Research drug discovery. Medical search. Frequent questions

MENAFN - GlobeNewsWire - Nasdaq) Dublin, Sept. 18, 2023 (GLOBE NEWSWIRE) -- The "Artificial Intelligence (AI) In Drug Discovery Global Market Opportunities and Strategies to 2032" report has been added to ResearchAndMarkets.com's offering. (menafn.com)
This half-day conference will feature oral presentations as well as poster presentations ( abstract submissions will be open until March 20, 2023 ) that showcase the robust community of drug discovery research led by these two institutions in the Baltimore area. (johnshopkins.edu)
Drug Discovery Alliances at CPHI Barcelona 2023! (drugdiscoveryalliances.com)
Igniting Innovation through Supplier Diversity: Collaborate with Drug Discovery Alliances at Chemoutsourcing 2023! (drugdiscoveryalliances.com)

Current research in pharmacology and drug discovery 2021 0 0. (cdc.gov)
An upcoming workshop, organized within the framework of a new theme at LINXS, Integrative Pharmacology and Drug Discovery, highlights the possibilities of developing new drugs using synchrotron imaging. (lu.se)
En kommande workshop, organiserad inom ramen för ett nytt tema vid LINXS, Integrative Pharmacology and Drug Discovery, lyfter fram möjligheterna att utveckla nya läkemedel med hjälp av synkrotronavbildning. (lu.se)

Researchers can now order their mutation of choice in bit.bio's opti-ox TM powered human-iPSC derived cells, receiving consistent, defined, cryopreserved products that can be immediately incorporated into drug discovery workflows. (businesswire.com)
This gives researchers a unique method to gain valuable insights into disease mechanisms and assess the efficacy of potential drugs for treatment. (businesswire.com)
With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! (frontiersin.org)
By automating complicated liquid handling activities at low quantities, mosquito systems assist researchers in accelerating drug discovery and maximizing research yield. (news-medical.net)
The simple-to-use equipment allows researchers to profit from the significant time and reagent savings of minimal dead volumes (less than 0.3 µL) while maximizing the return on research investment. (news-medical.net)
Over an approximate two year period, researchers work to determine if that drug has the best chance of having the desired effect on the disease with the lowest possible harm to the patient. (hnf-cure.org)
The Centre will bring together our cancer evolution scientists with our drug discovery researchers all under one roof, so they can more easily share ideas and spark new discoveries. (icr.ac.uk)
To turn into reality, researchers from various disciplines (chemists, biologists, clinicians) need to work together to optimise the drug engineering, read-out assays, and clinical trial design. (pasteur.fr)
The model helps researchers to design a drug compound that will fit into the protein and kill the cancer cell. (stratasys.com)
Craig oversees a team of four, manufacturing a range of medical instruments, phantoms, and devices using Stratasys 3D printers, working alongside researchers such as Amin Mirza, an analytical chemist who has worked with Craig since 2000, to support the ICR's and The Royal Marsden's cancer research and treatment development. (stratasys.com)
Since 2005 alone, ICR researchers have discovered more than 20 drug candidates, 11 of which have progressed into clinical development. (stratasys.com)
Today, Craig and Amin are continuing to push the boundaries of drug discovery by using 3D print technology to help researchers visualise the proteins being targeted by cancer drug discovery programmes at the biochemical level. (stratasys.com)
Griffith researchers develop smart materials platform capable of aiding in the creation of new drugs and the clean-up of polluted environments. (edu.au)
Using the beamlines and tools at MAX IV, researchers from drug discovery companies find brand new starting points for developing novel pharmaceutical substances. (lu.se)
The workshop takes place on October 19 and is aimed at researchers who are engaged in biomedical research, biomedical imaging or drug development in both academia and industry. (lu.se)

