Research used mouse. Medical search. Frequent questions

I'm sure it's chaos at the NIH for anyone doing mouse experiments," says Roger Reeves , a researcher at Johns Hopkins University in Baltimore who uses hundreds of so-called transgenic mice in his work on Down syndrome. (npr.org)
To maintain a colony of transgenic mice, every new pup must have its DNA tested by a highly trained researcher, Reeves says. (npr.org)
OBJECTIVE: We aimed to study the effect of chronic stress on the hippocampal proteome in male APPPS1 transgenic mice and wildtype (WT) littermates. (aau.dk)
No neurodegeneration is observed in transgenic mice. (neurodegenerationresearch.eu)
Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
Brain atypical proteinase K-resistant prion protein (PrP res ) of porcine PrP transgenic mice infected with an atypical scrapie (SC-PS152) agent (lane 4) versus sheep bovine spongiform encephalopathy (Sheep-BSE) agent (lane 2). (cdc.gov)

Federal research centers including the National Institutes of Health will have to kill some mice to avoid overcrowding, researchers say. (npr.org)
The NIH will face another problem with its mice, researchers say: overcrowding. (npr.org)
Importantly, the researchers showed that wild mice have more highly-activated myeloid cells - bone marrow cells that initiate immune responses. (bristol.ac.uk)
In the study , the researchers gave pairs of mice from three of the most commonly used strains a few different living options. (stanford.edu)
In a word, this report is a must-read for industry players, investors, researchers, consultants, business strategists, and all those who have any kind of stake or are planning to foray into the Wireless Mouse market in any manner. (marketpublishers.com)
The Olink Target 48 Mouse Cytokine Panel represents a new standard in immunoassays giving researchers the ability to accurately measure 43 carefully selected immune-related proteins using as little as 1µl of sample volume. (wgntv.com)
This suggests that these mice might provide researchers with a good model system for studying schizophrenia and testing new drugs designed to treat people suffering from it. (scienceblog.com)
This sets the stage for what pain researchers call a writhing test, though Mogil says that's not actually what the mice do. (wshu.org)
The Touch Mouse Sensor API SDK is a small library intended to enable students and researchers to experiment directly with Touch Mouse sensor output. (hanselman.com)
Researchers from the Trainor Labhave developed an effective and reliable technique for studying high-arched palate using a mouse model. (stowers.org)
KANSAS CITY, MO - Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. (stowers.org)
For this study, Trainor Lab researchers and their collaborators used a mouse model of Treacher Collins syndrome (TCS), a human congenital condition that affects about 1 in 50,000 live births and impairs the bone and tissue development of the head and face, including the palate. (stowers.org)
The researchers generated 3-D images of the palates of the mice at several stages of development using nuclear fluorescence imaging, which uses luminous dyes to observe objects that light-based microscopy cannot. (stowers.org)
In keeping with standard practices of clinical metrics, the researchers classified as abnormal features measuring more than two standard deviations from those found in the control group mice. (stowers.org)
In the current study, by generating TCS mice with impaired p53 gene function, the researchers were able to improve, or rescue, the high-arched palate phenotype, suggesting a link between tissue formed by cranial neural crest cells and the underdevelopment of the palatal shelf in the pathogenesis of high-arched palate. (stowers.org)
BTBR is a commercially available inbred strain of mice that displays several autism-like features, including impaired social interactions and a strange pattern of vocalization, which researchers say mimic communication deficits seen in autism. (spectrumnews.org)
The researchers housed BTBR mice and controls shortly after they were weaned from their mothers, with a healthy mouse. (spectrumnews.org)
After 40 days of living with the new mouse, the researchers found, both BTBR mice and controls are more likely to be interested in other unfamiliar mice rather than in unknown objects. (spectrumnews.org)
Unfortunately, the social deficits in BTBR eventually return: when researchers separated a BTBR mouse from its cage mate, they found that, after 40 days of isolation, the BTBR mouse shows no preference for the unfamiliar mouse over the object. (spectrumnews.org)
BTBR mice given MPEP groom for shorter periods and behave more like control mice, the researchers found. (spectrumnews.org)
And the researchers did it by using what's known as an adeno-associated virus (AAV) - a virus that's able to go into the body to infect and alter the cells of humans (or, in this case, mice) without actually causing disease. (sciencealert.com)
This library would make it easier and faster for researchers to obtain mouse stem cells with specific genes already 'knocked-out' so that they will not need to spend the time. (progress.org.uk)
Researchers can 'knock-out', or disrupt, a gene in the mouse to see the effect it has on its health and development. (progress.org.uk)
Researchers at the University of California-Irvine studied hundreds of mice changed to make them develop abnormalities known as plaques and tangles in brain tissue that are considered hallmarks of Alzheimer's disease in people. (healthjockey.com)
The use of mice allowed the researchers to closely study how their feeding experience affects brain function and further understand how facing food insecurity can elevate health risks. (dailycal.org)
From a neurological perspective, the researchers found that the synapses of neurons that release dopamine were altered in at least two parts of the brain in the mice who were exposed to food insecurity, added Wilbrecht. (dailycal.org)
Earlier today, at the annual meeting of the Society of Toxicology, NIOSH researchers reported preliminary findings from a new laboratory study in which mice were exposed by inhalation to multi-walled carbon nanotubes (MWCNT). (cdc.gov)
These protocols enabled the researchers to investigate whether MWNCT alone would initiate cancer in mice, or whether MWCNT would promote cancer where the initiator, methylcholanthrene, had already been applied. (cdc.gov)

