• From today through December 20th 2023, all researchers will earn 6.25x our normal bounty rates when Wordfence handles responsible disclosure for our Holiday Bug Extravaganza! (wordfence.com)
  • Meanwhile, CSIRO researchers in Australia are trying to alter a gene in wheat, so the wheat fibre resembles the fibre content of oats, which is clinically proven to reduce cholesterol. (abc.net.au)
  • National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. (nih.gov)
  • Toxic side effects actually are rarely observed by researchers who have designed gene therapies using an adeno-associated virus (AAV) as a vector to deliver the corrected gene to a specific point in the cell's DNA. (nih.gov)
  • For 10 years, NHGRI researchers have worked toward a gene therapy to treat MMA. (nih.gov)
  • In prior MMA gene therapy studies, researchers showed that mice bred to develop the condition could be restored to health by AAV gene therapy injection shortly after birth. (nih.gov)
  • When the AAV was inserted near Mir341, the vector caused elevated expression of the gene, which the researchers believe contributed to the occurrence of liver cancer in the mice. (nih.gov)
  • When the researchers used an alternate AAV vector to deliver the corrected gene in a study of just 10 mice, that vector did not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. (nih.gov)
  • The researchers found that this modification was a safer gene therapy. (nih.gov)
  • Scientists at the University of North Carolina at Chapel Hill have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent. (sciencedaily.com)
  • The Defense Advanced Research Projects Agency (DARPA)is providingfour U.S. Universities with $45 million in funding to enable researchers to alter the gene make-up of plants grown as crops on farms. (counterpunch.org)
  • The authors hold that gene modification achieved through HEGAA doesn't fit with the intention proclaimed by DARPA, that of protecting U.S. agriculture. (counterpunch.org)
  • We can help researchers identify SNPs, indels, gene copy numbers, and genomic rearrangements from the various types of DNA-sequencing and microarray data and provide tailored downstream analysis of variants and mutations. (nottingham.ac.uk)
  • Our expertise in dealing with both shotgun and high throughput sequencing data can empower researchers with accurate gene prediction and precise species categorisation. (nottingham.ac.uk)
  • The regulatory gene that impressed the researchers most was FGFRL1. (answersingenesis.org)
  • Epigenetic modifications such as the addition of chemical groups to histones lead to changes in chromatin organization, which can trigger either gene activation ("expression") or gene silencing. (mpg.de)
  • This was a breakthrough in the study of histone modifications, but Zhang thought pieces of the puzzle were still missing. (sciencedaily.com)
  • The red stained H4K16ac histone modification is clearly visible in the individual oocytes. (mpg.de)
  • Now, scientists from the laboratory of Asifa Akhtar discovered that one particular histone modification, the acetylation of histone H4 on the 16th lysine (H4K16ac in short) is intergenerationally maintained from the mother's oocyte to the young embryo. (mpg.de)
  • Our experience in working with RNA-sequencing or expression microarray data can enable researchers to pinpoint the molecular mechanisms that create associations between genotypes and phenotypes. (nottingham.ac.uk)
  • These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)
  • Without the modification, tRNAs are thought to be less able to participate in protein synthesis. (medlineplus.gov)
  • Researchers tied the accumulation of the toxic brain protein beta-amyloid to Alzheimer's disease, according to a new study. (sciencedaily.com)
  • Researchers tied the accumulation of the toxic brain protein beta-amyloid to Alzheimer's disease, according to a study reported at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals. (sciencedaily.com)
  • The team determined that m6A modification of both human and viral RNA influences the interaction between the HIV Rev protein and the RNA RRE. (infectioncontroltoday.com)
  • The method can be used for automated detection of chemical/post- translational modifications, quality control of experiments and labelling approaches, and to control the modification settings of protein identification tools. (lu.se)
  • The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)
  • The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)
  • Although becoming less commonly used, the array production LIMS of previous BASE versions is retained to support researchers with spotting facilities, e.g., protein array production and BAC array printing that may not be commercially available. (lu.se)
  • The Effectiveness of eHealth Interventions on Lifestyle Modification in Patients With Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-analysis. (bvsalud.org)
  • From an examination of almost two million tweets posted between 2014 and 2017, the researchers found that Russian troll accounts were significantly more likely to tweet about vaccination than were Twitter users generally. (humanevents.com)
