Researchers doses. Medical search. Frequent questions

A randomized controlled trial of 2,275 women in Kenya showed that a single dose of the human papillomavirus (HPV) vaccine was highly effective. (newswise.com)
The single-dose vaccine was highly effective at 18 months for HPV vaccination," said Ruanne Barnabas, principal investigator of the trial and a professor of global health at the University of Washington School of Medicine. (newswise.com)
She said a single-dose vaccine would simplify logistics and decrease costs. (newswise.com)
Like many African countries, the Kenya HPV vaccine program rollout has faced the challenges of vaccine delivery, low uptake of the second HPV dose coupled with global HPV vaccine shortages. (newswise.com)
Researchers said more studies need to be done to test how long the vaccine lasts. (newswise.com)
To address the urgent medical need during the 2014 to 2016 outbreak, the clinical development of the 2-dose vaccine regimen comprising of Ad26.ZEBOV and MVA-BN-Filo was accelerated. (plos.org)
This Phase II study was part of this accelerated program, evaluating the safety and immunogenicity of the 2-dose vaccine regimen in healthy and HIV-infected African adults, with 28-, 56-, and 84-day intervals between doses. (plos.org)
Uday Azizi told Israeli media he was feeling fine hours after being administered the vaccine, which is supposed to be given in two doses several weeks apart. (rt.com)
More than 183 million Americans and more than 45 million Britons have received their first dose of a two-shot COVID-19 vaccine. (businessinsider.com)
Both countries have authorized Johnson & Johnson's vaccine, which is a single dose. (businessinsider.com)
In the US, the Centers for Disease Control and Prevention (CDC) has recommended giving second doses of Pfizer's vaccine 21 days after the first, and 28 days after the first for Moderna, with an interval of up to six weeks if "necessary. (businessinsider.com)
Evans said there was "pretty clear evidence" that you get at least 80% protection - and "probably" better than 90% - for Pfizer's vaccine against COVID-19 with symptoms after a single dose. (businessinsider.com)
A new CDC study found that roughly 9 out of 10 people in the U.S. received their second dose of the COVID-19 vaccine within the recommended timeframe. (ktvu.com)
WASHINGTON - About nine out of 10 people in the U.S. who got the first shot of a coronavirus vaccine got the second in the two-dose series, according to a new study by the U.S. Centers for Disease Control and Prevention. (ktvu.com)
The CDC says it is essential for everyone who receives a two-dose vaccine to get the second shot in order to receive its full protection. (ktvu.com)
In total, more than 69.7 million people, or 21.0% of the U.S. population, have received at least one dose of a coronavirus vaccine to date, according to CDC data. (ktvu.com)
After recently writing an article titled ' History of Yellow Fever in the United States ,' I spoke with Dr. Derick Kimathi , a clinical researcher at the Kenya Medical Research Institute-Wellcome Trust Research Programme (KEMRI-Wellcome Trust) who is investigating the safety and efficacy of using smaller doses of yellow fever vaccine to induce similar immunologic protection as standard doses (also known as fractional dosing). (asm.org)
Recent yellow fever outbreaks have pushed the World Health Organization (WHO) to consider fractional doses to increase vaccine access and lower the potential of yellow fever to spread. (asm.org)
There is no specific treatment for yellow fever, but there is a vaccine that is highly effective and offers lifelong protection after just one dose . (asm.org)
The shortage was so severe during the 2015-2017 outbreak that the allotted global stockpile of yellow fever vaccine (6 million doses) was depleted numerous times . (asm.org)
This is a slow, tedious process yielding 100-300 doses per egg , and there are only 4 major yellow fever vaccine manufacturers in the world. (asm.org)
Interestingly, while WHO recommends a potency of 1,000 International Units (IUs) for a full dose of yellow fever vaccine, the actual potency is variable and ranges from about 13,000 to nearly 44,000 IUs per dose . (asm.org)
US researchers gave the first shot to the first person in a test of an experimental coronavirus vaccine - leading off a worldwide hunt for protection even as the pandemic surges. (gulfnews.com)
In 1991, the World at least 6-8 years before with 3 doses of Health Organization (WHO) recommended hepatitis B vaccine starting at birth to that hepatitis B vaccination be included provide information on the effect of the in national immunization programmes in immunization strategy for hepatitis B and countries with a hepatitis B surface antigen the need for booster doses. (who.int)
Scientists from the International Agency for Research on Cancer (IARC) have demonstrated, for the first time, the efficacy of a single dose of human papillomavirus (HPV) vaccine in adolescent girls against persistent infection with HPV types 16 and 18. (who.int)
The vaccine efficacy of a single dose against persistent HPV16/18 infection was 95.4%, which was not significantly different from the efficacy of two doses or three doses of the vaccine. (who.int)
Under current recommendations, nearly 60% of low- and middle-income countries have not been able to introduce HPV vaccination into their national immunization programmes because of the high cost and the logistical challenges related to delivering two doses of the vaccine. (who.int)
A recommendation of a single dose would make vaccination programmes against HPV much more affordable and cost-effective for public health decision-makers, potentially enabling those who currently lack access to the vaccine - nearly 90% of adolescent girls in low- and middle-income countries - to be as protected against HPV and its associated cancers as their counterparts in high-income countries. (who.int)
Public health agencies recommend 2 doses of influenza vaccine for children 6 months through 8 years of age receiving the vaccine for the first time. (cdc.gov)
OBJECTIVE: To systematically review studies comparing vaccine effectiveness (VE) and immunogenicity after 1 or 2 doses of inactivated influenza vaccine (IIV) in children. (cdc.gov)
We extracted geometric mean titers of serum hemagglutination inhibition (HAI) antibodies against influenza A(H1N1), A(H3N2), and B-lineage vaccine antigens after 1 and 2 IIV doses. (cdc.gov)
Similar vaccine strains across doses, not the timing of doses, positively affects immune response. (cdc.gov)

