Research using cells derived from fetal tissue clinical trials use fetal tissue fetal tissue research. Medical search. Frequent questions

He is a developmental biologist and neuroscientist who is pioneering the generation of midbrain dopamine neurons for transplantation and clinical applications. (wikipedia.org)
He successfully demonstrated that upon transplantation, these newly developed dopaminergic neurons can improve clinical symptoms in Parkinsonian rat models. (wikipedia.org)
There, he worked with Christian Spenger, culminating in the first clinical trial of fetal tissue transplantation for Parkinson's disease in Switzerland in 1995. (wikipedia.org)
We monitor our cells after transplantation using standard in vivo assessments as listed above. (lu.se)
The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced dyskinesia. (lu.se)
The TRANSEURO trial is currently ongoing as researchers have completed both recruitment into a large multicenter observational study of younger onset early-stage PD and transplantation of hfVM in 11 patients. (lu.se)
Prof. Parmar and colleagues showed that following transplantation, the embryonic stem cell-derived dopaminergic neurons exhibited the functional characteristics of native dopaminergic neurons, including dopamine production as well as long distance extension and connection with target regions in the brain. (medgadget.com)
My major research achievements have been in the field of cell transplantation and brain repair. (lu.se)
The studies are performed in 6-hydroxydopamine lesioned immunosuppressed (or immunodeficient) rats, following transplantation of cells into either the striatum, or into the substantia nigra where these cells normally reside. (lu.se)
Lines matched to specific individuals also offer the promise of personalized autologous stem cell transplantation. (scitechnol.com)
This study shows that one administration of engineered neural progenitors can provide new support cells and GDNF delivery to the ALS patient spinal cord for up to 42 months post-transplantation. (bvsalud.org)
Ex vivo gene therapy involves the genetic modification of cells outside of the body to produce therapeutic factors and their subsequent transplantation back into patients. (bvsalud.org)
Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. (hindawi.com)
By "laying out" (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. (hindawi.com)
Transplantation of immature cells has been considered a potential therapeutic strategy for the damaged adult brain and spinal cord, and there is currently sustained interest in the generation of stem cell lines that could be used to treat certain CNS injuries or disorders. (hindawi.com)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
Delivery of CS allows transplantation of cells along with matrix proteins to facilitate engraftment. (biomedcentral.com)
Delivery of ADSC by subcutaneous transplantation of CS is effective for stimulation of angiogenesis and tissue protection in limb ischemia with a potential for efficacy improvement by BV transduction to express VEGF165. (biomedcentral.com)
As genetic aberrations are the main causes of all forms of hereditary anemia, the optimal approach involves repairing the defective gene, possibly through the transplantation of normal hematopoietic stem cells (HSCs) from a normal matching donor or through gene therapy approaches (either in vivo or ex vivo) to correct the patient's HSCs. (sscb-stembiotech.com)
In conclusion, gene-corrected hematopoietic stem cell transplantation has promising outcomes for SCD, Fanconi anemia, and thalassemia, and it may overcome the limitation of the source of allogenic bone marrow transplantation. (sscb-stembiotech.com)

iPS cells avoid the heated debates over the ethics of embryonic stem cell research because embryos or oocytes are not used. (scitechnol.com)
She added that donors "can stipulate where their money goes and can ask that it not pay for embryonic stem cell research. (salon.com)
there are reasons to have conversations about embryonic stem cell research and fetal tissue research. (salon.com)
However, the ALSA has admitted that it gives some of its money to embryonic stem cell research and has no qualms about doing so in the future. (flfamily.org)
Note the ALSA page linked in the above has just recently been changed, and now notes that embryonic stem cell research "has raised ethical concerns. (flfamily.org)
Project ALS, another charity for ALS research, also funds embryonic stem cell research . (flfamily.org)
The MSCTC does not do any embryonic or aborted fetal stem cell research, ONLY ADULT and NON-EMBRYONIC STEM CELL RESEARCH and CLINICAL TRIALS. (flfamily.org)
The John Paul II Medical Research Institute in Iowa City is doing research in several areas including ALS, and does not support embryonic stem cell research. (flfamily.org)
The Adult Stem Cell Technology Center, LLC is developing new methods for growth and application of adult stem cells, and does not support embryonic stem cell research. (flfamily.org)
In recent years, several competing viewpoints have emerged about embryonic stem cell research. (ipl.org)
All of this debate raises an important question, Should embryonic stem cell research be conducted for treatment of present and future diseases? (ipl.org)
People who believe that an embryo should not be destroyed tend to say that embryonic stem cell research should not be conducted. (ipl.org)
On the other hand, people who believe that embryonic stem cell research creates means of curing diseases reply that the research should be conducted. (ipl.org)
Embryonic stem cell research "uses special cells found in three-to-five day old human embryos to seek cures for a host of chronic disease" (PRC). (ipl.org)

Human placenta-derived mesenchymal stromal cells (PMSCs) -- known for their neuroprotective qualities -- were preserved in hydrogel and applied to the site of the lesion. (sciencedaily.com)
Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Evaluation the efficacy of adipose derived mesenchymal stromal cells in patients with knee osteoarthritis. (cam.ac.uk)
The Wharton's jelly of the umbilical cord tissue contains a high density of mesenchymal stromal cells (MSCs). (clinicaltdd.com)
Wharton's jelly derived mesenchymal stromal cells have immunosuppressive potential that can be utilized for treatment of autoimmune diseases such as type 1 diabetes (T1D). (clinicaltdd.com)

Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Pazopanib also has activity against c-KIT (an abnormal tyrosine kinase found in gastrointestinal stromal tumors) and the platelet derived growth factor (PDGF) receptor. (nih.gov)
Endosialin (CD248, TEM-1) is expressed in pericytes, tumor vasculature, tumor fibroblasts, and some tumor cells, including sarcomas, with limited normal tissue expression, and appears to play a key role in tumor-stromal interactions, including angiogenesis. (hindawi.com)
Pericytes and stromal fibroblasts derive from mesenchymal stem cells [ 3 ] and, as such, endosialin has been described as a mesenchymal marker. (hindawi.com)
It is now accepted that the formation of solid tumors requires the proliferation of stromal cells to support cancer cell growth, invasion, and metastasis [ 5 ] and that the stromal cell compartment comprises a heterogeneous mix of cell types responsible for the formation of blood vessels as well as supporting a microenvironment commensurate with tumor growth and proliferation. (hindawi.com)
The coordinated growth and cross-talk between stromal cell components are critical for establishing a microenvironment that can support the growth and maintenance of tumor cells. (hindawi.com)
Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. (biomedcentral.com)
Mesenchymal stem/stromal cells including adipose-derived stromal cells (ADSC) are a promising cell source for this application. (biomedcentral.com)

With any hSC research, however, there are difficult dilemmas, including consent to donate materials for hSC research, early clinical trials of hSC therapies, and oversight of hSC research. (scitechnol.com)
Stem cell lines matched to persons with specific diseases can serve as in vitro models of diseases, elucidate the pathophysiology of diseases, and screen potential new therapies. (scitechnol.com)
The case sent a chill through the scientific community when it came to light 15 years ago and typifies some of the hurdles researchers have faced while trying to bring stem cell therapies to the market. (ibtimes.com)
Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
Further work is warranted to confirm these observations and to better understand the potential of CDVs a non-viral vector modality for cell-and-gene therapies. (selectbiosciences.com)
Parkinson's (PD) and Huntington's (HD) diseases are two such instances where a substantial amount of research is being conducted to discover the potential for structural repair of neuronal circuits (via cellular transplants) when effective alternative therapies (e.g., pharmacological therapy) become ineffective [ 5 - 7 ]. (hindawi.com)
However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. (lww.com)
Cell therapies derived from differentiated embryonic stem cells and induced pluripotent stem cells are also starting to feature prominently. (sscb-stembiotech.com)
Ethically, since eventually all such "research" will be applied to people, he cautions against the abuse of women "egg" donors, and against the premature use of vulnerable sick human patients for testing supposedly "patient-specific" stem cells in supposed "therapies", pointing to the obvious violations of standard international research ethics guidelines such clinical trials would necessarily entail. (lifeissues.net)
The use of various types of stem cells for research purposes to make disease "models" in the lab for regenerative medicine and for "therapies" to cure sick patients for diseases is constantly in the news. (lifeissues.net)

Mesenchymal Stem Cells (MSCs) have been successfully isolated from first-, second-, and third-trimester placental compartments, including the amnion, chorion, decidua parietalis and decidua basalis. (parentsguidecordblood.org)
The MSCs represent less than 1% of the cells present in the placenta, while the average yield of MSCs from chorions and amnions is between 1 to 10 million per gram of tissue. (parentsguidecordblood.org)
Regardless of their source, MSCs have potent immunosuppressive properties and MSCs obtained from the fetal membranes are no exception. (parentsguidecordblood.org)
Chorionic and amniotic MSCs suppress T cell proliferation to the same extent as bone marrow derived MSCs. (parentsguidecordblood.org)
Unlike MSCs, which are all plastic adherent, primary AECs have three subpopulations of cells that are adherent, loosely adherent, and free-floating. (parentsguidecordblood.org)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
The therapeutic effect of umbilical cord-derived mesenchymal stem cells(hUC-MSCs) in combination with pirfenidone(PFD) on pulmonary fibrosis in mice and its possible mechanism were investigated. (researchsquare.com)
It contains a valuable population of mesenchymal stem cells (MSCs), which possess the potential to differentiate into various cell types, including bone, cartilage, and fat cells. (acceleratewi.com)
MSCs derived from Wharton's Jelly are being investigated for their regenerative capabilities. (acceleratewi.com)
Research suggests that Wharton's Jelly-derived MSCs may have anti-inflammatory properties, which could be beneficial in conditions where inflammation plays a central role. (acceleratewi.com)
There is compelling evidence that mesenchymal stem cells (MSCs) can be utilized as delivery vehicles for cancer therapeutics. (sscb-stembiotech.com)
More recently, MSCs have been isolated from fetal tissues during gestation or after birth. (sscb-stembiotech.com)
Fetal MSCs derived from amniotic fluid, amniotic membrane, umbilical cord matrix (Wharton's jelly) and umbilical cord blood are more advantageous than adult MSCs, as they can be isolated noninvasively in large numbers without the ethical reservations associated with embryo research. (sscb-stembiotech.com)
The objectives of this study are to assess the safety and efficacy of allogeneic Wharton's Jelly derived MSCs (WJMSCs) in the treatment of T1D from the viewpoints of changes in beta-cell function, metabolic control, and diabetes treatment satisfaction during one year study period. (clinicaltdd.com)

