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Apolipoprotein C-IApolipoproteins CApolipoprotein C-IIILipoproteins, VLDLTriglyceridesApolipoprotein A-INK Cell Lectin-Like Receptor Subfamily AReceptors, NK Cell Lectin-LikeApolipoproteins EApolipoprotein B-100Antigens, LyApolipoproteins BApolipoprotein E4Apolipoprotein E3Apolipoprotein A-IIApolipoproteinsResearchApolipoprotein C-IIApolipoproteins AApolipoprotein B-48Apolipoprotein E2Lipoproteins, HDLApoprotein(a)CholesterolLipoproteinsLipoprotein(a)Research Support as TopicApolipoproteins DLipoproteins, LDLLipidsResearch DesignEthics, ResearchResearch PersonnelAtherosclerosisReceptors, LDLCholesterol, HDLArteriosclerosisNursing ResearchLiverCholesterol, LDLMice, KnockoutPhosphatidylcholine-Sterol O-AcyltransferaseRetinol-Binding Proteins, PlasmaAndrogen-Insensitivity SyndromeRetinol-Binding ProteinsEncyclopedias as Topic
APOELipoproteinAtherosclerosisAlleleLipoproteinsApoE4PolymorphismsAmyloidMonoclonal AntibodyCerebrospinalAntibodyMetabolismCholesterolKnockout miceGenotypesELISA KitSecretionProteinsGenesGeneticsAllelesSerumEpitopesSubstancesPeer-reviewApoB-100DetectsProteinLipidsNeuronsReactivityHepaticAtheroscleroticCharacterizeBaselineLipidNeuroscienceDeficiencyJournal
APOE20
  • To characterize the lipidation states of Aβ peptides and apolipoprotein E in the cerebrospinal fluid in adults with respect to cognitive diagnosis and APOE ε4 allele carrier status and after a dietary intervention. (nih.gov)
  • The lipidation states of apolipoproteins and Aβ peptides in the brain differ depending on APOE genotype and cognitive diagnosis. (nih.gov)
  • Purpose: To elucidate a potential association between the apolipoprotein E (APOE) E4 allele and glaucoma prevalence in large cohorts. (edu.au)
  • The relation of hypercholesterolemia and apolipoprotein E (ApoE) to cerebral aneurysm formation, has been unclear until now. (spandidos-publications.com)
  • Researchers highlight recent research investigating whether gut microbiota regulates tau pathology and tau-mediated neurodegeneration in an ApoE isoform-dependent manner. (news-medical.net)
  • Transcriptome analysis was performed using retinal pigment epithelium cells of apoE knockout and apolipoprotein E2 mice using microarray analysis. (geneticsmr.com)
  • The meta-analysis was performed according to the apolipoprotein E (APOE) ɛ4 allele status. (geneticsmr.com)
  • In the present study, the correlation of polymorphisms of the apolipoprotein E ( apoE ) gene with the susceptibility of essential hypertension (EH) was investigated. (geneticsmr.com)
  • We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have lived in that region for over 40 years, versus a group of elderly, locally born Brazilians living in the same region. (geneticsmr.com)
  • The major apolipoproteins (apo) on human cerebrospinal fluid lipoproteins are apoA-I and apoE. (elsevierpure.com)
  • Given the association between inheritance of the ε4 allele of the apoE gene (APOE4) and increased susceptibility to Alzheimer's disease, we tested the hypothesis that cerebrospinal fluid apolipoproteins may be influenced by APOE genotype and Alzheimer's disease. (elsevierpure.com)
  • The relative levels of apoE- and apoA-II-containing apolipoproteins correlated with APOE genotype but were not altered by Alzheimer's disease. (elsevierpure.com)
  • These differences in cerebrospinal fluid apolipoproteins may influence lipoprotein trafficking and may be an element in the stratification of risk for Alzheimer's disease with APOE genotype. (elsevierpure.com)
  • Thank you for your interest in NeuroMab™ Mouse Anti-Apolipoprotein E/APOE Monoclonal Antibody (CBP2519) . (creative-biolabs.com)
  • Methods: Aortic plaque deposition was assessed in streptozotocin-induced diabetic apolipoprotein E (Apoe) knockout (KO) and At 2 r (also known as Agtr2)/Apoe double-KO (DKO) mice. (monash.edu)
  • The aim of this investigation was to assess the effect of galantamine, an acetylcholinesterase inhibitor and allosteric modulator of nicotinic receptors, on brain atrophy in individuals with mild cognitive impairment (MCI), and to assess effect modification by apolipoprotein E (APOE) genotype. (biomedcentral.com)