These services are used to identify potential drug targets and validate their efficacy in treating diseases. (biospace.com)
The pathology-to-drug discovery takes the understanding of the pathophysiology as the initial step in identifying pharmacological targets. (frontiersin.org)
The reverse approach, (the so-called reverse translation approach ), which aims at gathering new data from clinical trials to formulate hypotheses experimentally testable in basic science might provide specific drug targets for treating human diseases, and deserves further attention. (frontiersin.org)
This Research Topic hosts studies on novel experimental paradigms in neuroscience that aim at providing druggable targets and/or on relevant insights from clinical settings that deserve to be further investigated in preclinical settings ( in silico, in vitro, in vivo ) - those that are likely to unravel so far unperceived druggable mechanisms and/or lead to drug repositioning, i.e. use of available approved drugs for novel indications. (frontiersin.org)
The research that won Kobilka the 2012 Nobel Prize focused largely on understanding the structural basis for how G-protein-coupled receptors work, which has enabled structure-guided drug discovery and optimization for these proteins, now the largest class of pharmaceutical targets. (stanford.edu)
This unique design allows us to offer our clients an excellent option for discovering Qualified Hits for High Hanging Fruit targets," said Debora Konz Makino Vice President Discovery Solutions of Proteros biostructures. (enamine.net)
Here, we describe the timeline of epigenetic drug discovery and development beginning with the early design based solely on phenotypic observations to the state-of-the-art rational epigenetic drug discovery using validated targets. (pasteur.fr)
Under the agreement, PeptiDream will utilize its proprietary Peptide Discovery Platform System ("PDPS") technology to identify high affinity macrocyclic peptide ligands to Lilly-elected targets of interest, capable of delivering a Lilly conjugated payload to certain cells and tissues of interest to Lilly. (pipelinereview.com)
Hence, CHDI strives to support all aspects of the drug development process from early exploratory efforts to identify and validate targets, to the screening, medicinal chemistry, preclinical optimization, on through the clinical and regulatory aspects of evaluating candidate molecules in human trials. (the-scientist.com)
ists, assay developers, pharmacologists, toxicologists and pharmacokinetic/drug metabolism experts, who identify novel drug targets arising from JHU faculty's research and translate them into new, small molecule drug therapies. (hopkinsmedicine.org)
This has never been done before, and we believe that it will transform dementia research', said Chas Bountra, 'We will work with the best academic and industrial scientists to identify potential new drug targets for dementia. (ox.ac.uk)
Easy and rapid access to brilliant synchrotron X-rays is a vital ingredient for three-dimensional structure determination of drug targets through macromolecular X-ray crystallography. (lu.se)
Pharmacotherapy for SARS-CoV-2 and Seizures for drug repurposing presumed on Mechanistic Targets. (cdc.gov)

Amrita is a multi-disciplinary, research-intensive university and is accredited with the highest possible A++ NAAC grade and is the country's 5th best-ranked university in the NIRF rankings 2021. (amrita.edu)
Critical reviews in therapeutic drug carrier systems 2021 0 0. (cdc.gov)

The two have struck up a research collaboration to evaluate RP101, RedHill's Phase 2-stage oncology drug candidate. (drugdiscoverynews.com)
Through our diverse and flexible business models, we have built up collaboration partnership with several hundred biopharmaceutical research organizations worldwide. (tmcnet.com)
The Structural Genomics Consortium is a global public-private partnership that seeks to accelerate drug discovery by fostering collaboration among a large network of scientists in academia and industry and making all research outputs openly available to the scientific community. (tmcnet.com)
The companies are engaging in a joint multi-target collaboration for early-stage drug discovery projects using Proteros' "High Hanging Fruit" Discovery Platform, and now have decided to combine their expertise to assemble a unique and chemically diverse small molecule library collection. (enamine.net)
As we all know, quality of the hits is a key success factor for speed and success in the drug discovery program," said Leena Otsomaa, Vice President Medicine Design of Orion Corp. "We are also very much looking forward to the collaboration for early-stage drug discovery in our key therapeutic target areas: oncology and pain indications. (enamine.net)
The Centre will also be one of the flagship buildings at The London Cancer Hub - a collaboration between the London Borough of Sutton and the ICR - and will enhance the ability of scientists at the ICR to partner with industry to take their discoveries to market. (icr.ac.uk)
The new Research Collaboration and License Agreement builds upon the long collaborative relationship between the Companies, with the first Collaboration and License Agreement in December 2013, followed by the nonexclusive license of PeptiDream's proprietary PDPS technology in March 2016, which specifically excluded work on PDC programs. (pipelinereview.com)

The Centre for Cancer Drug Discovery will house the world's first 'Darwinian' drug discovery programme alongside many other promising projects centred on discovering new strategies to defeat cancer. (icr.ac.uk)
The project will thus underpin a substantial programme of intersectoral knowledge transfer and research training and lead to significant innovation and advances in several areas of basic research as well as diagnostics and therapeutics development. (neurodegenerationresearch.eu)
The EU Joint Programme - Neurodegenerative Disease Research (JPND) is the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases, in particular, Alzheimer's. (neurodegenerationresearch.eu)
This initiative has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreements No. 643417, No. 681043 and No. 825664. (neurodegenerationresearch.eu)

CHDI has provided support for selected interventional trials which, to date, have only tested nutriceuticals or attempted to repurpose existing drugs. (the-scientist.com)
Our mission is to repurpose existing drugs for next-generation cardiovascular disease therapy. (hri.org.au)