Implementation of Studer's cell replacement therapy clinical trial which utilizes dopamine neurons generated from human embryonic/pluripotent stem cells for Parkinson's disease would be the first of its kind. (wikipedia.org)
Most notably, he has devised protocols for the transition (or "differentiation") of human pluripotent stem cells into neural and neural crest tissues and for the generation of functional dopaminergic neurons in large-scale quantities. (wikipedia.org)
In long-term studies, Studer demonstrated that these cells are non-tumorigenic, can integrate into the host brain and may serve as functional replacements for the substantia nigra dopamine neurons which die in Parkinson's disease. (wikipedia.org)
He currently also leads a multidisciplinary consortium to pursue the application of human stem cell-derived dopamine neurons for the treatment of Parkinson's disease. (wikipedia.org)
The following year, he joined Ronald McKay's lab at the National Institute of Health (NIH) to investigate how neural cells could be isolated, cultured, and differentiated to produce neurons with the aim of restoring brain function in Parkinson's disease mouse models. (wikipedia.org)
Dr. Wahlestedt defended her PhD thesis (Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells - for cell replacement therapy in Parkinson's disease) in 2013. (lu.se)
After her PhD studies she was employed at Skåne University Hospital in Lund, being responsible for tissue and cell preparation for the clinical trial TransEuro ( https://transeuro.org.uk/pages/partners.html ), in which patients with Parkinson´s disease was transplanted with dopaminergic neurons derived from human fetal tissue. (lu.se)
In 2017 she was recruited back to the research group of Prof. Malin Parmar as a staff scientist, mainly focusing on the translational work required to introduce hESC derived dopaminergic neurons to the clinic, the STEM-PD trial. (lu.se)
In line with this aim, we also perform extensive preclinical validation of the human dopamine neurons derived from our protocol in rat models of Parkinson's disease. (lu.se)
As a member of the European clinical trial TRANSEURO we also perform preclinical validation of human fetal dopamine neurons for clinical use. (lu.se)
This also allows us the unique opportunity to directly compare our hESC-derived dopamine neurons with those sourced from human fetal tissue both in vitro and in vivo. (lu.se)
However, with a growing number of novel cell sources (stem cells and reprogrammed cells) it becomes important to develop new methodologies for a more thorough assessment of human neurons generated using these approaches. (lu.se)
We utilise monosynaptic tracing technology, using pseudotyped rabies vectors, in order to visualise the synaptic contacts formed between host neurons and graft human cells. (lu.se)
The cells are called induced neurons (iNs) and offer a shortcut over induced pluripotent stem cells (iPSc) for generating patient and disease-specific neurons. (lu.se)
We are currently focusing on improving the yield and transplantability of directly reprogrammed dopamine neurons, and also developing reprogramming methodology that are compatible with clinical use. (lu.se)
Current efforts focus on identifying the optimal starting cell population for neural conversion, identification of gene combinations that yield subtype specificity and analysis of function and integration of the reprogrammed neurons. (lu.se)
Researchers from Lund University in Sweden have published an article in Cell Stem Cell describing the generation of functional dopaminergic neurons from human embryonic stem cells. (medgadget.com)
Led by Prof. Malin Parmar, the team differentiated dopaminergic neurons from human embryonic stem cells in culture, then transplanted them into the brains of rats that were modeled to exhibit the symptoms of Parkinson's. (medgadget.com)
Unlike fetal stem cells, which have been previously used to create dopaminergic neurons, embryonic stem cells (from existing stem cell lines) offer an abundant, readily accessible supply of cells. (medgadget.com)
I started this line of research in the mid 1970ies, based on the idea that immature neurons can be used to replace lost neurons, restore brain circuitry, and promote functional recovery in animal models of neurodegenerative diseases. (lu.se)
These trials, led by my close colleague and former student Olle Lindvall, have given proof-of-principle that immature dopamine neurons can survive and mature in the striatum in advanced PD patients, and restore dopamine neurotransmission in the area of the striatum re-innervated by the grafted neurons. (lu.se)
Our current efforts are focused on the development of stem cell-derived dopamine neurons, aimed at the development of transplantable neurons derived from human ES cells for clinical application. (lu.se)
Development of stem cell-derived dopamine neurons for neuronal replacement in Parkinson´s disease. (lu.se)
An important aspect of the work is the direct comparison of stem cell-derived cells with authentic midbrain dopamine neurons obtained from 6-9 week old aborted human fetuses. (lu.se)
Here we show that human neural progenitor cells transduced with GDNF (CNS10-NPC-GDNF) differentiated to astrocytes protected spinal motor neurons and were safe in animal models. (bvsalud.org)
Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons (spMNs) in vitro. (bvsalud.org)
In the case of PD, where the progressive and selective loss of dopaminergic neurons within the substantia nigra (SN) leads to dopaminergic denervation of the striatum, one possible solution has been to transplant embryonic nigral cells into the host substantia nigra (SN), in an attempt to rewire nigrostriatal circuit. (hindawi.com)
Brain tumors in general are derived mostly from glial cells, astrocytes and oligodendrocytes, but not neurons. (abta.org)

We highlight some of the major advances in this field including new autologous sources of pluripotent stem cells, safer ways to introduce therapeutic transgenes, and various methods of gene regulation. (bvsalud.org)
High amounts of these vesicles are produced through mechanical extrusion of cells and used to carry payloads with therapeutic benefit. (selectbiosciences.com)
These stem cells have implications for regenerative medicine and therapeutic applications. (acceleratewi.com)
Clinical trials exploring the therapeutic potential of Wharton's Jelly-derived stem cells are ongoing, with a focus on conditions ranging from spinal cord injuries to diabetic foot ulcers. (acceleratewi.com)
Wharton's Jelly, once considered a simple supporting structure, has emerged as a fascinating source of stem cells with tremendous potential in regenerative medicine and therapeutic applications. (acceleratewi.com)
However, further studies, clinical trials, and safety assessments are necessary to fully harness the therapeutic capabilities of Wharton's Jelly-derived stem cells, paving the way for innovative medical interventions that may benefit patients worldwide. (acceleratewi.com)
Because St. Jude is a research institution, patients are involved in both therapeutic and nontherapeutic clinical trials. (esri.com)
Cells' therapeutic potential can be also increased by expression of proangiogenic factors by viral transduction. (biomedcentral.com)
In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. (biomedcentral.com)
of donors and the side Inhibitors,research,lifescience,medical effects of immunosuppressive agents.12 The need for new approaches to rescue the failing heart provides a rationale for iPSC-derived therapeutic cells. (pdgfreceptor.com)
Stem cell therapy provides hope for many patients, but should be tempered with the realisation that the scientific and medical communities are still to fully unravel the complexities of stem cell biology, and to provide satisfactory data that support the rational, evidence-based application of these cells from a therapeutic perspective. (sscb-stembiotech.com)
Finally, and inexorably, a true professional scientist poses clearly challenging questions to his research colleagues, and to the scientific enterprise in general, about the dubious "scientific" justification for the current rush to clone human beings - for both "therapeutic" and for "reproductive" purposes. (lifeissues.net)
But he is equally concerned about the unethical aspects inherent in the rush to perform " therapeutic " human cloning research, including the abuses to all vulnerable human patients who would be required to participate in clinical trials. (lifeissues.net)
In particular, scientific developments in areas such as iPS cells open new possibilities of research and, at mid term, of therapeutic applications, but they also bring new ethical challenges and problems requiring further reflection and debate. (lifeissues.net)
Human clinical trials that investigate possible MDSC modulators are highlighted, and therapeutic strategies to leverage MDSC biology in bladder cancer immunotherapy are outlined. (iospress.com)
Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival. (cdc.gov)

