Researchers inhibitor proteins. Medical search. Frequent questions

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. (iu.edu)
Despite this knowledge, past efforts to develop an effective small-molecule inhibitor for RhoA have failed, explained Zheng, who has studied Rho GTPases for over two decades. (cincinnatichildrens.org)
A key challenge to binding a small-molecule inhibitor to RhoA is the protein's globular structure and lack of surface pocket areas suitable for easy binding, Zheng said. (cincinnatichildrens.org)

About 2 percent of our genes code for protein kinases," says Cole. (sciencedaily.com)
Using high-throughput DNA sequencing, the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial viruses. (eurekalert.org)
Given that more than 90% of drugs target a human protein encoded by a gene, the opportunity is there to use genetic variants within those druggable genes as instruments to anticipate the effects that drugs targeting the same protein will have. (sciencedaily.com)
Building on these known benefits of human genetics for drug discovery, Casas and his team set out to identify all genes that encode proteins that served as targets for FDA-approved drugs or drugs in clinical development. (sciencedaily.com)
After analyzing a set of genes involved in the cell's ability to dispose unneeded proteins in more than 2,500 patients who had come to the NIH with undiagnosed conditions, Dr. Kastner and his team discovered three middle-aged men who suffered from problems such as lung inflammation, skin lesions, and irritated cartilage in the nose and ears. (lupusresearch.org)
The IRF5 gene encodes the IRF5 protein that binds to specific regions of DNA and helps control the activity of certain genes. (lupusresearch.org)
Once the inhibitor enters cells, it keeps the IRF5 protein from traveling to the cell's nucleus, which houses DNA and activating genes that may encode proteins involved in an autoimmune attack. (lupusresearch.org)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)

Budigalimab (ABBV-181), an investigational PD-1 inhibitor from pharmaceutical company AbbVie, is being studied as an approach for achieving durable control of HIV without ART, also known as remission or a functional cure. (aidsmap.com)
At Northwestern University, the researchers combined chemotherapy with an investigational bromodomain (BET) inhibitor to target breast cancer that had spread to the brain in mouse models. (delveinsight.com)
The company concluded that its investigational CD47 inhibitor was unlikely to demonstrate a survival benefit, compared with standard care, for patients enrolled in the phase III ENHANCE-2 trial. (aacrjournals.org)

In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells. (eurekalert.org)
To put things into perspective, he refers to a gene that encodes a protein called PCSK9. (sciencedaily.com)
Researchers discovered that class of drugs because of studies showing that people carrying a certain variant within the PCSK9 gene tend to have high levels of cholesterol and are at greater risk for cardiovascular disease. (sciencedaily.com)
Scientists at the University of Miami Miller School of Medicine's Sylvester Comprehensive Cancer Center and other collaborating universities have been able to reproduce Kaposi's sarcoma in mice by overexpressing a single protein from the Rac1 gene. (univmiami.net)
The researchers further confirmed the overexpression of the MET gene and MET protein in these tumors using special techniques called fluorescent in situ hybridization and immunohistochemistry. (medindia.net)
The CDKN1B gene provides instructions for making a protein called p27. (medlineplus.gov)
Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. (medlineplus.gov)
One gene abnormality affects apolipoprotein E (apo E)-the protein part of certain lipoproteins, which transport cholesterol through the bloodstream. (msdmanuals.com)

The researchers used the algorithm to identify split sites on a number of proteins, including tyrosine kinase Lyn, guanosine nucleotide dissociation inhibitor, and guanine exchange factor. (genengnews.com)
Furthermore, pyrin interacts with proline-serine-threonine phosphatase-interacting protein (PSTPIP1), also known as CD2-binding protein 1 (CD2BP1), which is a tyrosine-phosphorylated protein involved in cytoskeletal organization and thereby involved in immunologic cellular interactions. (medscape.com)
The BCR-ABL and Src tyrosine kinase inhibitor (TKI) received the FDA's go-ahead as a treatment option for patients age 1 and older with chronic phase Philadelphia chromosome-positive disease, either newly diagnosed or relapsed/refractory. (aacrjournals.org)

Among 10,000 compounds, EBSELEN proved to be the most potent inhibitor. (scitechdaily.com)
EBSELEN proved to be the most potent inhibitor of Mpro in a study examining approximately 10,000 selected compounds. (scitechdaily.com)

The growth inhibitor p27 is a key regulator of cell division and motility, and resides in the nucleus. (univmiami.net)

