• In this study, we compared immune responses to the BNT162b2 mRNA Coronavirus Disease 2019 vaccine in patients with solid tumors ( n = 53) who were on active cytotoxic anti-cancer therapy to a control cohort of participants without cancer ( n = 50). (nature.com)
  • These clinical trials, however, largely excluded immunocompromised individuals, including patients on immunosuppressive therapies to control chronic inflammatory conditions, patients with primary immunodeficiencies, recipients of organ transplants and patients with cancer on cytotoxic chemotherapy. (nature.com)
  • Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
  • Surgical technique, use of radiotherapy, and method of administering chemotherapy are important factors. (medscape.com)
  • Since photodynamic therapy (PDT) does not compromise other treatment options and presents reduced long-term morbidity when compared with chemotherapy or radiotherapy, it appears as a promising alternative treatment for controlling malignant diseases. (oaepublish.com)
  • HER-2 overexpression in breast cancers is associated with invasiveness, poor prognosis and resistance to chemotherapy [ 4 , 5 ]. (oncotarget.com)
  • Indeed, tumour responses induced by HER1 TKIs are infrequent and transient, with sensitive patients rapidly developing secondary resistance. (biomedcentral.com)
  • Patients were randomized so that half pursued no set exercise regimen during chemotherapy, and the other half were instructed to follow a specific home-based, personalized prescription of aerobic walking and anaerobic resistance band training known as EXCAP (Exercise for Cancer Patients) for 6 weeks. (oncnursingnews.com)
  • Patients were asked to walk on a daily basis and used resistance bands on a daily basis," said Karen Michelle Mustian, PhD, MPH, lead author on the study and an associate professor in the UR Departments of Surgery and Radiation Oncology, Cancer Control Clinical Research Unit, as well as a Wilmot Cancer Institute researcher. (oncnursingnews.com)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • This regimen is associated with approximately 65% overall response rate (ORR) including ≈35% complete response (CR) and about 15 months overall survival (OS). (dovepress.com)
  • Pharmacokinetic parameters were independent from the other factors tested such as age, sex, chemotherapy regimen (fludarabine/cyclophosphamide versus bendamustine), IGHV mutational status, and FCGR3A 158VF status. (bmj.com)
  • Thapsigargin marketed ER stress protein mimicked ER stress-induced cardiomyocyte contractile anomalies including despondent top shortening and maximal speed of shortening/relengthening aswell as extended relengthening duration, the result which was abrogated with the autophagy inhibitor 3-methyladenine as well as the ALDH2 activator Alda-1. (health-e-nc.org)
  • Dox-induced over-production of reactive oxygen and nitrogen species (ROS and RNS) such as superoxide, hydrogen peroxide, hydroxyl radical and peroxynitrite has been proposed to be the main cause of Dox-induced acute cardiomyocyte toxicity and cell death by damaging various molecular constituents and organelles [ 9 - 12 ]. (oncotarget.com)
  • This antigen sequence represents the complete Bevacizumab binding site and using RFASE as adjuvant, the vaccine (hVEGF 26-104 /RFASE) induces an immune response with VEGF neutralizing activity and anti-tumor effect [15]. (researchsquare.com)
  • Immediate single instillation of epirubicin has been shown to act by destroying circulating tumour cells after TURB(Transurethral Resection of a Bladder Tumor), and by an ablative effect on residual tumour cells at the resection site and on small overlooked tumours.European Association of Urology Guidelines on Bladder Cancer advocates single immediate postoperative intravesical chemotherapy. (centerwatch.com)
  • In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
  • VEGF biological activity is mediated by its binding to VEGFR receptor 2 (VEGFR2) or VEGF receptor 1 (VEGFR1) [2], and both interactions have been implicated in tumor-induced angiogenesis and immunosuppression [3, 4]. (researchsquare.com)
  • However, the understanding of the immunomodulatory roles of TREM1 in the tumor microenvironment remains incomplete. (bvsalud.org)
  • These data recommend a beneficial function of ALDH2 against ER stress-induced cardiac anomalies perhaps through autophagy decrease. (health-e-nc.org)