The loss of specialty mice, many of which have genes that can cause them to develop versions of human diseases, is especially troubling to scientists - and expensive. (npr.org)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
We aim to identify new Nrf2-dependent genes relevant for TE homeostasis and intestinal TE absorp-tion both in young and old mice. (uni-potsdam.de)
It's reasonable to think that increasing myelination might similarly ease traits in some neurodevelopmental conditions, including Pitt-Hopkins syndrome: Mice with mutations seen in people with the condition differentially express oligodendrocyte genes and have fewer of the cells and the myelin they make, Maher found in a 2020 study . (spectrumnews.org)
This mouse carries a trisomy for a large portion of the distal region of the long arm of mouse chromosome 16 that has 60% of all human chromosome 21 homologous genes in this species. (bvsalud.org)
The mHTT and wtHTT groups showed the highest number of differentially expressed genes compared to the BACHD mouse model. (lu.se)
In BACHD mice, few hypothalamic genes were differentially expressed compared to age-matched WT controls. (lu.se)
Specter focuses on a young biologic engineer by the name of Kevin Esvelt, who has the idea of using genes to produce significant immunity to B burgdorferi (Lyme disease), splicing them into mice, and breeding that population so that it is effectively immune to Lyme disease. (medscape.com)
None of these sound as effective as an elegantly engineered approach in which mice have a couple of genes that only seem to target Lyme disease, and we effectively render them neutralized. (medscape.com)

UPPSALA, Sweden, September 19, 2023 (GLOBE NEWSWIRE) - Olink Holding AB (publ) (Nasdaq: OLK) today announced the introduction of Olink® Target 48 Mouse Cytokine Panel, a validated multiplexed protein panel that offers a detailed view of the murine immune system, enabling in-depth disease modelling, longitudinal studies and translational research. (wgntv.com)

the next generation in immunoassays designed to accelerate translational research. (wgntv.com)
Announcing the Olink® Target 48 Mouse Cytokine Panel - the next generation in immunoassays designed to accelerate translational research. (wgntv.com)

This poster was inspired by the September/October image of our 2014 JAX® Mice, Clinical & Research Services Calendar, representing the C57BL/6J (000664) gold standard mouse strain. (jax.org)
4-week-old C57BL/6 mice (After a 1-wk adaptation) were fed with basal diet and basal diet supplemented with 0.1% AMP, respectively. (foodandnutritionresearch.net)
Methods: Epac1 / and Epac2 / C57BL/6J mice were produced and compared with wild-type mice for transvascular flux of radio-labelled albumin in skin, adipose tissue, intestine, heart and skeletal muscle. (uib.no)
To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa −/− , Xpc −/− and wild-type control female mice in a pure C57BL/6J background were done. (aacrjournals.org)

Recently, isolated human lymphoid malignant cells have been successfully grown outside of the patient after transplant into immune deficient mice (a "xenograft", or cross-species transplant). (rochester.edu)
Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
We have characterized AEP-deficient mice as a disease model of human hemomphagocytic syndrome, which developed hemophagocytosis especially in bone marrow. (nii.ac.jp)
We have conducted further examinations so as to characterize AEP-deficient mice as a new model of lysosomal disease. (nii.ac.jp)
Additionally, Xpc -deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa −/− mice, whereas in both models mutant frequency is increased in liver. (aacrjournals.org)

Mouse is a well-established model for the study of mammalian embryology, and parallel comparison between mouse and human samples can be very informative and lead to a better understanding of human embryogenesis. (nature.com)
Participation in the Rodent Research missions is both exciting and inspiring, as the research advances our understanding of how microgravity conditions impact mammalian biology," said Dr. Gretchen Kusek, associate director of scientific services with Taconic Biosciences, in a company press release. (biopharminternational.com)