Current research efforts also include directing the fate and age of human pluripotent stem cells, and using pluripotent stem cells as valuable tools for modeling human diseases such as Familial Dysautonomia, Hirschsprung's disease, neurodevelopmental disorders such as autism, melanocyte-related diseases, as well as mechanisms of aging. (wikipedia.org)
On aging research, he has also been among the first to manipulate cellular age in pluripotent-derived lineages. (wikipedia.org)
While completion of TRANSEURO is not expected until 2021, we feel that sharing the rationale for the design of TRANSEURO, along with the lessons we have learned along the way, can help inform researchers and facilitate planning of transplants of dopamine-producing cells derived from human pluripotent stem cells for future clinical trials. (lu.se)
Here are their technical properties: AECs have multipotent differentiation potential and expression of pluripotent stem cell specific transcription factors including Oct4 and Nanog. (parentsguidecordblood.org)
The derivation of pluripotent stem cell lines from oocytes and embryos is fraught with disputes regarding the onset of human personhood and human reproduction. (scitechnol.com)
The reprogramming of somatic cells to produce induced pluripotent stem cells (iPS cells) avoids the ethical problems specific to embryonic stem cells. (scitechnol.com)
Pluripotent stem cell lines can be derived from the inner cell mass of the 5- to 7-d-old blastocyst. (scitechnol.com)
Pluripotent stem cell lines whose nuclear DNA matches a specific person have several scientific advantages. (scitechnol.com)
Pluripotent stem cells can be derived from fetal tissue after abortion. (scitechnol.com)
Human induced pluripotent stem cell (iPSC)-derived neural progenitors were stably transfected with the vector and transplanted into the adult mouse brain. (bvsalud.org)
The bad news comes in a case report showing zero improvement after transplanting a sheet of retinal pigment epithelial cells differentiated from induced pluripotent stem cells in a patient with neovascular age-related macular degeneration. (bmj.com)
These cells incorporate into the microvasculature and improve tissue perfusion and organ function.16, 17 Figure 1 Differentiation of human induced pluripotent stem cells (iPSCs) into endothelial cells (ECs). (pdgfreceptor.com)
Moreover, we expound the future research direction of HSC derivation from induced pluripotent stem cells (iPSCs), strategies to edit HSCs, gene therapy risk mitigation, and their clinical perspectives. (sscb-stembiotech.com)
But what is not getting such wide reporting is the use of pluripotent stem cells (as well as many other types of cells and genetic engineering techniques) for reproductive purposes . (lifeissues.net)

In 2015, he was named a recipient of the MacArthur Fellowship (also known as the "Genius Grant") for his innovative work on stem cell and Parkinson's disease research. (wikipedia.org)
In 1998, while at the lab of Ronald D. McKay at the National Institutes of Health in Bethesda, Maryland, he developed techniques that facilitate the generation of dopamine cells, the primary cell type affected in Parkinson's disease in vitro from dividing precursor cells. (wikipedia.org)
Overall, Studer's decades long investigation into neurological diseases such as Parkinson's disease and clinical applications of stem cells has helped advance the field of cell replacement therapy. (wikipedia.org)
He also established the Sloan-Kettering Center for Stem Cell Biology and has been involved in a number of stem cell research committees and initiatives including the Tri-Institutional Stem Cell Initiative, (a collaboration between Memorial-Sloan Kettering Cancer Center, Rockefeller University, and Weill-Cornell Medical College), Michael J. Fox Foundation for Parkinson's disease research, and the New York Stem Cell Foundation. (wikipedia.org)
As we have a strong focus on developing cells for cell replacement therapy in Parkinson's disease, we are currently adapting our protocols for GMP compliance through the EU-funded network NeuroStemcellRepair. (lu.se)
Clinical studies of Parkinson's disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. (lu.se)
In this review, we cover both preclinical animal studies and clinical human trials that have used ex vivo gene therapy to treat neurological disorders with a focus on Parkinson's disease, Huntington's disease, Alzheimer's disease, ALS, and stroke. (bvsalud.org)
Researchers investigating many other conditions, including Parkinson's , also have been known to use embryonic stem cells. (salon.com)
Recent research has shown that pieces of fetal nigral tissue placed in the striatum of 6-OHDA lesioned rats offer greater cell survival and predictability of graft function (in comparison to dissociated nigral cells) in the animal model of Parkinson's disease [ 20 ]. (hindawi.com)
The JPND database of Experimental Models for Parkinson's disease, developed in cooperation with the Italian Ministry of Education, Universities and Research ( MIUR ), aims to build an online network of scientists working in the field to more rapidly establish community consensus around currently available models. (neurodegenerationresearch.eu)

In collaboration with Malin Parmar´s group at the Wallenberg Neurosciece Center we are studying the in vivo efficacy and performance of dopamine neuron precursors derived from human embryonic stem cells. (lu.se)
At present, it is thought that the efficacy of cell replacement in the CNS would be greatly enhanced if a means to fully reestablish degenerated or disrupted pathways (e.g., nigrostriatal) could be developed. (hindawi.com)
The approval was based on recently published clinical efficacy and safety data from the Phase 3, randomized, open-label, controlled study (ET743-SAR-3007), which evaluated YONDELIS versus the chemotherapy agent dacarbazine, in patients with unresectable or metastatic LPS or LMS previously treated with an anthracycline and at least one additional chemotherapy regimen. (prnewswire.com)
Since the initial success of cell therapy for ischemic diseases many attempts have been made to increase its efficacy. (biomedcentral.com)
In addition, clinical studies typically only utilize white and male Western participants, which creates a bias in drug efficacy, especially as it is known that certain drugs are harmful to particular ethnic groups . (lifebeatnewspaper.com)
Optimizing Patient Selection to Maximize Drug Efficacy: the Expanding Role of Pharmacogenomics in the Clinical Development of Pembrolizumab for the Treatment of Non-Small Cell Lung Cancer. (cdc.gov)

