Reproductive human cloning somatic and embryonic stem cells derivation of stem cells from cloned human embryos. Medical search. Frequent questions

It is the policy of Washington state that research involving the derivation and use of human embryonic stem cells, human embryonic germ cells, and human adult stem cells from any source, including somatic cell nuclear transplantation , is permitted upon full consideration of the ethical and medical implications of this research. (cbc-network.org)
Dynamics of male canine germ cell development [6] "Primordial germ cells (PGCs) are precursors of gametes that can generate new individuals throughout life in both males and females. (edu.au)
This paper outlines the debates prompted through a reproduction mechanism involv- by progress in cloning research, with special ing male and female germ cells. (who.int)
Reproductive cloning versus germ cell (egg, ovum). (who.int)

If the cloned human organism is to be experimented upon and destroyed, the process is often called "therapeutic cloning. (cbc-network.org)
In particular, scientific developments in areas such as iPS cells open new possibilities of research and, at mid term, of therapeutic applications, but they also bring new ethical challenges and problems requiring further reflection and debate. (lifeissues.net)
But adult stem cells also raise some interesting ethical dilemmas alongside their great therapeutic promise. (eppc.org)
Therapeutic Cloning - Use of a donor cell to create pluripotent stem cells suitable for growing tissues for implantation into the donor or other patient. (schlich.co.uk)
Therapeutic cloning possesses enormous potential for revolutionizing medical and thera- peutic techniques. (who.int)
This is therapeutic cloning. (who.int)
This cell then has therapeutic cloning: the global the capacity to divide and grow into an exact replica of the original from whom the debate somatic cell was taken. (who.int)

In the case of asexually creating a human, the biotechnologist removes the nucleus from a mature human egg (an oocyte). (cbc-network.org)
Somatic cell cloning (cloning or nuclear transfer) is a technique in which the nucleus (DNA) of a somatic cell is transferred into an enucleated metaphase-II oocyte for the generation of a new individual, genetically identical to the somatic cell donor (Figure 1 ). (biomedcentral.com)
A matured oocyte (c) is then enucleated (d) and a donor cell is transferred into the enucleated oocyte (e). (biomedcentral.com)
The somatic cell and the oocyte is then fused (f) and the embryos is allowed to develop to a blastocyst in vitro (g). (biomedcentral.com)

… "human clone" means an embryo that, as a result of the manipulation of human reproductive material or an in vitro embryo, contains a diploid set of chromosomes obtained from a single - living or deceased - human being, fetus, or embryo. (hinxtongroup.org)
Assisted reproductive techniques for canines: preservation of genetic material in domestic dogs [3] "Assisted reproductive techniques (ARTs), such as artificial insemination, in vitro fertilization, and cryopreservation of gametes/zygotes, have been developed to improve breeding and reproduction of livestock and for the treatment of human infertility. (edu.au)
In vitro studies indicate that Dab2 establishes epithelial cell polarity and organization by directing endocytic trafficking of membrane glycoproteins. (biomedcentral.com)
Cells are collected from donor (a) and cultured in vitro (b). (biomedcentral.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)

Research advocates attack President Bush for "banning stem cell research," while pro-life advocates lament a Republican administration and Congress that have banned nothing-not embryo destruction, not human cloning, not fetal farming, not genetic engineering. (eppc.org)
But we can only wonder about the ethical propriety of producing the first human child with this technique, knowing that the hoped-for newborn would be a reproductive experiment, one that may end initially in numerous fetal failures. (eppc.org)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)

The second way to reproduce is a strictly human invention - known as "asexual" reproduction - or more commonly, cloning. (cbc-network.org)
Cloning of a human being" means asexual reproduction by implanting or attempting to implant the product of nuclear transplantation [e.g., an embryo] into a uterus or substitute for a uterus with the purpose of producing a human being. (cbc-network.org)
This is junk biology since implanting isn't the act of asexual reproduction: SCNT cloning is. (cbc-network.org)

Independently of the gestational periods, the qualitative evaluation showed the initial wash-in phase from the first appearance of the uterine artery to the rapid distribution in embryonic vesicles or placenta to the progressive washout, whilst there was no enhancement of either embryos or fetuses in any bitch. (edu.au)
Developmental defects, including abnormalities in cloned fetuses and placentas, in addition to high rates of pregnancy loss and neonatal death have been encountered by every research team studying somatic cloning. (biomedcentral.com)

