Researchers dendrimers. Medical search. Frequent questions

Dendrimers are large globular monodisperse polymers. (europa.eu)
For this purpose, researchers have been aiming to reach a similar degree of sophistication as natural viruses by developing artificial nanosystems with a wide range of applications - liposomes, polymers, micelles, dendrimers, inorganic nanoparticles made of iron oxide, and more recent hybrid organic-inorganic materials such as metal-organic frameworks (MOFs). (nanowerk.com)
Artzi and Edelman originally developed this tissue glue several years ago by combining two polymers-dextran (a polysaccharide) and a highly branched chain called dendrimer. (rdworldonline.com)
By changing the materials' molecular weight, the number of keys attached to each polymer, and the ratio of the two polymers, the researchers can tune it to perform best in different types and states of tissue. (rdworldonline.com)
Voit received the prize for her work on dendrimers and hyperbranched polymers, functional polymers, and bioactive polymers, as well as for her involvement in building scientific networks. (chemistryviews.org)
While a scientist at Dow Chemical, Tomalia created special treelike polymers called dendrimers that have numerous existing and potential applications, especially in biomedicine. (sciencehistory.org)
Lamm is studying how dendrimers (large polymers with many branches) bind to ligands (smaller molecules that bind with other molecules to form larger complexes). (acm.org)

According to Monter Ramirez, this project led him to design some structures called dendrimers, which are highly branched molecules with shape similar to a shrub or a tree with multiple branches. (sciencedaily.com)
The boronic acid derivative comprises a dendrimer of benzoboroxole units and other building blocks that together form a highly branched structure that resembles an octopus. (journalforclinicalstudies.com)

All of our studies focused on polyamidoamine (PAMAM) dendrimers. (confex.com)
Cationic dendrimers such as poly(propyleneimine) (PPI), poly(amidoamine) (PAMAM), poly(L-Lysine) (PLL) and carbosilane are able to form complexes with siRNA through charge interactions and shielding it from RNases. (polymerfactory.com)
His project was Novel Asymmetrical Bow-Tie PAMAM Dendrimer Conjugates as Model Systems for Anticancer Taxoid Drug Delivery. (stonybrook.edu)

Phosphorus dendrimers in biology and nanomedicine : synthesis, characterization, and properties. (wikipedia.org)
The main targets of our group is the design and synthesis of dendrimeric structures (dendrimers and dendrons) with biomedical applications. (dendrobionet.com)
1.- Synthesis of new dendrimers and dendrons with different peripheral groups. (dendrobionet.com)
Synthesis of all-aliphatic polyamide dendrimers based on a 3,3´-diaminopivalic acid scaffold. (dendrobionet.com)
Student of the doctorate in 'Ciencia y Tecnología Química', she has been working on the synthesis and application of water-soluble tetraphenylmethane dendrimers, and defended her PhD thesis titled "Funcionalización periférica de dendrímeros rígidos de tetrafenilmetano" (supervisors: Torneiro and Lazzari) in January 2020. (fun-nanotech.org)

Janus dendrimers, discovered by Virgil Percec of the University of Pennsylvania and coworkers a few years ago, are molecules that branch out repetitively from a point and, like the Roman god Janus, have two faces. (acs.org)
Researchers can now predict the size and properties of a vesicle based on the primary structure of its molecular precursors, thanks to a method developed by Virgil Percec and co-workers (DOI: 10.1021/ja208762u). (upenn.edu)

Some proposed applications involve dendrimer interactions with aromatic and hydrophobic hydrocarbons, or molecules containing moieties with these properties. (confex.com)
All-atom MD simulations with explicit water were used to investigate the mechanistic details of association of model aromatic hydrocarbon guest molecules, naphthalene (NPH), and its derivatives, with 3rd - 6th generation (G3-G6) dendrimers. (confex.com)
However, we observe dendrimer branches form local pocket-like structures around NPH molecules associated with the dendrimers. (confex.com)
Of particular note, we find that NPH molecules associated closer to the dendrimer center are not necessarily more protected from the water environment. (confex.com)
We found no clear saturation point, but instead observe a transition to NPH molecules aggregating together on the dendrimers. (confex.com)
The team studied dendrimers, which are branched amphiphilic molecules possessing both polar and apolar character. (upenn.edu)
Abstract Fluorescent dyes, or fluorophores, enable researchers to visualize specific biological molecules by fluorescence microscopy. (biruni.edu.tr)
Since the central core of a dendrimer is hollow, it can be thought of as a pouch or cavity that can be used to trap or store other molecules. (sciencehistory.org)
In the study conducted by Dr. Jasdave Chahal and Dr. Omar Khan, Dr Khan designed the RNA particles in which they packed the RNA vaccine in dendrimers that can be positively charged hence can form successful close association with negatively charged RNA molecules of about 150 nanometers. (delveinsight.com)

