Researchers ceramides. Medical search. Frequent questions

Therapeutics that target lipids called ceramides might hold potential for treating cardiometabolic disease, argues a review article published November 5th in the journal Trends in Pharmacological Sciences . (reachmd.com)
Statins also reduce blood levels of other lipids such as ceramides. (reachmd.com)
Ceramides-lipids that accumulate in tissues during hyperlipidemia and inflammation-are significantly associated with increased cardiovascular disease events, even among individuals with low low-density lipoprotein cholesterol (LDL-C) levels and no evidence of coronary stenosis. (aacc.org)
This increases the concentration of ceramides, a group of the body's lipids. (news-medical.net)
Within lysosomes, acid ceramidase breaks down fats (lipids) called ceramides. (medlineplus.gov)
Ceramides also serve as building blocks for more complex lipids. (medlineplus.gov)
Ceramides, cholesterol, and fatty acids are essential SC lipids. (keyaseth.in)
Ceramides are predominant lipid components of the stratum corneum and comprise 30-40% of the stratum corneum lipids by mass. (keyaseth.in)
Ceramides are component lipids that make up sphingomyelin, one of the primary lipids in the lipid bilayer, and are abundant in eukaryotic cells' cell membranes. (thedeconstruct.in)
Right: When Ceramide Synthase 6 is inactivated, mice are protected from the excessive storage of lipids in the liver, despite eating the high-fat diet. (healthcare-in-europe.com)
Ceramides are fats or lipids found in the skin's top layers, which make up approximately 50% of its composition. (kotasolo.id)
Interestingly, one of the lipids stored in muscle that is thought to disrupt normal insulin signaling, called ceramides, was significantly increased in our subjects after taking CLA. (secondopinionnewsletter.com)
Ceramide is a bad collection of lipids that can accumulate in your cell membranes and cause them to dysfunction. (secondopinionnewsletter.com)
Scott Summers and Mary C. Playdon are studying the effects of ceramide lipids on heart disease and stroke risk. (utah.edu)
Using a newly developed test, the researchers also found evidence that ceramides-a class of lipids that is part of the sphingolipid family-are an independent indicator, or biomarker, of these conditions, predicting the presence of coronary artery disease (CAD) as well as or better than cholesterol. (utah.edu)
The researchers say this finding suggests that ceramides and other lipids similar to them are a distinct and independent predictor of disease status and may in fact be a contributing factor to the development of heart disease and stroke. (utah.edu)
The study was also able to predict levels of ceramides - a class of lipids associated with obesity, diabetes and heart disease. (alphr.com)
Researchers at the Karolinska Institutet, University of Oxford and University of Copenhagen have shown that elevated levels of lipids known as ceramides can be associated. (healthnews2me.com)
Ceramides are lipids that work to keep skin moist, hydrated, and soft. (teslabookmarks.com)

Decreased ceramide levels: In several human skin diseases, diseased skin differs from healthy skin in the lipid composition of the SC's intercellular matrix. (cosmeticsandtoiletries.com)
Researchers describe the Treg-cell-inducing activity of lipid extracts from the feces of specific-pathogen-free mice. (news-medical.net)
The researchers also discovered that cannabinoids apparently worked by increasing the activity of ceramide, a lipid mediator of apoptosis, resulting in the functional inhibition of cells needed for VEGF production. (innovations-report.com)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. (keyaseth.in)
The intercellular lipid domain comprises equal concentrations of free fatty acids, cholesterol, and ceramides. (keyaseth.in)
All the phytoceramides ("Phyto" means plants) improved the recovery rate of the damaged stratum corneum and enhanced hydration as they have a similar lipid structure to the ceramides found in our skin. (keyaseth.in)
A decreased ceramide content in the lipid barrier of the skin characterizes most skin barrier disorders in inflammatory diseases such as acne. (keyaseth.in)
Ceramides are a waxy lipid molecule family. (thedeconstruct.in)
Ceramides are lipid-like molecules that supply moisture and repair the skin's barrier function. (kotasolo.id)
Ceramides are a natural lipid that helps protect our skin barrier and seal in moisture. (hellogiggles.com)
However, lipid moieties such as lysophosphatidylcholine (LPC) and ceramide (CER) contribute to atherogenic events. (bvsalud.org)
In fact, scientists at University of Utah Health recently discovered that people with high blood levels of ceramides are at least three or four times as likely to have a stroke or heart attack than those with lower blood levels of this lipid. (utah.edu)
In the past, researchers studying the interaction between lifestyle and lipid metabolism would have relied on questionnaires or expensive experimental studies. (alphr.com)