  • The Digital Research Service has been developed in collaboration with researchers and experts from across the university. (nottingham.ac.uk)
  • Five electronic databases ( PubMed , Cochrane Central, CINAHL, Embase, and Web of Science ) were searched for studies reporting the effect of lifestyle modification intervention using eHealth in patients with NAFLD published from inception to November 3, 2022. (bvsalud.org)
  • The researchers conclude that behavioral factors, such as concern over use of kidneys with greater donor risk, and/or inefficiency in kidney allocation may have played some role. (unos.org)
  • By comparing these self-reported experiences with the data from the heart rate monitors and surveillance cameras, the researchers were able to compare the fear-related and enjoyment-related elements of the attraction on subjective, behavioral, and physiological levels. (scitechdaily.com)
  • Such small behavioral modifications aren't "a panacea," the Schwartz Center researchers noted in their paper. (cnn.com)
  • cipants in lifestyle modification programs to improve diabetes- related health indicators: body weight, body mass index (BMI), Conclusion blood pressure, cholesterol, and hemoglobin A1C (HbA1C). (cdc.gov)
  • Providing incentives in lifestyle modification programs is a prom- ising strategy to decrease weight, BMI, and blood pressure. (cdc.gov)
  • Lifestyle modification is a crucial strategy for the treatment of NAFLD , which can lead to a reduction in liver fat with concomitant weight loss . (bvsalud.org)
  • Lifestyle modification interventions using eHealth technologies are significantly effective for BMI, AST, and ALT in patients with NAFLD . (bvsalud.org)
  • A related alternative approach is error tolerant searching [6-8] that considers a multitude of modifications or mutations. (lu.se)
  • For years, researchers have suspected that physiological arousal, such as a quickening pulse and a release of hormones in the brain, may play a key role in explaining why so many people find horror movies and haunted houses so attractive. (scitechdaily.com)
  • The HIV field has missed this modification in physiological RNA structure and HIV genome for more than 30 years," Rana said. (infectioncontroltoday.com)
  • We have specific expertise in studying fusion genes, epigenomics modification, lncRNAs, microRNAs and alternative splice patterns. (nottingham.ac.uk)
  • The researchers found that, compared to other mammals, the giraffe has multiple distinctive differences in 70 of its genes. (answersingenesis.org)
  • H4K16ac is an epigenetic modification that is typically associated with the activation of genes. (mpg.de)
  • When the researchers silenced the enzyme that removes m6A from RNA, HIV replication increased. (infectioncontroltoday.com)
  • Conversely, when they silenced the enzyme that adds m6A to RNA, HIV replication decreased - a finding the researchers say could be exploited pharmacologically to combat the infection. (infectioncontroltoday.com)
  • The enzyme MOF (green) is responsible for the deposition of the H4K16ac modification. (mpg.de)
  • Congratulations to Sara Moron-Polanco on receiving the 2018 Early Career Researcher Grant Scheme, an internal grant of the University of Melbourne. (earthbyte.org)
  • This scheme will allow public health officials, clinical researchers, and agencies that finance medical care to accurately monitor HIV diagnoses on death certificates and medical records. (cdc.gov)
  • By investigating how humans derive pleasure from fear, we find that there seems to be a 'sweet spot' where enjoyment is maximized," said Marc Malmdorf Andersen, a researcher at the Interacting Minds Center at Aarhus University and lead author of the paper. (scitechdaily.com)
  • We have experience in leading national research projects and have enabled hundreds of researchers across the university to deliver high impactful research outputs. (nottingham.ac.uk)
  • University of Nottingham researchers can find more detailed technical information and access instructions on how to use the Digital Research Service on the Digital Research SharePoint site (internal access only). (nottingham.ac.uk)
  • Researchers at the University of Nottingham thought that they had discovered an occurrences of the bacteria that causes plague in a rats from Liverpool and Vancouver. (nottingham.ac.uk)
  • Researchers at University of California, San Diego School of Medicine have discovered that HIV infection of human immune cells triggers a massive increase in methylation, a chemical modification, to both human and viral RNA, aiding replication of the virus. (infectioncontroltoday.com)
  • HREB also reviews external applications submitted by MRU's researchers working as part of research teams at other institutions, and research involving Mount Royal University participants that has been approved at other post-secondary institutions in Canada. (mtroyal.ca)
  • Even low doses were enough to identify the amyloid plaques in the GM mice's brains, the researchers found. (newscientist.com)