MALDI-TOF mass spectral analysis was used to characterize the novel unimolecular micelles that result from functionalization of the chain ends of poly(propylene imine) dendrimers with C 10 alkanoyl or C 12 alkyl groups. (edu.sa)

Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. (mdpi.com)

Dendrimers can self-assemble into nano- sized vesicles known as dendrimersomes, and scientists are interested in developing dendrimersomes because these hollow vesicles can encapsulate drugs and biomolecules for applications in both basic research and medicine. (upenn.edu)

A first generation phosphorus-containing dendrimer with twelve terminal benzyl dithiobenzoate functions was designed and subsequently used as a multifunctional agent to derive hybrid star copolymers consisting of a dendritic core surrounded by twelve polystyrene branches by reversible addition-fragmentation chain transfer (RAFT). (edu.sa)
in this case, the branches of the dendrimers capture pollutants, "says the researcher. (sciencedaily.com)
Chemists at the University of St Andrews, UK, have synthesised a range of tree-like catalysts which, to the researchers' surprise, show improved selectivity for certain reactions depending on the number of branches in the tree. (chemistryworld.com)
The idea was that if you attach small catalytic units to the branches of large dendrimers, the catalysts can take part in homogeneous reactions but, being part of a larger entity, are more easily recoverable,' says Russell Morris, the group's leader. (chemistryworld.com)
We discovered that if the dendrimer has a small number of outer branches, say eight, we typically obtained ratios of linear to branched aldehyde product of three, four or five to one,' said Morris. (chemistryworld.com)
However, when we increased the size of the dendrimer to 16 or 24 end branches, we obtained ratios of 13, 14 or 15 to one. (chemistryworld.com)

She has shown that the biological properties of dendrimers are influenced by their internal structures. (wikipedia.org)
Prior to this study, researchers could not systematically predict the properties of vesicles, such as size, membrane thickness, and stability, from the structures of their precursors. (upenn.edu)
A team of researchers from Newcastle University of Singapore and National University of Singapore, led by Mr Loh Tick Boon, with academic supervisors Dr JJ Chong and Dr Kheng Lim Goh, has developed a novel and practical method of assessing the mechanical properties of structures, with potential application to structural health monitoring of large structures such as bridges and viaducts in Singapore. (asiaresearchnews.com)

Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex. (tmd.ac.jp)

The company also provides chemists & researchers in the medical field with a selection of functionalized polysaccharides. (dalgonamagazine.com)

cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link) Dendrimers : towards catalytic, material and biomedical uses. (wikipedia.org)
Robert S. Langer is one among many researchers who now incorporate dendrimers into their biomedical research. (sciencehistory.org)

2011) Nanotechnologies for Alzheimer available narrative: inspiration, and site researchers. (drpulley.info)

Multibilayer vesicles made previously by other means required "very complex and time-consuming methods that do not control their size and size distribution in a precise way," the researchers note, adding that the new approach overcomes those limitations. (acs.org)
Dendrimersomes have a number of advantages over traditional lipid-based vesicles, such as increased stability, uniformity, and the ability to be tuned to have a specified size and shape by altering the composition of their dendrimer precursors. (upenn.edu)

In all dendrimer generations, NPH associates at a distance from the dendrimer center that is accessible to the water solvent. (confex.com)
Dendrimer generations. (sciencehistory.org)

Dendrimers offer desirable properties, such as precise control of the size, shape, and chemical functionality of the molecule. (confex.com)

We used all-atom molecular dynamics (MD) simulations to investigate the interactions between dendrimers and hydrocarbons. (confex.com)
We performed extensive simulations of aromatic hydrocarbon-dendrimer interactions, totaling several microseconds of simulation time for 70,000+ atom systems. (confex.com)
J. S. Klos, J.-U. Sommer, 'Simulations of Terminally Charged Dendrimers with Flexible Spacer Chains and Explicit Counterions', Macromolecules (2010). (ipfdd.de)