According to the article's authors, answering these questions might shed light on potential therapeutic approaches to safely and effectively lower ceramides and treat cardiometabolic disease. (reachmd.com)
The researchers also found higher versus lower ceramides risk scores associated with increased risk of cardiovascular events, even in participants with no evidence of CAD by angiography and in those with low LDL-C levels, 7.8% versus 2.2% and 16.4% versus 3.7% respectively. (aacc.org)
It provides us with an opportunity to design new types of personalized medical interventions tailored to lower ceramides and other sphingolipids in individual patients that can potentially improve their health and decrease their risk of cardiovascular disorders. (utah.edu)

More research is also needed to understand the genetic abnormalities that drive high ceramide levels and how ceramides damage cells and tissues. (reachmd.com)

This condition is characterized by the buildup of ceramides and other fats in cells throughout the body, particularly around the joints. (medlineplus.gov)
Consider adding healthy fats to your diet if you're seeking for a more "natural" strategy to increase ceramide formation in your skin. (thedeconstruct.in)
Researchers have known for some time that this process involves a specific group of fats known as ceramides. (healthcare-in-europe.com)
The researchers also carried out a variety of clinical tests including cardiac imaging and serum lipidomics (profiling of fats in the blood) and instructed the participants to complete lifestyle questionnaires. (alphr.com)
When these cells were mixed with others which had not been previously exposed to fats, the researchers found that they communicated with each other, transporting the signal in packages called extracellular vesicles. (nirogstreet.com)

The potential answer lies within a class of fatty compounds known as ceramides. (diwou.com)
In conclusion, this study provides novel information regarding the regulation of APP processing by synthetic ceramide analogues and reveals that the most potent of these compounds is EtDO-P4. (edu.au)
Considering the chemical structure of ceramides, they are highly lipophilic compounds because the ratio of long-chain fatty acids to the hydrophilic head part is high. (keyaseth.in)
Ceramide AP, NP, EOP, NG, and NS are some of the most prevalent ceramide compounds to search for in cosmetics. (thedeconstruct.in)
These compounds included 2 sphingomyelins, 1 phosphatidylcholine, 1 sphinganine-phosphate, and 1 ceramide, a finding that further supports the role of ceramides in human pancreatic cancer, the researchers say. (medscape.com)

A new mechanism of aging has been uncovered by researchers: the accumulation of sphingolipids. (scitechdaily.com)
Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss. (news-medical.net)
It is unclear how an accumulation of ceramides impairs the normal functioning of cells, but damage to the affected cells leads to the voice, skin, and joint problems that are characteristic of Farber lipogranulomatosis. (medlineplus.gov)
Systemic ceramide accumulation leads to severe and varied pathological consequences. (medlineplus.gov)
The fact that the mice become overweight and unhealthy on a poor diet is, probably, in part due to the accumulation of ceramides formed by ceramide synthase 6, in mitochondria. (healthcare-in-europe.com)

They treated old mice with ceramide blockers, such as myriocin and the synthetic blocker Takeda-2, and used adeno-associated viruses to block ceramide synthesis specifically in muscle. (ptproductsonline.com)
If, for example, ceramide synthesis is completely inhibited it can adversely affect the development of the animals,' explains Philipp Hammerschmidt, a doctoral student in Brüning's research group and first author of the study. (healthcare-in-europe.com)
In a separate study mice were not protected from moderate HS when kept on a 1% cholesterol diet for 28 days suggesting that LXR signaling is the dominant effect.5 Myriocin a known antagonist of ceramide MGL-3196 synthesis could help tease apart the relative effects of insulin and ceramides on HS. (biosemiotics2013.org)

Compared to what we know about cholesterol, much less is known about the role of ceramides in disease. (reachmd.com)

What are the common types of ceramides? (thedeconstruct.in)
Hence, we use the LC-MS/MS technology to simultaneously determine the content of more than 23 types of ceramides in various sample types, providing technical support for comprehensive analysis of intracellular ceramide content. (dispurnewsflash.com)

Meeusen and his colleagues found that for each one point increase in ceramides risk score, participants' risk rose by 9%, even after adjustment for other risk factors. (aacc.org)
The increase in ceramides and reduction in sphingosine and fatty acids likely play a role in the development of the features of SMA-PME, but the exact mechanism is unknown. (medlineplus.gov)

The sphingolipids and ceramides are complex yet very interesting fat class, and there is high potential to further study their role in aging, as they perform many diverse functions," says Dr Pirkka-Pekka Laurila, a medical doctor and the lead author of the study. (ptproductsonline.com)
Soybean oil is rich in health-promoting omega-6 fatty acids, which are broken down into smaller molecules called sphingolipids and ceramides. (massivesci.com)

