Researchers molecular structure. Medical search. Frequent questions

Single molecules don't absorb much light, making detection difficult to begin with," said Gruebele, who also is a researcher at the university's Beckman Institute for Advanced Science and Technology. (sciencedaily.com)
Researchers at Northwestern University have developed a new injectable therapy that repairs spinal cord injuries with the help of "dancing molecules. (anl.gov)
Injected as a liquid, the molecules came together in a solution to form tiny fiber structures (called nanofibers) that surrounded the spinal cord. (anl.gov)
The researchers discovered that the motion of molecules within the nanofibers could be controlled by changing their chemical structure. (anl.gov)
Knowing the structure of the molecular matrix allowed researchers to tune the motion of the molecules. (anl.gov)
Molecular cages are polyhedra made up of smaller 'bricks', usually protein molecules. (eurekalert.org)
Some of these molecules have densities as high as 0.94 g/mL, with their viscosities dependent on their structures and molecular weight. (greencarcongress.com)
Professor Ladizhansky's research group, meanwhile, is most interested in developing NMR spectroscopy techniques [3] to identify organic compounds and explore atomic interactions of biological molecules, getting detailed views of molecular structures. (uoguelph.ca)
The method works at subatomic resolution and can therefore image not only atoms in molecules but also the structure of the electron shell of an atom. (nanowerk.com)
Detailed models of the structure of interest are made by taking multiple images of individual molecules and averaging them into a 3D structure. (bigthink.com)
Trees survive Minnesota winters using combinations of molecules expressed naturally to stabilize critical biological structures. (umn.edu)
This work will involve looking at molecular pathways and other molecules to help stabilize these more complicated structures. (umn.edu)
When designing their new organic semiconducting compound, called 2,6-diphenylanthracene (DPA), the researchers kept the molecules closely packed to ensure a high mobility. (designworldonline.com)
But by making the molecules pack together in a strategic way, the researchers could also greatly reduce the fluorescence quenching. (designworldonline.com)
The researchers describe the new molecular arrangement as "herringbone packing," a zig-zag pattern that has weaker intermolecular interactions than other types of arrangements, even though the molecules are still very close together. (designworldonline.com)
Drug discovery spans many workflows, from exploring the chemical universe and predicting protein structures to scanning drug candidates and simulating molecules. (nvidia.com)
Molecular generative models encode chemical space, allowing researchers to optimize their search for molecules with desirable properties. (nvidia.com)
Paired with a molecular docking model and leveraging 3D information from protein structure prediction models accelerates the end-to-end virtual screening of small molecules. (nvidia.com)
Welcome to the fascinating world of molecular biology , where biologists study the intricate molecular mechanisms of biological molecules that determine our traits through genomics and mendelian genetics. (freescience.info)
Molecular biology , a field studied by biologists, focuses on the study of biological molecules and their interactions at the molecular level. (freescience.info)
Researchers have experimentally verified a longstanding theory that posited that electron density is unevenly distributed in aromatic molecules. (scitechdaily.com)
Researchers from the IOCB Prague, the Institute of Physics of the Czech Academy of Sciences, and Palacký University Olomouc, have once more made significant advancements in uncovering mysteries of the world of molecules and atoms. (scitechdaily.com)
Researchers have discovered a new way to determine the molecular weight ― by counting molecules. (lu.se)
For small molecules, the molecular weight is known by the chemical structure. (lu.se)
There are different methods for molecular weight measurements today but most work are at high concentration, which will give unreliable results if molecules or particles aggregate. (lu.se)
By knowing the total mass of the molecules in the sample, the average molecular weight can be directly calculated based on its definition: the mass divided by the number. (lu.se)

Co-authors of the paper with Gruebele and Lyding are postdoctoral researcher Joshua Ballard, graduate students Erin Carmichael and Dongxia Shi (now at the Chinese Academy of Sciences in Beijing). (sciencedaily.com)
Most of the incubators in her lab could only reach body temperature, so lead author Zhirui Zeng, a postdoctoral researcher in Welander's lab, figured out how to imitate the organism's home using a special small oven, she said. (stanford.edu)
Laboratory of Protein Structure International Institute of Molecular and Cell Biology (IIMCB), Warsaw, headed by Prof. Marcin Nowotny is looking for a Postdoctoral Researcher. (constantcontact.com)
As a Postdoctoral Researcher: you will be responsible for expression and purification of proteins and their complexes. (constantcontact.com)
The team, working with JQI Fellow Christopher Monroe and led by postdoctoral researcher Norbert Linke, sized up their own small-scale quantum computer against a device built by IBM. (lifeboat.com)