To date, this study is the most comprehensive comparison of physiological parameters and clinical outcomes between fixed and weight-based dosing," says Dr. Sophie Stukas, the study's co-first author and associate research scientist at the University of British Columbia (UBC) Faculty of Medicine. (vchri.ca)
Although randomized studies comparing tocilizumab doses require additional clinical consideration, this study adds to the body of observational data that demonstrates lower doses of tocilizumab - such as the 400 mg IV fixed dose strategy used in this study - increases the number of patients who will benefit from the medication in a climate of drug scarcity. (vchri.ca)
All clinical practice guidelines for knee OA recommend exercise, but "we do not know the optimal dose," Kim Bennell, PhD, a research physiotherapist at the University of Melbourne, Australia, told Medscape. (medscape.com)
the drug showed a clinical response, but the researchers said additional work is needed to assess long-term efficacy and safety. (centerforbiosimilars.com)
The warning comes a few months after the FDA said a clinical trial in patients with rheumatoid arthritis (RA) taking an as-yet unapproved 10-mg dose of tofacitinib twice each day found an increased risk of blood clots and death. (centerforbiosimilars.com)
Although the drug showed a clinical response in a randomized clinical trial of 448 patients, the researchers, noting safety concerns about this class of drugs overall, said additional research is needed to assess long-term efficacy and safety. (centerforbiosimilars.com)
Although it's been illegal in the U.S. since 1970, in recent years, researchers have been granted more opportunities to study its effects in clinical trials and look for potential health benefits. (yahoo.com)
In a landmark study, researchers at St. Joseph's Healthcare Hamilton and McMaster University have found that providing clinical (low) doses of penicillin to pregnant mice and their offspring results in long-term behavioural changes. (sciencedaily.com)
But there haven't been previous studies that have tested the effects of clinical doses of a commonly-used, narrow-spectrum antibiotic such as penicillin on gut bacteria and behaviour. (sciencedaily.com)
A previous study in 2014 raised similar concerns after finding that giving clinical doses of penicillin to mice in late pregnancy and early life led to a state of vulnerability to dietary induction of obesity. (sciencedaily.com)
While the full integration of this imaging method into clinical practice is yet to be confirmed, the preliminary findings of this research are promising, particularly in demonstrating the capability of detecting invasive breast cancer with low doses of fluorine-18-labeled FDG," Freitas said in a statement. (msdmanuals.com)

The UK is delaying the second dose of the vaccines for up to 12 weeks for most people to prioritize giving people their first shot because of an initial shortage of vaccines. (businessinsider.com)
Pfizer's shot was 52.4% effective at protecting against COVID-19 with symptoms between the first and second dose, according to the FDA documents . (businessinsider.com)
The researchers recommended scheduling second-dose appointments during the first-dose administration and sending reminders about the second-dose visit. (ktvu.com)
The pause would allow those who have received the first dose to get the second dose, but new first doses would not be given, according to the report. (timesofisrael.com)
Health Minister Yuli Edelstein confirmed that his ministry may stop administering first doses for "a short period," telling Channel 12 that "there will be no shortage of the second dose. (timesofisrael.com)