He co-founded Centaurus Therapeutics, a biotechnology company that is developing novel ceramide-reducing therapies to treat cardiometabolic disease. (wikipedia.org)

Summers has teamed up with Mary Playdon, PhD, MPH, nutritional epidemiologist and cancer epidemiologist at Huntsman Cancer Institute and Neli Ulrich, PhD, MS, Chief Scientific Officer and Executive Director of the Comprehensive Cancer Center at Huntsman Cancer Institute, to block ceramides in mice and explore if they predict cancer in general. (utah.edu)
One hour after intraperitoneal treatment with either tamoxifen or a control (corn oil), the researchers infected mice with a lethal dose of MRSA. (mdlinx.com)
The researchers treated the mice again with tamoxifen or the control at 1 hour and then at 8 hours after infection, and monitored the mice. (mdlinx.com)
Using data generated from patients and mice with genetic mutation for the disorder Usher syndrome, researchers from the University of Maryland School of Medicine, the National Institutes of Health's National Eye Institute, and National Institute on Deafness and Other Communication Disorders, documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss. (news-medical.net)
A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides. (ptproductsonline.com)
The ceramide blockers prevented loss of muscle mass during aging, made the mice stronger, and allowed them to run longer distances while improving their coordination. (ptproductsonline.com)
It turned out that blockade of ceramide production activates muscle stem cells, making muscles build up more protein and shifting fiber type towards fast-twitch glycolytic to produce larger and stronger muscles in aged mice," explains Dr Martin Wohlwend, the main collaborator in the study. (ptproductsonline.com)
The people who had this ceramide-reducing gene form were able to walk longer, be stronger, and were better able to stand up from a chair, indicating healthier aging, similar to mice treated with ceramide blockers. (ptproductsonline.com)
Other research groups have already shown that blocking ceramide production in mice prevents the development of insulin resistance. (healthcare-in-europe.com)
They discovered that ceramide molecules of a particular length, formed by both ceramide synthases 5 and 6, accumulate in the liver when mice become obese on a high-fat diet. (healthcare-in-europe.com)
Interestingly, only the genetic inactivation of ceramide synthase 6 in mice, resulted in protection from obesity, fatty liver, and insulin resistance. (healthcare-in-europe.com)
This was very surprising, as these two synthases produce exactly the same ceramide product but have completely different effects on the metabolism of the mice,' said Hammerschmidt. (healthcare-in-europe.com)
Switching off ceramide synthase 6 in a precisely controlled way resulted in a clear effect: "The mice continue eating the high-fat diet, nevertheless their glucose metabolism improves,' explains Hammerschmidt. (healthcare-in-europe.com)
Using a sophisticated unbiased lipidomic approach the researchers show that altering the gut microbiome in mice fed a high-fat diet (HFD) greatly increases intestinal levels of tauro-β-muricholic acid (T-β-MCA). (biosemiotics2013.org)
The experts also could have strengthened the causal association of ceramides with hepatic lipogenesis by MGL-3196 reintroducing ceramides into intestinal FXR-null mice which should presumably reverse the improved Mouse monoclonal to CD4 hepatic phenotype. (biosemiotics2013.org)
In healthy mice, increased levels of ceramides found in the liver have been shown to result in insulin resistance while those found in the blood are associated with cardiovascular disease. (massivesci.com)
The researchers, from University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, also found that tamoxifen treatment in mice also enhances clearance of the antibiotic-resistant bacterial pathogen MRSA and reduces mortality. (drugtargetreview.com)
One hour after treatment with tamoxifen or a control, the researchers infected mice with MRSA (methicillin-resistant Staphylococcus aureus). (drugtargetreview.com)

Researchers suspect that the small amount of enzyme activity in SMA-PME allows some ceramide breakdown to occur, so the ceramides do not accumulate and damage cells as extensively as seen in Farber lipogranulomatosis. (medlineplus.gov)

Ceramides are typically found within the membranes that surround cells and play a role in regulating cell maturation (differentiation), growth and division of cells (proliferation), and controlled cell death (apoptosis). (medlineplus.gov)
In addition, ceramide also plays an essential role in maintaining the integrity of cell membranes, cell stress response, inflammatory signal transduction, and cell apoptosis. (dispurnewsflash.com)