Epac2 / and wild-type mice had similar basal and ANP-stimulated clearances. (uib.no)
Xpc −/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa -deficient or wild-type mice. (aacrjournals.org)
BACHD mice with ubiquitous expression of full-length mutant HTT (mHTT) and wild-type mice with targeted hypothalamic overexpression of either wild-type HTT (wtHTT) or mHTT fragments. (lu.se)

European scientists aim to create a library of mouse embryonic stem cells that can be used to research human diseases. (progress.org.uk)

Recent studies demonstrate that similar epigenetic clocks for mice (Mus Musculus) can be slowed by gold standard anti-aging interventions such as calorie restriction and growth hormone receptor knock-outs. (sens.org)
The sandy inland mouse can be distinguished from several species including P. chapmani, P. delicatulus and Mus musculus by the pattern of the footpads. (wikipedia.org)
One of the obvious advantages in the use of animal models, especially the mouse (Mus musculus), is our ability to perform scientific studies that are technically or ethically not permissible in human beings. (bvsalud.org)

Laboratory mice may not be effective models for studying immune responses to disease. (bristol.ac.uk)
The research, published in Nature Communications, reveals limitations of laboratory mice as immunological models. (bristol.ac.uk)
The findings have implications for all aspects of medical and scientific research because laboratory mice underpin studies whose results have a transformative effect on human and animal lives through vaccination and other immune-based therapies. (bristol.ac.uk)
In 62 immunological measures, 57 differed between wild and laboratory mice. (bristol.ac.uk)
Professor Viney from Bristol's School of Biological Sciences said: "It's remarkable that despite the enormous number of studies of laboratory mice, ours is the first in-depth study of wild mice immune systems. (bristol.ac.uk)
A new study confirms what Joseph Garner , PhD, and his colleagues have long suspected - that laboratory mice are healthier, more fertile and have better welfare when they have the means to build a nest, which reduces stress and helps them naturally warm themselves. (stanford.edu)
Laboratory mice now are routinely housed in cold conditions, so the animals expend much of their energy trying to keep warm. (stanford.edu)
In the NIOSH study, a group of laboratory mice were injected with a chemical that is a known cancer initiator, methylcholanthrene. (cdc.gov)
The new NIOSH study is the first to show that MWCNT is a cancer promoter in a laboratory experiment, and reports the growth of lung tumors in laboratory mice following inhalation exposure to MWCNT rather than injection, instillation, or aspiration. (cdc.gov)
In the study, laboratory mice were exposed to one type of MWCNT through inhalation at a concentration of 5 milligrams per cubic meter of air for five hours per day for a period of 15 days. (cdc.gov)

These findings in mice may help shed light on how schizophrenia, an often severe and debilitating disease, emerges in humans. (scienceblog.com)
There's plenty of work to do yet, not least demonstrating that the same techniques can work in humans as well as mice, but this new study shows that the AAV and CRISPR approach is one of the most promising we have. (sciencealert.com)
This is particularly prevalent in the auditory modality with both humans with FXS and the mouse model ( fmr1 KO mouse) showing behavioral disruptions due to presence of constant and/or unpredictable sounds. (fraxa.org)
It's a really exciting thing to look at, but it probably needs maybe one more mouse or rat study before you actually take it into humans," she says. (spectrumnews.org)
Although the data are promising , much of the research has been conducted with mice or come from trials of short-term use in humans. (medscape.com)
Ticks will feed on mice that no longer have Lyme disease, so they will no longer effectively transmit it to humans. (medscape.com)

A campus neuroscience study revealed an association between food insecurity and behavior in mice. (dailycal.org)
A previous version of this article may have implied a causal relationship between dopamine levels in the brain and behavior in mice. (dailycal.org)

Taconic Biosciences, a provider of genetically engineered rodent model solutions, sent mice into space to advance research on new therapies for aging-related disease processes. (biopharminternational.com)
On Jan. 17, 2019, Taconic Biosciences, a provider of genetically engineered rodent model solutions, announced the completion of a recent mission to the International Space Station (ISS) to advance research on new therapies for aging-related disease processes. (biopharminternational.com)

A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background. (taconic.com)
The Binder laboratory has recently developed multielectrode array (MEA) technology for application to physiological studies of Fragile X syndrome (FXS) mutant mice and to localize the onset of epilepsy after brain trauma (posttraumatic epilepsy). (fraxa.org)