Most important, Cole says, is that their approach targets specific protein kinases. (sciencedaily.com)
We hope our approach will be used to further identify new growth inhibitors and their targets across bacterial species and in higher organisms. (eurekalert.org)
Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. (nature.com)
Our data provide proof-of principle of a new approach for directing small molecule inhibitors to disease causing RAFT targets in cellular membranes. (healthnewstrack.com)
Because these exosites play such an essential role in the toxin's ability to bind to and cleave the nerve-cell protein, they could serve as additional targets for the development of drugs designed to interfere with the toxin's deadly action," Swaminathan said. (bnl.gov)
Because the role of Rho GTPases in cellular processes and cancer formation is well established, researchers have spent years trying to identify safe and effective therapeutic targets for specific parts of the protein complex. (cincinnatichildrens.org)

Eculizumab (Soliris) and ravulizumab-cwvz (Ultomiris) are inhibitors that work to block complement protein C5. (webmd.com)
There's another complement protein called C6. (webmd.com)
Researchers are also looking at medicines that work against other players in the complement system. (webmd.com)
Complement system proteins are deposited onto synapses," Dr. Sia explained. (technologynetworks.com)
But in certain neurological diseases, the brain somehow is injured and begins to overproduce complement proteins, which leads to excessive synapse loss. (technologynetworks.com)
In mouse models of Alzheimer's disease, researchers have found that the removal of complement proteins from the brain protects it from neurodegeneration, he said. (technologynetworks.com)
We've known about the complement proteins, but there was no data to show that there were actually any complement inhibitors in the brain," Dr. Sia said. (technologynetworks.com)
Whether different neurons produce different complement inhibitors, each protecting a certain subset of synapses. (technologynetworks.com)
It could also explain why some people are more susceptible to synapse loss because they have lower levels of certain complement inhibitors. (technologynetworks.com)
The researchers focused on a neuronal complement inhibitor called SRPX2. (technologynetworks.com)
2020). The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development. (technologynetworks.com)
The complement system contains more than 40 proteins that circulate in the blood and these proteins play an important role in the innate defense against pathogens, and in the removal of unwanted materials. (lu.se)
one example is the intracellular functions of complement proteins in beta cells. (lu.se)
Our research aim is to further our understanding of the role of these complement proteins in physiology and metabolism of beta cells, focusing on intracellular complement factor C3 in beta cell survival and function, and membrane-bound complement inhibitor CD59 in insulin secretion. (lu.se)
Moving forward, we also want to develop new therapies and improve the selection of patients who can be treated with complement inhibitors, which are currently being developed by several different pharmaceutical companies. (lu.se)
The most scientifically exciting project right now focuses on new roles that complement proteins play inside cells, such as in pancreatic beta cells. (lu.se)
The most clinically exciting projects focus on the development and evaluation of diagnostic tests with complement biomarkers and studies of how COMP, a protein found in connective tissue, contributes to the development of different types of cancer, and whether it can be used as the basis for new treatment. (lu.se)

secretase is internalized from the cell membrane into intracellular compartments (endosomes) where it cleaves its substrate, Amyloid Precursor Protein (APP). (healthnewstrack.com)
One possibility would be to add a transmembrane sequence or some other means of intracellular transport to the inhibitor molecule. (bnl.gov)
G-protein coupled receptors (GPCRs) are membrane proteins that transmit the effects of extracellular ligands to effect changes in the intracellular G-protein signaling system. (gauss-centre.eu)

In a new study published in Inflammation and Regeneration , researchers from Tokyo Medical and Dental University (TMDU) investigated the effects of hypoxic (low oxygen) conditions on the neural stem cell niche during development. (news-medical.net)
Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered that an imbalance between an enzyme called neutrophil elastase and its inhibitor causes inflammation, obesity, insulin resistance, and fatty liver disease. (medindia.net)
The imbalance between neutrophil elastase and its inhibitor, α1-antitrypsin, is likely an important contributing factor in the development of obesity, inflammation, and other health problems. (medindia.net)
Texas A&M University researchers set out to investigate the role of botanical compounds, including dietary phenols, in reducing intestinal inflammation. (scienceboard.net)
Cryopyrin (also called NALP3, PYPAF1, or NACHT, leucine-rich repeat [LRR], and PYD domains-containing protein 3) is a member of the APAF-1/NOD1-like protein family, which regulates apoptosis and inflammation. (medscape.com)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
The protein protects tissue from inflammation when cells rupture. (lu.se)

Cite this: JAK Inhibitor Effects in RA Confirmed inReal-World Study - Medscape - Nov 02, 2023. (medscape.com)
July 31, 2023 Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. (sciencedaily.com)

PD-1 inhibitors - monoclonal antibodies such as pembrolizumab ( Keytruda ) and nivolumab ( Opdivo ) - are widely used for cancer immunotherapy. (aidsmap.com)
From the abstract: 'Concizumab is an anti-tissue factor pathway inhibitor monoclonal antibody designed to achieve hemostasis in all hemophilia types, with subcutaneous administration. (cdc.gov)