When ceramides need to be replaced, they travel to lysosomes where acid ceramidase breaks them down into a fat called sphingosine and a fatty acid. (medlineplus.gov)
The decrease in acid ceramidase activity leads to inefficient breakdown of ceramides and impaired production of its breakdown products sphingosine and fatty acids. (medlineplus.gov)
Sphingosine and a fatty acid make up ceramides. (thedeconstruct.in)
It is further divided into hexose ceramide (HexCer), lactose ceramide (LacCer), sphingosine (Sph), dihydro sphingosine (DhSph), and dihydroceramide (DhCer). (dispurnewsflash.com)

Ceramide-containing skin-care products claim to increase the skin's hydration level, repair the cutaneous barrier, prevent moisture loss, and reduce dry and flaky skin. (keyaseth.in)
Ceramides for skincare have helped to replace the moisture lost by the skin, reducing dryness and flakiness. (thedeconstruct.in)
Ceramides also build the skin's barrier, which protects it from external disruptors, locks in moisture and oils, and protects against UV-induced damage. (kotasolo.id)
The Derma Co Ceramide + HA Intensive Moisturiser is an efficient solution for healing extremely dry and injured skin by locking in and restoring moisture levels. (kotasolo.id)
Researchers found that eucalyptus extract increases the skin's ceramide -this helps lock moisture into your skin. (beardgains.com)
When used in skincare products, ceramides help repair the moisture barrier and keep skin looking healthy and hydrated. (monatglobal.com)
Ceramide has a solid ability to associate with water molecules, thus maintaining skin moisture by forming a network structure in the stratum corneum. (dispurnewsflash.com)
Other key ingredients include ceramide, which retains moisture to form a protective hydration barrier, and Argireline and Progeline which improve the appearance of signs associated with skin maturation. (natalielovesbeauty.com)
Sunscreen with moisturizing components will usually have humectants, emollients, and ceramides, to prevent moisture loss. (reequil.com)

Psoriasis symptoms were reduced when these patients used ceramides in their skincare. (thedeconstruct.in)
From keeping your skin moisturised to providing a barrier to protect the skin, the best ceramide creams can provide you a great way to include ceramides in your skincare routine. (kotasolo.id)
Choosing a proper ceramide cream, like other components of your skincare routine, is rather subjective. (kotasolo.id)
You've likely seen ceramides called out on many of the labels on the skincare products already in your routine. (hellogiggles.com)
Replacing ceramides using topical skincare is important to keep it hydrated, protected, and smooth. (hellogiggles.com)

Drugs are being developed to slow ceramide production, but you can also envision dietary strategies that influence ceramide levels to slow cancer growth. (utah.edu)
Decreased levels of ceramides occur in atopic skin as compared with age-matched healthy controls. (cosmeticsandtoiletries.com)
Prior research found elevated ceramides levels in individuals with confirmed heart disease. (aacc.org)
Meeusen and his colleagues followed for a median of 5.9 years 499 patients who had been referred for coronary angiography, assessing not only ceramides levels but also LDL-C, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, and lipoprotein-associated phospholipase A2. (aacc.org)
Grouping participants into risk scores based on ceramides levels-low (0-2), intermediate (3-6), moderate (7-9), and high (10-12)-the investigators found ceramides level significantly and independently associated with CAD after adjusting for both traditional novel cardiovascular risk factors. (aacc.org)
Further studies linked the tamoxifen effect to its ability to influence neutrophil ceramide levels. (mdlinx.com)
The researchers thought these disorders could be improved and increased ceramide levels by replacing them through topical applications. (keyaseth.in)
Sphingolipids, which can boost the levels of ceramides, are present in large amounts in eggs, dairy products, and soybeans. (keyaseth.in)
Psoriasis: Psoriasis is a skin disorder characterized by red patches of skin and low ceramide levels. (thedeconstruct.in)
As we mature, the ceramide levels in our skin decrease, leading to drier, more sensitive skin," Dr. Chang explains. (hellogiggles.com)
And although previous research has found a strong correlation between circulating ceramide blood levels and coronary heart disease, the magnitude of that risk had rarely been quantified, nor had a broader panel of other sticky sphingolipid molecules been evaluated. (utah.edu)
The study, published in the journal PLOS Biology , also showed lower levels of ceramides in active volunteers, compared to their more sedentary counterparts suggesting that the more active participants could be at less risk from obesity, diabetes and heart disease. (alphr.com)
The researchers explain that even low-level stress can cause your body to release cortisol and adrenaline levels that can interfere with the overall hormonal balance and contribute to cardiovascular issues, obesity, and mood. (diduknowonline.com)
According to researchers, hormone reductions or rapid fluctuations in their levels may cause mood swings and the blues. (liber-castuder.com)
The researchers measured fatty acid and sphingolipid levels in their blood and livers, and analyzed microbial DNA from their feces to determine the amount of gut bacteria present. (massivesci.com)