Optical microscopy, combined with fluorescent labels (such as GFP proteins and antibodies coupled with synthetic fluorophores), allows to showcase the specific structures of cells, including proteins. (pasteur.fr)
Depending on their position in the structure, not all gold atoms have to be used to attach adjacent proteins (an unused gold atom is marked in red). (eurekalert.org)
Dr. Wrobel is one of the members of an international team of researchers who have recently carried out the 'impossible': they built a cage similar in shape to a sphere out of eleven-walled proteins. (eurekalert.org)
In earlier molecular structures, proteins were glued together using many weak chemical bonds. (eurekalert.org)
Here, the information inscribed on the genetic material is constantly being used to synthesize thousands of molecular building blocks into proteins on the assembly line. (uni-muenchen.de)
In addition, the authors believe that the technology has great potential in the field of quantitative structural biology, as it will allow researchers to measure important parameters such as the labelling efficiency of antibodies, cellular proteins and nucleic acids directly. (nanotech-now.com)
Folding is a process in which the chains of amino acids that make up proteins fold into well-defined three-dimensional shapes, and the resulting structure is key to defining its function. (uoguelph.ca)
However, there has been a resolution gap between a cell's smallest structures, such as the cytoskeleton that supports the cell's shape, and its largest structures, such as the ribosomes that make proteins in cells. (bigthink.com)
From the 1940s to 1960s, biochemists worked to separate cells into their molecular components and learn how to determine the 3D structures of proteins and other macromolecules at or near atomic resolution. (bigthink.com)
Researchers have used this approach, for example, to show how proteins move and are degraded inside an algal cell . (bigthink.com)
GROMACS is an open-source software package designed for molecular dynamics simulations of biomolecules, such as proteins, nucleic acids, and lipids. (nvidia.com)
But for large systems e.g polymers, DNA, proteins or nanoparticles, the exact chemical structure is not known, so the molecular weight cannot be calculated. (lu.se)
Proteins in the GLI family function in the same molecular pathway as a protein called Sonic Hedgehog. (medlineplus.gov)
Below you can see some examples of the infrastructure for proteins, available for researchers at Lund University. (lu.se)
After that he joined Forschungszentrum Julich to work first on a project using coherent X-ray diffraction in molecular biophysics, and later joined JCNS in 2011 to start working on the structure and dynamics of intrinsically disordered proteins using small-angle neutron and X-ray scattering and neutron spin-echo spectroscopy. (lu.se)
His current research interests are focused on the investigation of the structure and dynamics of intrinsically disordered proteins and on the relevance of molecular flexibility for biological function. (lu.se)
With the O-PTIR technique, researchers can follow the aggregation of Alzheimer's proteins in fresh samples of the brain tissue. (lu.se)
With a novel microspectroscopy approach combining optical and photothermal imaging, MultiPark researchers can follow early alterations of proteins involved in Alzheimer's disease, before neurons degenerate. (lu.se)
With OPTIR, we can follow the formation of structures that precede the aggregation of amyloid proteins directly in the living tissue. (lu.se)
One example of what can be observed in living brain tissue is the formation of beta-sheet structures, characteristic of amyloid proteins involved in Alzheimer's and Parkinson's. (lu.se)

June 30, 2023 Researchers have demonstrated a new material for single-molecule electronic switches, which can effectively vary current at the nanoscale in response to external stimuli. (sciencedaily.com)
April 17, 2023 - Researchers at the Department of Energy's Oak Ridge National Laboratory have developed a machine-learning inspired software package that provides end-to-end image analysis of electron and scanning probe microscopy images. (hpcwire.com)
In May-June 2023, Andreas Stadler is a Guest Researcher at LINXS within the IPDD theme. (lu.se)

By combining the power of structural biology, biochemistry and multiscale molecular simulations, researchers from Germany and Finland found a key role of an accessory subunit in energy production by respiratory complex I, a central bioenergetic enzyme. (helsinki.fi)
The molecular simulations were performed in the group under Vivek Sharma at the Department of Physics, University of Helsinki. (helsinki.fi)
The work highlights the strength of combining structural biology approaches with molecular simulations in explaining the functioning of mitochondrial complex I, an enzyme of central importance in biological energy conversion and of biomedical relevance. (helsinki.fi)
Identifying local structure in molecular simulations is of utmost importance. (osti.gov)
Using ideas from computer vision, we adapt a specific type of neural network called a PointNet to identify local structural environments in molecular simulations. (osti.gov)
Our results suggest the approach will be broadly applicable to many types of local structure in simulations. (osti.gov)
article{osti_1542673, title = {A generalized deep learning approach for local structure identification in molecular simulations}, author = {DeFever, Ryan S. and Targonski, Colin and Hall, Steven W. and Smith, Melissa C. and Sarupria, Sapna}, abstractNote = {Identifying local structure in molecular simulations is of utmost importance. (osti.gov)
Previously, all-atom molecular dynamics simulations on such a large structure have been infeasible. (illinois.edu)
Also, AtomAI includes tools that allow researchers to conduct real-time analysis of the data being gathered and to import information directly into theoretical simulations. (hpcwire.com)
Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding. (cnr.it)