HitGen is a world leader in the development of DEL technology and applications to early-stage small molecule drug discovery. (tmcnet.com)

The overexpression of Hsp27, which results in anti-apoptotic effects, has been linked to tumor resistance to cytotoxic drugs as well as the development of metastasis. (drugdiscoverynews.com)
The development of pharmaceutical drugs is a long and costly process. (idtechex.com)
Artificial intelligence, particularly machine learning and deep learning algorithms, can help address issues of cost and time when applied to the drug development process. (idtechex.com)
An area in which AI is seeing significant interest and progress is drug discovery, a subset of the drug development process. (idtechex.com)
Amy and her team knew the importance of speed and capital in the high-risk business of oncology drug development where success often takes more resources and time than expected and competitors lurk. (hbs.edu)
The problem that we address is that the pharmaceutical companies do not develop radically new drugs anymore, because the development process lasts ten years and costs around one billion euro. (europa.eu)
Development of a new drug is subjected to regulatory approvals following three demonstrations: lab discovery in vitro, animal testing in vivo and clinical trial on patients. (europa.eu)
The growth of this market is primarily driven by the increasing outsourcing of drug discovery activities, growing number of clinical trials, and increased government funding for research and development (R&D). (biospace.com)
These services are provided by contract research organizations (CROs) that have expertise in various areas of drug discovery, such as target identification and validation, lead optimization, and preclinical development. (biospace.com)
Most pharmaceutical, biopharmaceutical, and medical device companies invest heavily in R&D activities for the development of new drugs and therapies. (biospace.com)
The use of CROs helps pharmaceutical and biopharmaceutical companies to reduce the time and cost associated with drug discovery and development. (biospace.com)
Established in 2001 as a spin-out from University College London, Birkbeck College and the Institute of Cancer Research, Domainex has been supported throughout its development by a consortium of UCL Business, Longbow Capital, Bury Fitzwilliam Lay, Juno Capital and a syndicate of other private investors. (ddw-online.com)
The D3i4AD project brings together a consortium of groups with internationally-leading expertise from academia and industries in chemistry, molecular design and modelling, biochemistry, diagnostic and drug development. (neurodegenerationresearch.eu)
PeptiDream has an extensive global network of discovery and development partners driving the development and commercialization of a broad and diversified pipeline of investigational therapeutics. (pipelinereview.com)
CHDI Foundation, a virtual biotech exclusively focused on the discovery and development of drugs for Huntington's disease (HD) is one such organization. (the-scientist.com)
A network of fee-for-service contract research organizations (CROs) provides the brick-and-mortar laboratories and skilled staff to execute CHDI-sponsored drug development activities. (the-scientist.com)
The projects are at different stages in the discovery and development process. (ed.ac.uk)
With the rising application of informatics solutions, gene sequencing is done through the identification of proteins and genes, which could further help in the development of potential drugs. (marketresearch.com)
The goal is to expedite the drug discovery research process, leading to the development of highly original and innovative hypotheses that would be challenging to conceive using conventional methods. (ticker.tv)
They provide critical solutions for research and development organizations, supporting scientific data-driven strategies. (ticker.tv)
Pardoll has a particular interest in cancer immunology and his lab's studies on basic immunologic mechanisms have led to the development and design of a number of cancer vaccines and discovery of key checkpoint ligands and receptors, such as PD-L2, LAG-3 and neuritin, many of which are being targeted clinically. (hopkinsmedicine.org)
Deborah has decades of business development experience marketing contract services, drug licensing and new technologies to the pharmaceutical industry. (drugdiscoveryalliances.com)
The technique encompasses the method of screening ligand libraries for the development of new candidate drug molecules. (bvsalud.org)
1. Health research is important for health development. (who.int)
These meetings discussed critical issues that limit the translation of research into health policy and systems development and identified strategies for using health research for disease control and improvement of public health in countries with high burdens of disease. (who.int)
Today, synchrotron techniques are rarely used in the later stages of biomedical drug development. (lu.se)
Synchrotron imaging techniques can, for example, be used when getting stuck in a drug development process. (lu.se)

These findings validate SKP2 as a cancer drug target and suggest that pharmacologic SKP2 inactivation may limit tumor progression and overcome chemoresistance via elimination of CSCs. (aacrjournals.org)
This is where we take standard basic and clinical research and use our knowledge and experience to turn those findings into something that will have a commercial value - in this case a medicine, but it could also be a diagnostic tool. (ed.ac.uk)
This ultimately led to the discovery of a drug candidate that we progressed into humans and allowed me to expand our activities and work with colleagues who were also keen to take their findings towards drug discovery. (ed.ac.uk)
All of the new findings from the research will made freely available to the world's research community. (ox.ac.uk)