Previous research has shown the safety and efficacy of JAK inhibitors in rheumatoid arthritis, but real-world data comparing the various drugs are lacking. (medscape.com)
The researchers reviewed data from 361 adults with RA treated at seven hospitals and compared safety and efficacy of the four JAK inhibitors using data collected at 2, 4, and 6 months after drug administration. (medscape.com)
The current study indicates that drug retention, efficacy, and safety of tofacitinib, baricitinib, peficitinib, and upadacitinib for the treatment of RA remained similar after adjustment for potential confounders, the researchers write. (medscape.com)
Efficacy of BRAF/MEK inhibitor combination highlights need for routine biomarker testing in pediatric brain cancer care. (aacrjournals.org)
As a next step, the researchers tested the efficacy of the clinically approved MET inhibitor crizotinib in two xenopatients. (medindia.net)
Given its reported efficacy in both types of hemophilia without inhibitors, concizumab is evolving as an attractive therapeutic for all patients with hemophilia. (cdc.gov)
We conducted the explorer7 trial to assess the safety and efficacy of concizumab in patients with hemophilia A or B with inhibitors. (cdc.gov)

In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)

The compounds used in this study are already in clinical trials to treat other cancer types, including blood-borne, lung, and pancreatic cancer," the researcher continues. (unibas.ch)

A quartet of Janus kinase (JAK) inhibitors approved in Japan to treat rheumatoid arthritis - tofacitinib , baricitinib , peficitinib, and upadacitinib - showed similar safety and effectiveness in adults in a real-world, multicenter, retrospective study. (medscape.com)
There are now four clinical trials testing Janus kinase (JAK) inhibitors,' Dr. Harris notes. (medlineplus.gov)

They hypothesized, on the basis of earlier research by Sacktor, that this protein (an enzyme called PKMzeta) acts as a miniature memory machine that keeps memory up and running. (jpost.com)
An enzyme causes structural and functional changes in other proteins: PKMzeta, located in the synapses (the functional contact points between nerve cells) changes some facets of the structure of synaptic contacts. (jpost.com)
Researchers, led by Massachusetts General Hospital, have found that inhibitors of an enzyme called Speckled Protein 140 can reverse intestinal abnormalities. (scienceboard.net)
Active, full-length Human Cyclic GMP-AMP synthase enzyme (cGAS enzyme), His-tagged protein expressed and purified from E.coli. (bellbrooklabs.com)

The researchers plan to do further studies with solid tumors such as lung, liver and colon cancers, which, compared with blood tumors such as leukemia, have been harder to achieve complete success with T cell-based therapies. (medicalxpress.com)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)

Bassoon protein and pLG72, are the current known proteins to physically interact and modulate human DAAO. (wikipedia.org)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
Understanding the detailed structures of the toxins and how they interact with their target proteins could also lead to advances in the ways they can be used safely in a medical setting. (bnl.gov)
In healthy individuals, cryopyrin and apoptosis-associated speck-like protein (ASC) interact via the oligomerization of ASC to induce both apoptosis and activate nuclear factor (NF)-kappa B. (medscape.com)
A team of researchers led by Prof. Dr. Holger Gohlke and Till El Harrar have been using high-performance computing (HPC) resources at the Jülich Supercomputing Centre (JSC) to better understand how aqueous ionic liquids and seawater interact with enzymes relevant for a host of biotechnological applications. (gauss-centre.eu)
Some mutations impair the protein's ability to interact with regulatory proteins, while others lead to the production of an unstable version of p27 that is quickly broken down. (medlineplus.gov)

The most common medicines work by inhibiting, or blocking, a couple of different proteins in your blood that make you lose red blood cells. (webmd.com)
According to Karolina Östbring, researcher at the Department of Food Technology, the oil cakes that remain from rapeseeds usually contain many different proteins, including oleosin. (lu.se)

Crystal structures often deviate from the natural system: Proteins, especially membrane-bound ones, do not necessarily crystallize in their biologically active structures and the measures needed to obtain suitable GPCR crystals tend to increase the diversity between the natural environment and the crystal. (gauss-centre.eu)

The researchers believe the most promising ACE2 therapy against COVID-19 is a drug that was developed before the pandemic began and has been evaluated in clinical trials to reduce inflammatory response in patients with severe respiratory disorders. (sciencedaily.com)
The researchers also grouped the patients based on the income level and rate of education in the place they lived. (cancer.net)
The researchers saw a response on MRI scans in 12 of the 18 patients after six months. (scienceboard.net)
Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. (mdanderson.org)
In a nonrandomized, open-label Phase II study, MD Anderson researchers demonstrated that talazoparib, a PARP inhibitor, showed activity in patients with germline BRCA1/2 mutation-positive, early HER2-negative breast cancer. (mdanderson.org)
Using the JURECA supercomputer, a team of University of Cologne researchers led by Prof. Dr. Joseph Kambeitz is simulating biophysical processes in the brain in pursuit of better understanding what leads to schizophrenia in patients. (gauss-centre.eu)
L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)
Among patients with hemophilia A or B with inhibitors, the annualized bleeding rate was lower with concizumab prophylaxis than with no prophylaxis. (cdc.gov)
In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)