Behind the groundbreaking development is an international team of researchers led by Prof. Ronit Sachi-Fainaro, Head of the Center for Cancer Biology Research and Head of the Laboratory for Cancer Research and Nanomedicine at the Sackler Faculty of Medicine, Tel Aviv University, and Prof. Helena Florindo and Prof. Rita Guedes from the Research Institute for Medicines at the Faculty of Pharmacy, University of Lisbon. (eurekalert.org)
Collaboratively led by NYU School of Medicine structural biologist Dr. Moosa Mohammadi, the investigation included researchers from UTSW, the Rockefeller University-based New York Structural Biology Center, and Wenzhou Medical University. (newswise.com)
He is a world-known expert in structural biology, molecular modeling, bioinformatics, and structure-based drug design. (sdsc.edu)
This newly developed approach represents a significant advance in molecular biology, opening the door to less invasive and more precise analyses of pathogenic microorganisms present in human host cells. (pasteur.fr)
It represents a major step forward in molecular biology studies, enabling the visualisation of microbial complexes at a scale of 30 nm without affecting their function. (pasteur.fr)
The development of a new optical microscopy approach by the researchers of the Institut Pasteur and CNRS offers unique perspectives for molecular biology. (pasteur.fr)
They are currently presenting this structure in the journal Nature Structural and Molecular Biology. (uni-muenchen.de)
SEA COAST 2020 is organized to provide basic instruction on fundamentals and principles of macromolecular X-ray Crystallo-graphy (MX) to graduate students, postdoctoral researchers, and more both from academia & industry, who have background and/or are interested in structural biology and MX. (constantcontact.com)
In this article series on molecular biology, we will dive deeper into the captivating realm of genomics, where biologists study the genome and explore the fascinating world of Mendelian genetics. (freescience.info)
Molecular biology, a branch of science that combines biology and chemistry, is crucial for advancements in medicine, biotechnology, agriculture, and our understanding of evolution and biodiversity. (freescience.info)
Let's delve into the significance of molecular biology in each of these areas. (freescience.info)
Molecular biology, a branch of science, has revolutionized the field of medicine by providing insights into the intricate mechanisms underlying diseases at a molecular level. (freescience.info)
For instance, in cancer treatment, molecular biology techniques have led to breakthroughs in genomics and genetics such as personalized medicine. (freescience.info)
Molecular biology aids in drug discovery by identifying potential therapeutic targets and evaluating their efficacy in DNA. (freescience.info)
Molecular biology techniques, such as DNA sequencing and genotyping, have facilitated the identification of genetic variations that impact drug metabolism and efficacy. (freescience.info)
Thanks to molecular biology techniques like DNA sequencing and gene expression analysis, biologists have made significant strides in understanding genetics and genomics. (freescience.info)
Molecular biology techniques are instrumental in designing safe and effective gene delivery systems for the manipulation of DNA and genome. (freescience.info)
Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. (lu.se)
Accordingly, recent evidence has paradigmatically shifted our understanding and urged researchers to drill down deep into these novel and clinically valuable facets of AhR biology. (bvsalud.org)

Researchers from the Institut Pasteur and CNRS have set up a new optical microscopy approach that combines two recent imaging techniques in order to visualize molecular assemblies without affecting their biological functions, at a resolution 10 times better than that of traditional microscopes. (pasteur.fr)
The previous resolution of 16 angstroms was the distance between chains, but imaging at 3.6 angstroms allowed the researchers to visualize patterns of close contacts along the chains. (materialstoday.com)
With the aid of a super-resolution technique called DNA-PAINT, the researchers are able to visualize nanostructures with unprecedented spatial resolution, allowing them to image each of the strands in the nanostructures. (nanotech-now.com)
So we can now directly visualize all components of the origami structure and determine how well it put itself together," says Strauss. (nanotech-now.com)
Researchers are beginning to be able to visualize this activity to a level of detail they haven't been able to before. (bigthink.com)
As the former editor-in-chief of Science magazine and as a researcher who has studied hard-to-visualize large protein structures for decades, I have witnessed astounding progress in the development of tools that can determine biological structures in detail. (bigthink.com)
This was first done using X-ray crystallography to visualize the structure of myoglobin , a protein that supplies oxygen to muscles. (bigthink.com)
Over the past decade, techniques based on nuclear magnetic resonance , which produces images based on how atoms interact in a magnetic field, and cryo-electron microscopy have rapidly increased the number and complexity of the structures scientists can visualize. (bigthink.com)
Cryo-electron microscopy, or cryo-EM , uses a camera to detect how a beam of electrons is deflected as the electrons pass through a sample to visualize structures at the molecular level. (bigthink.com)

The structures of some organisms' membranes are retained in the fossil record and can serve as molecular fossils or biomarkers, leaving hints of what lived in the environment long ago. (stanford.edu)
A new and innovative sub-discipline embraced within this theme is molecular palaeobiology, which concerns the investigation of fossil biomarkers and labile soft tissue structures, using cutting edge imaging, molecular and chemical techniques. (lu.se)

They provide insight into structures and interactions at the molecular level, allowing researchers to understand, predict and manipulate characteristics and properties with greater clarity. (elsevier.com)

