The molecule also plays a crucial role in the reprogramming of somatic cells (body cells) into pluripotent stem cells. (sciencedaily.com)
If E-cadherin is absent, somatic cells cannot be reprogrammed into viable pluripotent cells. (sciencedaily.com)

Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
Finally, the team demonstrated in vivo stem cell transportation using the microrobots in a live nude mouse. (physicsworld.com)

In the next clinical trial," continues Sugita, "we plan to use allogeneic iPS-retinal pigment epithelial cells from HLA homozygote donors. (neurosciencenews.com)
As reported in a Penn news release , Xiaowei "George" Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice. (scienceblog.com)
This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles," Xu says. (scienceblog.com)

Anatomy55

Organisms14

Diseases8

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology2

Phenomena and Processes49

Disciplines and Occupations11

Technology, Industry, Agriculture2

Humanities2

Information Science11

Named Groups3

Health Care8

Geographicals1

Embryonic stem11

Differentiation30

Neurons32

Tissues30

Genes28

Embryos9

Neural20

IPSCs14

Therapies9

Regenerative14

Scientists22

Lineages3

Neuronal6

Tissue36

Begin to differentiate1

Precursor2

Transplantation12

Bone marrow6

Populations2

Human64

Explains7

Research29

Types of stem cells3

Therapeutic5

Divide7

Hematopoietic3

Blood stem cells3

Organs in the body1

Reprogramming induced pluri1

Stromal cells1

Subtypes4

Progenitor cell1

Inducing the pluripotent1

Functional4

Vitro1

Genomic2

Reprogrammed into induced pluri1

Regenerate1

Spontaneously1

Generate4

Markers1

Maturation1

Found20

Reprogram2

Lund Stem Cell Center1

Undergo3

Cancer20

Successfully7

HPSC2

Originate3

Study8

Adult stem1

Somatic cells2

Vivo2

Epithelial3