Using in vivo single neuron and EEG recordings, we have found that the fmr1 KO (compared to WT) mouse cortical neurons show increased responses to individual sounds even well after sound offset, reduced habituation to ongoing sounds, increased background noise in the gamma frequency band and reduced temporal fidelity. (fraxa.org)
Mice in which the Pitx3 adeno-associated-virus serotype 2 (Pitx3-AAV2) was used to selectively overexpress the Pitx3 protein in midbrain neurons. (neurodegenerationresearch.eu)

Electrophoretic profiles and antibody labeling of PrP res detected with monoclonal antibodies Sha31 (A) or 12B2 (B). Profiles produced by atypical scrapie (SCPS152) (lane 3) and sheep-BSE (lane 1) before passage in the porcine mouse model are shown for comparison. (cdc.gov)
The Committee was informed of progress in research into chimeric chimpanzee/human monoclonal antibodies. (who.int)

To identify the Nrf2-modulated part of TE effects, Nrf2 knockout (KO) mice will be studied in parallel. (uni-potsdam.de)
Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)

The first genetically engineered mouse was created in 1980. (progress.org.uk)

Others will die because it is impossible to maintain certain lines of genetically altered mice without constant monitoring by scientists. (npr.org)
So Reeves and other scientists at Johns Hopkins agreed to talk about what a shutdown would mean for their lab animals and the research these animals make possible. (npr.org)
So, once federal scientists knew a shutdown was going to happen, they probably had to choose certain mice to eliminate. (npr.org)
Olink Target 48 Mouse Cytokine Panel gives scientists the ability to go deeper into preclinical and translational disease research, tackling some of the most important and challenging questions in biology," said Jon Heimer, CEO of Olink . (wgntv.com)
Perrin says that if scientists had been more careful with their initial mouse studies, they would have realized that these drugs were never good candidates and that it made no sense to try them in people. (hawaiipublicradio.org)
Scientists doing this research need to be rewarded for getting it right, he says, not just for getting it published. (hawaiipublicradio.org)
The scientists transferred bacteria flora from bears in winter hibernation as well as bears in summer to lab mice that were cultivated to be germ-free. (understandinganimalresearch.org.uk)
For the first time, scientists have managed to genetically modify stem cells inside the bodies of mice, a feat which could eventually open up new potential in stem cell therapy. (sciencealert.com)

This poster was inspired by the January/February image of our 2014 JAX® Mice, Clinical & Research Services Calendar, representing the NSG™ (NOD scid gamma, 005557). (jax.org)
From pre-clinical mouse models to human clinical applications, Olink provides industry-leading solutions encompassing all stages of drug development and disease modelling. (wgntv.com)
The recent results of AIDS Clinical Trials Group Protocol 076, a controlled clinical trial sponsored by the National Institutes of Health in collaboration with the National Institute of Health and Medical Research and the National Agency of Research on AIDS in France, indicate that zidovudine administered to a selected group of HIV-infected women and their infants can reduce the risk for perinatal transmission of HIV by approximately two-thirds. (cdc.gov)
And at the Buck, Newman and Stubbs will be evaluating the use of biomarkers that are often available in clinical labs ― insulin, C-reactive protein, cystatin, and natriuretic peptide tests ― for use as outcome measures that are responsive to treatment interventions and that can be used to track outcomes in future research on aging. (medscape.com)

The Rodent Research 8 mission, also referred to as Rodent Research Reference mission 1, studies the microgravity effects on groups of the company's young and old BALB/cAnTac mice flown on the same mission. (biopharminternational.com)
This study demonstrated that both forms can infect BALB/c A mice. (lu.se)
It is concluded that both spiral and coccoid forms of H. pylori can cause acute gastritis in BALB/c A mice. (lu.se)

Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)

These results point to us having to be much more cautious in extrapolating from the lab to the wild, but laboratory mouse models will continue to be hugely important in biological and biomedical research. (bristol.ac.uk)
This poster compares the benefits and considerations for the top 10 metabolic disease mouse models from JAX. (jax.org)

Although the genome-wide histone modification landscapes of mouse in vivo germ cells and in vitro PGCLCs have been profiled and several germline-specific properties of epigenetic reprogramming have been revealed, the study of genome-scale chromatin states in human FGCs is still challenging, due to the scarcity of materials and technical difficulties. (nature.com)
Research at the Hugill Anesthesia Research Centre at The University of British Columbia (UBC) found that a quaternary derivative of lidocaine, QX-314, produces robust nociceptive, sensory, and motor blockade of long duration in animals in vivo . (asra.com)
The results of this new study in mice indicate we might be able to remove the risky and complicated extraction step: the necessary genetic edits could be made in vivo , which is likely to be both faster and more effective than the techniques used today. (sciencealert.com)

