• 1] Therapeutic cloning, on the other hand, creates human embryos merely as a source of embryonic stem cells. (reasons.org)
  • Tragically, however, in order to harvest stem cells from human embryos, the embryos must be destroyed. (reasons.org)
  • Crudely put, therapeutic cloning looks to generate human embryos solely for the body parts they can provide. (reasons.org)
  • This means that hundreds of human embryos would die to achieve a single live human clone birth. (reasons.org)
  • And now Washington joins the infamous list with Senate Bill 5594, a thoroughly disingenuous piece of legislation that purports to outlaw the cloning of human beings, but by manipulating language and redefining terms, actually permits human cloning and gestation of the resulting cloned embryos through the ninth month. (cbc-network.org)
  • In the ongoing debate about cloning human embryos for research, and about destroying them in order to harvest their stem cells, it is important to keep some basic facts in mind. (actionlife.org)
  • Stem cells may be derived from adult tissues but the most potent are extracted from developing human embryos. (edu.au)
  • Photographs of (a) the procedure of somatic cell transfer (shown with the arrow) into the perivitelline space of an enucleated oocyte, (b) cloned bovine embryos used for transplantation to recipient animals, and (c) cloned calf (obtained in Russia for the first time). (isaaa.org)
  • I've been working with mammalian embryos for over 40 years, with some work in my lab specifically focusing on various methods of cloning cattle and other livestock species. (wptv.com)
  • Sometimes the process of cloning by somatic cell nuclear transfer still produces abnormal embryos, most of which die. (wptv.com)
  • His research blossomed after he came to Roslin Institute where in a series of papers he put the intellectual framework into the method of mammalian cloning that ultimately led to the birth of Dolly in 1996. (nottingham.ac.uk)
  • Eventually he cloned the GFP gene, but gave up on work to express the gene in mammalian cells. (pharmaceuticalintelligence.com)
  • is a British developmental biologist who was the first to use nuclear transfer of differentiated adult cells to generate a mammalian clone, a Finn Dorset sheep named Dolly, born in 1996. (mathisfunforum.com)
  • Spermatogonial stem cells (SSCs) are pivotal for maintaining the lifelong sperm production of mammalian males. (cyberleninka.org)
  • The second way to reproduce is a strictly human invention - known as "asexual" reproduction - or more commonly, cloning. (cbc-network.org)
  • Cloning of a human being" means asexual reproduction by implanting or attempting to implant the product of nuclear transplantation [e.g., an embryo] into a uterus or substitute for a uterus with the purpose of producing a human being. (cbc-network.org)
  • This is junk biology since implanting isn't the act of asexual reproduction: SCNT cloning is. (cbc-network.org)
  • But there was no way to easily know all the characteristics of the animal that would result from a cloned embryo or fetus. (wptv.com)
  • as well as diagnostic techniques, drug development and tissue transplantation. (who.int)
  • If there are intact cells in this tissue they have been 'stored' frozen. (wikiquote.org)
  • It is also our view that there are no sound reasons for treating the early-stage human embryo or cloned human embryo as anything special, or as having moral status greater than human somatic cells in tissue culture. (wikiquote.org)
  • A blastocyst (cloned or not), because it lacks any trace of a nervous system, has no capacity for suffering or conscious experience in any form - the special properties that, in our view, spell the difference between biological tissue and a human life worthy of respect and rights. (wikiquote.org)
  • XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
  • and altering cell and tissue characteristics for biomedical research and manufacturing. (nationalacademies.org)
  • When I set out to write this article my first challenge was how to present the information in a concise, yet shocking enough to wake up people who still believe that cloning humans for organ harvesting, splicing animal and human genes and making food out of human DNA or tissue is just science fiction. (real-agenda.com)
  • What was special about Dolly is that her "parents" were actually a single cell originating from mammary tissue of an adult ewe. (wptv.com)
  • A clone is an organism that is a genetic copy of an existing one. (who.int)
  • … "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
  • At that point - and this is important to understand - there is no more cloning to be done since a new human organism now exists. (cbc-network.org)
  • If the cloned human organism is to be experimented upon and destroyed, the process is often called "therapeutic cloning. (cbc-network.org)
  • If the authors of this bill really meant what they appear to have written, their legislation would ban all human cloning, since as we have seen, biologically, a new human organism, that is, a new human being, comes into existence with the completion of SCNT. (cbc-network.org)
  • Or to put it the other way around, cloning, not implantation, is what produces a new and distinct human organism. (cbc-network.org)
  • Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
