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Staphylococcus10

• Laboratory experiments also indicated that carbonate killed other bacterial pathogens such as Salmonella typhimurium, Streptococcus pyogenes, Klebsiella pneumoniae, and Staphylococcus aureus. (usda.gov)
• Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and ‑resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (druglib.com)
• Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (druglib.com)
• Only the hardiest and most numerous bacterial species-for example, Staphylococcus aureus and Streptococcus pyogenes , which can cause life-threatening infections-have been thoroughly studied in the laboratory. (popsci.com)
• Marraffini uses Staphylococcus epidermidis and Streptococcus pyogenes as model systems for studying CRISPR immunity. (rockefeller.edu)
• Following the recent publication of the Streptococcus pyogenes genome Makoto Kuroda and colleagues at Juntendo University, Tokyo, have published the entire genome of another medically important pathogenic bacterium, Staphylococcus aureus in 21 April Lancet . (the-scientist.com)
• Heiko Herwald has researched Sepsis in several fields, including Exocytosis, Coagulation, Thrombin and Staphylococcus aureus. (research.com)
• Conversely, gram-negative organisms are more common and are mainly represented by Klebsiel ae, E. coli and Pseudomonas fol owed by gram-positive organisms (Staphylococcus aureus, CONS, Streptococcus pneumoniae, and Streptococcus pyogenes) in developing countries (2,4). (who.int)
• General recommendations and organism-specific therapeutic regimens for necrotizing fasciitis are provided below, including those for Streptococcus pyogenes , methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S aureus (MRSA), and Clostridium species. (medscape.com)
• These agents are active against Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant S aureus [MSSA, MRSA] isolates), Streptococcus pyogenes , Streptococcus agalactiae , and Streptococcus anginosus group (includes Streptococcus anginosus , Streptococcus intermedius , and Streptococcus constellatus ), among others. (medscape.com)

Isolates7

• Furthermore, we show that the majority of genetically distinct and clinically relevant S. pyogenes isolates interact with SLRPs resulting in decreased survival in blood killing assays. (lu.se)
• IdeS is secreted by all S. pyogenes isolates and cleaves IgG antibodies with a unique degree of specificity and efficiency. (lu.se)
• The vast majority of clinical isolates associated with human infections, that are identified as GCS and GGS belong to the species Streptococcus dysgalactiae (SD). (lu.se)
• Among GCS causing human infections, isolates of Streptococcus equi (SE) have been found. (lu.se)
• Methods: Patients presenting postpartum with signs and symptoms of infection were cultured for β-haemolytic streptococci with cervical swabs and blood cultures, and bacterial isolates were species-determined with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and emm-typed. (lu.se)
• Lab received two isolates from the CSF of a case patient that was culture-positive for alpha-hemolytic streptococci and also received a small amount (80 µL) of refrigerated culture-negative CSF from a second case patient. (cdc.gov)
• Aim: To characterize the genetic variability of Streptococcus mutans isolates and to correlate this variability with different colonization profiles observed during dental caries in a sample of children. (bvsalud.org)

Pneumoniae5

• Pasireotide due to streptococcus pneumoniae and mrsa, your paper questionnaire. (amanovaraonlus.it)
• Enterica serovar Typhi, 5 of 5 for S. aureus, 5 of 6 for S. pneumoniae and 2 of 3 for S. pyogenes. (itg.be)
• These associations include a higher prevalence of methicillin resistance in tetracycline resistant S. aureus, penicillin resistance in S. pneumoniae, macrolide and clindamycin resistance in S. pyogenes, fluoroquinolone resistance in S. enterica subsp. (itg.be)
• Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines. (cdc.gov)
• Pneumococcal Disease As the most common bacterial cause of otitis media in children and a major cause of bacterial pneumonia, sepsis, and meningitis in adults, Streptococcus pneumoniae is responsible each year for at least one-third of the 24 million outpatient visits for otitis media and for 500,000 cases of pneumonia and meningitis in the United States. (cdc.gov)