But what is not getting such wide reporting is the use of pluripotent stem cells (as well as many other types of cells and genetic engineering techniques) for reproductive purposes . (lifeissues.net)

There are now two ways to create new mammalian life, including humans. (cbc-network.org)
Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. (biomedcentral.com)

While stem-cell research holds enormous potential for treating or even curing some diseases, the cloning of a human being is morally and ethically unacceptable…Any attempt to clone a human being is in direct conflict with the public policies of this state. (cbc-network.org)

To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)

your supposed cloning ban actually authorizes human cloning, implantation, and gestation through the ninth month. (cbc-network.org)
That is what New Jersey legislators did when they passed and then Governor James McGreevey signed S-1909 last year, a law that was sold to the public as outlawing human cloning but which actually permits the creation of cloned human life, and its implantation and gestation up to and including the very moment prior to the emergence of the cloned baby from the birth canal. (cbc-network.org)
And now Washington joins the infamous list with Senate Bill 5594, a thoroughly disingenuous piece of legislation that purports to outlaw the cloning of human beings, but by manipulating language and redefining terms, actually permits human cloning and gestation of the resulting cloned embryos through the ninth month. (cbc-network.org)
The blastocyst can then be transferred to a recipient (h) and cloned animals are born after completion of gestation (i). (biomedcentral.com)

Human enhancement, Harris argues, is a good thing--good morally, good for individuals, good as social policy, and good for a genetic heritage that needs serious improvement. (philpapers.org)
if you have a choice of starting material and are forced to use embryonic stem cells to carry out the invention, ensure you describe the use of embryonic stem cells from morally acceptable sources in your patent application. (schlich.co.uk)

Today, we can derive stem cells from a range of adult and newborn tissues: liver cells, kidney cells, brain cells, fat cells, and umbilical cord blood. (eppc.org)
Stem cell technologies promise to be the next transformative medical technology offering therapies for conditions and diseases that are currently beyond medical science by creating replacement or supplementary tissues for a patient. (schlich.co.uk)
reagents made using a patient's own cells used to regenerate disease or damaged tissues 14,15 , once the stuff of science fiction, may become science fact. (schlich.co.uk)
However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)
Stem cells may be derived from adult tissues but the most potent are extracted from developing human embryos. (edu.au)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)

These developmental defects have been attributed to incomplete reprogramming of the somatic nuclei by the cloning process. (biomedcentral.com)
These observations suggest that further studies on nuclear reprogramming are needed in order to understand the underlying mechanisms of reprogramming and significantly improve the ability of the differentiated somatic nuclei to be reprogrammed. (biomedcentral.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)

Many of these developmental abnormalities are common to human development. (edu.au)

The nucleus of a body cell from the DNA donor is removed, and put into the place formerly occupied by the egg's nucleus. (cbc-network.org)
When the nucleus of a stem cell has been the technique of cloning. (who.int)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)
The basic techniques of of the implanted nucleus, when it fully cloning have been known for some time, and develops. (who.int)

It is quite possible that the advances in human biology in the remainder of the twentieth century will be remembered as the most significant scientific achievement of the animal species known as Homo sapiens . (lifeissues.net)

However, somatic cloning has been inefficient in all species in which live clones have been produced. (biomedcentral.com)
Because cattle are a species widely used for nuclear transfer studies, and more laboratories have succeeded in cloning cattle than any other specie, this review will be focused on somatic cell cloning of cattle. (biomedcentral.com)

One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)

The holy grail of regenerative medicine-whatever one's ethical beliefs about destroying embryos-is to "reprogram" regular cells from one's own body so that individuals can be the source of their own rejection-proof therapies. (eppc.org)
In Enhancing Evolution, leading bioethicist John Harris dismantles objections to genetic engineering, stem-cell research, designer babies, and cloning and makes an ethical case for biotechnology that is both forthright and rigorous. (philpapers.org)
Cloning technology, however, is perceived as having the potential for reproductive cloning, which raises serious ethical and moral concerns. (who.int)
The ethical and legal controversies that were aroused in the ART debates during the 1980s have been re-ignited with the development of stem cell technology. (edu.au)
This issue was considered by the House of Representatives Standing Committee on Legal and Constitutional Affairs in its report entitled Human Cloning: Scientific, Ethical and Regulatory Aspects of Human Cloning and Stem Cell Research (hereafter the Andrews Report , after the Chair of the Committee, Mr Kevin Andrews, MP) released in September 2001. (edu.au)
The report arose out of a recommendation for the Committee to review the report of the Australian Health Ethics Committee (AHEC) of the NHMRC entitled Scientific, Ethical and Regulatory Considerations Relevant to Cloning of Human Beings (hereafter the AHEC Report ). (edu.au)