Our key technology platforms include world-leading DNA-encoded library technology (DEL), fragment-based drug discovery and structure-based drug design technologies (FBDD/SBDD), as well as the emerging technology platforms for synthetic therapeutic oligonucleotide technology (STO), and targeted protein degradation technology (TPD). (tmcnet.com)
In fact, the most widespread technology used to test therapeutic agents in vitro, a flat culture dish in which single cell populations are cultured and the drug to be tested is added to the culture, is obsolete. (europa.eu)
Drug discovery services are specialized research services that help pharmaceutical and biotechnology companies to identify and develop new therapeutic agents. (biospace.com)
To seize opportunities, AI in drug discovery companies are advised to focus on key areas, including AI-based drug screening and target selection, expansion in emerging and developed markets, competitive pricing, participation in industry events, B2B promotions, and targeting fast-growing therapeutic areas and end-users. (menafn.com)
The oncology market was the largest segment of the artificial intelligence (AI) in drug discovery market segmented by therapeutic type, accounting for 23.2% of the total in 2022. (menafn.com)
RapidFire, a robust, in-line solid phase extraction technology enables ultrafast, direct analysis of native compounds for a wide variety of biochemical assays including routine ADME and lead discovery applications across a range of therapeutic areas. (evotec.com)
His research mission in this area is to develop new small molecular chemical entities into drug-like substances with therapeutic potential in cancer and antimicrobial therapy. (who.int)

TEL AVIV, Israel-Biopharmaceutical company RedHill Biopharma Ltd. has reached out across the Mediterranean to partner with Leipzig, Germany-based Fraunhofer Institute for Cell Therapy and Immunology (IZI), a research unit of the Fraunhofer Society, one of the world's largest, most prominent applied research organizations. (drugdiscoverynews.com)
Partnering with one of the world's renowned leaders in process research capabilities, DDA will use our knowledge, experience, and expertise to help avoid any possible infringements. (drugdiscoveryalliances.com)

Biomedical Research -- methods. (who.int)

The growth of the Asia-Pacific drug discovery services market is driven by the increasing outsourcing of drug discovery activities to CROs in this region, growing number of clinical trials, and increased government funding for R&D activities. (biospace.com)
Join the Global Registry for Inherited Neuropathies (GRIN) and help develop drugs, gene therapies, and clinical trials for CMT and other Inherited Neuropathies! (hnf-cure.org)
Once a drug appears to work effectively in mice, it must undergo further testing before it can be used on humans in clinical trials. (hnf-cure.org)
At present, a few drugs targeting epigenetic enzymes as well as analogues of epigenetic modifications have been introduced into the clinic use (e.g. to treat haematological malignancies), and a wide range of epigenetic-based drugs are undergoing clinical trials. (pasteur.fr)

Alzheimer's disease represents an example where an intense research effort has been produced to understand the cellular and molecular mechanisms while a considerable number of biomarkers have been studied, but paradoxically, not a single new drug has reached approval. (frontiersin.org)
Our most advanced project is for Alzheimer's disease where we plan to test our discovery in people with disease this year (this is known as a Phase 2 clinical trial). (ed.ac.uk)
A protein that allows human cancer to resist multiple anticancer drugs also appears to play a key role in Alzheimer's disease, according to research conducted at Fox Chase Cancer Center. (news-medical.net)
The protein, active in brain tissue, could be a target for new drugs to treat patients with Alzheimer's. (news-medical.net)
The Alzheimer's Research UK Drug Discovery Institute was announced on the 16th February. (ox.ac.uk)
The Alzheimer's Research UK's Drug Discovery Alliance represents the best coordinated and strategic effort to make progress in dementia research and will build on successes in tackling other diseases to give us the best chance of making a difference. (ox.ac.uk)
We are crowd sourcing the discovery of new medicines for Alzheimer's disease. (ox.ac.uk)
A blood biomarker that measures astrocyte reactivity may help determine who, among cognitively unimpaired older adults with amyloid-beta, will go on to develop Alzheimer's disease (AD), new research suggests. (medscape.com)