Pathogen Streptococcus pyogenes2

• The important bacterial pathogen Streptococcus pyogenes secretes IdeS (immunoglobulin G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G (IgG) antibodies in the hinge region resulting in Fc (fragment crystallizable) and F(ab') 2 (fragment antigen-binding) fragments and protects the bacteria against phagocytic killing. (lu.se)
• These pathogens share approximately 80% genome sequence identity with the important human pathogen Streptococcus pyogenes. (st-andrews.ac.uk)

Pathogens4

• Some cattle harbor E. coli O157:H7 and other disease-causing bacteria, and these pathogens can persist in manure for long periods of time," said Agricultural Research Service microbiologist James B. Russell. (usda.gov)
• However, data on the prevalence of pathogens, including S. pyogenes , in throat infections in low-income countries are often lacking, and the science is flawed (6, 8). (lu.se)
• Group B Streptococcus (GBS) and E. coli are recognized as the dominant early onset sepsis pathogens and coagulase negative staphylococci (CONS) as the dominant late onset sepsis pathogen fol owed by GBS and Staph aureus, in developed countries. (who.int)
• Other pathogens targets including such as Streptococcus pyogenes (Group A streptococcus), Shigella, and respiratory syncytial virus (RSV) were identified as important by four or more regions and Plasmodium falciparum by the African region. (who.int)

Bacteria8

• To a lesser extent, bacteria other than S pyogenes are known to cause pharyngitis, and these are discussed in Causes . (medscape.com)
• While the majority of GAS infections cause relatively mild illnesses like strep throat and impetigo, sometimes the bacteria can become invasive and can cause more serious and potentially life-threatening infections when they get into muscles, blood and other organs. (snopes.com)
• Serious, sometimes life-threatening, group A strep disease may occur when bacteria get into parts of the body where bacteria usually are not found, such as the blood, muscle, or the lungs. (outbreaknewstoday.com)
• Through start-up support from the Advanced Molecular Detection (AMD) program, StrepLab now sequences whole genomes of group A strep and other bacteria. (cdc.gov)
• Streptococcus pyogenes is one of the bacteria in which the HZI scientists have studied the CRISPR-Cas system. (phys.org)
• Scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig have now shown that the dual-RNA guided enzyme Cas9 which is involved in the process has developed independently in various strains of bacteria. (phys.org)
• Subsequent work [ 5875 ] by this research group found that the antibacterial action of carboxyfullerene on Gram-positive bacteria is achieved by insertion into the cell wall and destruction of membrane integrity. (nanomedicine.com)
• In descending order, the three most important bacteria that cause tonsillitis are S. pyogenes , F. necrophorum and S. dysgalactiae subsp. (lu.se)

Species7

• S pyogenes, which contains group A antigens and displays beta-hemolysis, is the most common species referred to as a group A beta-hemolytic streptococci (GABHS). (medscape.com)
• Streptococcus dysgalactiae subspecies equisimilis and some species from the Streptococcus anginosus group may share laboratory characteristics with S pyogenes but do not commonly cause human disease. (medscape.com)
• The bacterial species Streptococcus pyogenes , or group A strep, is known for causing strep throat. (cdc.gov)
• These researchers, led by Heidi Kong, a dermatologist at the Center for Cancer Research at the National Cancer Institute and Julie Segre, a geneticist at the NIH, are just one part of the five-year, $173-million Human Microbiome Project (HMP), an effort to characterize the thousands of species of microbes that live on or in us. (popsci.com)
• In the past, researchers had to grow each species outside the body before they could identify it, a process that required intense research to determine optimum growing conditions. (popsci.com)
• The most studied BHS is the group A Streptococcus (GAS), which concurs with the species Streptococcus pyogenes (SP). (lu.se)
• We also highlight that S. equi, S. zooepidemicus, and S. pyogenes share a common phage pool that enhances cross-species pathogen evolution. (st-andrews.ac.uk)