  • Kaspersky Lab found similarities with a Petya modification called PetrWrap, and has dubbed it ExPetr. (darkreading.com)
  • In their comparison of demographic and academic variables, researchers found few significant differences between respondents and the general undergraduate population. (thearda.com)
  • Our experience working with our targeted approaches to validation, quality control, normalisation and clustering using machine learning approaches ensures that researchers get the most out of their data regardless whether the data was collected from cells, tissues or material surfaces. (nottingham.ac.uk)
  • But due to combinatorial explosion, the usage of a large number of variable modifications is inherently difficult, if not impossible, in these approaches. (lu.se)
  • The United States, they explain, actually may be working on an innovative mechanism of genetic modification programmed to reduce productivity rather than to maintain or increase it. (counterpunch.org)
  • I will not be surprised if other viruses with RNA genomes also exploit this m6A modification mechanism to evade immune surveillance and control their replication in human cells. (infectioncontroltoday.com)
  • These next-generation technologies have been developed by undergraduate and graduate students, researchers, faculty and alumni from all across Carnegie Mellon. (cmu.edu)
  • HREB reviews applications submitted by MRU researchers and research undertaken by undergraduate students under the supervision of faculty members including Honours thesis and student-directed research. (mtroyal.ca)
  • To further expand the tropism and thus potential applications of AAV vectors, we utilized an alternative approach that employs chemical modifications to covalently link small molecules to reactive exposed Lysine residues of AAV capsids. (nature.com)
  • Additionally, in using agent PIB (Pittsburgh Compound B) and positron emission tomography (PET), researchers "demonstrated that PIB PET is able to detect the early pathological changes of Alzheimer's disease long before the development of dementia," he indicated. (sciencedaily.com)
  • So noticeable in fact that researchers are exploring ways to detect the ears' features like they were fingerprints. (brookings.edu)
  • The method's focus is to globally detect mass differences, not to assign peptide sequences or modifications to individual spectra. (lu.se)
  • *Funded = contingent upon a modification in project scope\budget. (nps.edu)
  • BASE has an integrated file system to provide the possibility for researchers to collect all data files related to a project in one single storage location. (lu.se)
  • With some modification, the researchers say, it should prove a useful research tool in humans as well. (newscientist.com)
  • One of these modifications, known as N6-methyladenosine (m6A), is common in humans and other organisms. (infectioncontroltoday.com)
  • Erechim has a population and input from the study researchers. (cdc.gov)
  • In the study, Rana's team discovered m6A modifications in HIV RNA for the first time. (infectioncontroltoday.com)
  • A new study by the laboratory of Asifa Akhtar at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany, reveals that active epigenetic modifications are also passed from one generation to the next. (mpg.de)
  • This study aimed to evaluate published eHealth intervention studies for the improvement of lifestyle modifications among patients with NAFLD and to provide recommendations for future studies. (bvsalud.org)
  • Study selection, data extraction, and quality assessment were performed by 3 researchers independently. (bvsalud.org)
  • Join ResearchGate to contact this researcher and connect with your scientific community. (researchgate.net)
  • In 2012, researchers discovered that they could program the system itself so that it recognises and cuts not just pieces of virus, but any desired piece of genetic material. (wur.nl)
  • The Science magazine report focuses on a new delivery system Defense Department researchers are using to transfer altered genetic material to crops in the field. (counterpunch.org)
  • DARPA researchers are trying to insert altered genetic material into viruses, arrange for those viruses to infect certain insects, and then transfer the insects with doctored viruses to plants being grown for food. (counterpunch.org)
  • If you would like to give to a specific research program or support the work of a particular researcher, contact our fundraising team today. (edu.au)
  • Metabolomics and proteomics - Working closely with experts in data analytics our team can assist researchers investigating the global expression of proteins and metabolites, thus enabling the unbiased discovery of biomarker that can be used for further targeted studies. (nottingham.ac.uk)
  • A team of researchers has earned more than $100,000 from Google for an Android exploit chain that can be used to hack the company's Pixel phone remotely simply by getting the targeted user to access a malicious website. (securityweek.com)
  • However, researcher Guang Gong of Chinese security firm Qihoo 360 and his team did manage to find a couple of vulnerabilities that can be chained for a remote code injection exploit that works against Pixel and other Android smartphones. (securityweek.com)