  • His clinical research has primarily been directed toward surgical issues in complex congenital heart care and cardiac transplantation (focusing on advances with operative techniques, outcomes research and transplantation for congenital heart disease), with a particular emphasis on the development of mechanical ventricular assist devices for children, as well as stem-cell based valved conduits for pediatric application. (chop.edu)
  • Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
  • Furthermore, the pharmacologic caspase-3 activator PAC-1 mimicked both the killing effects and HER-2-suppressive activities of Th1 cytokines, while a caspase 3/7 inhibitor could prevent cytokine-induced HER-2 loss. (oncotarget.com)
  • The area in which the mutation occurs is an important epitope to which vaccine-induced neutralizing antibodies bind, however the mutant virus is not neutralized by antibody to this specificity. (ehd.org)
  • A recent neoadjuvant vaccine trial for early breast cancer induced strong Th1 immunity against the HER-2 oncodriver, complete pathologic responses in 18% of subjects, and for many individuals, dramatically reduced HER-2 expression on residual disease. (oncotarget.com)
  • This report contains modifications to the previously published recommendations of the Advisory Committee on Immunization Practices (ACIP) and is based on an ACIP review of the IOM findings and new research on vaccine safety. (cdc.gov)
  • In response to concerns about vaccine safety, the National Childhood Vaccine Injury Act of 1986 established a no-fault compensation process for persons possibly injured by selected vaccines (3). (cdc.gov)
  • You see, in the cat with FeCoV we realized that if the function of these cells is not perfect or is incomplete, the virus can cross the intestine, where it normally resides, generalize in the body and cause a serious disease, for which there is no vaccine or specific therapy and the outcome of which is almost always the death of the infected animal. (coronablues.org)
  • Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. (elifesciences.org)
  • Oddly enough, Alda-1-induced beneficial impact against ER tension was obliterated by autophagy inducer rapamycin, Akt inhibitor AktI and mTOR inhibitor RAD001. (health-e-nc.org)
  • Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. (oncotarget.com)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
  • In most patients with cancer, we detected spike receptor-binding domain and other S1-specific memory B cell subsets as potential predictors of anamnestic responses to additional immunizations. (nature.com)
  • These results suggest that a third dose of BNT162b2 is safe, improves humoral immunity against SARS-CoV-2 and could be immunologically beneficial for patients with cancer on active chemotherapy. (nature.com)
  • For example, patients with autoimmune conditions or chronic lymphocytic leukemia treated with B cell-depleting antibodies have predictably diminished humoral responses to vaccination, whereas responses by patients on anti-TNF therapies are less affected 6 , 7 . (nature.com)
  • Similarly, in patients with cancer with solid or hematological malignancies, antibody responses are markedly diminished after the first immunization but improve somewhat after the second 9 . (nature.com)
  • This report shows the characterization of the humoral response elicited after vaccination with 400 µg of antigen combined with 200 µg of VSSP in cancer patients representative of the Cuban real clinical practice setting. (researchsquare.com)
  • Polyclonal antibody response was specific to VEGF, and showed no cross reactivity with other VEGF family members like VEGF-C and VEGF-D. Specific IgM, IgA and IgG antibodies detected in the serum of vaccinated patients were able to block the binding of VEGF to its receptors VEGFR1 and VEGFR2. (researchsquare.com)
  • I am not sure how generalizable these preferences are given that these were older white physicians and is based on a single scenario (a relatively uncommon one at that but one that tends to provoke strong responses) however it's illustrative of how a substantial minority of patients (whatever the exact numbers) change their preferences over time. (pallimed.org)
  • Clinical scientists continue to observe superior survival of patients treated with combined chemotherapy and radiation approaches, yet the mechanisms behind this synergistic therapeutic approach are not fully understood. (mdanderson.org)
  • Her clinical and research interests lie in improving the outcomes of patients with lymphoma. (mdanderson.org)
  • In industrial countries, bacterial infections mainly affect the elderly (both in the community and in hospitals) and the immunocompromised (e.g. patients undergoing chemotherapy or infected with HIV). (ukri.org)