Dysgalactiae subspecies1

• Fusobacterium necrophorum, Streptococcus pyogenes and S. dysgalactiae subspecies equisimilis. (lu.se)

Necrotizing fasciitis1

• Two of the most serious, but least common, forms of invasive group A strep disease are necrotizing fasciitis and streptococcal toxic shock syndrome. (outbreaknewstoday.com)

Pathogenesis1

• These properties and the finding here that the proteinase is present and fully active at the bacterial surface in complex with SpnA implicate an important role for IdeS in S. pyogenes biology and pathogenesis. (lu.se)

Microbiology4

• Russell works at the ARS U.S. Plant, Soil and Nutrition Laboratory in Ithaca, N.Y., and is affiliated with the Nutrient Conservation and Metabolism Laboratory at Beltsville, Md. Russell collaborated with postdoctoral fellows Francisco Diez-Gonzalez and Graeme Jarvis, and with undergraduate student David Adamovich in Cornell's Department of Microbiology on the research. (usda.gov)
• This PCR is planned to be used in research, and possibly as a clinical analysis at Clinical Microbiology. (lu.se)
• His Microbiology research integrates issues from Pseudomonas aeruginosa and Streptococcus pyogenes. (research.com)
• Heiko Herwald interconnects DNA, Fragmentation, DNA fragmentation, Innate immune system and Streptococcus pyogenes in the investigation of issues within Microbiology. (research.com)

Nuclease3

• Dubbed CRISPR-Cas9, it's based on a bacterial CRISPR-associated protein-9 nuclease (Cas9) from Streptococcus pyogenes . (slashgear.com)
• Work in the Marraffini lab also demonstrated that the S. pyogenes crRNA-guided Cas9 DNA nuclease constitute a formidable tool for genetic engineering. (rockefeller.edu)
• SpnA (S. pyogenes nuclease A) is a cell wall-anchored DNase. (lu.se)

Subspecies1

• Streptococcus equi subspecies equi (S. equi) is a host-restricted pathogen of horses that has evolved from the zoonotic pathogen Streptococcus equi subspecies zooepidemicus (S. zooepidemicus). (st-andrews.ac.uk)

Antigens2

• Finally, specific IgG antibodies binding to S. pyogenes surface antigens were efficiently cleaved by surface-associated IdeS. (lu.se)
• Beta-haemolytic streptococci (BHS) are important causes of human infections and they have traditionally been grouped according to Lancefield antigens. (lu.se)

Outbreak5

• Though it is extremely rare, when the latter occurs a person is at extreme risk and requires medical treatment immediately, as described by Canada's Globe and Mail in response to the 2017 outbreak: "When strep A gets into tissue or bone - usually because a person has an open wound - it can turn deadly, and quickly. (snopes.com)
• Streptococcus Outbreak in Canada Is Part of a Larger Story. (snopes.com)
• Recent research in the Streptococcus Lab (StrepLab) at CDC is improving how scientists identify infections that are part of an outbreak. (cdc.gov)
• While these findings are alarming, this investigation helped identify an invasive group A strep outbreak across multiple facilities and stop it. (cdc.gov)
• Aim: To describe measures taken to control an outbreak of postpartum infections caused by S. pyogenes emm75 on a maternity ward. (lu.se)

