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Goosecoid ProteinRepressor ProteinsHomeodomain ProteinsTranscription FactorsActivinsOrganizers, EmbryonicGastrulaXenopus ProteinsInhibinsGenes, HomeoboxDNA-Binding ProteinsGene Expression Regulation, DevelopmentalLac RepressorsOperator Regions, GeneticEmbryonic InductionT-Box Domain ProteinsMolecular Sequence DataEmbryo, NonmammalianZebrafish ProteinsMesodermXenopusBase SequenceBody PatterningPromoter Regions, GeneticIn Situ HybridizationZebrafishTranscription, GeneticFacial BonesAmino Acid SequenceNotochordMorphogenesis
Homeodomain proteinsAmino AcidsRegulateDrosophilaTranscriptionAdenovirus proteinTranscriptionalGenesEpithelial-mesenchymaOrganizerNuclearMeSHBindInteractsRequirementFormDomainActivityRegionDomainsFoundCellsTranscription FactorHomeodomain ProteinHomeotic proteinsNodalRegulateXENOPUSGene expressionAdaptorCELL DIFFERENTIATIONZEBRAFISHBindsBone morphogCellular1998SubunitRegulatorySpeciesAminoDevelopmentalInteractionsComplexesFunctionalFactorsFamilyDevelopmentControlHumanAnalysisSourceBetaRegions
Homeodomain proteins5
  • Protein interactions of homeodomain proteins. (embl.de)
  • Homeodomain proteins are conserved DNA-binding factors that are involved in the transcriptional regulation of key developmental processes. (embl.de)
  • Many homeodomain proteins require additional cofactors to bind with high affinity and specificity to their DNA sites. (embl.de)
  • The recent structural determinations and biochemical analysis of several multimeric complexes have provided a better understanding of how protein interactions influence the DNA-binding activity of homeodomain proteins. (embl.de)
  • Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
Amino Acids1
  • Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). (nih.gov)
Regulate3
  • Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological processes such as antiviral and stress response, inhibition of cell proliferation and autophagy, and promotion of apoptosis or senescence. (bvsalud.org)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
Drosophila2
  • In a previous study, the activation domain of Xbra was replaced by repressor domain of Drosophila engrailed protein in order to form a dominant-interfering Xbra construct that would help to study the function and regulation of Xbra. (wikipedia.org)
  • The 2.5 A resolution structure of a cocrystal containing the paired domain from the Drosophila paired (prd) protein and a 15 bp site shows structurally independent N-terminal and C-terminal subdomains. (embl.de)
Transcription3
Adenovirus protein1
  • In this study, we designed and studied adenovirus protein fiber constructs with potential applications as carriers for the delivery of protein and nanoparticle cargoes. (bvsalud.org)
Transcriptional3
  • The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • A cellular transcriptional coactivator that was originally identified by its requirement for the stable assembly IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. (rush.edu)
Genes3
  • Using these devices, Otx2 and other head organizer TFs (for example, Lim1/Lhx1 (activator) or Goosecoid (repressor)) are able to upregulate or downregulate a large battery of target genes in the head organizer . (xenbase.org)
  • Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)
Epithelial-mesenchyma1
  • Of note, increased migration was accompanied by higher levels of the epithelial-mesenchymal transition (EMT) regulator Twist-related protein 2 (TWIST2). (bvsalud.org)
Organizer1
  • The promyelocytic leukemia protein (PML) is the core organizer of cognate nuclear bodies (PML-NBs). (bvsalud.org)
Nuclear3
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
MeSH1
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Bind1
  • Moreover, they can bind to proteins and nanoparticles through the biotin-streptavidin interaction and mediate their delivery to cells. (bvsalud.org)
Interacts1
  • A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. (bvsalud.org)
Requirement1
  • One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (embl.de)
Form1
  • Furthermore, two streptavidin-conjugated model proteins, alkaline phosphatase and horseradish peroxidase can be delivered into the cell cytoplasm in their enzymatically active form. (bvsalud.org)
Domain5
  • Taxonomic distribution of proteins containing HOX domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with HOX domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing HOX domain in the selected taxonomic class. (embl.de)
  • The N-terminal domain makes extensive DNA contacts, using a novel beta turn motif that binds in the minor groove and a helix-turn-helix unit with a docking arrangement surprisingly similar to that of the lambda repressor. (embl.de)
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
Activity1
  • Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)
Region1
  • Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (nih.gov)
Domains1
  • There are 130113 HOX domains in 120724 proteins in SMART's nrdb database. (embl.de)
Found1