  • Research also showed patients who were given clioquinol had a 1.4 percent decrease in their mental capacity, whereas patients who were given the placebo had an 8.9 percent decrease in their mental capacity. (digitalnaturopath.com)
  • The randomized, multicenter, phase III study accrued 619 patients with early-stage cancer who were beginning chemotherapy. (oncnursingnews.com)
  • The benefits shown in this study are very promising for early-stage cancer patients undergoing chemotherapy, said Mustian. (oncnursingnews.com)
  • Epirubicin is an anthracycline drug used for chemotherapy. (centerwatch.com)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • primary outcomes were immune responses, with a secondary outcome of safety. (nature.com)
  • Adenoviruses, particularly, have shown to be safe, inducing only mild adverse side effects in clinical trials, making them a great candidate for further clinical development. (helsinki.fi)
  • For about two years I have been interested in the immune response of the cat affected by FeCov, the feline coronavirus, with particular regard to the response mediated by macrophages, the cells that are responsible for "eating" the pathogens that infect us. (coronablues.org)
  • We hypothesize that ovarian cancer cells will induce human ovarian TVM expression. (nih.gov)
  • Similar patterns were observed for spike protein-specific serum antibodies and T cells, but the magnitude of each of these responses was diminished relative to the control cohort. (nature.com)
  • These elicited antibodies impaired the high affinity interaction between VEGF and monoclonal antibody Bevacizumab, an antiangiogenic drug approved in combination with chemotherapy for the treatment of different tumors. (researchsquare.com)
  • CIGB-247 was immunogenic in a broader patient population, and induced Bevacizumab-like polyclonal antibodies, indicating that the VEGF-specific antibody response could have a potentially relevant clinical activity. (researchsquare.com)
  • Elicited polyclonal antibody response in addition to its cross-reactivity with human VEGF, have also demonstrated in rats and monkeys its capacity to impair the binding of Bevacizumab to VEGF [15, 16], indicating the presence of antibodies that block binding sites on VEGF which have shown to be clinically relevant. (researchsquare.com)
  • In order to serve as a guide for the future development of pertinent therapeutic interventions, this review provides a systematic overview of recent research progress on the mechanisms disclosing cochlear hair cell injury as well as a detailed account of the molecular pathways regulating mammalian hair cell regeneration. (biomedgrid.com)
  • A detailed description of the pathways by which Dox induces production of ROS and RNS can be found in references [ 13 , 14 ]. (oncotarget.com)
  • The limitations of this research compared to the research by Zeng are that the Shao research was smaller in dimension and measured response fee as a substitute of survival. (ehd.org)
  • Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)
  • At 1 week after a third immunization, 16 participants demonstrated a median threefold increase in neutralizing antibody responses, but no improvement was observed in T cell responses. (nature.com)
  • Notably, organ transplant recipients mount very poor antibody responses to the first mRNA immunization relative to healthy individuals 10 , which increase somewhat after the second immunization 8 . (nature.com)
  • So far, the most successful passive immunotherapy directed to VEGF is Bevacizumab, a monoclonal antibody that neutralizes the binding of VEGF to its receptors [5], which has been approved, in combination with chemotherapy, for the treatment of different tumors [6-12]. (researchsquare.com)
  • Chronic lymphocytic leukemia (CLL) is the most common type of leukemia and the anti-CD20 monoclonal antibody, rituximab, represents the therapeutic gold standard for more than 2 decades in this pathology, when used in combination with chemotherapy. (bmj.com)
  • HepB vaccination results in protective anti-HBs responses among approximately 95% of healthy-term infants. (cdc.gov)
  • Incomplete instillation leads to an increase in recurrence and progression rates. (centerwatch.com)
  • Being at MD Anderson was the logical progression in her professional research and clinical development given that it encourages research at the post-doctoral level while offering the insight that can only be gleaned through clinical interactions. (mdanderson.org)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • NMIBC are divided into four groups as low-medium-high and very high risk according to EORTC (European Organization for Research and Treatment of Cancer). (centerwatch.com)