Infection15

• The infection is a type of Group A streptococcal infection (Group A strep). (wikipedia.org)
• Research published in October 2020 showed that infection of the bacterium by three viruses has led to more virulent strains of the bacterium. (wikipedia.org)
• Scarlet fever usually follows from a group A streptococcal infection that involves a strep throat such as streptococcal tonsillitis or more usually streptococcal pharyngitis. (wikipedia.org)
• In this study, we report a novel antimicrobial role played by SLRPs biglycan, decorin, fibromodulin and osteoadherin, specifically in promoting the eradication of S. pyogenes in a human sepsis model of infection. (lu.se)
• We reveal that infection of human monocytes by S. pyogenes induces the expression of decorin. (lu.se)
• A form of strep infection is capable of affecting the nasal cavity and face. (snopes.com)
• It is also possible for group A strep to spread from contact with sores from a group A strep skin infection. (outbreaknewstoday.com)
• Most group A strep infections are relatively mild illnesses such as strep throat, scarlet fever, and impetigo (a skin infection). (outbreaknewstoday.com)
• Outbreaks of invasive group A strep infections may occur in long-term care facilities where older adults are at increased risk for infection. (cdc.gov)
• This is now shown by Prof Emmanuelle Charpentier and her colleagues at the Helmholtz Centre for Infection Research (HZI) who published their finding in the international open access journal Nucleic Acids Research . (phys.org)
• 9 Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong Special Administrative Region, China. (nih.gov)
• Carboxyfullerene directly inhibits in vitro growth of Streptococcus pyogenes and enhances bactericidal activity of neutrophils in mice in vivo [ 5874 ], suggesting that the fullerene derivative "can be considered an antimicrobial agent for group A streptococcus infection. (nanomedicine.com)
• Case report: Co-infection of Rickettsia rickettsii and Streptococcus pyogenes: is fatal Rocky Mountain spotted fever underdiagnosed? (canlyme.com)
• Findings: During a three-month period, six cases of postpartum infection with S. pyogenes emm75 were identified on the maternity ward. (lu.se)
• A recent history of exposure to another individual with a "strep" infection may aid in the diagnosis. (medscape.com)

Genome3

• StrepLab scientists realized they could also use genome sequences to find connections between invasive group A strep infections. (cdc.gov)
• Before genome sequencing, scientists only knew the type of group A strep strains, not if they were identical or near identical. (cdc.gov)
• The conference was an opportunity to put the fast-progressing genetic modification research into a greater context since, as the committee pointed out, "the prospect of human genome editing raises many important scientific, ethical, and societal questions. (slashgear.com)

Beta-hemolytic streptococci2

• Beta-hemolytic streptococci have the ability to cause large zones of hemolysis on blood agar, aiding in microbiological identification. (medscape.com)
• Nygren D, Wasserstrom L, Holm K, Torisson G. Associations Between Findings of Fusobacterium necrophorum or beta-Hemolytic Streptococci and Complications in Pharyngotonsillitis-A Registry-Based Study in Southern Sweden. (lu.se)

Induces2

• Here the authors produce and characterize an intranasal liposomal vaccine against a peptide antigen from Streptococcus pyogenes and show that it induces a strong mucosal IgA response lasting for over one year, and that protection is dependent on cellular immunity mediated through IL-17, macrophages and neutrophils. (nature.com)
• Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. (microbiologyresearch.org)

Vitro1

• In this study, the effect of manuka honey on S. pyogenes (M28) was investigated in vitro with planktonic and biofilm cultures using MIC, MBC, microscopy and aggregation efficiency. (microbiologyresearch.org)

Meningitis1

• Patients with a personal history of invasive disease (bacteraemia, meningitis) due to Streptococcus pyogenes. (who.int)

Streptococcal3

• Scarlet fever develops in a small number of people who have strep throat or streptococcal skin infections. (wikipedia.org)
• In addition, each episode must keep at least one of the following criteria: tonsillar swelling or exudate, temperature >38ºC, tender anterior cervical adenopathy and positive throat culture for Streptococcal pyogenes. (who.int)
• A positive rapid antigen test or throat culture for Streptococcal pyogenes in the 28 days prior to initial care. (who.int)

Biofilm formation1

• Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation. (microbiologyresearch.org)