  • This is cloning, a process in which the body cell that donated the replacement nucleus supplies the chromosomes of the new human organism. (actionlife.org)
  • Whether the new organism is produced by fertilization or by cloning, each new human organism is a distinct entity. (actionlife.org)
  • Indeed, if passed, Hatch/Feinstein/Kerry would explicitly legalize doing in humans the very cloning procedure -- somatic cell nuclear transfer (SCNT) -- that was used to make Dolly the sheep . (lifeissues.net)
  • Comment: Indeed, if passed, "total cloning bans" H.R. 534, H.R. 234, H.R. 916, and S. 245 would not ban anything either - not even the SCNT cloning technique that was used to make Dolly the sheep. (lifeissues.net)
  • The primary cloning technique is called "somatic cell nuclear transfer" (SCNT). (cbc-network.org)
  • The team led by Galina Singina at the Ernst Federal Science Center for Animal Husbandry managed to clone the calf using somatic cell nuclear transfer (SCNT), with embryonic fibroblasts as donors of nuclei. (isaaa.org)
  • Can Humans Be Cloned Like Sheep? (probe.org)
  • Professor Campbell was instrumental in the creation of Dolly the Sheep, the first cloned mammal, a breakthrough which paved the way for the successful cloning of many other mammal species. (nottingham.ac.uk)
  • Dolly the Sheep, the first mammal to be cloned from an adult derived somatic cell, was born in 1996. (nottingham.ac.uk)
  • He then moved to PPLTherapeutics, the company that was spun out from Roslin Institute, where that procedure and his expertise led to the birth of cloned and genetically modified sheep, pigs and cattle. (nottingham.ac.uk)
  • Inevitably most people will remember him for Dolly the sheep although his recent work was focused on fundamental and applied stem cell research as a tool for the study of human disease. (nottingham.ac.uk)
  • It's been 20 years since scientists in Scotland told the world about Dolly the sheep , the first mammal successfully cloned from an adult body cell. (wptv.com)
  • Dolly was an exact genetic copy of that sheep - a clone. (wptv.com)
  • She lived to six and a half years, when she was eventually put down after a contagious disease spread through her flock, infecting cloned and normally reproduced sheep alike. (wptv.com)
  • WHA50.37 of 1997 argues that human cloning is ethically unacceptable and contrary to human integrity and morality. (who.int)
  • WHA50.37, which states "the use of cloning for the replication of human individuals is ethically unacceptable and contrary to human integrity and morality. (who.int)
  • While stem-cell research holds enormous potential for treating or even curing some diseases, the cloning of a human being is morally and ethically unacceptable…Any attempt to clone a human being is in direct conflict with the public policies of this state. (cbc-network.org)
  • Every human being begins as a single-cell zygote, grows through the embryonic stage, then the fetal stage, is born and develops through infancy, through childhood, and through adulthood, until death. (actionlife.org)
  • Dolly was the culmination of hundreds of cloning experiments that, for example, showed diploid embryonic and fetal cells could be parents of offspring. (wptv.com)
  • Advocates support the development of therapeutic cloning in order to generate tissues and whole organs to treat patients who otherwise cannot obtain transplants, to avoid the need for immunosuppressive drugs, and to stave off the effects of aging. (wikipedia.org)
  • Opponents of cloning have concerns that technology is not yet developed enough to be safe, and that it could be prone to abuse, either in the form of clones raised as slaves, or leading to the generation of humans from whom organs and tissues would be harvested. (wikipedia.org)
  • Serious ethical concerns have been raised by the future possibility of harvesting organs from clones. (wikipedia.org)
  • Advocates of human therapeutic cloning believe the practice could provide genetically identical cells for regenerative medicine, and tissues and organs for transplantation. (wikipedia.org)
  • Such cells, tissues, and organs would neither trigger an immune response nor require the use of immunosuppressive drugs. (wikipedia.org)
  • One such approach, called "xenotransplantation" (the transplantation of living cells, tissues, and organs from one species to another species), turns to pigs as a source of organs for human transplants. (reasons.org)
  • The researchers then used these cells as the source of genetic material to clone pigs with organs that lacked the sugar groups responsible for HAR. (reasons.org)
  • Continued development of new biotechnologies also will allow farm animals to serve as sources of both biopharmaceuticals for human medicine and organs for transplantation. (nationalacademies.org)
  • Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
  • Those two factors make attempts to clone humans for reproductive purposes ethically troubling. (reasons.org)
  • Stem cell technology in humans derives from earlier and complementary work in animal studies. (edu.au)
  • My question regarding genetic engineering deregulation was then: What would happen if scientists who are provided with unlimited money and resources have no legal liability to realize their experiments cloning humans and literally engineering new species? (real-agenda.com)