Aligns with the FDA Modernisation Act 2.0 that allows cell based assays as an alternative to animal testing for the purposes of drug and biological product applications. (businesswire.com)
Curiosity-driven discoveries in often obscure areas of basic biological science pave the way to unexpected applications in medicine, according to a panel of Nobelists. (stanford.edu)
Expert opinion: The practical advantages of zebrafish for basic biological study and drug discovery are indisputable. (whiterose.ac.uk)
The ability to determine expression levels of multiple genetic and/or proteomic signatures simultaneously from the same sample volume is of tremendous importance in a wide range of biomedical applications, including disease diagnostics, drug discovery and fundamental studies of complex biological processes. (illinois.edu)
Combining traditional chemical and biological insight with cutting-edge concepts from materials science, physics and engineering, our group brings an interdisciplinary approach to developing new tools in order to tackle longstanding refractory problems in the biological sciences - technologies that will enable fundamental biological discovery and, in some applications, expedite the transfer of biomolecular insight to the hands of the physician, where it can directly impact patient care. (illinois.edu)

With the pandemic prompting not only the need to discover drugs faster but also for new ways to work, AI in drug discovery companies have seen record amounts of funding raised in 2020. (idtechex.com)
The new Centre for Cancer Drug Discovery was given a virtual opening on Tuesday 17 November 2020 at an exclusive online event to celebrate all the support the ICR has received from donors, funders and partners who have made the building possible. (icr.ac.uk)

Understanding the mechanisms which increase or decrease the chance of a drug working is crucial to aid the developments of new treatments," explained Jason Yu, co-first author and postdoctoral training fellow in the Molecular Biology of Metabolism Laboratory at the Crick. (ddw-online.com)
therefore, genetic differences in oxidative metabolism can significantly impact the levels of active drug circulating in a patient. (medscape.com)
CYP2D6 is a member of the cytochrome P450 family of enzymes involved in the oxidative metabolism of drugs. (medscape.com)
CYP2D6 is among the most promiscuous of these enzymes, involved in the metabolism of approximately 20% of drugs in clinical use, and displays large individual-to-individual variability in activity due to genetic polymorphisms. (medscape.com)
The impact of CYP2D6 activity in drug metabolism is further complicated by the activity of the drug itself on CYP2D6. (medscape.com)

HitGen has established leading technology platforms to enable the discovery and optimization of small molecules and nucleic acid drugs. (tmcnet.com)
PeptiDream will lead peptide discovery and optimization efforts, and Lilly will lead payload discovery and optimization efforts. (pipelinereview.com)
These results show that computation can help address the difficult optimization problem that is central to photoactive drug design. (utoronto.ca)

The challenge we face is to facilitate and expedite the sharing of research tools and results among academic and industrial HD investigators while protecting publication rights and the ownership of intellectual property. (the-scientist.com)

Growing R&D expenditure in the pharmaceutical & biopharmaceutical industry and the increasing adoption of contract research organizations (CROs) for drug discovery services are expected to drive the growth of the global drug discovery services market. (biospace.com)
The rising R&D expenditure is also driving the adoption of CROs for drug discovery services. (biospace.com)

HitGen has multiple programmes from early discovery to clinical trial stage. (tmcnet.com)
bit.bio has partnered with leading contract research organisation Charles River Laboratories to provide disease models in their early drug discovery programmes. (businesswire.com)

Advancements in the drug discovery services coupled with product launches by significant companies and strategic alliances between pharmaceutical and drug discovery services companies. (biospace.com)

To accelerate the design of photoactive drugs, we develop new computational methods for predicting their properties. (utoronto.ca)
He worked under Prof. Eugene Shakhnovich (Chemistry) and Prof. Rafael Gomez-Bombarelli (Materials Science and Engineering, MIT), combining atomistic simulation with machine learning to accelerate drug discovery. (utoronto.ca)
Moreover, the technique is also able to accelerate cost-efficiency in the drug discovery process. (marketresearch.com)
The introduction of SciBite Search will further accelerate our efforts and enable the creation of groundbreaking concepts in drug discovery research," emphasized Mutsuo Kanzawa, CEO of Kissei. (ticker.tv)

These services help in identifying small molecule drugs that can bind to the target protein and modulate its activity. (biospace.com)
Professor of molecular and cellular biology Brian Kobilka , PhD, told the audience about his work with a class of cell-surface molecules, a field that has become exceedingly important: "My research on G-protein-coupled receptors began in the late 1980s, at a time when we knew there were maybe seven or eight members of this family," said Kobilka, the Hélène Irwin-Fagan Chair in Cardiology. (stanford.edu)
In drug discovery, we're working to develop drugs that will fit into the relevant gap or pocket within the protein structure and stop it working. (stratasys.com)
For example, photoactive drugs based on trans - cis isomerization must isomerize under light, absorb in the near-IR, have reasonably long cis lifetimes, and have differential cis - trans binding to a protein target. (utoronto.ca)
Treating the flies with low doses of anisomycin, a drug that blocks protein production, prevented nerve cell damage and restored the flies' movement even though levels of s15 phosphorylation remained high. (drugdiscoverytrends.com)
Our research focuses on understanding the protein quality control system inside platelets (known as protein ubiquitination)," says Dr Liu , leader of the Cardiovascular-protective Signalling and Drug Discovery Unit at the Heart Research Institute (HRI). (hri.org.au)
Sequence analysis (total HAV antibodies and HAV IgM) using the en- based on the viral protein 1/2A junction revealed that the causative virus belonged to genotype IB. (cdc.gov)