  • A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. (rush.edu)
Cells2
  • In addition, PML ablation in MDA-MB-231 cells led to higher protein levels of hypoxia-inducible factor 1-alpha (HIF1a), resulting in a higher cell hypoxic response. (bvsalud.org)
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
Transcription Factor4
  • So while ventral mesoderm is characterized by a high concentration of FGF and Xbra, the dorsal mesoderm is characterized by a reunion of two others transcription factors, Siamois and XnR, which activates the synthesis of Goosecoid Transcription Factor. (wikipedia.org)
  • The proline rich homeodomain protein (PRH), also known as haematopoietically expressed homeobox (HHEX), is an essential transcription factor in embryonic development and in the adult. (biomedcentral.com)
  • The proline rich homeodomain protein/haematopoietically expressed homeobox (PRH/HHEX), is a transcription factor encoded by the HHEX gene [ 1 - 3 ]. (biomedcentral.com)
  • 8. Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer. (nih.gov)
Homeodomain Protein3
  • Goosecoid protein is a homeodomain protein that was first identified in XENOPUS . (nih.gov)
  • 6. Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene. (nih.gov)
  • 17. The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression. (nih.gov)
Homeotic proteins1
Nodal2
  • The founding member of the nodal signaling ligand family of proteins. (lookformedical.com)
  • Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. (lookformedical.com)
Regulate2
  • In addition, like some other homeodomain proteins, PRH can regulate the translation of specific mRNAs. (biomedcentral.com)
  • AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
XENOPUS4
Gene expression2
Adaptor1
CELL DIFFERENTIATION1
  • Although PRH was first identified in haematopoietic cells and it plays an important role in haematopoietic cell differentiation, the protein is expressed in a wide range of cell types in the embryo and the adult. (biomedcentral.com)
ZEBRAFISH1
Binds3
  • The N-terminal domain makes extensive DNA contacts, using a novel beta turn motif that binds in the minor groove and a helix-turn-helix unit with a docking arrangement surprisingly similar to that of the lambda repressor. (embl.de)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Bone morphog2
  • Suppression of bone morphogenetic protein (BMP) signaling induces neural induction in the ectoderm of developing embryos. (molcells.org)
  • Moreover, Tmem150b negatively regulated bone morphogenetic protein (BMP) signaling, likely via physical interaction with activin receptor-like kinase 2 (ALK2). (bvsalud.org)
Cellular1
  • Protein Phosphatase 4 Catalytic Subunit (PPP4C) is an evolutionarily conserved protein involved in multiple biological and pathological events, including embryogenesis, organogenesis, cellular homeostasis, and oncogenesis. (bvsalud.org)
19981
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Subunit2
  • 7. Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1. (nih.gov)
  • A protein which is a subunit of RNA polymerase. (nih.gov)
Regulatory2
  • Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm . (echinobase.org)
  • Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. (lookformedical.com)
Species1
  • Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY). (lookformedical.com)
Amino1
  • PRH is a 270 amino acid protein encoded by the orphan homeobox HHEX gene located on human chromosome 10. (biomedcentral.com)
Developmental1
Interactions2
  • Protein interactions of homeodomain proteins. (embl.de)
  • The recent structural determinations and biochemical analysis of several multimeric complexes have provided a better understanding of how protein interactions influence the DNA-binding activity of homeodomain proteins. (embl.de)
Complexes1
  • The PRH protein has a predicted molecular mass of 30 kDa, but in vivo and in vitro PRH forms homo-oligomeric complexes that appear to be octameric and hexadecameric [ 23 - 25 ]. (biomedcentral.com)
Functional1
Factors1
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Family1
Development3
  • Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
  • Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development. (lookformedical.com)
  • Proteins that are preferentially expressed or upregulated during FETAL DEVELOPMENT. (lookformedical.com)
Control1
  • This is consistent with the involvement of multiple PRH-interacting proteins, including the oncoprotein c-Myc, translation initiation factor 4E (eIF4E), and the promyelocytic leukaemia protein (PML), in the control of cell proliferation and cell survival. (biomedcentral.com)
Human1
Analysis1
  • Analysis of RNA and protein in the adult indicates that PRH is widely expressed in many tissues including the haematopoietic compartment where it is preferentially expressed in myeloid cells but absent in T-lymphocytes. (biomedcentral.com)
Source5
Beta1
  • One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (embl.de)
Regions1
  • The boxed and bracketed areas represent the regions of PRH that interact with the proteins indicated. (biomedcentral.com)