The researchers designed the bisubstrate analog using an improved understanding of how protein kinases normally work at the molecular level. (sciencedaily.com)
Minor tinkering with bisubstrate analogs may produce a wide variety of the molecular red herrings, each designed to counteract a specific protein kinase. (sciencedaily.com)
A protein called TSC2 (tuberous sclerosis protein 2) can activate or block a molecular pathway that regulates the T cells. (medicalxpress.com)
My lab is interested in investigating the way cellular life works by targeting the molecular players, such as proteins and RNA, and to this extent, we have been developing tools to control those players," says Nikolay V. Dokholyan, Ph.D., G. Thomas Passananti Professor, Penn State College of Medicine. (genengnews.com)
secretase inhibitors for the treatment of Alzheimer's disease," noted Professor Kai Simons, Max-Planck Institute of Molecular Cell Biology and Genetics and co-founder of JADO. (healthnewstrack.com)
The catalytic domain of Clostridium botulinum neurotoxin type F (represented as a molecular surface, gray) bound to an inhibitor molecule (colored ribbon) designed to mimic the nerve-cell protein the toxin cleaves. (bnl.gov)
The explanation is centred on a small molecular messenger, called a Wnt protein, which carries information between cells about the initiation, spacing, and growth of body hair. (sciencealert.com)
What we're doing is laying the molecular foundation for these potential drug repurposing inhibitors by revealing their mode of action,' said ORNL corresponding author Andrey Kovalevsky. (labroots.com)
Most roadblocks stem from a lack of specificity in how researchers have been able to target RhoA, a resulting lack of efficiency in affecting molecular processes, problems with toxicity, and the inability to find a workable drug design. (cincinnatichildrens.org)
In order to gain a fundamental understanding of the process, the researchers ran computationally intensive molecular dynamics simulations of up to 600,000 atoms. (gauss-centre.eu)

The inhibitor was found to cripple the activity of a protein vital to bacterial cells -- a protein that maintains the bacterial cell structure. (eurekalert.org)
The researchers found the mutated T cells were acting no differently than normal ones when they were just resting and not being stimulated to attack a target. (medicalxpress.com)
After analyzing the data, the researchers found that young adults with colorectal cancer who lived in areas with the lowest income and lowest education had a 24% higher risk of dying than those who lived in areas with the highest income and education. (cancer.net)
In the past, researchers found that they could split proteins using light and chemical signals, but finding the precise spot to make the split was a matter of trial and error, which would not be practical for actual medical treatments and scientific procedures. (genengnews.com)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
They found that the compounds showing the most promising results were inhibitors of an essential cell cycle protein called polo-like kinase 1 (PLK1). (unibas.ch)
The researchers found that obese humans and mice have increased neutrophil elastase activity and decreased levels of α1-antitrypsin, a protein that inhibits the elastase. (medindia.net)
The researchers found that as mice age, overexpression of Rac1, in a form that is constitutively activated, triggers the development of a tumor that has all the scientific characteristics of human Kaposi's sarcoma. (univmiami.net)
The BET inhibitor worked by increasing beta-3 tubulin (TUBB3), a protein found in brain metastases. (delveinsight.com)
Researchers have found that smoking causes chromosomal damage and speeds up aging. (medicaldaily.com)
Although happiness may vary between people based on personal experiences, the researchers found that life satisfaction - one of the factors that determines happiness - decreases after the age of nine and increases between the ages of 70 and 96. (medicaldaily.com)
In normal mice, the plantar region of the foot is free of fur, but in all 40 mutant mice, the researchers found fully-formed, mature hair follicles embedded in that very spot. (sciencealert.com)
However, recently researchers have found that hepatitis C drugs may certainly do the trick in inhibiting/blocking the protease from functioning. (labroots.com)
This protein is found in cells and tissues throughout the body. (medlineplus.gov)
However, changes in regulation that reduce the amount or function of the p27 protein in the nucleus are found in many types of cancer. (medlineplus.gov)
We also found that CD59, a protein present on the surface of almost all cells which protects cells from being attacked by the immune system, can also be found inside cells, where it regulates insulin secretion. (lu.se)
The investigators found that the resultant transfected cells showed defects in ATP2A2 protein expression (15 mutants), ATP hydrolysis (29 mutants), calcium transport (4 mutants), and calcium binding and kinetics (3 mutants). (medscape.com)