Three drug-candidates developed by Dr. Tsigelny for treatment of Parkinson's disease, brain cancer, and hypertension are licensed by UCSD to pharmaceutical companies and are in various stages of development His computational study of molecular mechanisms of Parkinson's disease has been included in the US Department of Energy publication "Decade of Discovery" where the best computational studies of the decade 1999-2009 have been described. (sdsc.edu)
Researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen and the Julius Maximilians University Würzburg have elucidated the underlying molecular mechanisms by which the antiviral compound Molnupiravir blocks the replication of the coronavirus in the event of infection. (mpg.de)
Cryo-EM has revolutionized drug discovery by providing insights into molecular structure and disease mechanisms. (nvidia.com)
AutoDock is a growing collection of methods for computational docking and virtual screening for use in structure-based drug discovery and exploration of the basic mechanisms of biomolecular structure. (nvidia.com)
The molecular mechanisms and signal transduction cascades evoked by the activation of aryl hydrocarbon receptor (AhR) are becoming increasingly understandable. (bvsalud.org)
Bladder cancer is a therapeutically challenging disease and wealth of knowledge has enabled researchers to develop a clear understanding of mechanisms which underlie carcinogenesis and metastasis. (bvsalud.org)

In this study, researchers from Goethe University and the Max Planck Institute for Biophysics, Frankfurt, Germany, and the Department of Physics, University of Helsinki (UH), Finland studied the functioning of complex I by focusing on one accessory subunit of the enzyme (NDUFA6/LYRM6). (helsinki.fi)
Researchers at the Max Planck Institute of Biophysics and Goethe University in Frankfurt have now gained new insights into exactly how bacteria import DNA. (mpg.de)

The project is a collaboration between researchers from Karlstad University, Lund University, Chalmers, and Linköping University led by Professor Ellen Moons in Karlstad. (lu.se)
Our mission is to give support to clinical researchers at Skåne University hospital, the faculties and institutions at Lund University as well as national collaborators. (lu.se)
But new techniques and instruments available at MAXIV at Lund University shed light on these molecular mysteries. (lu.se)

Newswise - DALLAS - March 29, 2018 - Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called "anti-aging" protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. (newswise.com)
Over the course of three years, 2018-2020, researchers genotyped thousands of isolates. (cdc.gov)

Ethical issues in molecular epidemiologic research. (cdc.gov)
Contemporary and future molecular epidemiologic research will be conducted against a backdrop of massive biological databases, comprehensive and longitudinal electronic medical records, large medical care expenditures, aging populations, emerging infectious diseases in some countries, and global climate change. (cdc.gov)
These conditions will influence the ethical issues that arise in molecular epidemiologic research. (cdc.gov)
Further, it is important to realize that data that will be made available in the future from new genomic technology will continue to pose challenges to the ethical conduct of molecular epidemiologic research. (cdc.gov)

By comparing the information in the individual fluorescence images, we are able to attain a higher resolution, so that we can inspect the whole structure in detail," Strauss says. (nanotech-now.com)
This single-molecule counting method can be widely used to measure molecular weight of fluorescence objects, such as macromolecules, biomolecules and nanoparticles, at extremely low concentrations. (lu.se)
The photoluminescent properties of Mn-doped ZnS quantum dots were fully exploited, and room-temperature phosphorescence (RTP)-ratiometric fluorescence (RF) magnetic mesoporous molecularly imprinted polymers (PFMM-MIPs) were prepared by integrating molecular imprinting technology. (bvsalud.org)

and an international team of researchers. (uni-halle.de)

By providing a first look at the structure of the protein complex that includes FGF23 and its co-receptors, the FGF receptor and a-Klotho, the most recent study challenges the long-accepted belief that only the cell-attached form of aKlotho can serve as a receptor for FGF23 and hence that FGF23 action is restricted to tissues having the cell-attached form. (newswise.com)
The study provides evidence for how FGF23 signals to cells by forming a complex with a-Klotho and the two other molecular partners. (newswise.com)
The study characterises the compounds according to their weight and molecular structure. (technologyreview.com)
However, in the new study, the researchers demonstrated that they could mobilize and recover the isolated lithium to extend battery life. (scitechdaily.com)
A study coordinated by Dr Christophe Zimmer(1) (Institut Pasteur/CNRS), in collaboration with Dr Nathalie Arhel(2) within the lab headed by Pr Pierre Charneau(3) (Institut Pasteur/CNRS), shows that the association of two recent imaging techniques helps obtain unique images of molecular assemblies of HIV-1 capsids, with a resolution around 10 times better than that of traditional microscopes. (pasteur.fr)
This new imaging technique could become a key tool in the study of numerous microbial complexes and their interactions with host cells at the molecular level. (pasteur.fr)
For the electrically conductive polymer examined in this study, this meant the researchers could follow the direction along which electrons travel. (materialstoday.com)
In geomorphology, researchers instead study the landforms on the Earth's surface and the processes that create them. (umu.se)
And ongoing development of one particular technique, cryo-electron tomography, or cryo-ET , has the potential to deepen how researchers study and understand how cells function in health and disease. (bigthink.com)
In a recent study supported by AMD funding, researchers in CDC's Division of Parasitic Diseases and Malaria (DPDM) describe that Cyclospora cayetanensis is not one singular organism, but at least three similar yet distinctive single-celled microscopic animals. (cdc.gov)
With the help of various forms of mass spectrometry, synchrotron radiation, protein production & labelling, and bioinformatics, our facilities provide the opportunity to study protein structure and dynamics, molecular probes and drug design. (lu.se)
This technique has been used by MultiPark researchers in a new study led by Oxana Klementieva. (lu.se)
Moreover, the researchers can detect associated damage at the submicronscale, something that makes it possible to study potential treatments in acute brain tissue slices, organoids, or cultured neurons. (lu.se)
This approach allows us to study molecular structures directly in tissue which has not been possible before. (lu.se)
With a specialisation in Chemistry, you will first study the mandatory course Molecular Driving Forces and Chemical Bonding, KEMM30. (lu.se)
Never before had leading researchers from the U.S., Europe, and Asia met strategically to share their latest findings related to the occupational health aspects of nanotechnology, and to lay out the areas of study needed to fill critical gaps. (cdc.gov)