The researchers found that, in aging, there is an overload of the protein SPT and others, all of which are needed to convert fatty acids and amino acids to ceramides. (ptproductsonline.com)
Ceramides comprise long-chain sphingoid bases linked to long-chain free fatty acids via amide bonds. (keyaseth.in)
Ceramides are long-chain fatty acids that form bonds with other essential chemicals to help cells operate properly. (thedeconstruct.in)

Ceramides, known for their use in skin care products, are sphingolipids, a class of fat molecules that are not used to produce energy but rather perform different tasks in the cell. (ptproductsonline.com)
Like cholesterol, ceramides are sticky, greasy molecules that help maintain cell membranes and perform other critical life-sustaining tasks. (utah.edu)

The authors summarize the evidence supporting a strong relationship between ceramides and a range of diseases in animals and humans and compare it to the decades of datasets that drove the creation of cholesterol-lowering pharmaceuticals. (reachmd.com)
Our hope with the article was to compare the body of literature on ceramides with that of cholesterol in order to point out the critical gaps and emerging questions in the ceramide field. (reachmd.com)
Over the past couple of decades, studies in humans have shown that ceramides are standalone biomarkers of cardiovascular disease, independent of cholesterol. (reachmd.com)
Unlike cholesterol, ceramides have also been linked to metabolic conditions such as insulin resistance and diabetes in humans. (reachmd.com)
Ceramides may prove to be as deleterious as cholesterol, as they elicit a non-overlapping spectrum of tissue defects and ultimately trigger cell death," Summers says. (reachmd.com)
Trends in Pharmacological Sciences 42 (12), 1082-1095 Summers SA (2018) Could ceramides become the new cholesterol? (wikipedia.org)
Furthermore, Ceramide is used in the formulation of Cholesterol: Fatty Acid ratio of 3:1:1 has been shown to hasten skin barrier repair. (kotasolo.id)
Yet, until recently, ceramides were much harder to detect because they are 1,000 times less abundant than cholesterol. (utah.edu)
The scientists found that their new test, which relied on mass spectrometry to isolate tiny amounts of ceramides in the blood, was a better overall predictor of the presence of cardiovascular disease than currently used ceramide tests or LDL cholesterol measurements. (utah.edu)

Ceramide synthases - the enzymes responsible for the generation of ceramide - come in a variety pack of six different flavors: Ceramide synthase 1-6. (diwou.com)
Through their research, Senkal's team observed that the first flavor, ceramide synthase 1 (CerS1), was highly interactive with a particular protein known as heat shock protein 27 (Hsp27). (diwou.com)
This is achieved by switching off a protein, called ceramide synthase 6. (healthcare-in-europe.com)
Ceramide synthase 6 regulates the ceramide content in mitochondria, the cell's energy generators, influencing their structure and function. (healthcare-in-europe.com)
The discovery allowed the researchers to identify key proteins in mitochondria, which bind ceramides specifically from ceramide synthase 6 but not ceramides from the related ceramide synthase 5. (healthcare-in-europe.com)
It's possible that inhibition of ceramide synthase 6, or the ceramide-binding mitochondrial proteins we found, could be used as a basis for therapies in humans, but there is still a long way to go. (healthcare-in-europe.com)

Ceramides are essential for the integrity of the stratum corneum 's barrier function. (keyaseth.in)
The number of hydroxyl groups in the head group of ceramides is essential for the integrity of the stratum corneum 's barrier function. (keyaseth.in)

Optimal skin care, such as using ceramide-containing moisturisers as an adjunct to acne treatment, improves skin condition, reducing irritation and inflammation. (keyaseth.in)
Many studies revealed that ceramide-containing moisturisers supplement acne treatment, and the researchers recommended considering ceramides while seeking acne treatment. (kotasolo.id)

The researchers, therefore, investigated precisely which of the various ceramide synthases are involved in the development of insulin resistance, in the hope of providing more specific therapeutic targets. (healthcare-in-europe.com)
In particular, ceramide concentrations were higher in those who had had a previous heart attack or who had insulin resistance or type 2 diabetes. (utah.edu)

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19). (news-medical.net)

Now we want to see if we can modulate ceramides in stem cells to prevent cancer," Ying said. (utah.edu)
In the present study, we have assessed the capacity for a series of structurally related synthetic ceramide analogues to modulate APP processing in vitro. (edu.au)