A study that found high doses of the polyphenol, resveratrol, could inhibit exercise benefits in older people, has been attacked in the same journal that published the original work back in June for methodology and statistical errors. (nutraingredients-usa.com)
In a study aimed at understanding the effect of therapeutic drugs on the brains of people living with Huntington's disease, researchers used electroencephalography (EEG) to measure immediate changes in the animals' brain waves once ketamine - an anaesthetic and pain relief drug - was administered. (eurekalert.org)
Now, a new study published by Chen and his team in The Lancet Regional Health - Americas , found that a lower, fixed-dose tocilizumab strategy is both clinically and economically effective. (vchri.ca)
The study was a collaboration between researchers at VCH, UBC and Yale University, with support from the Hsu & Taylor Family through VGH & UBC Hospital Foundation. (vchri.ca)
Study limitations include that some healthy adult participants either did not receive dose 2 or received dose 2 outside of their protocol-defined interval and that the follow-up period was limited to 365 days for most participants. (plos.org)
Until now, there has been minimal guidance about what dose of EPA and DHA should be tested in a study, as outlined by the report. (nutritioninsight.com)
The researchers explain that if the dose of EPA and DHA in a study is not high enough to make an impact on blood levels (i.e. the Omega 3 Index), there may be no effect on the observed outcome of omega 3 supplementation, leading to a neutral result. (nutritioninsight.com)
A low dose could make a study show no effect of EPA and DHA, which makes the literature more indecisive and the medical community more skeptical of omega 3 benefits. (nutritioninsight.com)
THURSDAY, Nov. 6, 2014 (HealthDay News) -- Some patients in the early stages of rheumatoid arthritis may be able to have their medication doses safely lowered once their symptoms are well under control, according to a study published in the Nov. 6 issue of the New England Journal of Medicine . (healthday.com)
Reduced or no "padding" during ECG-triggered coronary CT angiography results in a substantial reduction in radiation dose without affecting image quality and interpretability, according to a new study. (sciencedaily.com)
July 23, 2020 A CT scan technique that splits a full X-ray beam into thin beamlets can deliver the same quality of image at a much reduced radiation dose, according to a new study. (sciencedaily.com)
Results of a new study by researchers at Nofima suggest that peracetic acid can safely be used as a water disinfectant in recirculating aquaculture systems (RAS) that contain salmon parr. (thefishsite.com)
A low-dose daily supplement of folic acid improved levels homocysteine in people with high levels of the amino acid and could reduce the risk of coronary artery disease, suggests a small study from Taiwan. (nutraingredients-usa.com)
The new study, published in the journal Nutrition Research (Vol. 26, pp. 460-466), reports that even a low-dose folic acid supplement (400 micrograms) could lead to significant reductions in hyperhomocysteinemic elderly people. (nutraingredients-usa.com)
The researchers report that, while the low-dose folic acid supplements had no significant effect on homocysteine concentrations in the general study population, levels did significantly decrease in hyperhomocysteinemic subjects by 1.8 micromoles per litre. (nutraingredients-usa.com)
"The significant result of this study was that a low dose of folic acid supplementation (400 microg/d) could significantly decrease plasma homocysteine concentration in hyperhomocysteinemic patients with CAD but not in normohomocysteinemia patients," wrote the researchers. (nutraingredients-usa.com)
The review of a study by Dr. Emmanuelle Schindler , medical director of the Headache Center of Excellence at Yale School of Medicine, "found a roughly 50% reduction in weekly migraine days, as well as significantly reduced attack intensity, for two weeks following administration of a single, low (non-psychedelic) dose of psilocybin," with no "serious or adverse events" reported. (yahoo.com)
Now, a study from researchers in Brazil provides a more robust answer to at least one key question: can vitamin D help prevent COVID-19 complications in particularly ill hospitalized patients? (medicalnewstoday.com)
The study found that high doses of vitamin D administered to hospital patients with moderate or severe COVID-19 did not affect the course of the disease. (medicalnewstoday.com)
The researchers say this study is the first of its kind. (medicalnewstoday.com)
The design of the study was to discover whether a high dose of vitamin D was associated with a shorter hospitalization - the researchers found that it was not. (medicalnewstoday.com)
Vitamin D also seemed to have no effect on mortality, although Pereira cautions that a larger study with more participants is required before researchers can draw final conclusions. (medicalnewstoday.com)
Having suggested that a single high dose of vitamin D is not a solution to severe COVID-19, Pereira is now leading a new study to determine whether a vitamin D deficiency has any effect on a person's ability to overcome SARS-CoV-2. (medicalnewstoday.com)
CDC Director Dr. Rachelle Walensky also called the findings 'very encouraging' and said 'systems were in place' so that the 3% of missed doses in the study were not wasted. (ktvu.com)
A study in which 24 trans women and 24 trans men who were taking gender-affirming hormone therapy were directly observed to take a daily dose of the standard formulation of the HIV prevention medication PrEP found that the levels of the two PrEP drugs tenofovir and emtricitabine were similar to the levels seen in similar cis men and women, and were all above levels associated with efficacy. (aidsmap.com)
The study "raises many questions about what is the 'just-right' dose of testosterone," writes Robert Vigersky, MD, of the Walter Reed Army Medical Center. (foxnews.com)
A single dose of 30 mg saffron extract (Safr'Inside) improves psychological stress response after exposure to a lab-based stressor, according to a new double-blind, placebo-controlled, randomised, cross-over study. (nutraingredients.com)
This is the first study of its kind to establish a dose-response relationship between radiation dose from Chernobyl and thyroid cancer. (scienceblog.com)
This is the first study of its kind to establish a dose-response relationship between radiation dose from Chernobyl and thyroid cancer," said Davis, referring to the observation that as radiation doses increase, so does the risk of thyroid cancer. (scienceblog.com)
Researchers did a laboratory study in 2016. (cancerresearchuk.org)
In another laboratory study in 2017 researchers developed a chemical from NDGA. (cancerresearchuk.org)
However, accurate quantification can be challenging, and many researchers find it difficult to study in a robust manner. (lu.se)
This study revealed which machine operators exceed 100% noise dose per the MSHA Permissible Exposure Level (PEL) - the noise limit a mine worker can be exposed to for their shift. (cdc.gov)
WEDNESDAY, Feb. 14, 2024 (HealthDay News) -- Low-dose positron emission mammography (PEM) is feasible for detecting invasive breast cancer, according to a study published online Feb. 9 in Radiology: Imaging Cancer . (msdmanuals.com)