Post-doctoral researcher Dr. Rita Acúrcio started with thousands of molecular structures, and by using computer-aided drug design (CADD) models and databases, we narrowed down the list of candidates until we reached the best structure,' says Prof. Satchi-Fainaro. (eurekalert.org)

A molecular structure drawing application used by millions of scientists worldwide. (acdlabs.com)
Electron microscopy and scanning probe microscopy allow materials scientists, physicists and other researchers to probe atomic and molecular structures at extremely high resolutions. (hpcwire.com)
Skilfully used by an international team of scientists, the bonds have made it possible to construct molecular nanocages with a structure so far unparalleled in nature or even in mathematics. (eurekalert.org)
In a paper published in Science, the Rutgers CCB scientists show how the molecular machine responsible for transcription initiation--a protein complex that consists of the enzyme RNA polymerase and the initiation factor δ- recognizes a specific site on DNA preceding a gene, binds to DNA, unwinds the DNA helix, and pre-organizes the unwound DNA to enable subsequent reactions. (rutgers.edu)
Scientists discovered a protein that modifies a microbe's membrane and helps it survive in hot, acidic environments, proving a long-standing hypothesis that these structures have a protective effect. (stanford.edu)
Many of the steps researchers once had to do manually to determine the structures of cells are becoming automated, allowing scientists to identify new structures at vastly higher speeds. (bigthink.com)
Dr. Joel Barratt, a bioinformatician and molecular parasitologist with DPDM, says this discovery allows scientists and public health workers to discuss the organisms by unique names, much as it is possible to discuss and differentiate strains of SARS-CoV-2. (cdc.gov)

Work to determine the structure of Paxlovid was done at the Industrial Macromolecular Crystallography Association Collaborative Access Team ( IMCA-CAT ) beamline at the APS , operated by the Hauptman-Woodward Medical Research Institute on behalf of a collaboration of pharmaceutical companies, of which Pfizer is a member. (anl.gov)
The Methods in Molecular and Materials Modelling series seeks to address this issue, providing detailed guidance on available methods and highlighting the pros and cons of different techniques within the context of specific research fields and application areas. (elsevier.com)
Some of the issues will be unique to molecular epidemiology, and others will be relevant to all research. (cdc.gov)
If the conduct of molecular epidemiology is to contribute to medical and publ ic health research and have a positive impact, there is a need for investigators to be aware of and adhere to the generally accepted ethical principles discussed in this chapter. (cdc.gov)
Working with a cryo-electron microscope with a resolution of seven angstroms, she has elucidated the three-dimensional structure of this machine, known as a secretin complex, in collaboration with research groups headed by Werner Kühlbrandt and Gerhard Hummer. (mpg.de)
The work described in Nature magazine took place with the participation of researchers from universities in Osaka and Tsukuba (Japan), Durham (Great Britain), Waterloo (Canada) and other research centres. (eurekalert.org)
The structure we found has never been seen before," said Professor Christie, a pharmacologist with the School of Medical Sciences and Associate Dean Research. (edu.au)
The sample that prompted the research had been taken from the Tasmanian estuary as part of a program involving Professor Rob Capon, a natural products chemist from from UQ's Institute for Molecular Bioscience. (edu.au)
Led by Professor Stephen Dooley in Trinity's School of Physics, the Trinity researchers undertook the project as a result of an open competition by TOTAL, where their proposal welcomed several applications from research teams across the globe. (tcd.ie)
Researchers in Sandia's Combustion Research Facility (CRF) are developing the understanding necessary to build cleaner combustion technologies that will in turn reduce climate impact. (sandia.gov)
The hope is to accelerate an increased level of competence among researchers and other professionals in FAIR research data management and open science. (umu.se)
Harmonised curricula and training paths in open science for researchers, research data management professionals, policymakers, organisations offering thematic or discipline-specific training, and training targeted at research infrastructures. (umu.se)
The doctoral network EnvSeis brings together ten leading research groups from seven countries to train twelve early-stage researchers in both seismology and geomorphology. (umu.se)
Whether using crystallography or cryo-EM, MiTeGen supports your research with the leading tools for the techniques your lab uses to solve structures. (constantcontact.com)
As one of the researchers involved, Bruno de la Torre from the Czech Advanced Technology and Research Institute (CATRIN) of Palacký University Olomouc, points out, the success of the experiment described here is mainly due to the excellent facilities at his home institution and the participation of excellent Ph.D. students. (nanowerk.com)
For recent articles published within this research theme, click on the various researchers. (lu.se)
and (c) managed coordination through formal structures to manage the research undertaken and the allocation of resources to support them. (who.int)
You will meet and be taught by active and internationally well recognised researchers, and you will be in contact with several research groups. (lu.se)

