AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
MSX1 Transcription FactorTranscription FactorsRepressor ProteinsTranscription, GeneticHomeodomain ProteinsBase SequencePromoter Regions, GeneticDNA-Binding ProteinsMolecular Sequence DataGene Expression RegulationSp1 Transcription FactorMutationGenes, RegulatorAmino Acid SequenceOperator Regions, GeneticPlasmidsBinding SitesTranscriptional ActivationProtein BindingTrans-ActivatorsNuclear ProteinsBasic Helix-Loop-Helix Transcription FactorsEscherichia coliRNA, MessengerOperonGene Expression Regulation, DevelopmentalCloning, MolecularGene Expression Regulation, BacterialBacterial ProteinsCell LineGenes, BacterialTranscription Factor AP-1Signal TransductionDNAForkhead Transcription FactorsLysogenyBasic-Leucine Zipper Transcription FactorsKruppel-Like Transcription FactorsCell DifferentiationTransfectionCell NucleusGenes, ReporterTranscription Factor AP-2Chromatin ImmunoprecipitationHeLa CellsZinc FingersYY1 Transcription FactorTranscription Factors, TFIIIsopropyl ThiogalactosideCells, CulturedViral Regulatory and Accessory ProteinsElectrophoretic Mobility Shift AssayDNA, BacterialReverse Transcriptase Polymerase Chain ReactionRecombinant Fusion ProteinsGenesSTAT3 Transcription FactorGATA4 Transcription FactorRegulatory Sequences, Nucleic AcidActivating Transcription Factor 3Transcription Factor TFIIDPaired Box Transcription FactorsEnhancer Elements, GeneticNFATC Transcription FactorsSp3 Transcription FactorLac RepressorsTranscription Initiation SiteNF-kappa BProtein Structure, TertiaryTetracyclineGene Expression ProfilingGene Expression Regulation, FungalSequence Analysis, DNAGene ExpressionTranscription Factor TFIIBActivating Transcription Factor 2Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsE2F1 Transcription FactorRestriction MappingDNA Transposable ElementsLuciferasesMEF2 Transcription FactorsRNA Polymerase IISequence Homology, Amino AcidBacteriophage lambdaTCF Transcription FactorsGATA1 Transcription FactorGATA3 Transcription FactorSaccharomyces cerevisiae ProteinsGATA Transcription FactorsCell Line, TumorGATA2 Transcription FactorSaccharomyces cerevisiaeModels, BiologicalChromatinGene Expression Regulation, PlantDrosophila ProteinsHelix-Loop-Helix MotifsColiphagesPhosphorylation
ProteinHomeoboxEvolutionarily conserved transcriptionEncodeBasal transcription machineryProteins are transcription factorsMutationsRegulatesHomeodomainChromatinRegulationDifferentialPromoterSequence-specificSequencesSignaling pathwayDataSetsEmbryonic developmentMetabolismMyogenicDeficiencyRegulatorsAccessionSomaticFunctionalRepressesRegulatoryPhosphoproteinProfilesRoleFamilyGeneticMotifsComplexHumanSearchCellMouseSourceCriticalStudiesStructureAdditionActivationSimilarForm
Protein11
  • The protein of MSX1 serves as a repressor for gene transcription and interchanges with other homeoproteins. (wikipedia.org)
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • MSY3 is a DNA binding protein, which acts as a transcriptional repressor. (biomedcentral.com)
  • HD binding specificity increases by protein-protein interactions with a diversity of cofactors that outline the Hox interactome and determine the transcriptional landscape of the selected target genes. (biomedcentral.com)
  • Of particular interest are the protein interactions that occur between Hox proteins and general transcription factors (GTF) from the RNA Pol II basal transcription machinery. (biomedcentral.com)
  • This plethora of Hox protein-protein interactions clearly points to a Hox-driven transcription process in which every Hox homeoprotein could selectively recruit GTFs to achieve specificity and activate or repress target genes during Drosophila development, although the precise molecular mechanisms remain elusive [ 25 ]. (biomedcentral.com)
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
  • The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
  • What does this gene/protein do? (cancer-genetics.org)
  • What pathways are this gene/protein implicaed in? (cancer-genetics.org)
Homeobox1
  • MSX1 consist of homeobox encoding sequence of 60 amino acid long DNA binding homeodomain. (wikipedia.org)
Evolutionarily conserved transcription2