The single-dose efficacy was the same as multiple doses. (newswise.com)
In the first namic research models offer promising approaches to half of this article, we discuss pharmacokinetic/pharmaco- define the determinants of resistance selection and drug dynamic (PK/PD) research approaches that can aid regula- doses that optimize efficacy and reduce resistance selec- tory decision making on the treatment of resistant tion. (cdc.gov)

Vancouver, B.C. - Scarcity of a drug central to the treatment of critically ill COVID-19 patients inspired British Columbia researchers to develop a novel dosing strategy that resulted in more people being treated with smaller doses of a life-saving drug. (vchri.ca)

This paper proposes a high-quality computed tomography (CT) image reconstruction method from low-dose X-ray projection data. (edu.sa)
Diagnostic tools that physicians use to conduct initial tests for lung cancer can include chest X-rays and low-dose computed tomography (CT) scans. (uml.edu)

By reducing or eliminating "padding" we shorten the scanner "on time" and lower the radiation dose," said LaBounty. (sciencedaily.com)
Results showed that increased padding was associated with a greater radiation dose (45 percent increase per 100-millisecond increase in padding)," said LaBounty. (sciencedaily.com)
Our data show that use of minimal or no padding can result in reduced radiation dose with preserved image interpretability in examinations of patients with excellent heart rate control," he said. (sciencedaily.com)
Concerns regarding the radiation exposure associated with coronary CTA have resulted in the development of new techniques to reduce radiation dose. (sciencedaily.com)
The risk of thyroid cancer rises with increasing radiation dose, according to the most thorough risk analysis for thyroid cancer to date among people who grew up in the shadow of the 1986 Chernobyl power-plant disaster. (scienceblog.com)
The incidence of thyroid cancer was 45 times greater among those who received the highest radiation dose as compared to those in the lowest-dose group. (scienceblog.com)
The incidence of thyroid cancer was 45 times greater among those who received the highest radiation dose as compared to those in the lowest-dose group, according to a team of American and Russian researchers led by Scott Davis, Ph.D., and colleagues at Fred Hutchinson Cancer Research Center. (scienceblog.com)
We found a significant increased risk of thyroid cancer among people exposed as children to radiation from Chernobyl, and that the risk increased as a function of radiation dose. (scienceblog.com)
However until now nobody had taken the next step to find out just how much a risk there is and whether it rises along with radiation dose. (scienceblog.com)
But ours is the first report that provides quantitative estimates of thyroid-cancer risk in relation to individual estimates of radiation dose," said Davis, also chairman of the Department of Epidemiology at the University of Washington School of Public Health and Community Medicine in Seattle. (scienceblog.com)
A team of researchers led by electrical and computer engineering Assoc. Prof. Hengyong Yu is developing a new ultralow-dose CT screening method to improve the image quality and resolution of CT scans while reducing the radiation dose. (uml.edu)
Currently, the average effective radiation dose of a low-dose CT scan for lung cancer screening for an adult is about 1.5 millisieverts. (uml.edu)

These findings are a gamechanger that may substantially reduce the incidence of HPV-attributable cervical cancer and positions single-dose HPV vaccination as a high value and high impact public health intervention that is within reach for us," said Kenya Medical Research Institute (KEMRI) Acting Director General, Prof. Sam Kariuki. (newswise.com)
We investigated safety, tolerability, and immunogenicity of the heterologous 2-dose Ebola vaccination regimen in healthy and HIV-infected adults with different intervals between Ebola vaccinations. (plos.org)
course of vaccination, and a booster dose does not seem necessary [ 11 ]. (who.int)
The researchers' findings could signal a fundamental shift in the accessibility of vaccination against HPV. (who.int)

A low-dose exercise regimen helped patients with knee OA about as much as a more intense workout plan, according to trial results published online January 23 in Annals of Internal Medicine . (medscape.com)
The low-dose regimen consisted of five exercises ― cycling, squats, step-ups, step-downs, and knee extensions ― performed for 20-30 minutes. (medscape.com)
High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant (HDC/ABMT or just ABMT), was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. (wikipedia.org)