Mutans3

• Several studies have demonstrated that the colonization and accumulation of Streptococcus mutans is associated with dental caries in humans, since they are influenced by various factors in the oral cavity, such as nutrition and hygiene conditions of the host, salivary components, cleaning power and salivary flow and characteristics related with microbial virulence factors 3 . (bvsalud.org)
• Streptococcus mutans is the key contributor to the formation of polysaccharide-based extracellular matrices in dental biofilms 4 . (bvsalud.org)
• Streptococcus mutans is widely distributed not only among populations with a moderate-to-high incidence of caries 5 but also among populations with little or no incidence of the disease 6 , which suggests that colonization by this microorganism alone is not sufficient for the development of caries 5 . (bvsalud.org)

Cas91

• Our initial efforts to use gene editing to destroy HSV-1, while very successful, used either transcription activator-like endonucleases (TALENs) or bacterial editing enzyme of the CRISPR/Cas9 family, derived from Streptococcus pyogenes (SPy), both of which work well but have size issues. (duke.edu)

Group17

• Minimum spanning tree of invasive group A Streptococcus emm 93.0 type from Israel, 2016-2019, and global strains (Spain and Kenya). (cdc.gov)
• Scarlet fever, also known as scarlatina, is an infectious disease caused by Streptococcus pyogenes, a Group A streptococcus (GAS). (wikipedia.org)
• Invasive group A streptococcus (iGAS) infections are definitely not new. (snopes.com)
• Officials with The Epidemiology Department of the Autonomous City of Buenos Aires (CABA) issued a statement indicating that from Aug 26 through Sep 9, five cases of invasive disease due to Streptococcus pyogenes, or Group A streptococcus (GAS) were reported in the city and province. (outbreaknewstoday.com)
• These infections are termed "invasive group A strep disease. (outbreaknewstoday.com)
• In the United States, a surveillance system including CDC, healthcare facilities, and labs tracks invasive group A strep infections. (cdc.gov)
• While CDC's scientists were developing the cluster detection tool in 2017, epidemiologists in Minnesota noticed an increase in invasive group A strep infections. (cdc.gov)
• StrepLab has since used the tool to detect multi-facility outbreaks of invasive group A strep infections in other states. (cdc.gov)
• The group A streptococcus (GAS, Streptococcus pyogenes) is a leading bacterial pathogen of the human pharynx and skin. (uky.edu)
• Group A streptococcus is a bacterium often found in the throat and on the skin. (healthimpactnews.com)
• People may carry group A streptococci in the throat or on the skin and have no symptoms of illness. (healthimpactnews.com)
• We investigated the contributions of lipoteichoic acid and M protein to reversible and irreversible adhesion of group A streptococci and the effects of such adhesion on release of interleukin-6. (tau.ac.il)
• We applied an emm cluster typing system to group A Streptococcus strains in New Zealand, including those associated with acute rheumatic fever (ARF). (nih.gov)
• Sentinel hospital surveillance was instituted in Australia to detect the presence of pandemic group A Streptococcus strains causing scarlet fever. (nih.gov)
• In the last decades, several studies have shown an increase of invasive infections caused by beta-haemolytic streptococci group C (GCS) and group G (GGS). (lu.se)
• The Group A Streptococcus (GAS), or Streptococcus pyogenes, is a strict human pathogen that colonizes a variety of sites within the host. (umd.edu)
• Studies have documented that group A Streptococcus responds better to tedizolid, a second-generation oxazolidinone antibiotic, than to linezolid. (medscape.com)

Relatively mild illnesses1

• Most GAS infections are relatively mild illnesses such as "strep throat," or impetigo. (healthimpactnews.com)

Antibiotic2

• Strikingly, in the specimen of one patient who had received antibiotic previous to clinical sampling, S. pyogenes was detected by means of FISH, whereas the culture method could not detect this bacterium. (um.edu.my)
• To be receiving antibiotic treatment whose spectrum of action includes Streptococcus pyogenes (penicillin, amoxicillin, amoxicillin clavulanate, macrolides or first, second or third generation cephalosporins. (who.int)

Clinical2

• 4 University of Queensland Centre for Clinical Research, Brisbane, Australia. (nih.gov)
• Journal of Experimental and Clinical Cancer Research. (ncku.edu.tw)