The bill purports to promote stem-cell research, while outlawing the cloning of a human being. (cbc-network.org)
The use of various types of stem cells for research purposes to make disease "models" in the lab for regenerative medicine and for "therapies" to cure sick patients for diseases is constantly in the news. (lifeissues.net)
increased public sensitivity and awareness together with the development of national regulations of governance of human cloning and embryo research in general. (lifeissues.net)
An in-depth analysis aiming at re-defining this terminology according to the new developments in human embryo research would be highly beneficial . (lifeissues.net)
3. National regulations of governance of human cloning and embryo research in general adopted so far confirm the convergence of views of the refusal to adopt legislation or guidelines permitting reproductive cloning , while they still show variations on the legitimacy of human cloning carried out as part of research agendas. (lifeissues.net)
But they are also less equipped to produce every cell type of the body and less able to reproduce themselves indefinitely, which makes them less appealing to scientists interested in basic research. (eppc.org)
These moral perils are surely not a reason to oppose adult stem cell research, which deserves vigorous and expanded public support. (eppc.org)
Since 1995, Congress has annually reauthorized a law-called the "Dickey Amendment"-prohibiting federal funding for research "in which" embryos are destroyed while leaving embryo destruction in the private sector entirely unregulated. (eppc.org)
Before leaving office, President Clinton sought to get around the existing law without actually changing it, by funding research on embryonic stem cells so long as the actual embryo destruction was paid for with private dollars. (eppc.org)
Assisted reproductive technology (ART) and embryo research have posed many challenges to the different timeframes of science, ethics and law. (edu.au)
Embryonic stem cell technology is still at a preliminary research stage and announcements about its potential may be premature. (edu.au)
Experts from around the world are assessing the difficult issue of the extent to which embryonic stem cell research should be allowed to proceed, and to date there is little international consensus on this matter. (edu.au)
How, then, should embryonic stem cell research be regulated in Australia? (edu.au)
In this article we examine embryonic stem cell research and explore the current regulatory framework associated with this research in Australia, with particular reference to the Andrews Report . (edu.au)

The primary cloning technique is called "somatic cell nuclear transfer" (SCNT). (cbc-network.org)
Currently, the efficiency for nuclear transfer is between 0-10%, i.e., 0-10 live births after transfer of 100 cloned embryos. (biomedcentral.com)
Various strategies have been employed to modify donor cells and the nuclear transfer procedure in attempts to improve the efficiency of nuclear transfer. (biomedcentral.com)
Although the efficiency of nuclear transfer has been dramatically improved from the initial success rate of one live clone born from 277 embryo transfers [ 1 ], none of the aforementioned efforts abolished the common problems associated with nuclear transfer. (biomedcentral.com)

In addition, the possibility of reprogramming adult stem cells back to a "pluripotent" (or embryonic-like) state raises the biological prospect of going back too far. (eppc.org)

However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
Reproductive Cloning - Use of a donor cell to create a new human genetically identical to the donor. (schlich.co.uk)
Most of these efforts are focused on donor cells. (biomedcentral.com)

In July 2005, for example, scientists announced that they had engineered adult mouse stem cells into usable mouse eggs, a technique that might one day allow for the creation of human eggs from ordinary human cells. (eppc.org)

Over the past few years, the debate over stem cells and cloning has grown both more complex and more profound. (eppc.org)

… "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
Meanwhile, the ability of the mature egg to transform and begin embryonic development remains fully potent. (cbc-network.org)
The study of the new dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. (biomedcentral.com)
Conditional deletion indicates that Dab2 is dispensable for organ development, when the vast majority of the embryonic cells are dab2 null. (biomedcentral.com)
Stem cell technology is the latest development in this controversial branch of science. (edu.au)

Adult stem cells are easier to control than embryonic stem cells and thus less likely to form tumors. (eppc.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)