According to researchers, The skin's barrier is damaged when it lacks ceramides, resulting in dryness and irritation. (thedeconstruct.in)
This face cream, infused with the goodness of ceramides and hyaluronic acid, intensely moisturises dry skin while also strengthening the skin's barrier function. (kotasolo.id)

One sphingolipid in particular, ceramide, plays a role in regulating the activity of neutrophils. (mdlinx.com)
However, the test, called Sphingolipid Inclusive CAD risk score, or SIC, will need to be validated and refined before it can be used clinically, according to the researchers. (utah.edu)
Ceramide is the central hub of the sphingolipid pathway, which includes sphingomyelin, glucosylceramide, and galactosylceramide. (dispurnewsflash.com)
Meanwhile, sphingolipid is a class of phospholipids consisting of the ceramide backbone and has a variety of physiological and pharmacological functions, such as regulating cellular immunity, delaying aging, and acting as an anti-tumor agent. (dispurnewsflash.com)

To address these concerns, Summers and his U of U Health colleagues Mary C. Playdon, Ph.D. , assistant professor in the Department of Nutrition & Integrative Physiology, and doctoral student Annelise Poss used machine learning, a type of advanced statistical analysis that allows computers to train using the data to predict outcomes, to identify 32 ceramides or their precursors that are likely the most predictive biomarkers of coronary artery disease. (utah.edu)
Sphingomyelins and ceramides: possible biomarkers for dementia? (ku.dk)
A dynamic portrait of metabolic profiles known as "metabolomics" has been used to identify new blood-derived metabolite biomarkers that can distinguish between pancreatic ductal adenocarcinoma and chronic pancreatitis with a high degree of accuracy and at an earlier disease stage than conventional diagnostic testing, researchers say. (medscape.com)

They lowered ceramides in various tissues of mouse models, but when they removed ceramides in the gut, the mouse models developed intestinal problems. (utah.edu)

Ceramides strongly predict major adverse cardiovascular events, including death due to coronary artery disease and acute coronary syndrome. (reachmd.com)
The researchers defined coronary artery disease (CAD) as 50% stenosis in at least one coronary artery. (aacc.org)

Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form. (ki.se)
A major study published in JAMA led by researchers at Karolinska Institutet suggests that a possible cause of spontaneous brain haemorrhage could be transmitted via blood transfusion. (ki.se)

Blood ceramides are now being measured clinically to assess disease risk. (reachmd.com)
Though the idea was initially controversial, it has gained traction within the medical community, to the extent that blood ceramides are now measured clinically as markers of cardiometabolic disease risk. (wikipedia.org)

Their article, "Ceramides increase fatty acid utilization in intestinal progenitors to enhance stemness and increase tumor risk," has been published in Gastroenterology . (utah.edu)

In patients with chronic pancreatitis with an increased risk for pancreatic cancer, the biomarker signature detected 98% of resectable pancreatic cancers (55 out of 78, stages IA to IIB) with an accuracy of 90.4%," the researchers report, adding that "this can be regarded as a significant advance in the field. (medscape.com)
The biomarker signature distinguished pancreatic cancer from chronic pancreatitis, assuming a cumulative incidence of 1.95%, with an area under the curve of 0.96, a sensitivity of 89.9%, and a specificity of 91.3%, the researchers report. (medscape.com)
When separating out patients who have pancreatic cancer from those who have benign pancreatic disease, the test's sensitivity is 78.2% and its specificity is 82.8%, the researchers point out. (medscape.com)
The current 5-year survival rate for pancreatic adenocarcinoma is about 6%, and pancreatic cancer is projected to be the third leading cause of cancer-related death by 2030, thanks to delayed diagnosis and few new treatment options, the researchers note. (medscape.com)

Naturally, Ceramide can also be found in the skin. (keyaseth.in)
Our pores and skin naturally accommodates ceramides that start to deplete over time. (teslabookmarks.com)

That's because ceramides are intensely hydrating and effective for anti-aging. (hellogiggles.com)

But as he's demonstrated with other diseases, ceramides change the way every cell type reacts to its nutritional environment. (utah.edu)
Ceramide content and changes of composition are involved in aging, and skin diseases such as atopic dermatitis (AD), psoriasis, contact dermatitis (CD) and irritant dermatitis. (cosmeticsandtoiletries.com)
But in metabolic diseases, which are long term conditions, the signals can kill the cells, make symptoms more severe, and worsen the illness, said researchers at University of Leeds in the UK. (nirogstreet.com)