Understanding the very first pathological events at the molecular level is key to developing treatments preventing neurodegenerative diseases. (lu.se)

The series is designed first for graduate students and researchers predominantly in computational and theoretical chemistry as well as materials science and biomolecular science, who are seeking to use and understand molecular modelling methods and approaches for the first time. (elsevier.com)

However, the results obtained by the researchers of the Institut Pasteur and CNRS indicate that numerous capsids remain unaltered until entry of the virus into the nucleus, confirming and strengthening earlier studies based on electron microscopy. (pasteur.fr)
Electron microscopy is useful for gaining precise information on the structure of a material, whereas scanning probe microscopy is more often used to learn about a material's functional properties, such as superconductivity or magnetism. (hpcwire.com)
Adding antioxidants can push the resolution limit of polymer electron microscopy to reveal structures at smaller scales (blue) than could previously be observed (pink) in this false-color image. (materialstoday.com)
The researchers were now able to use cryo-electron microscopy to prove that the enzyme hangs just below the exit of the ribosomal tunnel and "can swing back and forth like a hammock," emphasizes first author and doctoral student Alexandra Knorr. (uni-muenchen.de)
In the 20th century, electron microscopy offered even greater detail, revealing the elaborate structures within cells , including organelles like the endoplasmic reticulum, a complex network of membranes that play key roles in protein synthesis and transport. (bigthink.com)
We investigated the molecular origin of the instability using a combination of neutron and X-ray scattering techniques as well as cryo-transmission electron microscopy. (lu.se)

Molecular epidemiology: principles and practices. (cdc.gov)

This improvement to data analysis allows researchers to engineer quantum atomically precise abnormalities in materials, and can be used to gain deeper insights into the materials' physical and chemical qualities. (hpcwire.com)
A new method uses swirls of light to enable researchers to observe previously invisible quantum states of electrons. (uni-halle.de)
Now, researchers at the JQI have performed a first-of-its-kind benchmark test of two small quantum computers built from different technologies. (lifeboat.com)

These datasets routinely include hundreds of images that each contain thousands of atoms and abnormalities in molecular structure. (hpcwire.com)
So, although all the rings of the new nanocages are physically the same, depending on their place in the structure they connect with their neighbours with a different number of gold atoms, and thus function as polygons with different numbers of vertices. (eurekalert.org)
24 nanocage walls presented by the researchers were held together by 120 gold atoms. (eurekalert.org)
The molecular sites where oxygen is added are targets for additional reactions that can lead to formation of a five-member ring containing four carbon atoms and an oxygen atom, which is known as a furan. (sandia.gov)
Biological structures can be visualized by either starting at the level of the whole organism and working down, or starting at the level of single atoms and working up. (bigthink.com)

The term 'DNA origami' refers to a method for the design and self-assembly of complex molecular structures with nanometer precision. (nanotech-now.com)
Their seemingly simple-looking structures mask the intricate and complex molecular activity that enables them to carry out the functions that sustain life. (bigthink.com)

To reduce the noise, the researchers combined several special techniques -- each insufficient by itself -- into a method that allows them to detect single molecule absorption under laser illumination by scanning tunneling microscopy. (sciencedaily.com)
People used to treat microscopy as a purely qualitative tool," said Maxim Ziatdinov, a researcher at ORNL and the lead developer of AtomAI, "but recently there was sort of a shift in the mindset of the community: Microscopy can actually be used to extract quantitative physical information. (hpcwire.com)
Qualitative microscopy methods generally rely on researchers noting holistic information about a sample, while the new quantitative methods allow for precise numerical representations of a material's structure or properties. (hpcwire.com)
From left to right: Chemical structure of the investigated molecule, calculated electrostatic potential map of the molecule, experimental Kelvin probe force microscopy (KPFM) image, and simulated KPFM image. (nanowerk.com)
Modern force microscopy has long been the domain of researchers at the Institute of Physics. (nanowerk.com)

The book "Protein Structure Prediction: Bioinformatic Approach" that he edited, has been called "The Bible of all current prediction techniques" by BioPlanet Bioinformatics Forums. (sdsc.edu)