  • Partner 1: Inserm U698, Cardiovascular Bioengineering Group - France - Partner 2: CNRS UMR 7057, Biological Physics Group - France - Partner 3: National University of Singapore, Bioengineering, Regenerative Nanomedicine Lab - Singapore - Partner 4: Institute of Materials Research and Engineering (IMRE), Nanoimprinting Group - Singapore Development of a functional small-diameter vascular graft for the treatment of vascular disease remains a challenge for coronary arterial bypass surgeries and lower limb peripheral arterial disease. (studylibfr.com)
  • The model can effectively predict the response to several treatment options, underscoring its potential clinical utility. (bvsalud.org)
  • At present, the FDA and China state drug administration have yet to approve any drugs or methods for prevention and treatment of hearing loss caused by chemotherapy drugs. (biomedgrid.com)
  • regardless, emerging scientific research appears to indicate promise in certain areas of treatment. (hypnotherapynewcastle.org)
  • In this review, we set out to perform a broad up-date on PDT in cancer research and treatment, discussing how this approach has been applied and what it could add to breast cancer therapy. (oaepublish.com)
  • In this review, we set out to perform a broad up-date on PDT and it implication in cancer research and treatment. (oaepublish.com)
  • Risk of inflammation and cognitive impairment due to chemotherapy,often called "chemobrain", may be reduced by maintaining physical activity during treatment, according to a University of Rochester (UR) Medical Center study presented at the 2015 ASCO Annual Meeting. (oncnursingnews.com)
  • Chondronecrosis in relapsing polychondritis is secondary to inflammation from an autoimmune response. (medscape.com)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • People taking it also experienced stabilized body weight and a reduction in the fatigue and inertia that usually accompany this combination of chemotherapy agents. (peacehealth.org)
  • The FLT3 inhibitors sorafenib, midostaurin, quizartinib and gilteritinib have been tested in monotherapy in several settings including refractory or relapsed AML (R/R AML), post-transplant maintenance as well as in combination with intensive chemotherapy (ICT) or non-intensity regimens. (dovepress.com)
  • Using a combination of biophysical methods as well as cell and ovary culture experiments we explain how TAp63α is kept inactive in the absence of DNA damage but causes rapid oocyte elimination in response to a few DNA double strand breaks thereby acting as the key quality control factor in maternal reproduction. (elifesciences.org)
  • L-dopa is now rarely used by itself, but rather in combination with carbidopa (Sinemet) or benserazide (Madopar) that protects it from breaking down before it reaches the brain tissue. (digitalnaturopath.com)
  • Zinc is necessary for normal cell functioning, nerve signaling, and for the body to protect against infection or disease. (mskcc.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • in particular, HER3 signalling buffered against incomplete inhibition of HER2 kinase activity has been suggested to be the mechanism that allows HER2 over-expressing breast cancer cells to escape HER TKIs. (biomedcentral.com)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • The principal goal of my research is to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work. (nih.gov)
  • This research paper will focus on the underlying mechanisms of cancer development related to the consumption of processed foods, specifically by highlighting the production of reactive oxygen species (ROS), which are unstable molecules containing oxygen that can easily damage cells. (nhsjs.com)
  • It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
  • Nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate-oxidase (NOX) enzymes play an important role in Dox-induced production of ROS [ 15 ]. (oncotarget.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
  • The irradiation and chemotherapy drugs that are used to destroy cancer cells also damage healthy cells. (elifesciences.org)
  • C. rodentium causes a self-limiting infection and triggers robust immune responses, proliferation of epithelial cells and displacement of the normal gut bacteria which mimic the characteristics observed during human infection with pathogenic E. coli. (ukri.org)