  • article: Now, he's done it again by signing up as a co-sponsor (along with Senators Orin Hatch and Dianne Feinstein) of what could be called the Human Cloning Legalization and Legitimization Act of 2003 (S. 303) . (lifeissues.net)
  • The cloning "bans" being supported in his article could likewise be called "the Human Cloning Legalization and Legitimazation Acts of 2003" (e.g. (lifeissues.net)
  • from nationalreview.com Let's call it "stealth human-cloning legalization. (cbc-network.org)
  • In bioethics, the ethics of cloning refers to a variety of ethical positions regarding the practice and possibilities of cloning, especially human cloning. (wikipedia.org)
  • Clonaid's claim to have produced the first human clones propelled the ethical debate about human cloning to the headlines last December. (reasons.org)
  • It is the policy of Washington state that research involving the derivation and use of human embryonic stem cells, human embryonic germ cells, and human adult stem cells from any source, including somatic cell nuclear transplantation , is permitted upon full consideration of the ethical and medical implications of this research. (cbc-network.org)
  • The ethical and legal controversies that were aroused in the ART debates during the 1980s have been re-ignited with the development of stem cell technology. (edu.au)
  • This issue was considered by the House of Representatives Standing Committee on Legal and Constitutional Affairs in its report entitled Human Cloning: Scientific, Ethical and Regulatory Aspects of Human Cloning and Stem Cell Research (hereafter the Andrews Report , after the Chair of the Committee, Mr Kevin Andrews, MP) released in September 2001. (edu.au)
  • The report arose out of a recommendation for the Committee to review the report of the Australian Health Ethics Committee (AHEC) of the NHMRC entitled Scientific, Ethical and Regulatory Considerations Relevant to Cloning of Human Beings (hereafter the AHEC Report ). (edu.au)
  • Developments in biotechnology have raised new concerns about animal welfare, as farm animals now have their genomes modified (genetically engineered) or copied (cloned) to propagate certain traits useful to agribusiness, such as meat yield or feed conversion. (wikiquote.org)
  • 3] An international research team genetically engineered pig cells that lacked a functional form of the gene that codes for a key enzyme involved in the production of the cell surface sugars that cause HAR. (reasons.org)
  • One bioethicist, Jacob M. Appel of New York University, has gone so far as to argue that "children cloned for therapeutic purposes" such as "to donate bone marrow to a sibling with leukemia" may someday be viewed as heroes. (wikipedia.org)
  • This pioneering study has helped pave the way for others to develop gene and stem-cell based strategies for therapeutic purposes. (nottingham.ac.uk)
  • His pioneering studies into cell-cycle control and cellular differentiation led to the programme of work at Roslin that gave birth to the first mammal to be cloned from adult cells - ie. (nottingham.ac.uk)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
  • 3. Media reports on nuclear transfer are usually about one form, reproductive nuclear transfer, also known as reproductive cloning of human beings . (who.int)
  • More than 100 nuclear transfer procedures could be required to produce one viable clone. (wikiquote.org)
  • The advent of techniques to propagate animals by nuclear transfer, also known as cloning, potentially offers many important applications to animal agriculture, including reproducing highly desired elite sires and dams. (nationalacademies.org)
  • In contrast, Dolly was produced by what's called somatic cell nuclear transfer. (wptv.com)
  • By my calculations, Dolly was the single success from 277 tries at somatic cell nuclear transfer. (wptv.com)
  • Most researchers obtain embryonic stem cells from the inner mass of a blastocyst, an embryonic stage when a fertilized egg has divided into 128 cells. (jcpa.org)
  • The stem cells derived from the inner mass of a blastocyst lack the ability to form a fetus when implanted into a woman, but are self-renewing and can be maintained for long periods of time in the laboratory as undifferentiated stem cells. (jcpa.org)
  • In Aubrey de Grey's proposed SENS (Strategies for Engineered Negligible Senescence), one of the considered options to repair the cell depletion related to cellular senescence is to grow replacement tissues from stem cells harvested from a cloned embryo. (wikipedia.org)
  • Some in the biomedical community hope to develop techniques to generate replacement tissues from these embryonic stem cells. (reasons.org)
  • CD140b is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. (thermofisher.com)
  • Given that we have an efficiency of 1% cloning for livestock species and if only one in a thousand cells are viable then around 100,000 cells would need to be transferred. (wikiquote.org)
  • In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
  • Experts from around the world are assessing the difficult issue of the extent to which embryonic stem cell research should be allowed to proceed, and to date there is little international consensus on this matter. (edu.au)