Researchers have found that tamoxifen is not only an estrogen receptor modulator for the treatment of breast cancer, but it also boosts bactericidal capacity against methicillin-resistant Staphylococcus aureus (MRSA) and a variety of other pathogens, according to a study published online October 14, 2015 in Nature Communications . (mdlinx.com)

reported the difference in ceramide composition between dry skin (lesional) and normal skin (nonlesional) in AD. (cosmeticsandtoiletries.com)
The weight of total ceramides in dry skin of patients with AD was signifi cantly lower than that in normal individuals and the percentage of ceramide 1 was decreased to 52% compared with healthy controls. (cosmeticsandtoiletries.com)
Variations in Ceramides species within this layer have been linked to most skin disorders, including atopic dermatitis, contact dermatitis, some genetic disorders, dry skin, psoriasis and xerosis. (keyaseth.in)
Most skin disorders with a diminished barrier function present a decrease in total ceramide content with some differences in the ceramide pattern. (keyaseth.in)
Ceramide ingredients function primarily as skin & hair conditioning agents miscellaneous in cosmetics. (keyaseth.in)
Green leafy vegetables, mostly kale, broccoli, mustard greens and spinach, will help keep the skin healthy and are a rich source of ceramides. (keyaseth.in)
Ceramide for skin and hair care is something you should incorporate into your routine. (thedeconstruct.in)
Ceramides, in other words, aid to keep your skin hydrated and smooth. (thedeconstruct.in)
Ceramides assist to maintain skin smooth and supple, they also play a crucial part in hair growth. (thedeconstruct.in)
Our skin barrier fails to operate optimally when we don't have the right ratio of ceramides, and our skin's health suffers as a result. (thedeconstruct.in)
Ceramides are the glue that holds our skin cells together in order to keep our skin barrier intact. (thedeconstruct.in)
Ceramides that are already present in your skin are "natural. (thedeconstruct.in)
Your skin will benefit as long as ceramides are restored. (thedeconstruct.in)
Ceramides have been shown to help with a variety of skin issues. (thedeconstruct.in)
Aging: According to studies, topical ceramides improved the function of the skin barrier, making skin appear softer and younger. (thedeconstruct.in)
Ceramides can strengthen skin barriers, preventing bacteria and other unwanted substances from entering. (thedeconstruct.in)
Sensitive skin: Ceramides act as a mortar for the skin cells that make up the barrier. (thedeconstruct.in)
Ceramides are gentle on all skin types and believe in achieving balance. (thedeconstruct.in)
If your skin feels parched and dry, it may be due to a deficiency of ceramides. (kotasolo.id)
According to research, ceramide creams promote skin hydration and improves skin barrier function, making it an excellent choice for combating dry skin. (kotasolo.id)
After using a ceramide-containing cream twice a day for 28 days, it has been observed by researchers that a significant increase in hydration, barrier function, and skin pH can be witnessed. (kotasolo.id)
Here's a list of the best 5 ceramide cream brands in India for moisturised skin! (kotasolo.id)
This Minimalist ceramide cream has a 0.3% active concentration of 5 skin necessary ceramides as well as ursolic acid to repair the compromised skin barrier. (kotasolo.id)
How to choose the best ceramide cream for your skin? (kotasolo.id)
When shopping for a ceramide cream, search for products that contain a variety of ceramides, as this more nearly mimics the natural ceramides in the skin. (kotasolo.id)
The other is ceramides, an important constituent of skin, that is used in many cosmetic products to moisten and rejuvenate aging epidermis. (utah.edu)
But in a new wrinkle, scientists have found that the effects of ceramides run more than skin deep. (utah.edu)
The researchers explain that overeating can increase ceramides, fat cells under the skin that can encourage your body's resistance to insulin. (diduknowonline.com)
Alongside leading skin researchers, she developed a line that offers the finest and safest ingredients, including skin-loving peptides, ceramide, and botanical extracts. (natalielovesbeauty.com)
CeraVe also uses ceramides, that are meant to assist retain water within the pores and skin. (teslabookmarks.com)
CeraVe products contain three completely different ceramides, that are meant to assist not solely protect the pores and skin but in addition to maintain it hydrated all day lengthy. (teslabookmarks.com)

Ceramides are well known for their role in constructing and maintaining the skin's water permeability barrier function. (thedeconstruct.in)

Other studies have shown that ceramides can lead to an increase in fat storage, a decrease in glucose use, and lower mitochondrial efficiency-hallmarks of metabolic syndrome. (reachmd.com)
By deliberately blocking the activity of Hsp27 in these cells, the researchers confirmed the decreased presence of Hsp27 led to a heightened reactivation of CerS1, which in turn forced a reduction in mitochondrial function. (diwou.com)