  • Based on human-mouse evolutionarily conserved transcription factor binding sites (TFBSs) in 76600 conserved blocks for 5169 genes, we compiled the human transcriptional connections into a matrix, and examined the number of FFC appearances in comparison with randomized networks. (biomedcentral.com)
  • Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
Encode1
  • Studies done in mice, have shown that MSX1 and PAX9 encode transcription factors with different DNA binding sequence patterns, a paired domain and homeodomain, which are co-expressed during tooth development. (wikipedia.org)
Basal transcription machinery2
  • Here, we focused on the interplay between Antp and the basal transcription machinery and show the direct interaction of Antp with TBP through the poly-glutamine (PolyQ) regions of both proteins. (biomedcentral.com)
  • They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (childrensmercy.org)
Proteins are transcription factors1
Mutations5
  • The reason for tooth agenesis has not been completely understood, despite the identification of several mutations in MSX1 and PAX9 genes which are related to tooth agenesis and mutations in AXIN2 gene which cause oligodontia. (wikipedia.org)
  • Furthermore, mutations of other genes have been identified in syndromes and congenital abnormalities in which tooth agenesis is a regular characteristic. (wikipedia.org)
  • Mutations of gene that are responsible for the structure or function of cilia can lead to abnormal cilia signal transport, which in turn leads to ciliopathies. (bvsalud.org)
  • This review summarizes the key genes involved in the regulation of craniofacial development in primary cilia and the disease phenotypes caused by important cilia gene mutations, in order to provide a reference for understanding the etiology of primary cilia-related craniofacial congenital developmental defects. (bvsalud.org)
  • Mutations in this gene have been found in somatic sebaceous tumors. (cancer-genetics.org)
Regulates3
  • One of the simplest network motifs is autoregulation, in which a regulator (TF) regulates the gene that encodes the regulator itself. (biomedcentral.com)
  • SHH signaling regulates dorsoventral patterning of the neural tube by repressing genes that are associated with dorsal and lateral fates and by activating genes associated with ventral fates (reviewed by Briscoe and Ericson, 2001 ). (silverchair.com)
  • It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE. (rush.edu)
Homeodomain2
  • As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. (biomedcentral.com)
  • Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
Chromatin1
Regulation2
  • There has been one previous report showing that overexpression of Sirt6 in aged human dermal fibroblasts could improve iPS generation via regulation of miR-766 transcription [ 19 ]. (biomedcentral.com)
  • Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (nih.gov)
Differential1
  • RNA sequencing was measured to identify the differential expressed genes due to loss of Sirt6 in somatic and pluripotent cells. (biomedcentral.com)
Promoter1
  • These novel interactions open the possibility to analyze promoter function and gene expression to measure transcription factor binding dynamics at target sites throughout the genome. (biomedcentral.com)
Sequence-specific1
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
Sequences2
  • However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
  • We compiled the human transcriptional connections into a connection matrix, based on the computationally identified human-mouse conserved TF binding sites (TFBSs) of 82 well-annotated TFs in 76600 conserved blocks located within the 8-kb upstream sequences of 5169 human genes that were stringent orthologs to mouse counterpart genes. (biomedcentral.com)
Signaling pathway1
DataSets1
Embryonic development1
  • Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. (biomedcentral.com)
Metabolism1
Myogenic1
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
Deficiency1
  • In studies of homozygous mice, it has been found that deletion of the MSX1 gene has resulted in a double cleft palate, deficiency of the alveolar bone, failure of incisor and molar development. (wikipedia.org)
Regulators2
  • The first regulator has effects on the second regulator such that the two regulators jointly regulate a target gene. (biomedcentral.com)