They identified inhibitors against the enterovirus capsid protein and protease. (europa.eu)
Currently, there are no inhibitors approved by the Food and Drug Administration that target the SARS-CoV-2 main protease,' said ORNL lead author Daniel Kneller. (labroots.com)
In addition, researchers used the assistance of modern-day X ray technology to look at the atomic arrangements of how protease and drug inhibitors work. (labroots.com)

Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)

By a broad mass spectrometry based approach on whole cells we are in the process of identifying additional such proteins and their phosphorylation status. (lu.se)

Their research, described in this month's Nature Structural Biology, explains how a blockading molecule, called a bisubstrate analog, effectively prevents protein kinase enzymes from docking with other molecules in the body - in short, from working. (sciencedaily.com)
The enzymes help ferry a small, reactive cluster of atoms containing phosphorus - called a phosphoryl group - to cell proteins. (sciencedaily.com)
This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)
Key members of the deubiquitinase (DUB) family of enzymes are thought to play a central role in the development and progression of PD by allowing the build-up of toxic proteins. (michaeljfox.org)
This study will determine if inhibitors of these enzymes can prevent or halt the progression of PD. (michaeljfox.org)
Currently, these researchers are studying the role of these histone modifying enzymes in cancer. (iu.edu)

In the spring of 2020, they managed to solve and started to analyse one of these proteins, Nsp10, by using the BioMAX beamline at MAX IV Laboratory. (lu.se)

Our research efforts on developing chemical probes include design and synthesis of small molecules targeting EPAC, which are exchange proteins directly activated by cAMP including cAMP-regulated guanine nucleotide exchange factors. (utmb.edu)
The researchers also wanted to make sure Rhosin effectively blocked what are known as guanine nucleotide exchange factors (GEFs). (cincinnatichildrens.org)

Checkpoint inhibitors that block PD-1 can restore T-cell activity. (aidsmap.com)
In these studies, budigalimab was used at doses 50 to 100 times lower than the checkpoint inhibitor doses typically used for cancer treatment. (aidsmap.com)

Unlike other approaches to block protein kinases, the researchers say, the new technique works both on the molecules that donate the phosphoryl groups and on the protein molecules that accept them. (sciencedaily.com)
Their bisubstrate analog simultaneously attaches to both molecules, crowding out protein kinases. (sciencedaily.com)
Indeed, the mimic molecules have such high affinity for the toxin and bind to it so tightly that they themselves could possibly serve as anti-toxin drugs with further modification, the researchers said. (bnl.gov)
The scientists are also exploring the possibility that the inhibitor molecules they used in this study as mimics for the nerve-cell protein could themselves serve as anti-toxin drugs. (bnl.gov)

The drug is based on protein A1M, an endogenous substance that captures and neutralises toxic substances in the body. (lu.se)

In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
This study proposes to investigate why highly metabolic cells are sensitive to NMT inhibition, critical information to inform future preclinical studies using NMT inhibitors in lung cancer. (uclahealth.org)

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8 + T cells can make the cells more robust, potentially opening the door for better use of people's own immune system T cells to fight cancer. (medicalxpress.com)
Using mice models, researchers from Japan and China have shown that dendritic cell immunoreceptor (DCIR) protein deficiency is resistant to colonic tumors. (scienceboard.net)
The inhibitor is a protein called Dickkopf 2 (DKK2), and when it is removed from mice completely, the researchers noticed something curious. (sciencealert.com)
Preliminary data published in this study showed human tumors with MET amplification, grown in mice, responded to MET inhibitor drugs. (medindia.net)

It's still being studied, but you would take it by mouth as an add-on to C5 inhibitor therapy with eculizumab or ravulizumab if you still have serious red blood cell damage. (webmd.com)
In a phase I clinical trial, the researchers studied the approach in 20 adults with complex single-tract Crohn's perianal fistulas who had not responded to conventional therapy. (scienceboard.net)
New findings just published in the Proceedings of the National Academy of Sciences by University of Miami Miller School of Medicine researchers suggest that antioxidant therapy could help prevent and treat Kaposi's sarcoma, a major AIDS-related malignancy. (univmiami.net)
researchers await results of combination therapy trial. (aacrjournals.org)

The researchers are continuing their study of bacterial viruses in the hope of identifying compounds and processes that facilitate improved treatment of antibiotic-resistant bacteria using yet uncharacterized bacterial viruses' proteins. (eurekalert.org)
University of Basel researchers have identified compounds that artificially mature breast cancer cells of the highly aggressive triple negative subtype and convert them to a state that resembles normal cells. (unibas.ch)
The OpenZika researchers are continuing to screen millions of chemical compounds as they look for potential treatments for the Zika virus. (worldcommunitygrid.org)
Except for a few stragglers, we have received all of the results for our experiments that involve docking 6 million compounds versus the proteins NS1, NS3 helicase (both the RNA binding site and the ATP site), and NS5 (both the RNA polymerase and the methyltransferase domains). (worldcommunitygrid.org)