  • Here, we will use the Citrobacter rodentium model to investigate the temporal consequences of bacterial infection on metabolism and immune responses in intestinal epithelial cells (IECs), as well as dysbiosis. (ukri.org)
  • Kanthasamy discovered that the protein kinase-C (specifically PKCd) is killing the dopamine-producing cells which Parkinson's sufferers lack and he, and his research staff, discovered a compound that neutralizes the cell-killing kinase-C and allows the dopamine-producing cells to survive and function. (digitalnaturopath.com)
  • to counterbalance the production of ROS and protect the cells from oxidative damage, cells also possess a robust antioxidant system. (nhsjs.com)
  • having lowered damage of deoxy ribonucleic acid (DNA) and in human volunteers induces greater activity of repairing ( Southon, 2000 ). (scialert.net)
  • Notably, the high-risk group exhibited an impaired response to anti-PD-1/PD-L1 (Programmed death-1 receptor/Programmed death-1 receptor-ligand) therapy compared to the low-risk group. (bvsalud.org)
  • The overall goal is to update the healthcare professional's knowledge of cancer detection and prevention and to understand current and new research regarding state-of-the-art care for those with or at risk for cancer. (oncnursingnews.com)
  • Thirty-seven percent of study participants received chemotherapy every 2 weeks (n = 229), 62% received chemotherapy every 3 weeks (n = 380), and 1% every 4 weeks (n = 9). (oncnursingnews.com)
  • TAp63α is kept in an inactive and exclusively dimeric state but undergoes rapid phosphorylation-induced tetramerization and concomitant activation upon detection of DNA damage. (elifesciences.org)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • Additionally, drug sensitivity analysis observed that the model could effectively predict efficacy and sensitivity to chemotherapy. (bvsalud.org)
  • At the same time, it doesn't take scientific research to notice that when calories and/or body fat fall below a certain minimum, girls and women stop ovulating. (starshipnivan.com)
  • Open Access is an initiative that aims to make scientific research freely available to all. (intechopen.com)
  • With an alarming rise in mortality rates, from approximately 6 million deaths in 2000 2 to 10 million deaths in 2022 3 , it has emerged as a formidable research challenge in the scientific community. (nhsjs.com)
  • The objective of this study was to investigate the association between persistent use of statins and the risk of overall and site-specific cancer in adults, to assess dose-response relationship, and to examine the effects of varying types of statins. (cdc.gov)
  • Taurine has been shown to be depleted in people taking chemotherapy. (peacehealth.org)
  • Disinfection methods currently used in water systems have been shown to be ineffective against legionella over the long-term, allowing recolonization by the biofilm-protected microorganisms. (frontiersin.org)
  • They divided responses into 'most aggressive' preferences, 'intermediate' preferences (essentially would take IV fluids and antibiotics but nothing else), and 'least aggressive' (essentially would want no life-prolonging medical therapies). (pallimed.org)
  • Contact investigations are complicated undertakings that typically require hundreds of interdependent decisions, the majority of which are made on the basis of incomplete data, and dozens of time-consuming interventions. (cdc.gov)
  • These data suggest that the studied compounds, especially dendrimers, could be considered as novel molecules in the design of research projects aimed at the development of efficacious anti-biofilm disinfection treatments of water systems in order to minimize legionellosis outbreaks. (frontiersin.org)
  • Adenoviruses can be genetically modified to increase their infectivity or improve the anti-cancer immune responses induced by the virus, e.g., through the expression of immunostimulatory molecules. (helsinki.fi)
  • Diets including processed foods directly increase ROS generation while reducing the capability of the body's antioxidant system, thus inducing oxidative stress. (nhsjs.com)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • Protecting People. (cdc.gov)
  • In the future, with the continuous focus of research hotspots, the mechanism of inner ear hair cell regeneration and the therapeutic drugs derived from it will gradually be explained clearly. (biomedgrid.com)
  • Considering the huge application of quantum dots, the researcher highlights more in-depth research in the field. (sciwriteglobal.com)