The researchers measured outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS) , which assesses pain, other symptoms, function in daily living, function in sports and recreation, and knee-related quality of life. (medscape.com)

Millions of people worldwide have had one shot of two-dose COVID-19 vaccines. (businessinsider.com)
Pfizer and Moderna's vaccines are likely 80% effective against symptomatic COVID-19 after one dose. (businessinsider.com)
The data for how well the vaccines work after one dose isn't clear cut - it depends on what you're measuring, and when you're measuring it. (businessinsider.com)
Concerns about undermining trust in vaccines persist, and researchers are cautious about potential misinterpretation of their findings. (scientificinquirer.com)

The Journal of Physiology published the response in October written by researcher James Smoliga, PhD, from High Point University in North Carolina and Otis Blanchard, the president and chief technology officer of Texan player, Wilmore Labs. (nutraingredients-usa.com)
When the drug wore off and the sheep regained consciousness, the researchers were surprised to see the brain activity start switching between high and low frequency oscillations. (eurekalert.org)
After the high dose of ketamine the brains of these sheep completely stopped. (eurekalert.org)
The researchers say that such high doses can cause liver damage, may stop the heart, and be fatal. (eurekalert.org)
Both high and low doses of exercise reduced pain and improved function and quality of life. (medscape.com)
Participants were randomly assigned to low- or high-dose exercise plans, which they performed three times per week for 12 weeks under the supervision of a physiotherapist. (medscape.com)
Participants in the high-dose group performed 11 exercises during each session, which lasted 70-90 minutes. (medscape.com)
Patients in both groups improved significantly over time, but high-dose exercise was not superior to low-dose exercise in most comparisons," Torstensen and his co-authors report. (medscape.com)
High-dose exercise was associated with better function in sports and recreational activity and knee-related quality of life at 6 months. (medscape.com)
It was slightly lower in the high-dose group, the researchers say. (medscape.com)
Interestingly, it seems that high-dose treatment could be preferable to low-dose treatment in the long run for people who lead active lives," they write. (medscape.com)
Hopefully, ensuring the dose of EPA and DHA is high enough to reach a target Omega 3 Index level will clarify whether or not EPA and DHA are effective," explains Kristina Harris Jackson, Ph.D., co-lead author on this paper. (nutritioninsight.com)
A low-dose (400 microg/d) rather than a high-dose of folic acid supplementation may be sufficient to reduce plasma homocysteine concentration in hyperhomocysteinemic patients with CAD. (nutraingredients-usa.com)
With an overall idea that more is better, this process involved taking cells from the person's bone marrow to store in a lab, then to give such high doses of chemotherapy drugs that the remaining bone marrow was destroyed, and then to inject the cells taken earlier back into the body as replacement. (wikipedia.org)
3 The idea for high-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT) originated in the 1950s as a leukemia treatment, when E. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person. (wikipedia.org)
The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. (wikipedia.org)
To belabour the point further Hortobagyi, using data from the University of Texas M. D. Anderson Cancer Center in Houston, reported in May 1995 that those eligible for high-dose chemotherapy survived 65% longer on conventional chemotherapy than those who would not have been eligible for the protocol. (wikipedia.org)
While cannabis companies generally like to tout high-level THC products, Dr. Molly McCann, New Frontier's senior director of consumer insights, thinks the industry should cater more to people looking for lower doses. (eastbayexpress.com)
You unknowingly take a placebo, high dose or low dose of psilocybin. (yahoo.com)
We decided to investigate whether a high dose of the substance could have a protective effect in the context of an acute viral infection, reducing either the inflammation or the viral load. (medicalnewstoday.com)
Assessment of the effectiveness and safety of high daily 125 μ g (5000 IU) or 250 μ g (10 000IU) doses of vitamin D 2 during 3 months, in rapidly obtaining adequate 25 hydroxyvitamin D (25OHD) levels. (nature.com)
In high doses NDGA causes liver damage. (cancerresearchuk.org)
By using dose-response curve principles for both experimental design and analysis, it is possible to increase the sensitivity and robustness, leading to accurate quantification of phagocytosis that is comparable across experiments and systems.Here, we describe how to quantify phagocytosis using flow cytometry with a robust, high-throughput, and easy-to-use approach. (lu.se)

Contradicting findings of studies further underline the significance of omega 3 dose. (nutritioninsight.com)
Our findings show increased HAI titers after 2 doses, compared with 1. (cdc.gov)
CONCLUSIONS: Findings support policies recommending 2 IIV doses in children to provide optimal protection against influenza. (cdc.gov)

British Columbia began using tocilizumab with weight-based dosing (8 mg/kg to a maximum 800 mg) in January 2021 for critically ill patients with COVID-19. (vchri.ca)