A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. (sciencedaily.com)
Based on their analyses, the researchers call for prioritizing clinical trials of drugs targeting the proteins IFNAR2 and ACE2. (sciencedaily.com)

A team of Japanese researchers led by Shinya Hayashi, MD, PhD, of Kobe University, Japan, conducted the study, which was published online November 1 in the journal Rheumatology . (medscape.com)
The relatively small study population limits generalizability, and the researchers could not adjust for all potential confounding factors or account for potential bias or the impact of dosing changes during the study period. (medscape.com)
In their study, the researchers at Politecnico elucidate key aspects of the Mpro blocking mechanism by EBSELEN. (scitechdaily.com)
That kind of genetic study was pivotal to identify the PSCK9 protein as a target for drug discovery," Casas says. (sciencedaily.com)
In this study, researchers wanted to find out whether where young adults with colorectal cancer lived affected their chance of recovery. (cancer.net)
The researchers in this study analyzed data from the National Cancer Database of 26,768 young adults diagnosed with colorectal cancer between 2004 and 2016. (cancer.net)
The team published its study (" Computational design of chemogenetic and optogenetic split proteins ") in Nature Communications . (genengnews.com)
This study looked specifically at how the catalytic domain of one type of neurotoxin, neurotoxin F, recognizes and binds to its target nerve-cell protein to perform this final, paralyzing step," said Brookhaven Lab biologist Subramanyam Swaminathan, who led the research team. (bnl.gov)
In this study, we've shown the skin in hairless regions naturally produces an inhibitor that stops Wnt from doing its job. (sciencealert.com)
When the study was first started, the researchers thought that DKK2 might be responsible for the pattern of hair follicles that develops on the body. (sciencealert.com)
In a recent study published in Blood, researchers from Indiana University School of Medicine shed new light on the underlying causes of immune response to factor VIII, providing valuable insights that could lead to more effective and safer hemophilia A treatments in the future. (cdc.gov)

Researchers also treated an extensively tested line of neuronal cells with Rhosin, along with nerve growth factor, a protein that is important to the growth and survival of neurons. (cincinnatichildrens.org)

Oral DUB inhibitors could potentially benefit those with PD by addressing symptoms or slowing progression of the disease. (michaeljfox.org)
For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)

The pursuit for more information about the COVID-19 coronavirus has led a group of College of Medicine researchers to West Reading, Pa. (drexel.edu)
The main proteases is a critical protein in the life cycle of the coronavirus, ultimately allowing it to reproduce. (labroots.com)

To find the best sites for protein splits, the researchers analyzed how several proteins were split in the past and used that data to create a mathematical model of the protein's structure, or physical scoring model. (genengnews.com)

So, in certain cases where this inhibitor is not present, the Wnt signalling pathway is left to its own devices, activating the appropriate stem cells , called β-catenin, and causing hair follicles to develop in places where they shouldn't. (sciencealert.com)

Now, researchers in Japan have shed new insight into the dynamics of the neural stem cell niche, the home of stem cells in the brain. (news-medical.net)
Chan is proposing to target heat shock factor (HSF) 1, a protein that is stimulated by HCMV, which could both inhibit the replication of HCMV and eliminate infected cells. (upstate.edu)
Once thought to be a mere housekeeping procedure, this transfer, researchers now know, is crucial to cells. (sciencedaily.com)
We demonstrate SPELL by applying it to proteins of various shapes and sizes in living cells. (genengnews.com)
You want to turn them off and turn them on, and people in the field are trying to find ways to control those proteins, just to be able control those cells. (genengnews.com)
Parkinson's disease (PD) involves accumulation of toxic proteins in cells in specific areas of the brain. (michaeljfox.org)
These cells normally have protective mechanisms to remove these toxic proteins and dysfunction of these mechanisms may play a role in the development of PD. (michaeljfox.org)
To find new ways to treat triple-negative breast cancer, researchers have differentiated cancer cells to convert them into less harmful cells that no longer divide. (unibas.ch)
Researchers at the University of Basel and the University Hospital Basel have tested the possibility of artificially maturing (or more precisely, differentiating) breast cancer cells as an approach to turn them into a more normal type of cell. (unibas.ch)
To the researchers' surprise, this did not just convert the triple-negative breast cancer cells to a more manageable type of cancer cells. (unibas.ch)
CD4 T cells are called that way because they have a protein called CD4 on their surface. (aidsmap.com)
In theory, Routy said, PD-1 inhibitors could also potentially reverse T-cell exhaustion and restore immune function in people living with HIV, and they might also act as a latency reversal agent to push virus out of cells. (aidsmap.com)
In lab and animal studies, Dr. Barnes developed a nontoxic inhibitor molecule that penetrates the cell membrane and enters into a variety of immune cells, including those called plasmacytoid dendritic cells, a rare type of immune cell known to secrete large quantities of type 1 interferons, which are the main disease drivers in lupus. (lupusresearch.org)
Researchers at Mayo Clinic have identified mesenchymal stem cells (MSCs) as a potential way to address the problem. (scienceboard.net)
That overexpression of TUBB3 improved chemotherapy's ability to target and kill the cancer cells in the brain, also reported by the researchers. (delveinsight.com)
To do so, we'd need to find a way for the inhibitor to reach the toxin inside nerve cells. (bnl.gov)
After conducting a series of laboratory cell tests to verify the targeting and binding capabilities of Rhosin to RhoA, the researchers then tested the candidate drug's impact on cultured breast cancer cells and nerve cells. (cincinnatichildrens.org)
studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)
Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid, and the development of neurofibrillary tangles. (msdmanuals.com)
The scientists discovered that T cells, which play a vital role in the immune system and help trigger factor VIII inhibitor formation, rely on a specific set of other cells to move coagulation factor VIII to the regions of the spleen where T cells reside. (cdc.gov)