1988 Alexander von Humboldt Foundation Fellow[citation needed] 1989 French National Centre for Scientific Research Bronze medal 2006 Société chimique de France Organic Chemistry Award 2011 Appointed to the advisory board of the Chemical Society Reviews 2021 Société chimique de France Achille le Bel Grand Prize Caminade was awarded the Société chimique de France Achille le Bel Grand Prize for her contributions to dendrimers and the application of dendrimers in catalysis. (wikipedia.org)
I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Christiana Rissing, a Ph.D. student in SMU's Chemistry Department , studies the interaction of dendrimers based on a tetravinylsilane core with metals like copper, platinum and silver. (smu.edu)
But it's not all that computing power that's driving three Iowa State University and Ames Laboratory researchers as they develop computational chemistry at the petascale. (acm.org)
Iowa State researchers Lamm, Windus and Mark Gordon , Distinguished Professor and Frances M. Craig Chair in chemistry, Ames Laboratory senior chemist and director of the lab's Applied Mathematics and Computational Sciences Program, are leading Iowa State's work to develop computational chemistry software that can be scaled up to petascale computing systems. (acm.org)
The Iowa State researchers are working to scale up two computational chemistry software codes for use on Blue Waters and its thousands of parallel processors and high-speed connections. (acm.org)
It houses the Organic Semiconductor Centre which provides extensive facilities for the study of organic semiconductor materials and devices and collaborates with researchers in chemistry, biology and medicine. (miledi-h2020.eu)

Starting in 2008, researchers could buy dendrimers to use as vectors to carry DNA into cells. (sciencehistory.org)

After postdoctoral researcher at Eastman Kodak in Rochester, NY, USA, she became a Research Assistant at the Technical University Munich, Germany, in 1992. (chemistryviews.org)

Percec's group identified the new Janus dendrimers during a molecular library search. (acs.org)
To do his studies, he's using a computational method that allows researchers to look at a large molecular system by splitting it into fragments. (acm.org)

Her research considers dendrimers and heterochemistry. (wikipedia.org)
This method will take some of the guess work out of dendrimer research and speed the development of dendrimersomes as useful cell membrane mimics. (upenn.edu)
Since inventing dendrimers Tomalia has remained deeply involved in dendrimer-related research and has developed a working partnership with Dow, his former employer. (sciencehistory.org)
Now, however, researchers at Tohoku University's Advanced Institute for Materials Research in Japan have developed a framework to predict how the structure of solid-state electrolytes can affect the performance of a battery. (asiaresearchnews.com)
These 17 early career materials researchers from around the world are pushing scientific boundaries, conducting impactful research at the forefront of fundamental or applied research, and interfacing with other disciplines. (conde-nanolab.com)
Current research includes the study of their photophysics, with particular emphasis on exciton diffusion, the development of new materials such as light-emitting dendrimers, and research on devices such as solar cells, light-emitting diodes and lasers. (miledi-h2020.eu)

15, 2021 Researchers have developed a more eco-friendly way to remove heavy metals, dyes and other pollutants from water. (sciencedaily.com)

The study encompassed dendrimers of generation one to four (G1-G4), modified to bear 6-48 amino end-groups, where the G2-G4 proved to be capable of siRNA complexation and protection against RNase-mediated degradation. (mdpi.com)
Many researchers are now looking into the development of siRNA-based therapeutics. (polymerfactory.com)
Amino-functional bis-MPA dendrimers of generation 1 to 4 (G1 to G4) have been investigated as a non-viral vector for siRNA delivery in primary neurons, astrocytes, glioma, and glioblastoma cell lines. (polymerfactory.com)
Alternatively, it might also due to a strong charge-interaction between dendrimer and siRNA which inhibits the release of siRNA. (polymerfactory.com)
Since this is the first study on bis-MPA dendrimers as a potential non-viral carrier for siRNA delivery, the results are relatively promising and more studies are required to understand the system better and potentially discover ways to take measures to improve the existing protein knockdown rate. (polymerfactory.com)
Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies. (news-medical.net)

The authors prepared dendrimers which were functionalized on the periphery with tetraphenylethene. (advancedsciencenews.com)

The number of bilayers formed in the dendrimersomes depends on the concentration of the dendrimer starting material used to make them. (acs.org)
For example, researchers can tailor dendrimersomes to mimic cell membranes and perform fundamental biological studies to better understand how cells grow and divide. (upenn.edu)

Dendrimers are a class of branched macromolecules with generational growth that have been explored for applications in fields including water purification, drug delivery and light harvesting. (confex.com)
A detailed description of the interactions between dendrimers and aromatic hydrocarbons can assist researchers in selecting and tuning dendrimer properties for specific applications. (confex.com)
We highlight the importance of considering both dendrimer-guest and guest-guest interactions when designing dendrimers for host-guest applications. (confex.com)
Insights from our results can be used when designing dendrimers for specific applications. (confex.com)
It has expanded the range of organic semiconductor materials with light-emitting dendrimers, and the range of OLED applications with skin cancer treatment. (miledi-h2020.eu)
The series is essential reading for materials science researchers interested in current developments in ceramic manufacturing and applications. (eurekaselect.com)
Solid Oxide Fuel Cells (SOFCs) have received great attention among researchers in the past few decades due to their high electrochemical energy conversion efficiency, environmental friendliness, fuel flexibility and wide range of applications. (eurekaselect.com)