Initially, the same response was seen as with a lower dose. (eurekalert.org)
At lower doses ketamine has a pain-relieving effect, and its use in adult humans is mainly restricted to field situations such as frontline pain-relief for injured soldiers or victims of road traffic accidents. (eurekalert.org)
The improvements with the lower-dose plan and its 98% adherence rate are encouraging, said Nick Trasolini, MD, assistant professor of orthopedic surgery at Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina. (medscape.com)
I'm not saying we should never lower patients' doses,' she added. (healthday.com)
But while one might get more stoned from more THC, that doesn't mean a different product with a lower dose won't offer a more pleasant experience. (eastbayexpress.com)
Many of the pot-curious people who are piling into pot shops in legal states are increasingly looking specifically for lower-dose THC products. (eastbayexpress.com)
The drug was later approved by the FDA at the lower dose, under the name Olumiant, with a black box warning that includes a caution related to deep venous thrombosis, pulmonary embolism, and arterial thrombosis, among other warnings. (centerforbiosimilars.com)
Multi-targeted drug therapy holds more promise than single-class drug regimens (Lapchak 2011 ) since some drug combinations exhibit pharmacological synergism, translating into lower doses, fewer adverse side effects, and extending the therapeutic window (Saleh et al. (springer.com)
Lower X-ray dose means the patient will be exposed less to ionizing radiation, which can damage healthy cells and increase the risk for malignancy. (uml.edu)

The healthcare worker responsible for the unfortunate mishap was reportedly unaware that each vial of the drug typically contains at least five doses. (rt.com)
The final phase takes place the day after dosing and typically lasts for a few weeks. (yahoo.com)
Researchers typically administered one-half the standard dose of IIV. (cdc.gov)

Other studies have shown that large doses of broad-spectrum antibiotics in adult animals can affect behaviour. (sciencedaily.com)

Cite this: 'Very Doable' Low-Dose Workout Enough to Treat Knee OA - Medscape - Jan 23, 2023. (medscape.com)

PrEP drugs and sex hormones are metabolised in different ways so there is no reason to expect significant interactions, the researchers say. (aidsmap.com)

When it comes to cardiovascular disease (CVD), in particular, the literature supporting the benefits of omega 3 types EPA and DHA has been mixed, note the study's researchers. (nutritioninsight.com)
The fact that most people are completing the two-dose series to be fully vaccinated shows the system's working,' said Robin Toblin of the CDC, one of the study's authors. (ktvu.com)

At that point, the authors randomly assigned them to one of three groups: reduced-dose etanercept plus methotrexate (combination-therapy group), methotrexate alone, or placebo. (healthday.com)
About six months later, some patients remained in remission, including 44 percent of those who had received combination therapy with reduced-dose etanercept and methotrexate, 29 percent of those who had received methotrexate alone, and 23 percent of those who had received placebo. (healthday.com)
Lead researcher Ping-Ting Lin from the Chung Shan Medical University, Taiwan, and co-workers recruited 46 people (42 men, average age 73) and randomly assigned to either a placebo group or a folic acid group (General Nutrition Corp.) for eight weeks. (nutraingredients-usa.com)

Benefits were seen with the mid-level dose (300 micrograms) but not the low dose. (foxnews.com)

Anamnestic responses were observed in all healthy participants receiving Ad26.ZEBOV as booster at 1 year after the first dose. (plos.org)
The scientists gave participants in the first group a single 200,000-unit dose of vitamin D3 dissolved in peanut oil. (medicalnewstoday.com)
Twenty-five female participants newly diagnosed with breast cancer underwent low-dose PEM with up to 185 MBq of fluorine 18-labeled fluorodeoxyglucose ( 18 F-FDG). (msdmanuals.com)

The researchers found 88% of individuals completed the series, and another 9% did not but still had time to complete the series within the six weeks that CDC officials recommend as the maximum span between doses. (ktvu.com)
Researchers found completion rates varied across states and U.S. territories. (ktvu.com)
Barium sulphate, a chemical found in photo paper and cosmetics, was used by the researchers. (marksmendaily.com)
The researchers found that chaparral wasn't safe and did not work well for treating cancer. (cancerresearchuk.org)
Researchers found that it stopped glioma cells from growing. (cancerresearchuk.org)

Skin reactions to the patches were "mild or moderate," write the researchers. (foxnews.com)
There is no need to worry about the accumulation of moderate radiation doses any more than one should worry about the accumulation of moderate sunlight energy, the accumulation of daily doses of vitamins, or the accumulation of moderate exercise. (atomicinsights.com)

And in April 2018, the FDA's Arthritis Advisory Committee voted to recommend a low dose of Eli Lilly's JAK inhibitor, baricitinib, but voted against recommending approval of a higher dose given concerns about the potential for dose-dependent adverse events such as thrombosis. (centerforbiosimilars.com)
In addition, two stringent regulators have approved in 2018 the first single-dose radical cure for P. vivax, which is a health challenge in the Horn of Africa, representing a major improvement over the current 14-day standard of care for this indication. (who.int)

The strategy surmised that the smaller dose would likely provide an equivalent short-term anti-inflammatory effect while allowing nearly twice as many patients to receive tocilizumab. (vchri.ca)