We are also working on the discovery of DeltaFosB inhibitors, neurexin modulators, and FGF14/Nav1.6 channel complex protein-protein interaction inhibitors as CNS probes and potential therapeutics. (utmb.edu)
the company also just ended codevelopment of I-Mab's lemzoparlimab, another CD47 inhibitor, besides recently dropping Harpoon Therapeutics' anti-BCMA trispecific T-cell engager, HPN217. (aacrjournals.org)

In addition, researchers contributed to the field of anti-viral drug development by studies involving screening of small molecule libraries and in silico drug design. (europa.eu)

then this catalytic domain binds to and cleaves a nerve-cell protein, making it impossible for the nerve cell to "fire," or send signals. (bnl.gov)

Researchers are at work now to develop an inhibitor drug for it. (webmd.com)
They then injected a drug to block a specific protein into the taste cortex - an area of the brain associated with taste memory. (jpost.com)
researchers then compared CDAI, C-reactive protein (CRP), modified scores on the Health Assessment Questionnaire (mHAQ) after drug initiation, and remission or low disease activity after 6 months. (medscape.com)
Conversely, blocking VEGF-A with a drug inhibitor diminished the increase in neurosphere formation under low oxygen conditions. (news-medical.net)
This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
Drug Discovery Targeting Bromodomain-Containing Protein 4 (BRD4). (utmb.edu)
The combination the Northwestern team tried consisted of the chemotherapy drug vinorelbine and a BET inhibitor called I-BET-762. (delveinsight.com)
These inhibitors are attractive candidates for anti-botulinum drug development," Swaminathan said. (bnl.gov)
According to Bardelli, a MET inhibitor in combination with an anti-EGFR drug caused maximum antitumor activity and sustained response in both xenopatients. (medindia.net)
The US Food and Drug Administration (FDA) has approved Ruconest, a recombinant human C1 esterase inhibitor (rhC1-INH), for the treatment of acute, symptomatic attacks of HAE in adults and adolescents. (medscape.com)
From the paper: 'It is reassuring that this first-in-class drug is effective in treating hemophilia A or B with inhibitors. (cdc.gov)

The researchers evaluated a protein called vascular endothelial growth factor -A (VEGF-A) as a potential candidate. (news-medical.net)

Existing drugs as broad spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. (utmb.edu)
UPTON, NY - New structures of a botulism toxin interacting with a mimic of the nerve-cell protein it destroys suggest new ways to block this often-fatal interaction. (bnl.gov)

Researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have discovered a new class of proteins that protect synapses from being destroyed. (technologynetworks.com)
We discovered proteins that inhibit this function and essentially act as 'don't eat me' signals to protect synapses from elimination. (technologynetworks.com)

Specifically, we have adapted the AlphaLISA technique into a high throughput screen (HTS) platform to identify PRMT5 small molecule inhibitors. (iu.edu)
Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases. (iu.edu)

Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)

The mimic protein interacts with the toxin at several exosites (purple-, brown-, and green-shaded areas) in addition to the active site (red) that performs the cleaving action, suggesting that blocking these interactions could thwart the toxins deadly action. (bnl.gov)

The researchers were able to use differentiation to treat an especially aggressive type of carcinoma called triple negative breast cancer. (unibas.ch)
The awardees are selected through a highly competitive and rigorous process by a scientific committee comprised of leading cancer researchers who are innovators themselves. (damonrunyon.org)
They enable new investigators from all areas of cancer research to explore innovative ideas and established researchers to leverage previous discoveries, with the goal of advancing basic, translational, clinical and population science. (uclahealth.org)
The Ali Jassim Family Cancer Research Program is funding Seed Grants for the following UCLA researchers. (uclahealth.org)
For some time, researchers have known that the protein p27 is an important inhibitor of the cell division that spreads cancer. (univmiami.net)
Joyce M. Slingerland, director of the Braman Family Breast Cancer Institute at Sylvester at the University of Miami Miller School of Medicine, led a team of researchers in collaboration with David Helfman, professor of cell biology and anatomy at Sylvester. (univmiami.net)
This, along with other tests the scientists performed, indicated Rhosin's effectiveness in targeting RhoA-mediated breast cancer proliferation, according to the researchers. (cincinnatichildrens.org)