This gives the researchers a molecular "fingerprint" by which to identify the compounds. (technologyreview.com)

Through the manipulation of materials at atomic, molecular, and macromolecular levels, nanotechnology makes it possible to create new structures and systems with unique properties and benefits. (cdc.gov)

Comparison of Illumina and Oxford Nanopore Sequencing Technologies for Pathogen Detection from Clinical Matrices Using Molecular Inversion Probes. (cdc.gov)

Single molecule absorption spectroscopy can enhance molecular analysis, surface manipulation and studies of molecular energy and reactivity at the atomic level. (sciencedaily.com)
It plays a critical role in advancing our understanding of biological systems at the molecular level. (nvidia.com)
MRI comprises a variety of tools ranging from high-resolution anatomical structure visualization to functional studies and even molecular-level description of metabolic events in the cell. (lu.se)

Determining the structure of a functional, specific transcription initiation complex has been a goal of researchers for three decades," said Ebright, a professor in Rutgers CCB and a laboratory director at the Waksman Institute of Microbiology at Rutgers. (rutgers.edu)
Thus researchers are already using DNA origami to develop functional nanomachines. (nanotech-now.com)
The goal of the new project is to make efficient solar cells from molecular semiconductors through improved processing technology and better understanding of how the fundamental molecular interactions govern the structure in these functional materials. (lu.se)

In contrast, renewable fuels containing purely paraffinic or isoparaffinic hydrocarbons in the C 10 -C 14 range have densities from about 0.73-0.76 g/mL, while renewable diesel range hydrocarbons with their average higher molecular weights have densities of up to ~0.78 g/mL. (greencarcongress.com)

Journal of Molecular Structure is a scientific journal published by Elsevier ScienceDirect since 1968. (wikipedia.org)

Single-particle cryo-EM is a popular experimental technique used to determine large molecular structures at near-atomic resolution. (nvidia.com)

A perfect chemical drawing package for students, educators, and researchers. (acdlabs.com)
Generate chemical names according to IUPAC rules, convert chemical names to structures, and handle challenging areas of nomenclature. (acdlabs.com)
Guided by this fragment, the molecular machinery needed for cell movement begins accumulating at the leading edge, or front of a cell in response to a variety of chemical messengers, and begins the directed process of migration. (news-medical.net)
Molecular modelling methods are now indispensable tools in chemical, materials, and biomolecular sciences. (elsevier.com)
The researchers, led by Enrique Gomez, professor of chemical engineering and materials science and engineering at Penn State, report their findings in a paper in Nature Communications . (materialstoday.com)
The Trinity team (Professor Stephen Dooley, Dr Andrew Ure, Dr Manik Ghosh, Dr John O Brien), adapted pre-existing theories of chemical reaction kinetics and molecular thermodynamics for use with more modern machine learning techniques, making use of the super-computing facilities of the Irish Center for High End Computing (ICHEC). (tcd.ie)
When a drug is first discovered, it is given a chemical name, which describes the atomic or molecular structure of the drug. (msdmanuals.com)
Next, a shorthand version of the chemical name or a code name (such as RU 486) is developed for easy reference among researchers. (msdmanuals.com)

Journal of Molecular Structure: THEOCHEM Else, Holly (March 14, 2022). (wikipedia.org)

Software such as AtomAI has enabled this shift, providing a method to quantitatively analyze the structures of whole samples to find meaningful data that qualitative methods might misrepresent or simply not notice. (hpcwire.com)
Although the researchers did not quantitatively test the resolution limits that resulted from this method, they were able to image the polymer at a resolution of 3.6 angstroms, an improvement on their previous resolution of 16 angstroms. (materialstoday.com)

A team of researchers has now applied this concept to the task of preventing imaging damage to the conducting polymers found in soft electronic devices such as organic solar cells, organic transistors, bioelectronic devices and flexible electronics. (materialstoday.com)
According to Gomez, visualizing the structures of conducting polymers is crucial to the further development of these materials and their commercialization in soft electronic devices - but the imaging process can cause damage to the polymers that limits what researchers can see and understand. (materialstoday.com)
Polymers are made up of molecular chains lying on top of each other. (materialstoday.com)
According to Gomez, this allows them to better understand the conductive structures in the polymers. (materialstoday.com)
Researchers have unexpectedly discovered that ions conduct faster than electrons in conjugated polymers. (materialstoday.com)

Now a team led by Ralf Jungmann, Professor of Experimental Physics at LMU Munich and Head of the Molecular Imaging and Bionanotechnology lab at the Max Planck Institute for Biochemistry (Martinsried), reports an important advance in this regard. (nanotech-now.com)

Just as it becomes easier to understand how complicated systems work when you know what they look like, understanding how biological structures fit together in a cell is key to understanding how organisms function. (bigthink.com)

These features are useful for gaining insights into the energetics and optical, electronic and magnetic properties of the physical structures being observed. (hpcwire.com)
It promises to deliver new insights into electron motion, which is crucial in understanding material properties such as electrical conductivity, magnetism and molecular structures. (uni-halle.de)