Furthermore, conditions that were treated unsuccessfully by aborted tissue, are now routinely treated by adult stem cells. (fli.org.nz)
Adult stem cells and cord blood stem cells do not raise special ethical concerns and are widely used in research and clinical care. (scitechnol.com)
Dozens of adult stem cell treatments are moving through clinical trials and showing early success, raising hopes that some could reach the market within five years. (ibtimes.com)
The cells used are derived from adult tissue such as fat, or bone marrow, thereby circumventing the ethical concerns raised by the use of cells derived from embryos. (ibtimes.com)
HSCs are a type of multipotent adult stem cell, characterized by their ability to self-renew and differentiate into erythrocyte (red blood cell) and leukocyte (white blood cell) cell lineages. (asu.edu)
The Archdiocese suggests people who want to do the challenge contribute to the John Paul II Medical Research Institute, "where the research is only conducted using adult stem cells. (salon.com)
Dr. Deisher was the first person to discover adult cardiac derived stem cells, and has been a champion of adult stem cell research, both professionally and privately, for two decades. (medicalkidnap.com)
Dr. Deisher was a plaintiff in the U.S. federal lawsuit to prohibit use of federal tax payer dollars for embryo destructive research, which was instrumental in steering science towards adult stem cell research, which has led to 14 U.S. FDA approved adult stem cell products and the Washington Post Dec 2013 headline "Scientists Go Ethical in 2013. (medicalkidnap.com)
Indigenous cells rarely regenerate across the adult CNS, and neural circuitry reconstruction is made difficult by the fact that the adult CNS expresses molecules, that inhibit axonal growth, and/or fails to express precise gradients of growth-promoting cues that would stimulate/direct axonal growth [ 1 - 4 ]. (hindawi.com)
Past studies have shown that some fetal nigral cells transplanted in this way can grow a limited number of axonal projections towards the striatum, but most are generally incapable of growing over the distance required to establish functional connections in the striatum in the adult brain [ 8 - 10 ]. (hindawi.com)
One potential future trial would be using adult stem cells for ALS. (flfamily.org)
Researchers at the Mayo Clinic are currently doing clinical trials for patients with ALS, using ADULT STEM CELLS. (flfamily.org)
NOTE that the second trial is in association with an Israeli company, Brainstorm Cell Therapeutics , that is developing the adult stem cell treatment for ALS and other neural conditions. (flfamily.org)
While this is still an experimental trial, the early results using adult stem cells for ALS treatment have been positive . (flfamily.org)
Donate to ethical adult stem cell research! (flfamily.org)
Adult stem cells are helping patients now! (flfamily.org)
There is limited ability of the adult stem cells to grow in culture for long time and they cannot distinguish from others(Joseph). (ipl.org)

Farmer and Wang are the first to combine fetal surgery with a placental stem cell treatment to reduce the effects of spina bifida, which in children can range from barely noticeable to severe. (sciencedaily.com)
A more realistic service is offered by a few cord blood banks that preserve the stem cells from placental blood and placental tissue. (parentsguidecordblood.org)
During this period, health care providers lack key information on human placental transfer, fetal exposure, optimal maternal dosing in pregnancy, and maternal and fetal drug toxicity, including teratogenicity risk. (springer.com)

Umbilical cord blood (UCB) stem cells are hematopoietic stem cells (HSC) that are recovered from the blood of the umbilical cord and placenta after birth. (asu.edu)
Umbilical cord blood is rich in cells that express the CD34 molecule, a surface protein that identifies cells as stem cells. (asu.edu)
Named after the English physician Thomas Wharton, Wharton's Jelly, a gelatinous substance found within the umbilical cord, holds a unique place in medical research and regenerative medicine. (acceleratewi.com)
Salvador, a five-year-old Portuguese boy who was diagnosed with autism spectrum disorder, recently underwent treatment using stem cells from his own umbilical cord blood with the aim of improving his condition. (sscb-stembiotech.com)

Clinical trials of pazopanib in malignant diseases in humans have shown activity against renal cell carcinoma and soft tissue sarcoma and promising effects in ovarian and thyroid cancer. (nih.gov)
We evaluated a cohort of 94 soft tissue sarcoma samples to assess the correlation between gene expression and protein expression by immunohistochemistry for endosialin and PDGFR- β , a reported interacting protein, across available diagnoses. (hindawi.com)
LPS and LMS are subtypes of soft tissue sarcoma (STS) and represent more than 35% of all STS cases. (prnewswire.com)

For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)

Opinions differ as to whether those breast cancers supplemented by 10% fetal bovine serum, penicillin, and streptomycin. (lu.se)

Overall, given the current outcomes from researchers and clinical trials, along with exciting new developments in ex vivo gene and cell therapy, we anticipate that successful treatments for neurological diseases will arise in the near future. (bvsalud.org)
One of the nontherapeutic trials is the Sickle Cell Clinical Research and Intervention Program (SCCRIP), which follows participants with SCD throughout their lives to better understand clinical outcomes. (esri.com)
Through its website, www.dhaomega3.org , The DHA/EPA Omega-3 Institute located within the University of Guelph Research Park, (Guelph, ON, Canada) has focused its efforts for many years on the provision of evidence-based information on the relationship between the dietary consumption of long-chain omega-3 fatty acids throughout the human lifecycle and health outcomes. (dhaomega3.org)
The effects of routine supplementation during pregnancy on maternal and neonatal clinical outcomes have not been investigated in the Middle East, where hypovitaminosis D is prevalent. (who.int)