For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. (taconic.com)
Learn the highlights of mouse strain nomenclature with this poster. (jax.org)
For the most commonly used mouse strain, laboratories that invest 60 cents in nesting material over six months will gain an additional $273 on average in pups, he calculates. (stanford.edu)

In conclusion, mice with targeted overexpression of HTT (wtHTT or mHTT) in the hypothalamus show dysregulation of pathways, of which there are subsets of shared pathways and pathways unique to either wtHTT or mHTT overexpression. (lu.se)

Therefore, mice exposed to microgravity via spaceflight are a valuable model to understand and develop new therapies for aging-related immune, bone, and muscle disease processes. (biopharminternational.com)
And in related research, the Trainor Lab and collaborators have recently shown that the neuroepithelial cells that give rise to neural crest cells show a marked sensitivity to oxidative stress, and that maternal antioxidant supplementation can lessen or prevent craniofacial abnormalities in the TCS mouse model. (stowers.org)
New pharmacological and behavioral interventions can reverse characteristics of autism in a mouse model of the disorder, according to unpublished results presented in poster sessions today at the Society for Neuroscience meeting. (spectrumnews.org)
The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
Over the past 10 years, we have studied the auditory system of the fmr1 KO mice and identified a 'quadruple-hit' model for hypersensitivity. (fraxa.org)
Treatment of mice with inhibitors of MMP-9 reduces the phenotypes of the quadruple hit model. (fraxa.org)
Model mice treated with clemastine (bottom) have more newly formed oligodendrocytes than untreated mice (top). (spectrumnews.org)
One mouse model in particular, the Ts65Dn, has been used preponderantly in the area of DS research. (bvsalud.org)
A knock-out mouse model similar to the mut0 human form of methylmalonic acidemia has been developed. (medscape.com)
[ 16 ] This model may facilitate further research into the pathophysiology of the disease and broaden its therapeutic options. (medscape.com)
Here, we used the established anti- interferon treated Rag1-/- mouse model of ZIKV vertical transmission to compare genomic variation within ZIKV populations in matched placentas , fetal bodies, and fetal brains via RNASeq. (bvsalud.org)

The study found that these two groups of mice have major differences in their immune make-up. (bristol.ac.uk)
But given the means to build a nest, the mice will thrive, producing more pups that are healthier and more likely to survive, he and his colleagues report in a study out this week. (stanford.edu)
We found several microscopic pathologies and behavioral traits that are hallmarks of schizophrenia, says Ulrich Mueller, Ph.D., a professor at Scripps Research who was senior author of the study. (scienceblog.com)
In the study Mueller, Research Associate Claudia Barros, and colleagues also showed that the schizophrenic mice could recover normal behavior when treated with clozapine, a decades-old drug sometimes used to treat schizophrenia in people. (scienceblog.com)
Overall, this study demonstrates that there are trade-offs when it comes to epigenetic clocks in mice. (sens.org)
A new study shows that a mouse can sense another mouse's pain. (wshu.org)
Published online ahead of print in the journal Developmental Biology , the study was enabled by a 10-year research effort by the Trainor Lab and collaborators to understand the causes and effects of TCS. (stowers.org)
One promising finding of the study showed that TCS mice born to mothers with reduced p53 gene function showed no signs of cleft palate. (stowers.org)
There is something about a live mouse that is deterring social behavior," says graduate student Adam Katz, who conducted the study. (spectrumnews.org)
The mutated mouse stem cells created at EUCOMM will be used to study function. (progress.org.uk)
Since then, mice have been important in the study of how human diseases progress, because the mouse and the human genomes are so similar. (progress.org.uk)
The mice that performed the task experienced slower development of the protein beta amyloid clumping in the brain and forming plaques, gooey buildup that accumulates outside nerve cells, the study found. (healthjockey.com)
Clemastine improves myelination and normalizes brain activity and behavior in the mice, he found in a study published in Brain in April. (spectrumnews.org)
A study by UC Berkeley neuroscientists found that mice who faced food insecurity during early adolescence experienced effects on their dopamine synapses in adulthood as well as their behavior. (dailycal.org)
The study does not suggest that MWCNTs alone cause cancer in mice. (cdc.gov)
This research is an important step in our understanding of the hazard associated with MWCNT, but before we can determine whether MWCNT pose an occupational cancer risk, we need more information about actual exposure levels and the types and nature of MWCNT being used in the workplace, and how that compares to the material used in this study. (cdc.gov)
To better understand what happens when participants accept false feedback about their choices ongoing projects are using a number of measures other than self-report to study choice blindness, including eye-movements, pupil dilation and mouse-arm movements. (lu.se)