  • Some patients might respond well to a low fat diet, some patients might respond better to statin medications, depending on their apoE genotype,' states Dr. Jonathan Stein, PhD and Director of Science and Research at SpectraCell Laboratories. (news-medical.net)
  • The so-called human apolipoprotein E (APOE) gene encodes instructions for creating the homonymous protein. (medicalnewstoday.com)
  • Genetic analysis of families with Alzheimer disease has revealed a disease-associated variant of the APOE gene, which encodes apolipoprotein E, a transporter of lipids in the blood and central nervous system. (columbia.edu)
  • In addition, researchers did not gather data on apolipoprotein (APOE) haplotypes, noting that their effect on lipid profiles and dementia risk could "further impact lipid variabilities' association with AD/ADRD. (medscape.com)
Lipoprotein12
  • Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. (jci.org)
  • Lipoprotein(a) consists of a low-density lipoprotein containing apolipoprotein (apo) B-100 and of the genetically polymorphic apo(a). (jci.org)
  • Each lipoprotein is characterized by its lipid composition and by the type and number of apolipoproteins it possesses. (medscape.com)
  • these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
  • Associations were not systematically stronger when comparing traditional lipids (total cholesterol, low-density lipoprotein or high-density lipoprotein) to apolipoproteins. (nih.gov)
  • Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
  • Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
  • Apo E (Apolipoprotein E) plays an important role in the metabolism of lipids in the plasma, and is also is a constituent of various plasma lipoprotein-lipid particles. (thermofisher.com)
  • ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. (portlandpress.com)
  • Trends in apolipoprotein B, non-high-density lipoprotein, and low-density lipoprotein for adults 60 years and older by use of lipid-lowering medications: United States, 2005-2006 to 2013-2014 [Research Letter]. (cdc.gov)
  • Apolipoprotein A-I (Apo-A1) is a structural and functional protein that constitutes approximately 70% of the protein in high density lipoprotein (HDL). (medscape.com)
  • The Ratio of High-Density Lipoprotein Cholesterol to Apolipoprotein A-I Predicts Myocardial Injury Following Elective Percutaneous Coronary Intervention. (medscape.com)
Atherosclerosis4
Allele2
  • Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease. (bmj.com)
  • 2011. The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. (creative-biolabs.com)
Lipoproteins5
  • Unlike other lipoproteins, which are mainly produced in the liver, apolipoprotein D is mainly produced in the brain and testes. (wikipedia.org)
  • Other apolipoproteins (A, C, D, E, and their subtypes) are soluble and are exchanged between lipoproteins during metabolism. (medscape.com)
  • Circulating lipoproteins and their protein constituents, apolipoproteins, are risk factors for chronic kidney disease (CKD). (nih.gov)
  • Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
  • The group has defined epitopes on apolipoprotein B-containing lipoproteins targeted by immunoglobulins, and have shown that plasma levels of these immunoglobulins can predict future cardiovascular disease. (lu.se)
ApoE43
  • However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. (aston.ac.uk)
  • New research in mice suggests that people who already have a copy of the APOE4 gene and are thus at risk of Alzheimer's may experience cognitive decline as a result of exposure to cadmium - a neurotoxic heavy metal. (medicalnewstoday.com)
  • Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). (lu.se)
Polymorphisms2
  • Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A. Polymorphisms in apolipoprotein B and risk of ischemic stroke. (prosci-inc.com)
  • Apolipoprotein E polymorphisms status in Iranian patients with multiple sclerosis. (cdc.gov)
Amyloid1
Monoclonal Antibody1
  • The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
Cerebrospinal2
  • Lipid-depleted Aβ42 and Aβ40 and apolipoprotein E in cerebrospinal fluid. (nih.gov)
  • 2002. Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease. (creative-biolabs.com)
Antibody2