Tissue engineering is a field of regenerative medicine that integrates the knowledge of scientists, physicians, and engineers into the construction or reconstruction of human tissue. (asu.edu)

this interaction takes place at the maternal-fetal interface and is necessary for a healthy pregnancy. (parentsguidecordblood.org)
The switch in a mother's immune system during pregnancy is largely mediated by regulatory T cells in the maternal bloodstream. (parentsguidecordblood.org)
They are responsible for triggering cellular events such as activating the maternal regulatory T cells that maintain tolerance and promoting their proliferation, while concurrently inducing the death of activated T cells that could compromise the pregnancy. (parentsguidecordblood.org)
The HLA-G molecule plays a major role in immune tolerance during pregnancy, particularly at the maternal-fetal interface, where HLA-G inhibits the migration and proliferation of maternal immune cells. (parentsguidecordblood.org)
For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
Moreover, all anti-hypertensive treatments should be based on considerations of maternal and fetal safety. (clinicaltdd.com)
He then completed an OBGYN Residency at the University of Maryland, followed by a fellowship in Maternal Fetal Medicine (MFM) at Yale University. (uic.edu)
Dr. Buhimschi received many prizes recognizing research excellence from the Society for Maternal Fetal Medicine (SMFM) including the "March of Dimes Best Research in Prematurity" award. (uic.edu)

Initiation of collaborative research relationships and establishment of an active research network with Nationwide Children's Hospital in Columbus has facilitated Dr. Buhimschi's trainees and faculty to seek and attain extramural funding from sources such as the American College of Obstetrics and Gynecology (ACOG). (uic.edu)

It is interesting to note that only very minute amounts of the short-chain omega-3 fatty acid known as LNA (alpha-linolenic acid, 18:3 n-3) are found in these neural tissues. (dhaomega3.org)

Mammalian fetal organ regeneration. (nih.gov)

The most serious risks associated with YONDELIS are neutropenic sepsis (severe infections due to decreased white blood cells), rhabdomyolysis (severe muscle problems), cardiomyopathy (heart muscle problems, including heart failure), hepatotoxicity (liver problems, including liver failure), anaphylaxis, and extravasation (leakage of YONDELIS out of the vein during infusion) leading to tissue necrosis (tissue cell damage or death) and embryofetal toxicity. (prnewswire.com)

He is the founder and director of the Center for Stem Cell Biology at Memorial-Sloan Kettering Cancer Center in New York City. (wikipedia.org)
Development: For advances in developmental biology and stem cells. (lu.se)
Development of vaccines and Basic biology research. (fli.org.nz)
3 Epithelial Cell Biology in ENT Research Group (EpiCENTR), Developmental Biology and Cancer, Great Ormond Street UCL Institute of Child Health, University College London , London, U.K. (biorxiv.org)
Tissue engineering is one of the disciplines involved in translating knowledge of developmental biology into the clinical setting. (asu.edu)
Dr. Deisher is a genetic engineer with over 20 years experience in the pharmaceutical industry, from basic human biology through clinical trials. (medicalkidnap.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

This new trial, TRANSEURO (NCT01898390), is an open-label study in which some individuals in a large observational cohort of patients with mild PD who were undergoing identical assessments were randomly selected to receive transplants of hfVM. (lu.se)

The study, conducted in an animal model, was led by Diana Farmer, the fetal surgeon who helped pioneer in utero treatment for spina bifida -- a congenital birth defect that occurs when the spinal cord does not close properly, leading to lifelong cognitive, urological, musculoskeletal and motor disabilities. (sciencedaily.com)
The most common and disabling form of the disorder, called myelomeningocele, causes the spinal cord to emerge through the back, often pulling brain tissue into the spinal column and causing cerebrospinal fluid to fill the interior of the brain. (sciencedaily.com)
As Rebecca Taylor has pointed out , ALSA also has given money to an affiliate, NEALS, that has given money to a trial that uses stem cells derived from the spinal cord of an aborted fetus. (flfamily.org)
That trial is being run by the University of Michigan and Emory University, and sponsored by a company called Neuralstem which uses aborted fetus cells for research ("from the donated spinal cord tissue of an 8-week-old aborted fetus. (flfamily.org)
Over 200 clinical studies applying various stem cell approaches to treat neurological disease have been registered to date (Clinicaltrials.gov), the majority of which are for multiple sclerosis, stroke and spinal cord injuries. (sscb-stembiotech.com)

His expertise in cell engineering spans a wide range of cells/tissues within the nervous system geared toward disease modeling and exploring cell replacement therapy. (wikipedia.org)
The lower-limb paralysis associated with spina bifida may be effectively treated before birth by combining a unique stem cell therapy with surgery, new research has found. (sciencedaily.com)
With additional evaluation and FDA approval, the new therapy could be tested in human clinical trials. (sciencedaily.com)
However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
Pazopanib is a multi-kinase inhibitor active against vascular endothelial growth factor receptors-1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma and soft tissue sarcomas. (nih.gov)
Our findings provide proof of concept for combining gene and stem cell therapy for effective modulation of ectopic protein expression in transplanted cells. (bvsalud.org)
We believe that over time there will be some very significant clinical progress, and valuations will improve, but we're still a long way from an approved therapy. (ibtimes.com)
This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
The Midwest Stem Cell Therapy Center (MSCTC) at the University of Kansas Medical Center is only a year old, but is starting an increasing number of clinical trials and educational efforts. (flfamily.org)
To clearly illustrate the importance of cell and gene therapy in hereditary anemia, this paper provides a review of the genetic aberration, epidemiology, clinical features, current management, and cell and gene therapy endeavors related to SCD, thalassemia, Fanconi anemia, and G6PDD. (sscb-stembiotech.com)
Many forms of stem cell therapy exist, including the use of neural, haematopoietic and mesenchymal stem cells. (sscb-stembiotech.com)
Advances in medicine emerge from prospective clinical trials, which allow patients with a given disease and meeting specific eligibility criteria to access studies that provide a controlled assessment of a therapy. (abta.org)
In this article R. Alta Charo states that we have a right to use fetal tissue for research and therapy (Fetal Tissue, 1) The article goes into how a lot of people find this to be a moral issue and a matter of the conscience and explains how the antiabortion activist that don't agree with the research are actually benefitting from the fetal tissue. (ipl.org)
They argue that the research supports abortions but have taken part in receiving vaccines and therapy that comes from the research. (ipl.org)
This document summarizes the results of the trial, discusses limitations in the interpretation of the results, reviews the potential long-term adverse effects of this ZDV regimen for infants and women, and provides recommendations for the use of ZDV to reduce perinatal transmission and for medical monitoring of pregnant women and infants receiving this therapy. (cdc.gov)

abstract = "Clinical studies of Parkinson{\textquoteright}s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. (lu.se)