Offering multiplexing with unparalleled specificity combined with high sensitivity, the T48 Mouse Cytokine panel unlocks true longitudinal studies over multiple timepoints in individual mice. (wgntv.com)
Dr. JEFFREY MOGIL (Professor of Pain Studies, McGill University, Montreal): It appeared that the order in which you tested mice for pain from a cage of mice had an effect on their pain sensitivity. (wshu.org)
Expression of transgene restores sensitivity to MPTP treatment which is usually absent in mice lacking endogenous alpha-synuclein. (neurodegenerationresearch.eu)
We have also identified that abnormal sensitivity develops between post-natal day (P)14 - P21 in the mouse due to a mechanism that depends on elevated matrix-metalloproteinase-9 (MMP-9). (fraxa.org)

Physically similar to the several other species including the house mouse it differs in lacking the notched incisors and distinctive musty odour of M. domesticus. (wikipedia.org)

As well as giving us more effective stem cell tools for tackling diseases at their very core, the research also opens up different options for studying genetically edited stem cells in their natural habitat rather than the lab. (sciencealert.com)

The findings give way to yet another ides that's also taking the face of another research that also has emerged in other research - that exercising one's mind is important to warding off Alzheimer's disease, the degenerative brain malady that is the most common form of dementia among the elderly. (healthjockey.com)

The company reports that previous spaceflight studies demonstrated that mice undergo rapid loss of muscle and bone mass, resembling accelerated aging. (biopharminternational.com)

In contrast, food insecurity in female mice did not impact how they responded to errors, but instead impacted their body weight as adults, according to Wilbrecht. (dailycal.org)
Female mice who encountered food insecurity were significantly heavier after their adolescent period than the female mice who had steady access to food. (dailycal.org)

In early 2014, his focus shifted from an emphasis on climate change and the environment to biomedical research. (hawaiipublicradio.org)

A multi-tissue full lifespan epigenetic clock for mice. (sens.org)

Trials have indicated that sandy inland mouse will select seed with high water content over seed with lower water content, which is an important dietary adaptation for survival in the conditions of arid Australia. (wikipedia.org)

Additionally, mice exposed to MWCNT and to MWCNT plus the initiator chemical had larger tumors than the respective control groups. (cdc.gov)

Khaleel Razak is an auditory neurophysiologist whose long-term research goals are to understand how the auditory system represents everyday sounds, and how such representation changes during development, aging and syndromes with communication implications such as FXS. (fraxa.org)
Handbook of mouse auditory research: from behavior to molecular biology. (cdc.gov)

In tests on mice, AAVs packing CRISPR gene-editing technology were delivered to different types of skin, blood, and muscle stem cells, and progenitor cells (similar to stem cells but more specific and developed). (sciencealert.com)
EUCOMM is forecasted to produce 20,000 ' mutant ' mouse stem cells , each with one gene 'knocked-out', and will complement the World Stem Cell Hub. (progress.org.uk)
In AAV groups, from the combined limma with GSEA using ClusterProfiler, we found both shared and unique gene sets and pathways for mice with wtHTT overexpression compared to mice with mHTT overexpression. (lu.se)
People have pointed out that these gene editing technologies could weaponize creatures-mosquitoes, mice, and others-and that this could produce far graver circumstances. (medscape.com)

Professor Mark Viney and colleagues from the University of Bristol and the London School of Hygiene & Tropical Medicine studied the immune systems of 460 wild mice taken from 12 sites in the UK and compared them with mice bred in captivity. (bristol.ac.uk)
The wild mice had highly-activated immune systems, most likely because they are more exposed to infections. (bristol.ac.uk)
The wild mice also tightly control their responses to new infections, probably to prevent immune-mediated disease. (bristol.ac.uk)
What this shows is that wild mouse immune systems are working at 'warp-speed', compared with their lab cousins. (bristol.ac.uk)
Moreover, flow cytometric analysis showed a comparatively greater overall level of activation of cells of the immune system in wild mice. (bristol.ac.uk)
Engraftment of human chronic lymphocytic leukemia cells (hCD20+, brown) in an immune deficient mouse spleen showing typical follicle-like structures (arrows, Hemotoxylin and Eosin stain, H&E). (rochester.edu)
This mouse Adiponectin ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. (innov-research.com)

When the BTBR mouse is paired with another BTBR cage mate, in contrast, its social deficits do not improve. (spectrumnews.org)