The findings point to ceramides as a "potentially better marker than LDL-C in predicting first and repeat cardiac events," according to the study's first author, Jeff Meeusen, PhD, co-director of cardiovascular laboratory medicine at Mayo Clinic in Rochester, Minnesota. (aacc.org)
These findings were confirmed in a 2014 study published in the International Journal of Cosmetic Science , where researchers found that bakuchiol was able to stimulate collagen production in vivo, and found that 12-week application improved texture, tone, photo-damage , and more. (hellogiggles.com)
It is also important for learning why certain recurrent infections are difficult to cure, and provides more credence for researchers focused on findings signs of microbial life on Mars. (massivesci.com)

For example, lowering ceramides through genetic or pharmacological interventions prevents cardiovascular disease and diabetes in rodents. (reachmd.com)
Dr. Klee says Emery and Aiden's disease-causing genetic variant was discovered by researchers in Norway in 2021. (mayoclinic.org)

Senkal and his team began extensively screening cells in the lab to identify what proteins regularly interact with ceramide-producing proteins to identify potential patterns that could warrant further investigation. (diwou.com)

Scientists have a lot to do if we are going to realize the potential of ceramide-lowering therapies," says senior study author Scott Summers (@ScottSummers339) of the University of Utah College of Health. (reachmd.com)

The researchers also noticed that Hsp27 activity was higher in many colon cancer cells while at the same time CerS1 activity was significantly lower, prompting Senkal and his team to consider if the absence of one was connected to the presence of the other. (diwou.com)
The ability of cannabinoids to alter VEGF production was significantly stifled following the introduction of a ceramide inhibitor. (innovations-report.com)

The investigation of ceramides as a potential cancer driver has earned Summers millions of dollars in grant money, seeding an enormous amount of activity in his lab. (utah.edu)
Every time RENEW flags a match, as it did with the Diffendorfer boys, a team of genomic researchers launches an in-depth investigation. (mayoclinic.org)

The Lipidomic platform employs the liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method, which implies the QTRAP 4500 LC-MS/MS system for the efficient and accurate detection of ceramide content changes. (dispurnewsflash.com)
With highly specialized technical capabilities and professional knowledge derived from mass spectrometry experts, we are fully prepared to cooperate in the rapid development of the field of lipidomic and, at the same time, support researchers from research design to the final report," he further added. (dispurnewsflash.com)

To confirm and broaden the applicability of these results, which was based on blood drawn from Caucasian men and women in Utah, the researchers plan to validate the SIC score using blood samples collected up to 12 years before the onset of cardiovascular disease among multiracial populations throughout the United States, United Kingdom, China, and other countries. (utah.edu)

Calpains are an essential protein that regulates this process, prompting researchers to investigate whether silencing calpains minimizes TBI-related brain damage. (asbmb.org)

In this case, removing the ceramides also removes a signal that tells stem cells to regenerate. (utah.edu)

Ceramides influence various cell functions, and it is likely that abnormal regulation of these processes also contributes to the features of this condition. (medlineplus.gov)
It has recently been reported that ceramide can affect hair loss prevention and growth enhancement by affecting cell growth and cell survival. (keyaseth.in)
KI researchers Georgios Sotiriou and Haipeng Li at the Department of Microbiology, Tumor and Cell Biology have developed an inexpensive, fast, and reproducible manufacturing process of nanosensors for food safety diagnostics. (ki.se)

Anatomy3

Organisms1

Diseases2

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology1

Phenomena and Processes7

Disciplines and Occupations5

Technology, Industry, Agriculture1

Humanities2

Information Science6

Named Groups2

Health Care4

Geographicals1

Lipids19

Lipid13

Lower ceramides3

High ceramide levels1

Fats5

Compounds5

Accumulation5

Synthesis3

Role of ceramides1

Types of ceramides2

Increase in ceramides2

Sphingolipids and ceramides2

Treat cardiometabolic disease1

Mice18

Accumulate1

Apoptosis2

Sphingosine4

Moisture9

Skincare5

Levels15

Fatty acids3

Molecules2

Cholesterol9

Synthase6

Stratum corneum2

Moisturisers2

Insulin resistance2

20191

Modulate2

Skin's barrier2

Sphingolipid4

Biomarkers3

Tissues1

Coronary artery2

Karolinska Institutet2

Clinically2

Intestinal1

Pancreatic4

Naturally2

Intensely1

Diseases3

Found that tamoxifen1

Skin31

Barrier function1

Mitochondrial2

Findings3

Genetic2

Proteins1

Therapies1

Significantly2

Investigation2

Lipidomic2

Cardiovascular disease1

Regulates1

Stem cells1

Cell3