Glial cell line-derived neurotrophic factor (GDNF) has provided benefits to Parkinsonian patients and is being used in a clinical trial for amyotrophic lateral sclerosis. (bvsalud.org)

However, human embryonic stem cell (hESC) research is ethically and politically controversial because it involves the destruction of human embryos. (scitechnol.com)

Indeed, cell culture studies have demonstrated endosialin to be directly involved in regulating cellular proliferation [ 13 ] and in a subset of cells this proliferation appears to involve the PDGFR- β pathway [ 14 , 15 ]. (hindawi.com)
G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)

The discovery of hematopoietic stem cells (HSCs) provided a pioneering step in stem cell research. (asu.edu)

The recent desperation to clone human embryos may be seriously undermining accepted ethical principles of medical research, with potentially profound wider consequences. (lifeissues.net)

Prenatal surgery revolutionized spina bifida treatment by improving brain development, but it didn't benefit motor function as much as we hoped," said Farmer, chair of the UC Davis Department of Surgery and senior author of the study, published online in Stem Cells Translational Medicine . (sciencedaily.com)
Through the use of human embryonic stem cells (hESCs), we can mimic brain development towards different regions of the human brain, and thereby investigate the effect of novel genes on neural differentiation. (lu.se)
While much study has been devoted to genetic "triggers" of CNS neurodegeneration-notably mutant Htt in Huntington's disease (HD)-such inherited triggers are typically expressed from early fetal development and are fundamentally inaccessible to timely clinical intervention. (hdsa.org)
Even with the recent Ebola virus scare, statements were made that foetal tissue was "absolutely critical" for the development of a vaccine. (fli.org.nz)
This claim is not isolated with research documenting these horrific acts since the 1930's - including development of the polio vaccine. (fli.org.nz)
They also play an important role in the formation of vital organs such as the liver and spleen during fetal development. (asu.edu)
Epidermal growth factor is a signaling molecule that stimulates the growth of epidermal tissues during development and throughout life. (asu.edu)
Fetal and infant safety concerns have led to the exclusion of pregnant and lactating women from clinical trials during drug development programs for licensure, unless the drug is intended for a pregnancy-specific condition [ 4 , 5 ]. (springer.com)
The U.S. approval for YONDELIS exemplifies our commitment to improving the health of people living with cancer and addressing unmet needs," said Roland Knoblauch , M.D., Ph.D., Clinical Leader, YONDELIS, Janssen Research & Development, LLC. (prnewswire.com)
In total, we identified 17 neurological indications in clinical stage development. (sscb-stembiotech.com)
increased public sensitivity and awareness together with the development of national regulations of governance of human cloning and embryo research in general. (lifeissues.net)
Celgene concentrated on the research and development of chemical and biotreatment processes for the chemical and pharmaceutical industries. (encyclopedia.com)

For over two decades, Dr. Catalin Buhimschi has been committed to basic science and translational research. (uic.edu)
He has published over 170 original research articles in journals such as Circulation, Hypertension, The Lancet, Science Translational Medicine, and JAMA Pediatrics. (uic.edu)

Next, I will present recent results and discuss our attempts to identify EV-based biomarkers in sickle cell disease and preeclampsia. (selectbiosciences.com)
More than 300,000 babies are born each year with sickle cell disease (SCD), according to the World Health Organization. (esri.com)
Researchers use indexes, such as the Economic Hardship Index (EHI), to understand factors in sickle cell disease (SCD) patients' social and physical environments that could affect treatment. (esri.com)
Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi anemia, glucose-6-phosphate dehydrogenase deficiency (G6PDD), and thalassemia. (sscb-stembiotech.com)

However, use of fetal tissue is ethically controversial because it is associated with abortion, which many people object to. (scitechnol.com)

Dr Karl Butterworth and PhD Student Dr Kathryn Brown have applied high precision cancer radiotherapy techniques used to treat human patients to improve the reproducibility and translatability of preclinical animal trials. (nc3rs.org.uk)

However, most widely-known is the usage of aborted cells in the manufacture of vaccines. (fli.org.nz)
The chickenpox, rubella, hepatitis A, shingles and one rabies vaccine all derive from fetal embryo fibroblast cells cultivated in the 1960s -- and Catholic leadership has wrestled with the ethics of using those vaccines. (salon.com)
This is a very important interview between Robert F. Kennedy, Jr. and Dr. Theresa Deisher regarding the use of human fetal tissue to culture viruses for vaccines, because Dr. Deisher reveals that human DNA fragments are found in vaccines. (medicalkidnap.com)
Most of the COVID vaccines being developed are using human fetal tissue to culture the coronavirus. (medicalkidnap.com)
One of the more interesting questions Mr. Kennedy asked Dr. Deisher was why the manufacturers of vaccines switched from exclusively using animal tissue to culture viruses for vaccines, to start using aborted fetal tissue some years back. (medicalkidnap.com)
On June 15th, Robert F. Kennedy, Jr. interviewed the founder and president of Sound Choice Pharmaceutical Institute , Dr. Theresa Deisher, on the use of aborted fetal tissue in vaccines. (medicalkidnap.com)
Mr. Kennedy and Dr. Deisher covered a wide range of topics including which vaccines contain human fetal tissue, what the existing research tells us in terms of health risks, and what alternatives might be used in place of human DNA in vaccines. (medicalkidnap.com)
This report 1) describes the clinical features of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants, 2) reviews available evidence of pertussis vaccination during pregnancy as a strategy to prevent infant pertussis, 3) summarizes Tdap vaccination policy in the United States, and 4) presents recommendations for use of Td and Tdap vaccines among pregnant and postpartum women. (cdc.gov)

