Mitalipov and Paula Amato, a reproductive endocrinologist also at Oregon Health & Science University in Portland, said at a news conference that they think mitochondrial replacement therapy should be tested in a clinical trial-despite concerns about the mother's defective mitochondrial DNA making a comeback. (scientificamerican.com)
Embryonic stem2
In 2013, a group of scientists led by Shoukhrat Mitalipov published the first report of embryonic stem cells created using SCNT. (wikipedia.org)
Shoukhrat Mitalipov, Masahito Tachibana, and their team of researchers replaced the mitochondrial genes of primate embryonic stem cells via spindle transfer. (asu.edu)
Therapeutic3
In 2005, the United Nations called on countries to ban it, and the United States prohibits the use of federal funds for either reproductive or therapeutic cloning. (medscape.com)
Two commonly discussed types of human cloning are therapeutic cloning and reproductive cloning. (wikipedia.org)
these are the "holy grail" that would be useful for therapeutic or reproductive cloning. (wikipedia.org)
Nuclear transfer2
But nuclear transfer is also the first step in reproductive cloning, or producing a genetic duplicate of someone - a technique that has sparked controversy since the 1997 announcement that it was used to create Dolly, the clone of a ewe. (medscape.com)
A year ago, Mitalipov led the team that used nuclear transfer of fetal and infant DNA to produce stem cells, the first time that had been accomplished in humans of any age. (medscape.com)
Human3
Without regulations in place, such embryos could also be used for human reproductive cloning, although this would be unsafe and grossly unethical," said Dr Robert Lanza, chief scientist of Massachusetts-based biotech Advanced Cell Technology and a co-author of the new study. (medscape.com)
Reproductive cloning would involve making an entire cloned human, instead of just specific cells or tissues. (wikipedia.org)
If human embryo editing for reproductive purposes or germline editing were space flight, the new data are the equivalent of having the rocket explode at the launch pad before take-off," says Fyodor Urnov, who studies genome editing at the University of California, Berkeley, but was not involved in any of the latest research. (frogheart.ca)
Team1
Reproductive biologist Shoukhrat Mitalipov of Oregon Health and Science University, who developed the technique the CHA team adapted, was more positive. (medscape.com)