The mechanisms by which specific ATP2A2 mutations impact the function of the ATP2A2 protein have been investigated using an in vitro model. (medscape.com)

To further probe this curious neutrophil elastase-obesity relationship, the researcher turned once again to mouse models. (medindia.net)

Controlling protein activity with chemogenetics and optogenetics has proven to be powerful for testing hypotheses regarding protein function in rapid biological processes. (genengnews.com)

So we systematically screened for such proteins in the bacterial viruses for over two and a half years. (eurekalert.org)

Her initial studies suggest that an IRF5 inhibitor could be a good candidate to treat lupus. (lupusresearch.org)
Amaria and other researchers are continuing to follow patient outcomes and will be conducting further translational studies to discern the mechanisms of response and resistance to this combination. (mdanderson.org)
Some studies of keratosis follicularis (Darier disease) have suggested that alterations in calcium regulation may affect the synthesis, folding, or trafficking of desmosomal proteins. (medscape.com)
[ 25 ] In particular, studies have revealed that keratosis follicularis (Darier disease) keratinocytes displayed abnormal trafficking of the desmosomal protein desmoplakin and abnormal expression of cytokeratins 10 and 14. (medscape.com)

Another way researchers are trying to make PNH treatment better is by looking at new medicines and combinations of medicines. (webmd.com)
Lu T and Prabhu L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. (iu.edu)
Prophylactic treatment includes attenuated androgens and the C1 inhibitor protein product Cinryze. (medscape.com)

For example, it might work to target both C3 and C5 proteins at the same time. (webmd.com)
The protein is the target of a class of drugs called PCSK9 inhibitors, which are used to lower cholesterol and prevent cardiovascular disease. (sciencedaily.com)
There are no current therapies for PD that target the elimination of toxic proteins that can lead to PD. (michaeljfox.org)
The team first synthesized two different mimics of the target nerve-cell protein. (bnl.gov)

Since HSF1 is a cellular protein needed by the virus to replicate, resistance against HSF1 inhibitors is unlikely. (upstate.edu)
SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)

Researchers have identified two therapeutic approaches that could treat multiple forms of amyotrophic lateral sclerosis (ALS), raising hope that it may. (scienceboard.net)

In this particular work, we tried to establish design principles on how one can look at the structure, or sequence of a protein and identify the sites that enable this splitting and reassembling," says Dr. Dagliyan. (genengnews.com)
Two Drexel researchers received prestigious Individual Biomedical Research Awards from The Hartwell Foundation to support their work aimed at benefitting the health of children of the United States. (drexel.edu)
JAK inhibitors work to prevent the signaling of specific proteins that cause vitiligo. (medlineplus.gov)

ATP2A2, located on 12q23-24.1, encodes the sarcoplasmic/endoplasmic reticulum Ca 2+ -ATP isoform 2 protein (SERCA2), which is a calcium pump. (medscape.com)

Anatomy14

Organisms8

Diseases1

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology9

Phenomena and Processes39

Disciplines and Occupations19

Anthropology, Education, Sociology and Social Phenomena10

Technology, Industry, Agriculture1

Humanities9

Information Science40

Named Groups3

Health Care37

Geographicals1

Small-molecule inhibitor3

Genes8

Investigational3

Gene8

Tyrosine3

Potent inhibitor2

Growth inhibitor1

Targets7

Complement17

Intracellular3

Inflammation7

20232

Monoclonal2

Efficacy7

Nivolumab1

Pancreatic1

Janus2

Enzyme4

Cancers3

Interact6

Different proteins2

Membrane-bound1

Patients9

Molecular10

Found17

Protease3

Localization1

Phosphorylation1

Enzymes6

20201

Guanine2

Checkpoint2

Molecules4

Endogenous1

Preclinical2

Mice4

Therapy4

Compounds4

Clinical trials2

Study11

Neuronal1

Progression2

Coronavirus2

Protein's1

Pathway1

Cells20

Therapeutics2

Viral1

Catalytic1

Drug11

Evaluated a protein called1

Interaction2

Synapses2

High-throughput2

Cell membrane1

Toxins1

Cancer7

Mutations1

Obesity1

Regarding protein function1

Systematically1

Studies4

Treatment3

Target4

Cellular2

Therapeutic1

Work3

Encodes1