  • How, then, should embryonic stem cell research be regulated in Australia? (edu.au)
  • In this article we examine embryonic stem cell research and explore the current regulatory framework associated with this research in Australia, with particular reference to the Andrews Report . (edu.au)
  • it's highly variable, though, depending on the cell type used and the species. (wptv.com)
  • In summary, Dr. Prather had been working at Wood's Hole in Massachusetts trying to discover, isolate, then clone the protein which allowed a species of jellyfish living in the cold waters of the North Pacific, Aequorea victoria , to emit a green glow. (pharmaceuticalintelligence.com)
  • … "human clone" means an embryo that, as a result of the manipulation of human reproductive material or an in vitro embryo, contains a diploid set of chromosomes obtained from a single - living or deceased - human being, fetus, or embryo. (hinxtongroup.org)
  • In biology , cloning is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria , insects or plants reproduce asexually . (wikiquote.org)
  • Professor Sinclair said: "Keith was a giant in the field of reproductive biology. (nottingham.ac.uk)
  • Dolly demonstrated that adult somatic cells also could be used as parents. (wptv.com)
  • It is, however, important to distinguish the use of bST from other biotechnologies, such as transgenic or cloned animals. (nationalacademies.org)
  • In fact, one of the coauthors of the paper announcing Dolly worked in our laboratory for three years prior to going to Scotland to help create the famous clone. (wptv.com)
  • Dolly was an important milestone, inspiring scientists to continue improving cloning technology as well as to pursue new concepts in stem cell research. (wptv.com)
  • Article 11 of UNESCO's Universal Declaration on the Human Genome and Human Rights asserts that the reproductive cloning of human beings is contrary to human dignity, that a potential life represented by the embryo is destroyed when embryonic cells are used, and there is a significant likelihood that cloned individuals would be biologically damaged, due to the inherent unreliability of cloning technology. (wikipedia.org)
  • In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
  • This pattern goes on so that each of the trillions of cells in an adult is genetically exactly the same - whether it's in a lung or a bone or the blood. (wptv.com)
  • He is the co-author of the book The Natural Limits to Biological Change , served as general editor of Creation, Evolution and Modern Science , co-author of Basic Questions on Genetics, Stem Cell Research and Cloning (The BioBasics Series) , and has published numerous journal articles. (probe.org)
  • Note: Please read The Little Lamb That Made a Monkey of Us All for the author's comments on the news of a successful lamb cloning (March 7, 1997). (probe.org)
  • More than 90% of cloning attempts fail to produce viable offspring. (wikiquote.org)
  • Two other independent researchers, Severino Antinori (an Italian working in an undisclosed Muslim country) and Panos Zavos (from Lexington, Kentucky) have also been hinting at human cloning success and suggesting that a birth will be announced soon. (probe.org)
  • This incredibly high 50% success rate for human cloning leaves most researchers believing that either this isn't really a clone or they simply aren't revealing all the other failures. (probe.org)
  • Researchers from the Ernst Federal Science Center for Animal Husbandry, Skolkovo Institute of Science and Technology (Skoltech), Moscow State University, and their colleagues have produced the first viable cloned calf in Russia - and she recently turned one. (isaaa.org)
  • In this process, researchers remove the genetic material from an egg and replace it with the nucleus of some other body cell. (wptv.com)
  • Similarly, when the fertilized egg divides from two cells into four cells, each of these four cells has the potential to individually form a human fetus. (jcpa.org)
  • However, by the time the fertilized egg divides into 8 or 16 cells something changes and each respective cell, if separated, no longer has the potential to create a fetus. (jcpa.org)
  • She is now an adult animal weighing over 410 kilograms with a regular reproductive cycle. (isaaa.org)
  • In 1966, his final year at Nottingham, he received a scholarship to conduct research for a summer under English biologist Ernest John Christopher Polge in the Unit of Reproductive Physiology and Biochemistry, then a division of the Agricultural Research Council at the University of Cambridge. (mathisfunforum.com)
  • Cloning in biotechnology refers to processes used to create copies of DNA fragments ( molecular cloning ), cells (cell cloning), or organisms . (wikiquote.org)
  • Detailed descriptions of methods used in animal cloning and biotechnology are provided in the report Animal Biotechnology: Science-Based Concerns (NRC, 2002). (nationalacademies.org)
  • So it is unlikely that the cells would be viable. (wikiquote.org)
  • Let's say that one in a thousand cells were nevertheless viable, practical issues come into play. (wikiquote.org)
  • Although the development of research tools, whether imaging tools, vectors, animal models, cell lines, and such are not heralded, they always assist in the pivotal discoveries of our time. (pharmaceuticalintelligence.com)