  • We also examined the number of appearances of the 'regulator chain backbone', which represents a simple two-regulator one-way connection irrespective of the presence of a target gene common to the two regulators. (biomedcentral.com)
Accession1
  • The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
Somatic2
  • Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. (biomedcentral.com)
  • Differentiated somatic cells can be reprogrammed into a pluripotent-like state through four defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc (OSKM) [ 1 , 2 ]. (biomedcentral.com)
Functional1
  • We aimed to test the Arl15 gene as a functional candidate for metabolic traits in the mouse. (bvsalud.org)
Represses1
  • It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
Regulatory2
  • The transcriptional regulatory network of a cell is a complex system in which many transcription factor (TF) proteins turn gene expressions on and off according to spatiotemporal contexts. (biomedcentral.com)
  • It is crucial to find an appropriate set of such basic network motifs to intelligibly describe the gene regulatory system. (biomedcentral.com)
Phosphoprotein1
  • The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). (jefferson.edu)
Profiles4
  • Below are the most recent publications written about "Host Cell Factor C1" by people in Profiles. (rush.edu)
  • Below are the most recent publications written about "p300-CBP Transcription Factors" by people in Profiles. (childrensmercy.org)
  • Below are the most recent publications written about "Hepatocyte Nuclear Factors" by people in Profiles. (umassmed.edu)
  • Below are the most recent publications written about "G-Box Binding Factors" by people in Profiles. (ucdenver.edu)
Role2
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
  • NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. (ouhsc.edu)
Family3
Genetic1
  • Traits that are used for kinship analysis must be determine by genetic factors, must be rare in the general population, and the individual traits must be genetically independent from each other. (wikipedia.org)
Motifs1
  • One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (embl.de)
Complex1
  • Pharmacological disruption of the Notch transcription factor complex. (harvard.edu)
Human4
  • Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
  • Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
  • Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)
  • Genes down-regulated by everolimus [PubChem=6442177] in mouse prostate tissue transgenically expressing human AKT1 gene [GeneID=207] vs untreated controls. (gsea-msigdb.org)
Search1
  • Search results: The pahtway p1588 has 240 genes in the original annotation. (uth.edu)
Cell3
  • Particularly, by performing transcriptome analysis, we observed that several pluripotent transcriptional factors increase in knockout cell line, which explains the underlying loss of pluripotency in Sirt6-null iPS-like cell line. (biomedcentral.com)
  • Host Cell Factor C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Host Cell Factor C1" by people in this website by year, and whether "Host Cell Factor C1" was a major or minor topic of these publications. (rush.edu)
Mouse1
  • Mouse embryonic fibroblasts isolated from transgenic Oct4-GFP reporter mice with or without Sirt6 were used for reprogramming by Yamanaka factors. (biomedcentral.com)
Source1
Critical1
  • We have revealed that the configuration of autoregulation integrated in the FFCs is a critical factor for abundance or avoidance of the appearance of the FFCs. (biomedcentral.com)
Studies1
  • Previous studies revealed that multiple factors, including impaired intracellular or intercellular signals, and incoordination of oral organs led to cleft palate, but were little concerned about the contribution of the extracellular matrix (ECM) during palatogenesis. (bvsalud.org)
Structure1
Addition1
  • In addition, encoded proteins by PAX9 genes have a 128 amino acid long DNA binding paired domain. (wikipedia.org)
Activation1
  • IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)
Similar1
  • The N-terminal domain makes extensive DNA contacts, using a novel beta turn motif that binds in the minor groove and a helix-turn-helix unit with a docking arrangement surprisingly similar to that of the lambda repressor. (embl.de)
Form1