This process has 99.9% overall failure, of which 96.4% because the drug efficacy measured in vitro is not confirmed in animals. (europa.eu)
These genetic variants can affect the safety and efficacy of certain drugs. (medscape.com)

She founded Drug Discovery Alliances, Inc. in 2001 to connect pharmaceutical and biotech companies with top industry contractors who facilitate and speed projects. (drugdiscoveryalliances.com)

According to latest study from Emergen Research , the global drug discovery services market is expected to grow at a CAGR of 7.7% from 2016 to 2022 to reach USD 18.06 billion by 2022. (biospace.com)
Domainex first moved to Unity Campus in January 2022, taking 7,000 sq ft of laboratory space at Iconix 2 to provide a dedicated facility for its biology department and freeing up space at its closely located Chesterford Research Park site. (ddw-online.com)
The global artificial intelligence (AI) in drug discovery market reached a value of nearly $1,042.3 million in 2022, having grown at a compound annual growth rate (CAGR) of 30.5% since 2017. (menafn.com)
The deep learning market was the largest segment of the artificial intelligence (AI) in drug discovery market segmented by technology, accounting for 33.9% of the total in 2022. (menafn.com)
Going forward, the deep learning segment is expected to be the fastest growing segment in the artificial intelligence (AI) in drug discovery market segmented by technology, at a CAGR of 29.12% during 2022-2027. (menafn.com)
North America was the largest region in the artificial intelligence (AI) in drug discovery market, accounting for 41.9% of the total in 2022. (menafn.com)

Her team collaborates extensively with faculty at the Bloomberg~Kimmel Institute for Cancer Immunotherapy and leads the BKI immunotherapy drug discovery core, aimed at developing new immune-targeting drug therapies for laboratory and clinical testing at Johns Hopkins. (hopkinsmedicine.org)

Its platform includes over 1.2 trillion small molecules generated by the DEL technology, and the efficiency of the screening process has made it possible for HitGen to enable drug discovery projects for many organizations around the world. (tmcnet.com)
Companies in the pharmaceutical and biotechnology industries typically spend more than $1 billion to bring a drug to market, in a process that often lasts over 10 - 15 years. (idtechex.com)
iPSC-derived cells from patients offer a human model for disease research, but sourcing them with the disease-specific mutation of interest can be a complex and time-consuming process. (businesswire.com)
A recent, informative article from the MDA outlined the process for drug discovery and bringing a drug to market. (hnf-cure.org)
The research team was inspired by a widely-used drug discovery process and built and screened large libraries of membranes with diverse pore structures in order to identify those capable of binding to lithium ions. (lbl.gov)
The technique is gaining popularity, owing to its wide applicability in the drug discovery process. (marketresearch.com)
Kissei Pharmaceutical Co., Ltd. is revolutionizing the drug discovery research process through the integration of digital technology. (ticker.tv)

North America is expected to account for the largest share of the global drug discovery services market in 2016. (biospace.com)
From its inception in 2016, when it drew 250 attendees, the Stanford Drug Discovery Symposium has grown immensely in both reach and roster. (stanford.edu)

The courses given in the Faculty of Science research schools are open for PhD students at the faculty. (lu.se)

Arneric SP, Holladay M, Williams M. Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. (medlineplus.gov)

Can The Pharmaceutical Companies Use Basic Aging Biology To Develop Drugs For Age-Related Diseases? (wikipedia.org)
Evotec is the first Pharmaceutical Contract Research Organisation in Europe to offer these services. (evotec.com)
Damian and I secured one of the first worldwide Discovery Partnerships with Academia (DPAc) collaborations with the pharmaceutical company GSK, which has been very successful. (ed.ac.uk)

The disease model cells will support scientists in the generation of data in a human context with improved translatability in early stage drug discovery. (businesswire.com)
With this new offering, we can cater to the vast diversity of scientific research into human diseases, providing scientists with the models they need to study their specific interests. (businesswire.com)
Still, after completing multiple dose escalation cohorts, Cleave's scientists told Amy that they could not draw any definitive conclusions about the benefits of the drug. (hbs.edu)
By analysing drug exposure data from the project, the scientists found that communities with auxotrophs are more likely to have tolerance against hundreds of drugs, than communities without these cells. (ddw-online.com)
Scientists at The Institute of Cancer Research, London, are moving into the new building this month - with hopes that the work they do will lead to a new generation of 'anti-evolution' treatments. (icr.ac.uk)