If the authors of this bill really meant what they appear to have written, their legislation would ban all human cloning, since as we have seen, biologically, a new human organism, that is, a new human being, comes into existence with the completion of SCNT. (cbc-network.org)
Moreover, while the term "human being" is not defined in the legislation, in this context, it can only mean the birth of a cloned baby. (cbc-network.org)
Last May, the House of Representatives passed a bill to create a cord blood stem cell bank, legislation that is likely to become law with virtually unanimous support. (eppc.org)

The genetically modified egg now has 46 chromosomes, the full human compliment. (cbc-network.org)

However, it appears that the ability of the In its simplest form, cloning is defined stem cells to transform is limited, except as the exact replication of cells. (who.int)

Or to put it the other way around, cloning, not implantation, is what produces a new and distinct human organism. (cbc-network.org)

XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
At that point - and this is important to understand - there is no more cloning to be done since a new human organism now exists. (cbc-network.org)
On the other hand, a chimera is defined as an organism in which cells from two or more different organisms have contributed. (frontiersin.org)

Citizens disagree about whether we should destroy human embryos for their stem cells-and if so, which embryos, with whose money, under what regulatory guidelines. (eppc.org)

In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. (frontiersin.org)

Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)

Already, non-embryonic stem cells are being used to treat a variety of diseases-most notably certain cancers of the blood. (eppc.org)
Stem cells offer the prospect of treatments for diseases and injuries that are currently beyond medical science. (schlich.co.uk)
Stem cells may underpin the next generation of pharmaceuticals, with even greater promise for successful treatment of diseases that are intractable or scarcely treatable now. (schlich.co.uk)

In a new preface, Harris offers a glimpse at the new science and technology to come, equipping readers with the knowledge to assess the ethics and policy dimensions of future forms of human enhancement. (philpapers.org)
This paper identifies human enhancement as one of the most significant areas of bioethical interest in the last twenty years. (philpapers.org)

Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)

Long before the controversy emerged over human embryonic stem cells, scientists and doctors began using first-generation stem cells from adult bone marrow. (eppc.org)
Stem cell technologies have been dogged by controversy because of objections over the morality of sacrificing human embryos to produce the first human embryonic stem cell lines. (schlich.co.uk)

We now see a patent landscape where stem cell technologies and related therapies can, with very few exceptions, be protected via patents, provided the appropriate form of claim wording is used. (schlich.co.uk)

and the general public debate about reproductive cloning. (edu.au)

In this review, we summarize the history of interspecies chimerism in various animal models to find hints for BC application and describe the challenges and prospects of utilizing BC for human organ generation. (frontiersin.org)
In ancient history, humans used the term "chimera" to describe mythical creatures and hybrids. (frontiersin.org)

B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)

The unique properties of human stem cells have aroused considerable optimism about their potential as new pathways for alleviating human suffering caused by disease and injury. (edu.au)

If it is to be brought to birth, the process is usually called "reproductive cloning. (cbc-network.org)
Schematic diagram of the somatic cloning process. (biomedcentral.com)

And recent experimental trials, while still very preliminary, suggest that adult stem cells may one day help us treat a host of terrible pathologies. (eppc.org)

But if we are to make wise policy the stem cell/cloning arena, we need to step back, sort out the various scientific alternatives and moral issues, and search for a way forward that all citizens can embrace. (eppc.org)
To this end, we offer a detailed analysis of the stem cell/cloning question-where is the science, what are the political alternatives, and what moral obligations should guide us? (eppc.org)

A recent UNESCO draft document, although rather vague and deficient in itself, probably does the best job of at least initially identifying and describing some of these new reproductive technologies in relatively simple form, with a few generalized helpful sketches online. (lifeissues.net)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)

Patent law around the world has now developed to define the boundaries between stem cell technologies that can be patented and those that cannot. (schlich.co.uk)

Furthermore, the first source of stem cell technology is controversial. (schlich.co.uk)
Stem cell technology in humans derives from earlier and complementary work in animal studies. (edu.au)

But we need to proceed carefully, recognizing that we are gaining new powers over human origins even when we do not use human embryos, and recognizing the danger of blurring the line between cellular parts and embryonic wholes. (eppc.org)

But in order to become a part of medical history, parahuman reproduction and human genetic engineering must circumvent the recalcitrance of an antiquated culture. (lifeissues.net)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)

Anatomy53

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