Virulence factors1

• Research efforts to date have focused on identifying how either components of the phosphoenolpyruvate-phosphotransferase system (PTS) or global transcriptional networks affect the regulation of virulence factors, but not the synergistic relationship between the two. (umd.edu)

Equi1

• We conclude that the complex interplay of functional loss, pathogenic specialization, and genetic exchange between S. equi, S. zooepidemicus, and S. pyogenes continues to influence the evolution of these important streptococci. (st-andrews.ac.uk)

Biology1

• 1Radiation Biology Research Center, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran. (who.int)

Infectious disease1

• Report contains key findings for stakeholders engaging in AMR surveillance, research, policy, regulatory decision-making, and other infectious disease prevention and control programs in Bangladesh and wider Asia, supported by the Fleming Fund. (ivi.int)

Complexes2

• Gel filtration showed that IdeS forms proteolytically active complexes with SpnA in solution, and super-resolution fluorescence microscopy revealed the presence of SpnA-IdeS complexes at the surface of S. pyogenes. (lu.se)
• Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production. (research.com)

Tonsillitis1

• Recently, we showed that S. pyogenes and F. necrophorum are equally associated with the development of complications in findings in tonsillitis (1), and F. necrophorum has been described as the most common cause of throat abscess (2), as well as an increasing cause of invasive infections in Sweden (3). (lu.se)

Rheumatic Fever1

• S. pyogenes causes, in addition to complicated and invasive infections and the non-purulent complications, rheumatic fever and heart disease, but in high-income countries this rheumatic complication has almost disappeared as socioeconomics have improved (4-8). (lu.se)

CRISPR1

• His current research employs molecular genetic and biochemical approaches to analyze the function of CRISPR-Cas systems. (rockefeller.edu)

Genomic2

• African scientists will conduct genomic research on kidney disease, diabetes, heart disease, obesity, tuberculosis and African sleeping sickness through inaugural grants of the Human Heredity and Health in Africa Consortium (H3Africa). (nih.gov)
• The H3Africa initiative will help develop expertise among African scientists, foster increased collaboration among African investigators, enhance the infrastructure for genomics research in Africa, and contribute to the training of the next generation of African researchers in the use of contemporary genomic approaches in the study of important health problems. (nih.gov)

Molecular1

• 1 Institute of Environmental Science and Research, Wellington, New Zealand Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand University of Otago, Wellington, New Zealand [email protected]. (nih.gov)

Extracellular2

• In severe invasive infections, S. pyogenes encounters and interacts with components of the extracellular matrix (ECM), including small leucine rich-proteoglycans (SLRPs). (lu.se)
• His Streptococcus pyogenes research integrates issues from Extracellular, Degranulation, Neutrophil degranulation, Vascular permeability and Myeloma protein. (research.com)

Pharyngitis2

• Background and Objectives: Streptococcus pyogenes ( S. pyogenes) is an important cause of pharyngitis. (um.edu.my)
• If left untreated, S pyogenes pharyngitis may lead to local and distant complications. (medscape.com)

Throat infections1

• Streptococcus pyogenes is a major human pathogen that causes a variety of diseases ranging from mild skin and throat infections to fatal septicemia. (lu.se)

20231

• June 21, 2023, SEOUL, Republic of Korea - The International Vaccine Institute (IVI) and Seoul National University signed an agreement to expand collaboration in research. (ivi.int)

Human1

• Sublethal concentrations of manuka honey effectively prevented the binding of S. pyogenes to the human tissue protein fibronectin, but did not inhibit binding to fibrinogen. (microbiologyresearch.org)

Interaction1

• Experiments with radiolabeled IdeS and flow cytometry demonstrated that IdeS binds to the surface of S. pyogenes, and the interaction was most prominent in conditions resembling those in the pharynx (acidic pH and low salt), the habitat for S. pyogenes. (lu.se)