Amy Burroughs' mandate to successfully commercialize Cleave Therapeutics' drug for a cancer with no current successful therapy was on track but faced an unclear future. (hbs.edu)
Founded in 2006, PeptiDream employs its proprietary Peptide Discovery Platform System (PDPS) technology, a state-of-the-art highly versatile discovery platform which enables the production of highly diverse (trillions) non-standard peptide libraries with high efficiency, for the identification of highly potent and selective macrocyclic peptide candidates, which then can be developed into peptide-based, small molecule-based, or peptide-drug conjugate (PDC)-based therapeutics and diagnostics. (pipelinereview.com)

Furthermore, despite the great effort of the scientific community and the financial support of public funding for neuroscience-related research, the approval of innovative drugs acting on central nervous system (CNS) has been rare in recent years. (frontiersin.org)
To improve the impact of drug treatments on cognition and memory, we need not only a better understand of cellular and molecular neuroscience, but also reliable animal paradigms for drug testing, i.e. experimental models which provide functional (behavioral) data predictive of human outcomes. (frontiersin.org)

According to Simon Lovestone, 'Advances in science and technology are revolutionising our approach to healthcare, but dementia is playing catch up with other areas of disease research and needs a step change. (ox.ac.uk)
Despite global advances in science and technology, and extensive investment in research, some of the key questions related to public health are not adequately addressed. (who.int)

Scientific and institutional review boards and ethical review committees are functionally weak.4 Management of research projects as well as synthesis, documentation and management of information are not strong. (who.int)

Additionally, there is a brief project where participants conduct a preliminary search with an associated search strategy within their research field. (lu.se)

For more news on cancer research, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/content/early/by/section . (aacrjournals.org)

I am confident that this partnership has the potential to be transformative," said Aled Edwards , Chief Executive of the SGC, "We look forward to providing the ML community with high-quality, well-curated data so they can contribute to our global effort to find drug starting points for all human proteins. (tmcnet.com)
Within drug discovery, R&D projects using synchrotron X-rays focus on challenges such as optimising and improving drugs and their effects, studying proteins and their active sites, and investigating modes of binding drug candidates to target proteins. (lu.se)

Bioprinting, especially 3D printing, is opening doorways to in vitro drug discovery and toxicology research. (corning.com)
Instead of in vitro cultures composed entirely of a single cell type, such as fibroblasts, toxicology research and cosmetic screening can be carried out on layered prints that mimic skin anatomy. (corning.com)

Research services provider Domainex has secured a new, fully fitted, three-storey building in Unity Campus in Cambridgeshire, UK. (ddw-online.com)

Virtual biotechs target and develop translational research. (the-scientist.com)
Their considerable financial (in the tens of millions of dollars for many foundations) and intellectual involvement has triggered collaborative translational drug discovery efforts. (the-scientist.com)
Looking from the industrial and academic edges of the translational research chasm, any effort to build a bridge seemed daunting, but looking up from the basin, we saw an opportunity. (the-scientist.com)
This symposium is made possible thanks to the UMB-JHU Institute for Clinical & Translational Research (ICTR) . (johnshopkins.edu)

Indeed, while a plethora of substances have been shown to exert neuroprotective effects in animal models of ischemia, traumatic injury, neurodegenerative diseases, no specific treatment has so far reached approval (though several compounds, including prescription drugs, over-the-counter, nutraceuticals, vitamins are claimed to exert neuroprotective effects, mainly because of their putative antioxidant activity). (frontiersin.org)
The announcement by Pfizer Inc. that they will pull out of research programs for neurodegenerative diseases, including Parkinsons and Alzheimers, has caused a stir and suggests that drug discovery for neuropsychiatric disorders might not improve in the coming years. (frontiersin.org)

Research from the Francis Crick Institute has revealed a key mechanism that increases tolerance to drugs amongst microbial communities. (ddw-online.com)
An 'heirloom' piece of jewellery has been bestowed to Griffith Research Institute for Drug Discovery (GRIDD) Director Professor Jennifer L Martin AC to honour her inspiring achievements in the field. (edu.au)
This may be a major discovery for Parkinson's disease patients," said Ted Dawson, director of the Johns Hopkins University (JHU) Morris K. Udall Center of Excellence for Parkinson's Disease, Baltimore, Md. Ted Dawson and his wife, Valina Dawson, director of the JHU Stem Cell and Neurodegeneration Programs at the Institute for Cell Engineering, led the study published in Cell. (drugdiscoverytrends.com)
Every donation to the Heart Research Institute is an investment into the lives of millions. (hri.org.au)
It will be located in the University's newly-established built-for-purpose Target Discovery Institute. (ox.ac.uk)
We're proud to be hosting a Drug Discovery Institute here at the University of Oxford. (ox.ac.uk)