  • The following product was used in this experiment: Apolipoprotein E Polyclonal Antibody from Thermo Fisher Scientific, catalog # BS-4892R. (thermofisher.com)
  • PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
Metabolism1
  • However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. (geneticsmr.com)
Cholesterol3
Knockout mice1
  • Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. (cdc.gov)
Genotypes2
  • Methods: Apolipoprotein E alleles and genotypes were determined, and their distributions were compared on the basis of glaucoma status. (edu.au)
  • Association of apolipoprotein E genotypes with prognosis in multiple sclerosis. (cdc.gov)
ELISA Kit1
  • Mouse Apolipoprotein B48 (apo-B48) ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
Secretion2
  • Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic ß-Cells via a G-Protein-cAMP-PKA-FoxO1-Dependent Mechanism. (medscape.com)
  • Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)
Proteins1
  • Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
Genes4
  • Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria para. (edu.au)
  • This paper summarizes the recent findings from studies investigating the potential environmental modulation of the genetic variation of apolipoprotein genes on metabolic traits. (itg.be)
  • We reviewed nutrigenetic studies evaluating variations on apolipoproteins-related genes and its associated response to nutrients (mostly dietary fatty acids) or any other dietary or environmental component. (itg.be)
  • Although current knowledge shows that variations on apolipoprotein genes may contribute to the different response on metabolic traits due to dietary interventions, evidence is still scarce and results are inconsistent. (itg.be)
Genetics1
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Alleles1
  • Apolipoprotein alleles and the response to interferon-ß-1b in multiple sclerosis. (cdc.gov)
Serum1
  • Higher serum apolipoprotein A1 was associated with lower prevalence of CKD and higher eGFR estimated by the CKD-EPI equation in two large multiethnic population-based samples. (nih.gov)
Epitopes1
Substances1
Peer-review1
  • PLOS ONE promises fair, rigorous peer review, broad scope, and wide readership - a perfect fit for your research every time. (plos.org)
ApoB-1002
  • Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
  • Buy Human Apolipoprotein B-100 (ApoB-100) from Lee Biosolutions. (leebio.com)
Detects2
  • MIA1609 detects Apolipoprotein B which has a predicted molecular weight of approximately 502 kDa. (thermofisher.com)
  • Detects mouse and rat Apolipoprotein H/ApoH in Western blots and detects recombinant mouse Apolipoprotein H/ApoH in direct ELISAs. (rndsystems.com)
Protein1
  • Apolipoprotein D (ApoD) is a protein that in humans is encoded by the APOD gene. (wikipedia.org)
Lipids1
Neurons2
  • Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. (nih.gov)
  • In the CNS, it is the most abundant apolipoprotein, and is secreted primarily by astrocytes and taken up by neurons. (columbia.edu)
Reactivity2
  • MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
  • In direct ELISAs, approximately 40% cross-reactivity with recombinant human Apolipoprotein H/ApoH is observed. (rndsystems.com)
Hepatic1
  • The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
Atherosclerotic1
  • The aim of our research is to understand the interplay between molecular, cellular, metabolic, and immunological mechanisms contributing to atherosclerotic cardiovascular disease. (lu.se)
Characterize1
Baseline1
  • Prospective analyses related baseline apolipoprotein levels to subsequent CKD incidence over 10 years using the ARIC Carotid MRI follow-up cohort (n=1659). (nih.gov)
Lipid1
Neuroscience1
  • Creative Biolabs is the very first company to provide a wide range of leading technologies and products in the neuroscience research field. (creative-biolabs.com)
Deficiency1
  • Aoki T, Moriwaki T, Takagi Y, Kataoka H, Yang J, Nozaki K and Hashimoto N: The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation. (spandidos-publications.com)
Journal2
  • Hungarian Educational Research Journal. (ntu.edu.sg)
  • Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2011 Dec 16 (12): 1519-24. (cdc.gov)