Every 21 days a female mouse can have a litter," which can mean 10 or more pups, he says. (npr.org)
A female mouse can have a litter of six to 10 pups every 21 days. (npr.org)
This poster is a great resource for accurately aging mouse pups of various coat colors. (jax.org)
This double sided laminated poster allows you to quickly and easily identify your mice by visual examination of the external genitalia and accurately age mouse pups of various coat colors. (jax.org)
The mice with nesting material produced more pups per litter, the pups reached a healthy weight faster, the mortality of the pups is reduced, and the mice used less food. (stanford.edu)

We've learned so much recently about how ketone bodies interact with aging biology," John Newman, MD, PhD, of the Buck Institute for Research on Aging in Novato, California, and the study's principal investigator, told Medscape Medical News . (medscape.com)

The mice that Mueller, Barros, and colleagues studied would seem to lend credence to this hypothesis. (scienceblog.com)

The next step for this research, according to Wilbrecht, is understanding whether facing food insecurity during the developmental stage of a person's life creates vulnerability toward substance abuse and metabolic alteration. (dailycal.org)

Garner has done a series of studies in these mice not only to enhance their living conditions and well-being, but also to improve the results of research studies. (stanford.edu)
This changes their physiology and may compromise the outcome of research studies, says Garner, an associate professor of comparative medicine at Stanford. (stanford.edu)
One day, while reviewing a series of mouse studies, Mogil and his team noticed something odd. (wshu.org)
So Steve Perrin, who runs the ALS Therapy Development Institute in Cambridge Mass., decided to take a close look at the mouse studies that had initially suggested these drugs were promising. (hawaiipublicradio.org)
A great advantage over human studies is the availability of murine tissue samples, in which effects of different TE diets will be studied in close collaboration with all experimental groups of the Research Unit. (uni-potsdam.de)

This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
These mice also experienced a slower accumulation of another protein in the brain, hyperphosphorylated-tau, which can lead to the formation of neurofibrillary tangles - twisted fibers in brain cells. (healthjockey.com)
avenue of research has been the development of protein-based "point-of-care" diagnostic assays for antigen and antibody detection. (who.int)

namely the reduction, refinement and replacement of animals used in scientific research. (bristol.ac.uk)
3 The resolution recognizes the need to respect the freedom of ethical scientific research and to ensure access to the benefits of its application. (who.int)

Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. (nature.com)
We find 116 887 and 137 557 nucleosome-depleted regions (NDRs) in human and mouse FGCs, covering a large set of germline-specific and highly dynamic regulatory genomic elements, such as enhancers. (nature.com)
Our work offers a comprehensive and high-resolution roadmap for dissecting chromatin state transition dynamics during the epigenomic reprogramming of human and mouse FGCs. (nature.com)
NERC co-ordinates some of the world's most exciting research projects, tackling major issues such as climate change, environmental influences on human health, the genetic make-up of life on Earth, and much more. (bristol.ac.uk)
Horses can read human facial expressions, according to new research at the University of Sussex. (understandinganimalresearch.org.uk)
Mice have long been used in genetic disorder research to mimic human diseases. (stowers.org)
Our products are intended for in-vitro use only for manufacturing and research and are not suitable for human or animal use. (innov-research.com)
TFCat is a catalog of mouse and human TFs based on a reliable core collection of annotations obtained by expert review of the scientific literature. (pasteur.fr)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

RESULTS: We identified significantly up- and downregulated proteins in both APPPS1 and WT mice exposed to chronic stress compared to the control groups. (aau.dk)
Results: Epac1 / mice had constitutively increased transvascular macromolecule transport, indicating Epac1-dependent restriction of baseline permeability. (uib.no)
These results indicate that MWCNT can increase the risk of cancer in mice exposed to a known carcinogen. (cdc.gov)
In resolution WHA60.1, the Health Assembly requested the Director-General to undertake a major review in 2010 of the results of the research undertaken in accordance with the terms of resolution WHA55.15, so that the Sixty-fourth World Health Assembly may reach global consensus on the timing of the destruction of existing variola virus stocks. (who.int)

Mogil says that for the mice, waiting to be tested was like sitting in a dentist's lobby and seeing one patient after another emerge in obvious pain. (wshu.org)

Ticks effectively transmit Borrelia burgdorferi mainly by feeding on small mammals, such as deer mice, which are chronically infected with the Lyme disease bacterium. (medscape.com)

METHODS: APPPS1 and WT mice were subjected to 4 weeks of chronic stress followed by 3 weeks of continued diurnal disruption. (aau.dk)

NEW YORK, September 21, 2003 - New research from Memorial Sloan Kettering Cancer Center (MSKCC), Cornell University, and The University of Connecticut describes a novel way of producing therapeutic nerve cells that can cure mice with Parkinson's-like disease. (mskcc.org)
Current research is aimed at understanding these astrocytic contributions to epileptogenesis and developing astrocyte-targeted therapeutic approaches. (fraxa.org)