  • Finally, it's just a matter of a machine scanning your ears again, and matching it up to what's already stored in the system, which the researchers were able to do accurately 99.6 percent of the time. (brookings.edu)
  • To resolve this, the researcher typi- cally defines a small set of modifications for inclusion in the matching process. (lu.se)
  • We also welcome interdisciplinary work from diverse teams of researchers as long as the paper's primary contribution focuses on economic questions. (elsevier.com)
  • Researchers documented biomechanically-related changes, such as to work postures, duration or level of exerted force, etc. depending on the nature of the intervention. (cdc.gov)
  • Researchers used NIOSH standard testing procedures (STPs) to simulate exhalation resistance expected in a healthy person performing work while wearing an EHMR to determine if the modified EHMRs met NIOSH's minimum performance requirements. (cdc.gov)
  • The post COVID-19: Digital Research support for researchers appeared first on Digital Research . (nottingham.ac.uk)
  • CMU researchers are developing a platform of services to support the reuse and recycling of electric vehicle lithium-ion batteries. (cmu.edu)
  • 4 Therefore, the researchers believe they have discovered how the giraffe simultaneously evolved its long neck and the cardiovascular system to support it. (answersingenesis.org)
  • This dataset contains the American Values Scale, which is a modification of the Rokeach Values Survey . (thearda.com)
  • Now, in a long-term follow-up of the treated mice - after mice reached about two years of age - the researchers documented a 50-70 percent higher occurrence of liver cancer in AAV-treated mice compared with a 10 percent liver cancer rate in untreated mice. (nih.gov)
  • The researchers scanned five normal mice and eight mice genetically modified to have Alzheimer-like plaques, after injecting them with the tracer. (newscientist.com)
  • Participated five graduated students, trained to evaluate the material and the alternatives of modifications to reality. (bvsalud.org)
  • The researchers fitted each participant with a heart rate monitor, which recorded real-time data as they walked through the attraction. (scitechdaily.com)
  • NIOSH researchers collected data on nine different combinations of facepieces, filters, and other required parts that make up an EHMR. (cdc.gov)
  • CDC has updated the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes for human immunodeficiency virus (HIV) infection for use with United States morbidity and mortality data. (cdc.gov)
  • They also have a government office called: Beijing Weather Modification Office, which is under the national weather control office. (wikipedia.org)
  • T. gondii case-control studies ( 12,13 ), with modification children in this area is low ( 4-6 ). (cdc.gov)
  • Importantly, we and other researchers using PIB PET have also observed that by the time dementia has developed--and a diagnosis of Alzheimer's disease can be made by a clinician--the decline in cognitive function then continues without a further increase in amyloid, highlighting the need for early intervention and prevention of dementia," he added. (sciencedaily.com)
  • In general, Full Board Reviews are required for high risk and ethically complex studies, or where diverse opinions across researchers are likely. (mtroyal.ca)
  • Mass [10] together with information on modifications induced by sample prepa- ration procedures for mass spectrometric analysis, but mass changes are only given as integer values. (lu.se)
  • 4) What recent discoveries have ID researchers made? (skepticfriends.org)
  • Modifications made to the EHMR involved the removal of inhalation valves to allow expelled breath to exit through the filters while the exhalation valves were blocked with duct tape. (cdc.gov)
  • Weather modification is the act of intentionally manipulating or altering the weather. (wikipedia.org)
  • The most common form of weather modification is cloud seeding, which increases rain or snow, usually for the purpose of increasing the local water supply. (wikipedia.org)
  • Weather modification in warfare has been banned by the United Nations under the Environmental Modification Convention. (wikipedia.org)
  • Not having adequate systems to handle weather modification may have disastrous consequences. (wikipedia.org)
  • In 'The Fog Medium: Visualizing and Engineering the Atmosphere' Yuriko Furuhata highlights the genealogy of the fog and how strategies of weather modifications form an extensive history and narrative around 'atmospheric explication,' the transformation of the environment into an object of manipulation, often to disastrous ends. (lu.se)
  • At the end, the material consisted of five stories, followed by questions of free modifications and alternatives of modification in the story. (bvsalud.org)
  • Change history for biomaterial items is available if configured and can be used to track modifications in the database. (lu.se)