Six of the sheep were given a single higher dose of ketamine, 24mg/kg. (eurekalert.org)
Ketamine abusers are known to take doses many times higher than those given to the sheep in this research. (eurekalert.org)
It is also likely that progressively higher doses have to be taken to get the same effect. (eurekalert.org)
My hypothesis," she wrote this week, "is that many people who tried cannabis in the past and had a bad experience took a dose much higher than their minimum effective dose, and that most people should probably be taking products with less THC, or what the industry calls 'low dose. (eastbayexpress.com)
But the 52.4% figure includes the 11 days before protection kicks in after the first dose, so the real percentage could well be higher. (businessinsider.com)
A higher dose wasn't more beneficial, write the researchers. (foxnews.com)
The downside is that the procedure exposes the patient to a higher dose of radiation than the chest X-ray. (uml.edu)
The oral dose of vitamin D 2 required to rapidly achieve adequate levels of 25OHD is seemingly much higher than the usual recommended vitamin D 3 dose (20 μ g/day). (nature.com)

The researchers highlight that dose likely played a role in the relative success or failure of previous studies that have focused on omega 3 as a research variable. (nutritioninsight.com)
The researchers call for more studies of the testosterone patch's safety and effectiveness. (foxnews.com)
Recent studies are reviewed on the consequences of the radioactive releases and on benefits of medical treatments with low doses of radiation that were carried out until the 1950s, before the radiation scare was created. (atomicinsights.com)
More studies are needed to determine the necessity for or timing of booster doses. (who.int)
Researchers have tested M4N in laboratory studies on mouse and human cancer cells. (cancerresearchuk.org)

Several testosterone doses were tested. (foxnews.com)
He likens the hunt for the best dose of testosterone to the nursery rhyme character Goldilocks, who sought a "just-right" chair, bed, and bowl of porridge. (foxnews.com)

400 mg fixed dose tocilizumab holds out hope of extending the supply of life-saving medication and providing benefit to a larger number of severe COVID-19 patients. (vchri.ca)
To help alleviate shortages of the crucial drug, Vancouver Coastal Health Research Institute researcher Dr. Luke Chen proposed a unique strategy - providing patients with smaller, fixed doses of the drug, rather than the standard weight-based dose strategy. (vchri.ca)
When supply shortages of tocilizumab hit, British Columbia adopted Chen's strategy and switched to fixed dosing 400 mg IV for patients weighing more than 50 kg. (vchri.ca)
In a final step, the researchers had patients who were still in remission stop all treatment. (healthday.com)
Padding duration can be adjusted on a patient by patient basis, and decreased padding should be considered in dose reduction strategies for patients with excellent heart rate control," said LaBounty. (sciencedaily.com)
The FDA Friday issued a black box warning for the 10-mg, twice-daily dose of tofacitinib, which is used in patients with ulcerative colitis (UC). (centerforbiosimilars.com)

Decreased sexual desire is one of women's top four common sexual problems, write the researchers. (foxnews.com)

Only recently has this assumption been called into question, with many researchers declaring that the whole thing is a crock ("total nonsense," one respected researcher told me ), and that cannabis vendors were taking advantage of a myth. (eastbayexpress.com)

Cynomolgus monkeys (Macaca fascicularis) were exposed by fine-particle aerosol to lethal doses of monkeypox virus, Zaire strain. (blogspot.com)
Researchers suspect that exposure to particulate matter and other contaminants from wildfire smoke, heavy physical exertion, existing health and behavior risk factors, and cardiovascular strain could contribute to sudden cardiac events for wildland firefighters. (cdc.gov)
In the other area, mosquitoes have a resistance factor to pyrethroids of at least 10 fold compared to a susceptible strain, meaning that when exposed to the same chemical dose as a susceptible strain, it takes at least 10 times as long to kill them. (cdc.gov)

A large number of cases are seen that a booster dose is not needed before the in eastern Asia and sub-Saharan Africa [ 3 ]. (who.int)

Researchers and public health officials called the results 'encouraging. (ktvu.com)
Dr. Jerry Cuttler has been concentrating his research on the health effects of low dose radiation for more than 15 years. (atomicinsights.com)
In the morning session, Dr. John Howard, the WTC Health Program Administrator, gave opening remarks, followed by two panels of leading researchers who each discussed the health effects from the 9/11 attacks and their recent research. (cdc.gov)
National Institute for Occupational Safety and Health (NIOSH) researchers strive to reduce noise-induced hearing loss for coal miners. (cdc.gov)

Researchers have discovered several compounds that can cure mice of malaria in a single dose. (popsci.com)
A single dose of these compounds, called bicylic azetidines, left mice infected with P. falciparum or another species, P. berghei , parasite-free for 30 days. (popsci.com)
A treatment for malaria that works in a single dose is especially appealing because it could be easier and cheaper to use than drugs that people must take repeatedly. (popsci.com)
Our goal is to reduce the dose to less than 0.5 millisievert, which is comparable to a single radiographic chest X-ray," explains Yu. (uml.edu)