A lack of funding to labs is likely to mean an early death for thousands of mice used in scientific and medical research. (npr.org)
The cell bank, which cost 2.6 million pounds, is funded by the Medical Research Council (MRC. (progress.org.uk)

This initiative has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreements No. 643417, No. 681043 and No. 825664. (neurodegenerationresearch.eu)
Scanlan emailed Maher a few weeks after the 2020 paper came out, at which point Maher was already studying the use of clemastine and other promyelinating drugs in Pitt-Hopkins mice. (spectrumnews.org)

The sandy inland mouse (Pseudomys hermannsburgensis) is a species of rodent in the family Muridae. (wikipedia.org)
Then these mice could be released to breed with native mice and therefore eventually render the entire rodent population free of this. (medscape.com)

The planned introduction of a new biosafety level 4 laboratory at the Centers for Disease Control and Prevention in the United States of America in 2009 will increase capacity for research. (who.int)

The EU Joint Programme - Neurodegenerative Disease Research (JPND) is the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases, in particular, Alzheimer's. (neurodegenerationresearch.eu)
Lyme Disease: Treat Mice to Treat Ourselves? (medscape.com)
The second issue is that for this experiment to succeed, the proposal is to release these mice on an island in a controlled experiment on Martha's Vineyard or Nantucket, where Lyme disease is endemic and a major problem. (medscape.com)

TCS mice also showed significantly higher arched palate compared to their control counterparts, as defined by shelf height and angle differences - a clear validation of the research team's criteria. (stowers.org)
Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Mice receiving both the initiator chemical plus exposure to MWCNT were significantly more likely to develop tumors (90% incidence) and have more tumors (an average of 3.3 tumors/mouse lung) than mice receiving the initiator chemical alone (50% of mice developing tumors with an average of 1.4 tumors/lung). (cdc.gov)

Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise -induced hearing loss in mice. (cdc.gov)
Genetic basis for susceptibility to noise -induced hearing loss in mice. (cdc.gov)

The nest-builders proved to be healthier in many respects - good news for the mice, as well as for the research labs that maintain them. (stanford.edu)

The European Union has approved funding for the £9.3 million program, to be called the European Conditional Mouse Mutagenesis Programme (EUCOMM) and to be located in Heidelberg, Germany. (progress.org.uk)

The government shutdown is likely to mean an early death for thousands of mice used in research on diseases such as diabetes, cancer and Alzheimer's. (npr.org)

In 2001, Lorenz Studer, MD , Head of the Stem Cell and Tumor Biology Laboratory at MSKCC, and his colleagues at Rockefeller University published research in which they generated unlimited numbers of genetically matched dopamine nerve cells using cloned stem cells whose genetic material originated from the mouse's own tail. (mskcc.org)

It's true for cancer research as well. (hawaiipublicradio.org)
AACR Special Conference in Cancer Research. (bvsalud.org)
An AACR Special Conference in Cancer Research. (bvsalud.org)

The addition of a targeted mouse panel with absolute quantification capabilities adds to Olink`s broad portfolio of proteomics solutions. (wgntv.com)

Anatomy7

Organisms8

Diseases6

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology30

Phenomena and Processes15

Disciplines and Occupations37

Anthropology, Education, Sociology and Social Phenomena43

Technology, Industry, Agriculture4

Humanities14

Information Science36

Named Groups5

Health Care97

Geographicals5

Transgenic mice6

Researchers28

Genes9

20231

Translational research2

C57BL4

Deficient mice5

Mammalian2

Wild-type mice3

Embryonic stem1

Musculus3

Laboratory Mice10

Humans6

Behavior in mice2

Taconic Biosciences2

Mutant mice2

Neurons2

MONOCLONAL Antibodies2

Knockout2

Genetically engineered1

Scientists8

Clinical4

BALB3

Heterozygous1

Models2

Vivo3

Strain3

CONCLUSION1

Model11

Study17

Sensitivity4

Domesticus1

Edited stem cells1

Findings1

Undergo1

Female mice2

Biomedical research1

Lifespan1

Content1

Additionally1

Auditory2

Gene4

Immune7

Contrast1

Pups5

Novato1

Hypothesis1

Metabolic1

Studies5

Protein3

Scientific research2

Human9

Results4

Emerge1

Mammals1

METHODS1

Therapeutic2

Medical research2

20202

Rodent2

Centers1

Disease3

Significantly4

Susceptibility2

News1

Programme1

Alzheimer's1

Nerve cells1

Cancer research3

Proteomics1