J. Klos, J.-U. Sommer, 'Properties of dendrimers with felxible spacer-chains: A Monte Carlo study', Macromolecules 42 (2009) 4878-4886. (ipfdd.de)

He has been working again in the laboratory as post-doc researcher, from June 2017 to May 2018. (fun-nanotech.org)

In this approach, the initially constructed organometallic dendrimers are irradiated with 365 nm wavelength, transforming them to fully organic dendrimers which are emissive in solution and in the aggregate state. (advancedsciencenews.com)
These organic dendrimers possess tunable dual emissions at 368 nm, as well as at 469 nm. (advancedsciencenews.com)

Fluorescence microscopy experiment also suggested efficient endo-lysosomal escape with distinct mitochondrial subcellular localisation for all generation dendrimers. (polymerfactory.com)

Traditionally, researchers have relied on chalcogenides, materials with reversible electrical properties during transitions between crystalline and amorphous states. (asiaresearchnews.com)
Associate Professor Taweechai Amornsakchai and his team of international researchers have developed novel bio-degradable rigid foams derived from pineapple waste, showcasing impressive properties. (asiaresearchnews.com)

Using this data, the researchers created a model to help them alter the composition of the material depending on the circumstances. (rdworldonline.com)

In a recent study published in Macromolecular Rapid Communications , the researchers report on the preparation of a dual-emissive dendrimer with tunable aggregate and solution state emission . (advancedsciencenews.com)
Our recent advances in image correlation spectroscopic techniques now allow researchers to precisely follow the macromolecular dynamics in living cells. (mcgill.ca)

The reaction produces both linear and branched aldehydes, and certain sizes of dendrimer produced a significantly higher proportion of the linear configuration, which is the form that is more useful to the chemical industry. (chemistryworld.com)
Deepak Verma from Chulalongkorn University and his international team of researchers are exploring ways to enhance chitosan using techniques like adding photosensitizers, dendrimers, and chemical modifications. (asiaresearchnews.com)
This volume is essential to chemical engineering researchers and industrial professionals interested in hydrogen production systems and the science behind the materials driving the reactions in key processes. (eurekaselect.com)

Researchers in the He lab study key ingredients in this deadly cocktail, a family of injected proteins called AvrE/DspE, that cause diseases ranging from brown spots in beans and bacterial specks in tomatoes to fire blight in fruit trees. (earth-news.info)

This volume is a contribution from renowned researchers in the scientific community interested in functional materials for SOFCs. (eurekaselect.com)

The finding suggests that for this sealant or any other kind of biomaterial designed to work inside the human body, scientists must take into account the environment in which the material will be used, instead of using a "one-size fits all" approach, according to the researchers. (rdworldonline.com)
After characterizing the adhesive material's performance in different diseased tissues, the researchers created a model that allows them to predict how it will work in different environments, opening the door to a more personalized approach to treating individual patients. (rdworldonline.com)

Estimation of dendrimers binding capacity and checking their influence on plasma proteins will be performed to construct detoxication dendrimers. (europa.eu)
Researchers have identified how certain harmful bacterial proteins, AvrE/DspE, cause diseases in crops by suppressing plants' immune systems. (earth-news.info)
Researchers had identified a number of proteins in the AvrE/DspE family that suppressed the plant's immune system, or that caused dark water-soaked spots on a plant's leaves - the first telltale signs of infection. (earth-news.info)
Researchers have looked for other proteins with similar sequences for clues, but none with any known functions showed up. (earth-news.info)

The aim of the proposal is to enable the top-class young researcher from Belarus to work in a new promising branch of knowledge - on the edge of nanotechnology and medicine. (europa.eu)
In a 2009 paper, the researchers demonstrated that such adhesives work better when tailored to specific organs. (rdworldonline.com)
The researchers' work is supported by grants of more than $1.6 million from the National Science Foundation. (acm.org)

It would seem that the optimal size of dendrimer creates the most efficient thermodynamic environment for the selective formation of linear aldehyde, providing the specific angles and distances between the bonds of the catalyst that are needed for the optimal selectivity,' Morris says. (chemistryworld.com)
The researchers believe their new diagnostic tool could be used to detect prostate-specific antigens (PSA) as a screen for prostate cancer. (journalforclinicalstudies.com)