If we can start with two cell types and add one or two genes at a time and get these structures to develop, that would be very exciting," she says. (technologyreview.com)
By unraveling the complex interactions between genes and their regulatory elements, researchers can identify disease-causing mutations more accurately. (freescience.info)
Researchers are working to identify the genes targeted by the GLI3 protein during development. (medlineplus.gov)

These high-resolution methods allow researchers to clearly observe atomic structures, making them an important tool in understanding and engineering materials at the nanoscale. (hpcwire.com)

The high energy of the X-ray beam allows researchers to penetrate the whole battery, while the high beam intensity at the APS reduces measurement time from days to minutes. (anl.gov)

You will be involved in preparation of the samples for cryo-EM data collection, EM data collection, structure solution, refinement and analysis. (constantcontact.com)

Although octane boosters are used extensively there is currently no complete understanding on their molecular mechanism of action. (tcd.ie)

The IMCA-CAT beamline at the Advanced Photon Source, where work was done to determine the structure of Pfizer's new COVID-19 antiviral treatment candidate. (anl.gov)

MBP-mediated assembling of lipid bilayers proceeds in two steps, with a slow second step occurring over many days where native lipid membranes assemble into well-defined multilayer structures, whereas MS diseased lipid membranes form folded assemblies with high local curvature. (lu.se)

The researchers say their findings also shed new light on how kidney disease leads to an abnormal thickening of heart muscle tissue called hypertrophy, which is a leading cause of death in people with kidney disease caused by high blood pressure, diabetes, and other illnesses. (newswise.com)
While the drugs have not yet been tested in humans, researchers say that they carry a high potential for abuse because they are easy to make. (technologyreview.com)
SLAC and Stanford researchers discovered that adding a brief, high-current discharging step right after charging the battery nudges the island to grow in the direction of the anode, or negative electrode. (scitechdaily.com)
The method achieves as high as 99.5% accuracy in crystal structure identification. (osti.gov)
The molecular positions are then calculated with high accuracy by computer programs and compiled into a single high-resolution image. (pasteur.fr)
For the first time, researchers have combined these two methods in order to obtain high-resolution images of molecular structures in either fixed or living cells. (pasteur.fr)
NAWCWD researchers have been pursuing high-density biofuels for a number of years (e.g., earlier post , earlier post ). (greencarcongress.com)
The resolution of this image is high enough that researchers - or computer programs - can identify the individual components of different structures in a cell. (bigthink.com)
The reason why high mobility and high luminescence don't mix is because they generally require opposite types of molecular structures. (designworldonline.com)
Benefiting from the synergistic effects of MoS2 and C3N4, the 3D MoS2/2D C3N4 nanocomposite displayed numerous active sites, a 3D mesoporous structure, high conductivity and excellent catalytic activity. (bvsalud.org)

Because of the growing demand for design and development of delivery systems to overcome the existing limitations with the current therapeutic strategies, researchers are exploiting multifaceted aspects of nanotechnology to improve delivery of the drug payload. (bvsalud.org)

From the fungus, the researchers discovered three versions of tetrapeptides, a chain of four amino acids (the 'molecular building blocks of life) joined by peptide bonds. (edu.au)

Researchers at the Department of Energy's SLAC National Accelerator Laboratory and Stanford University believe they have discovered a means to revive rechargeable lithium batteries, which might increase the range of electric cars and battery life in next-generation electronic devices. (scitechdaily.com)
Stanford University researchers have identified a protein that helps these organisms form a protective, lipid-linked cellular membrane - a key to withstanding extremely highly acidic habitats. (stanford.edu)

The work may assist other researchers in interpreting data from soot measurements by providing the masses of oxygenated species formed during different combustion conditions. (sandia.gov)

A drug is defined by U.S. law as any substance (other than a food or device) intended for use in the diagnosis, cure, relief, treatment, or prevention of disease or intended to affect the structure or function of the body. (msdmanuals.com)
Glioblastoma rapid progression, drug resistance, and recurrence have been scientifically linked to several factors, including its rapid growth rate, loss of apoptosis, pro-survival signalling, molecular heterogeneities and hallmark features to infiltrate vital brain structures. (bvsalud.org)

Anatomy3

Organisms8

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology8

Phenomena and Processes79

Disciplines and Occupations21

Anthropology, Education, Sociology and Social Phenomena7

Technology, Industry, Agriculture5

Humanities4

Information Science36

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Health Care25

Geographicals1

Molecules26

Postdoctoral researcher5

Proteins20

20233

Simulations10

Biology19

Visualize9

Biomarkers2

Interactions at the molecular level1

Mechanisms6

Biophysics2

Lund University3

20182

Epidemiologic4

Fluorescence3

International team of researchers1

Study16

Thousands of molecular1

Scientists7

Research18

Diseases1

Graduate students1

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Epidemiology1

Quantum3

Atoms5

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Level3

Functional3

Hydrocarbons1

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