Take a video tour of the new Centre for Cancer Drug Discovery to learn more about the building and the research that will go on within it. (icr.ac.uk)
The ICR continues to seek philanthropic support to equip the building to get research in the new Centre off to the best possible start. (icr.ac.uk)
The Centre will help us find new ways to overcome drug resistance so that we can manage patients for much longer with a good quality of life, just as is done with diseases like HIV and diabetes, while also increasing their chances of cure. (icr.ac.uk)
We are now focusing on raising funds to help us equip the building and to get our research in the new Centre off to the best possible start. (icr.ac.uk)

Zebrafish xenograft models of cancer and metastasis for drug discovery. (whiterose.ac.uk)
Areas covered: The authors discuss the advantages and disadvantages of the zebrafish xenograft model for the study of cancer, metastasis and drug discovery. (whiterose.ac.uk)

I work on various drug discovery projects across a range of disease areas. (ed.ac.uk)
It also requested Member States to determine priority research areas, develop research policies and strategies, create an enabling environment for research, and build research capacity. (who.int)

Brian Kobilka, Jennifer Doudna, Carolyn Bertozzi and Marc Tessier-Lavigne discuss the importance of basic research at the Drug Discovery Symposium on April 25. (stanford.edu)
The discussion took place during the seventh annual Stanford Drug Discovery Symposium, held April 24 and 25 at Berg Hall on the Stanford School of Medicine campus. (stanford.edu)
The UMB-JHU Joint Symposium on Drug Discovery will provide an open forum for scientific exchange and interactive communication among students, postdoctoral fellows, and faculty at two of Baltimore's prime academic institutions. (johnshopkins.edu)

The MOAB allows to culture 3D organoids of few millimetres in size, under continuous perfusion of the culture medium, infusion of the drug to be tested and diagnostics of cell response both in real time and also post-cultivation. (europa.eu)

Hence, the purpose is the celebration of the scientific work of Professor Maya Neytcheva, the sharing of current research, and fostering future research in the field. (lu.se)

Ultimately, their goal is to create highly useful and innovative new drugs that contribute to the well-being of people worldwide. (ticker.tv)

Intriguingly, depletion or pharmacologic inhibition of SKP2 also diminished the accumulation and self-renewal potential of prostate cancer stem cells (CSC), likely via suppression of AKT-mediated glycolysis and stimulation of senescence, and enhanced the sensitivity of prostate cancer cells to chemotherapeutic drugs. (aacrjournals.org)
The blockbuster prostate cancer drug abiraterone (trade name Zytiga), which was discovered at the ICR, is generating worldwide sales of more than $2.5bn per year for the manufacturer. (stratasys.com)

In the historic period, the artificial intelligence (AI) in drug discovery market witnessed significant growth, driven by emerging markets, the increasing prevalence of chronic diseases, and the adoption of AI for cost-efficient drug discovery. (menafn.com)
Light-activated drugs are a promising way to treat localized diseases for which existing treatments have severe side effects. (utoronto.ca)
Risk of Underlying Diseases and Effectiveness of Drugs on COVID-19 Inpatients Assessed Using Medical Claims in Japan: Retrospective Observational Study. (cdc.gov)

Anatomy7

Organisms6

Diseases11

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology6

Phenomena and Processes44

Disciplines and Occupations48

Anthropology, Education, Sociology and Social Phenomena14

Technology, Industry, Agriculture12

Humanities8

Information Science33

Named Groups1

Health Care28

Geographicals2

20234

PHARMACOLOGY AND DRUG DISCOVERY3

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Targets13

20212

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Findings4

Therapeutic7

World's2

Biomedical Research1

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Alzheimer's8

Biological5

20202

Metabolism5

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Expedite1

CROs2

Programmes2

Advancements1

Accelerate4

Protein7

Efficacy2

Biotech1

20226

Therapies1

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20162

Faculty of Science1

Decades1

Pharmaceutical3

Scientists5

Therapeutics2

Neuroscience2

Advances2

Synthesis1

Search1

Content1

Proteins2

Vitro2

Domainex1

Translational4

Neurodegenerative diseases2

Institute6

Centre4

Metastasis2

Areas2

Symposium3

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Work1

Ultimately1

Prostate cancer2

Diseases3