The host institution re presents a high scientific level and large training expertise, is the participant of well established international collaborations networks and is actively present in the dendrimer field from its very beginning. (europa.eu)
Dow assigned its entire intellectual property portfolio and associated royalties in the field of dendrimers to Dendritech, a dendrimer production company in Midland, Michigan, cofounded by Tomalia in 1992. (sciencehistory.org)

However, the researchers noticed that the dendrimer systems showed markedly improved selectivity for the reaction that the team was studying - phosphine-mediated hydroformylation of olefins to make aldehydes - depending on the size of dendrimer. (chemistryworld.com)
Further increasing the size of the dendrimer, however, resulted in a decreased efficiency of selectivity, suggesting that there is an optimal size of tree. (chemistryworld.com)
Nutraceutical researchers working to improve the bioavailability, biocompatibility, and stability of various formulations measure particle size, particle shape, and zeta potential. (horiba.com)
The size of dendrimers is measured using dynamic light scattering. (horiba.com)

RNA has always fascinated scientists as it can induce production of multiple copies of immune cells and by customizing the RNA sequences, the researchers can design vaccines that can produce nearly any protein of choice. (delveinsight.com)

He explains that through dendrimers the team converted a microfiltration membrane into a nanofiltration one. (sciencedaily.com)
Morris's team base their dendrimers around cubic polyhedral silsesquioxanes. (chemistryworld.com)
A team of researchers from Singapore and the UK, led by Dr Wei Liang Lai, with supervisor, Associate Professor Kheng Lim Goh, has developed a portable device for repairing hard-to-see damage in carbon fiber materials. (asiaresearchnews.com)

Caminade was a doctoral researcher at Toulouse III - Paul Sabatier University. (wikipedia.org)
Researchers from Duke University might have discovered a method to neutralize them, potentially averting $220 billion in yearly agricultural losses. (earth-news.info)
After serving as scientific director of the National Dendrimer and Nanotechnology Center at Central Michigan University, Tomalia departed in 2010 to establish a nanotechnology company called NanoSynthons LLC. (sciencehistory.org)

We find that the mechanism of NPH association with the dendrimers is similar for G3-G6 dendrimers. (confex.com)

This motivated a young graduate researcher at the National Polytechnic Institute (IPN) in Mexico, Gabriel Ramirez Monter, to create a technology capable of removing such contaminants at low cost and with an efficiency that surpasses existing technologies. (sciencedaily.com)

Researchers can access related articles from current and back volumes by purchasing access to these collections. (eurekaselect.com)
With new articles being added to these collections on a daily basis, the collections serve as an ideal tool to keep researchers updated with new developments in the respective fields. (eurekaselect.com)

He is currently CEO and director of the National Dendrimer and Nanotechnology Center located at the NanoSynthons site in Mount Pleasant. (sciencehistory.org)

A group of researchers have unraveled the mysteries behind a recently identified material-zirconium nitride (ZrN) -that helps power clean energy reactions. (asiaresearchnews.com)

This would allow the researchers to create two or three different versions that could cover a wide range of tissues. (rdworldonline.com)

Tomalia called them dendrimers, after dendra , the Greek word for tree . (sciencehistory.org)

Researchers at UCLA have successfully manipulated nanomaterials to create a new drug-delivery system that promises to solve the challenge of the poor water solubility of today's most promising anticancer drugs and thereby increase their effectiveness. (news-medical.net)

In this case, bis-MPA dendrimers came in handy by being more biocompatible and biodegradable at physiologically relevant pH and temperature. (polymerfactory.com)

That allows researchers to make quicker calculations while maintaining accurate results. (acm.org)

The main idea of the project is studying the possibility to use dendrimers as new detoxication agents. (europa.eu)

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes2

Disciplines and Occupations1

Technology, Industry, Agriculture7

Named Groups1

Polymers7

Highly branched2

PAMAM3

Synthesis5

Virgil Percec2

Molecules9

Micelles1

Cationic1

Self-assemble1

Branches6

Structures3

Ligands1

Chemists1

Biomedical2

Nanotechnologies1

Vesicles2

Generations2

Molecule1

Simulations3

Chemistry7

Vectors1

Postdoctoral1

Molecular2

Research6

20211

SiRNA6

Periphery1

Dendrimersomes2

Applications7

Chains1

20181

Organic2

Generation1

Properties2

Composition1

Macromolecular2

Chemical3

Study1

Functional1

Approach2

Proteins4

Work3

Specific2

Field2

Size4

Sequences1

Team3

University3

Similar1

Efficiency1

COLLECTIONS2

Center1

Material1

Range1

Tree1

Drug1

Case1

Make1

Project1