  • Dr. Tsien however realized the importance of Douglas's cloning work as pivotal for their research, contacted Douglas (who now due to the bad economy was working at a Toyota dealership in Alabama) and invited him to the Nobel Prize Award Ceremony in Sweden as his guest. (pharmaceuticalintelligence.com)
  • If you cannot or do not want to get into the heavy research, I am about to give you a detailed report on the state of genetic engineering, human-animal cloning and gene splicing. (real-agenda.com)
  • article: But, S. 303 does not outlaw the act of human cloning at all . (lifeissues.net)
  • General Assembly the adoption of a declaration on human cloning by which Member States were called upon to prohibit all forms of human cloning inasmuch as they are incompatible with human dignity and the protection of human life. (who.int)
  • It's given name is the "Human Cloning Ban and Stem Cell Research Protection Act of 2003," the stated purpose of which, supposedly, is to "prohibit human cloning and to protect important areas of medical research, including stem cell research. (lifeissues.net)
  • Given this fanfare, the debate has tended to focus on reproductive cloning-the use of cloning to generate a human being-and its bizarre societal and familial side effects. (reasons.org)
  • As the fertilized egg divides from one cell into two, physicians can separate these two cells and implant each one of them into a woman's uterus to generate two genetically identical children. (jcpa.org)
  • Even then, many of the clones which survive to birth develop complications in their first months of life, as high as 10% in cattle. (probe.org)
  • Assisted reproductive technology (ART) and embryo research have posed many challenges to the different timeframes of science, ethics and law. (edu.au)
  • 1. Cloning is an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. (who.int)
  • A number of scientists are trying to create life in the lab, specifically artificial cells. (reasons.org)
  • This policy is similar to that of other countries, including Israel, where scientists are funded by Government to study embryonic stem cells despite the aforementioned bioethical issue. (jcpa.org)
  • These germ cells are the only ones in the body that have their genetic material all jumbled up and in half the quantity of every other kind of cell. (wptv.com)
  • There he continued his research on the cloning and genetic modification of livestock. (nottingham.ac.uk)
  • As part of its charge, the committee was asked to prepare a subreport evaluating methods for detecting potential unintended compositional changes across the spectrum of messenger ribonucleic acid (mRNA), proteins, metabolites and nutrients that may occur in food derived from cloned animals that have not been genetically modified via genetic engineering methods. (nationalacademies.org)
  • 1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)
  • animals are currently cloned in laboratories and in livestock production. (wikipedia.org)
  • Cloning of animals is opposed by animal-groups due to the number of cloned animals that suffer from malformations before they die, and while meat of cloned animals has been approved by the US FDA, its use is opposed by some other groups concerned about food safety. (wikipedia.org)
  • In addition to low success rates, cloned animals tend to have more compromised immune function and higher rates of infection, tumor growth, and other disorders. (wikiquote.org)
  • In addition, the committee was charged with evaluating methods to detect potential, unintended, adverse health effects of foods derived from cloned animals. (nationalacademies.org)
  • 2. Over the years, the international community has tried without success to build a consensus on an international convention against the reproductive cloning of human beings. (who.int)
  • cloning and splicing genes is not its existence, but the results of this unregulated practice. (real-agenda.com)
  • In the present study, we tested TALEN and double-nicking CRISPR/Cas9 on GS cells, targeting Rosa26 and Stra8 loci as representative genes dispensable and indispensable in spermatogenesis, respectively. (cyberleninka.org)
  • In fact, this was shown to be possible by the transfection of genes into GS cells (Kanatsu-Shinohara et al. (cyberleninka.org)
  • The bill purports to promote stem-cell research, while outlawing the cloning of a human being. (cbc-network.org)
  • In order to better appreciate the role of stem cell research in reproductive medicine, there is a need to understand the critical biological principles of stem cell research and its potential applications to medicine. (jcpa.org)
  • While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
  • Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
  • Stem cell technology is the latest development in this controversial branch of science. (edu.au)
  • Embryonic stem cell technology is still at a preliminary research stage and announcements about its potential may be premature. (edu.au)
  • Though fraught with problems, reproductive cloning at least strives to reproduce a human being and, in principle, preserves the value of human life. (reasons.org)
  • Claims that you could clone individual treatments of human beings to treat common diseases like diabetes, suggests you need a huge supply of human eggs. (wikiquote.org)