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  • antibodies
  • However, it is not able to mediate signal transduction itself due to its short cytoplasmic tail, so TCR still requires CD3 and zeta to carry out the signal transduction in its place, just as antibodies require binding to FcRs to initiate signal transduction. (wikipedia.org)
  • mechanisms
  • How this occurs and if autoimmunity inevitably requires defects in tolerance enforcing mechanisms or if even healthy individuals with a normally selected T cell repertoire and without any genetic predisposition can develop autoimmunity remains unknown. (rupress.org)
  • generation
  • We propose that CCI and PICS after trauma or sepsis are the result of an inappropriate bone marrow response characterized by the generation of dysfunctional myeloid populations at the expense of lympho- and erythropoiesis. (frontiersin.org)
  • lack
  • In early 2012, the Carabinieri's Anti-Adulteration Group and the Italian Pharmaceutical Agency began an inspection, which revealed non-compliance with the requirements of safety and hygiene, and a lack of documents required by law. (wikipedia.org)
  • critical
  • However, a substantial proportion of severe trauma and sepsis survivors will develop protracted organ dysfunction termed chronic critical illness (CCI), defined as ≥14 days requiring intensive care unit (ICU) resources with ongoing organ dysfunction. (frontiersin.org)
  • short
  • However, it is not able to mediate signal transduction itself due to its short cytoplasmic tail, so TCR still requires CD3 and zeta to carry out the signal transduction in its place, just as antibodies require binding to FcRs to initiate signal transduction. (wikipedia.org)