AECs also release HLA-G, a histocompatibility leukocyte antigen that can aid with tissue repair. (parentsguidecordblood.org)
Endosialin, also known as Tumor Endothelial Marker-1 (TEM-1) or CD248, was first described as a vascular endothelial cell surface antigen in human fetal fibroblasts [ 1 ]. (hindawi.com)

Aastrom Biosciences Inc recently presented promising results from a mid-stage trial of its treatment for patients with critical limb ischemia, a disease in which blood flow to the extremities is restricted, at the American Heart Association's annual meeting. (ibtimes.com)
We have used noninvasive molecular imaging to document the survival of iPSCs-ECs injected into ischemic tissue in animal models of myocardial or limb ischemia. (pdgfreceptor.com)

Pericytes are essential to the process of angiogenesis, especially neoangiogenesis, and serve as scaffolding for endothelial cells but also communicate with endothelial cells by direct physical contact and paracrine signaling pathways [ 4 ]. (hindawi.com)
Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)
Experimentally, iPSCs have been shown to differentiate into each of the major cardiovascular components, including smooth muscle Inhibitors,research,lifescience,medical cells,13 endothelial cells, vascular mural cells, and cardiomyocytes.14, 15 Cardiovascular regeneration will require the effective generation of each of these cell types. (pdgfreceptor.com)
Our laboratory focuses on endothelial cells (ECs) as they are essential components in cardiovascular regeneration. (pdgfreceptor.com)

We're actually developing products now," said Timothy Mayleben, chief executive of Aastrom, which is using cells derived from a patient's own bone marrow to develop treatments for cardiovascular disease. (ibtimes.com)
Thus, SCD patients who have higher levels of HbF in their bodies have more rounded red blood cells in their circulatory systems and tend to experience fewer symptoms, which include severe body pain, leg ulcers, osteonecrosis (the destruction of bone tissue), and acute chest syndrome (a pneumonia-like illness that can be fatal). (esri.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
Human iPSCs are grown on low adhesion dishes in the presence of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-4 (BMP4) to induce the … There remain substantial hurdles to overcome before iPSC-derived cardiovascular cells are ready for clinical trials. (pdgfreceptor.com)

The clinical onset is typically within 4 to 12 weeks of starting pazopanib and the pattern of serum enzyme elevations is usually mixed. (nih.gov)
Teratomas are embryonal tumors that normally arise from germ cells and are typically benign. (asu.edu)

Since 2005, Dr. Buhimschi was funded continuously by the NIH to pursue research in the field of uterine healing, fetal injury, and antenatal damage. (uic.edu)
The regimen used in this trial included antenatal oral administration of ZDV beginning at 14-34 weeks of gestation and continuing throughout pregnancy, followed by intrapartum intravenous ZDV and postnatal oral administration of ZDV to the infant for 6 weeks after delivery. (cdc.gov)

Our preliminary data suggest that young healthy people already harbor cells in their brain showing mutations that we know drive brain cancer. (abta.org)
Acquisition of these mutations by normal cells can lead to microscopic abnormalities starting years before detectable tumors appear. (abta.org)
We developed a method that, for the first time, is able to study the complete genome of glial cells and see how they accumulate somatic mutations, starting from fetal life and through older stages. (abta.org)

This includes long-term survival of transplanted cells in vivo to assess cell fate, maturation and integration, as well as functional behavioural assessment for graft function in vivo. (lu.se)
Studies have identified pericytes and reactive fibroblasts, two essential cell types required for tumor survival and growth, as the major sites of expression of endosialin. (hindawi.com)
Tissue analysis of 13 participants who died of disease progression showed graft survival and GDNF production. (bvsalud.org)
RESTORE - recovery and survival of stem cell originated red cells - currently pending approval from the Health Research Authority. (cam.ac.uk)

The fetal membranes - amnion and chorion - also contain stem cells and stem cell-like cells that can be isolated and banked for clinical use. (parentsguidecordblood.org)
We now know that some of the stem cells and stem-like cells of the placenta and fetal membranes have a vital role to play in this immunological switch. (parentsguidecordblood.org)
DHA is found in all tissues and cells throughout the human body and is by far the most abundant omega-3 fatty acid in cellular membranes. (dhaomega3.org)
Qu: Does DHA have any special physico-chemical properties which underlie its important functioning in cell membranes? (dhaomega3.org)

Various cell types can be genetically engineered. (bvsalud.org)

Anatomy26

Organisms11

Diseases16

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Psychiatry and Psychology11

Phenomena and Processes31

Disciplines and Occupations27

Anthropology, Education, Sociology and Social Phenomena16

Technology, Industry, Agriculture1

Humanities13

Information Science17

Named Groups4

Health Care69

Geographicals4

Transplantation20

Embryonic stem cel14

Mesenchymal stromal cells5

Stromal8

Therapies10

MSCs16

Neurons28

Therapeutic16

Pluripotent14

Parkinson's10

Efficacy6

Adult17

Placental3

Umbilical4

Soft tissue3

20171

Bovine serum1

Outcomes4

Regenerative medicine1

Maternal8

Obstetrics and Gyneco1

Neural Tissues1

Mammalian1

Toxicity1

Biology7

TransEuro1

Spinal cord5

Therapy15

Abstract1

Parkinsonian1

HESC1

Proliferation2

Hematopoietic Stem1

Embryos1

Development12

Translational2

Sickle cell di4

Ethically1

Preclinical animal1

Vaccines8

Antigen2

Limb ischemia2

Endothelial cells5

Bone4

Typically2

Antenatal2

Mutations3

Survival4

Membranes4

Genetically engineered1