For years, exercise scientists tried to quantify the ideal "dose" of exercise for most people. (indiatimes.com)
Low-dose folic acid supplementation for eight weeks for the TT genotype people led to a significant 2.1 micromoles per litre reduction in homocysteine levels, and 1.4 micromoles per litre for people who carry the T-allele either hetero- or homozygously. (nutraingredients-usa.com)
People with depression, anxiety, posttraumatic stress disorder, anorexia and smoking or substance abuse disorders tend to have low levels of serotonin, but some researchers are hoping psilocybin may offer a solution. (yahoo.com)
Researchers have wondered whether vitamin D may help people avoid SARS-CoV-2 infections and mitigate the effects of COVID-19. (medicalnewstoday.com)

Newswise - In the push to eliminate cervical cancer, researchers delivered hopeful news Nov. 17 at the 34th International Papillomavirus Conference in Toronto. (newswise.com)

In the context of ongoing drug shortages, a fixed-dose 400 mg of tocilizumab may be a practical, feasible and economical option. (vchri.ca)

The research pool was highly sexually active with men reporting an average of about 13 male partners in the six weeks prior to enrollment, thus making them ideal candidates for PrEP, researchers said. (washingtonblade.com)
Researchers said more behavioral research is needed before event-based dosing is recommended. (washingtonblade.com)

Both doses demonstrated comparable reduction of inflammation and improvement on lung function," says Chen. (vchri.ca)

Low-dose penicillin taken late in pregnancy and in early life of mice offspring, changes behavior and the balance of microbes in the gut. (sciencedaily.com)
In this paper, we report that low-dose penicillin taken late in pregnancy and in early life of mice offspring, changes behaviour and the balance of microbes in the gut. (sciencedaily.com)

As malaria parasites develop resistance to existing drugs, researchers have been looking for new treatments. (popsci.com)

The researchers report no safety concerns with either intervention. (medscape.com)

Knowledge of the nature of the exposure-dose-response endorsement or recommendation for use. (cdc.gov)

The current standard for women is three-doses. (newswise.com)
This method generates an overcomplete dictionary from patches of standard-dose CT images and reconstructs low-dose CT images by minimizing the sum of a data fidelity and a regularization term based on sparse representations with the dictionary. (edu.sa)

Rearranging the equation, one can calculate the approximate EPA/DHA doses (of triglyceride forms) needed to achieve a mean omega 3 index of 8 percent in 13 weeks. (nutritioninsight.com)

Pereira says, "The ideal approach is case-by-case analysis, if necessary dosing the substance periodically by means of blood work, with supplementation if a deficiency is detected. (medicalnewstoday.com)

For example, the researchers measured mortality of the mosquitoes for only 24 hours after they were collected. (cdc.gov)

Researchers in the National Cancer Institute (NCI) did not believe that the treatment would be effective and were wary of the consequences of this treatment. (wikipedia.org)
Saffron is more effective at treating attention deficit hyperactivity disorder (ADHD) in children and young adults than conventional pharmaceutical treatment (methylphenidate), according to researchers. (nutraingredients.com)
Though the researchers zeroed in on just a handful of molecules that were effective against malaria, others may still lurk in the 100,000-compound library. (popsci.com)

The researchers proceeded with Phase II trials, which showed very promising results. (wikipedia.org)
In addition, the gestational window is critical because exposures outside certain gestational periods may be nontoxic, while the same doses can cause devastating results within the window. (medscape.com)
These results were achieved also thanks to crucial partnerships with a large network of African researchers. (who.int)

A dose-response effect is observed (ie, more severe effect with increasing dose). (medscape.com)

The 10-mg twice-daily dose of tofacitinib is not approved for RA or psoriatic arthritis (PsA). (centerforbiosimilars.com)

Anatomy4

Organisms4

Diseases4

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment72

Psychiatry and Psychology19

Phenomena and Processes17

Disciplines and Occupations27

Anthropology, Education, Sociology and Social Phenomena25

Technology, Industry, Agriculture2

Humanities16

Information Science62

Named Groups6

Health Care90

Geographicals5

Vaccine32

Clinical11

Second dose5

Study34

Efficacy2

Smaller doses1

Computed tomography2

Radiation dose12

Vaccination4

Regimen3

Outcomes1

Vaccines4

High23

Findings3

20211

Lower9

Typically3

Adult1

20231

Interactions1

Study's2

Placebo3

Micrograms1

Participants3

Found5

Moderate2

20182

Anti-inflammatory1

Higher8

Studies5

Testosterone2

Patients6

Sexual1

Nonsense1

Strain3

Booster1

Health4

Single4

People4

News1

Shortages1

Research2

Reduction1

Pregnancy2

Treatments1

Report1

Recommendation1

Standard2

Equation1

Supplementation1

Mortality1

Effective3

Results3

Severe1

Daily1