Cellular proteinsReplicationInteractsTranscription FactorsCharacterizationEukaryoticEncodesEndogenousInteractionMediateGenomeViralGENESInducesBacteriaGene expressionPathwayInitiationSynthesisRegulationOrganellesProteolyticAssemblyHumanExpressionAlgorithmMarkersLeadsGeneticDomainTargetCellsLevelsStructureCellAddition
Cellular proteins3
- E2 is expressed throughout the differentiation-dependent virus life cycle and is functionally regulated by association with multiple viral and cellular proteins. (microbiologyresearch.org)
- Here, we show for the first time to our knowledge that HPV16 E2 directly associates with the major capsid protein L1, independently of other viral or cellular proteins. (microbiologyresearch.org)
- 577Role of Cellular Proteins in RV Replication. (vdocuments.net)
Replication3
- The human papillomavirus (HPV) E2 protein is a multifunctional protein essential for the control of virus gene expression, genome replication and persistence. (microbiologyresearch.org)
- Using cell-based assays, we show that co-expression of L1 and E2 results in enhanced transcription and virus origin-dependent DNA replication. (microbiologyresearch.org)
- Upon co-expression in keratinocytes, L1 reduces nucleolar association of E2 protein, and when co-expressed with E1 and E2, L1 is partially recruited to viral replication factories. (microbiologyresearch.org)
Interacts2
- Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)
- RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. (harvard.edu)
Transcription Factors1
- this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
Characterization1
- Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. (microbiologyresearch.org)
Eukaryotic1
- Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
Encodes2
- Following Cre-mediated recombination, the Braf exon 15-18 element is removed, and the Braf(CA) allele then encodes the Braf V600E protein (from the introduced mutated exon 15). (refine.bio)
- The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
Endogenous3
- The effects of miR2911 on endogenous E6/E7 mRNA and protein levels were detected in HPV16/18-positive cervical cancer cells by RT-qPCR and Western blotting. (bvsalud.org)
- In addition, the endogenous E6/E7 mRNA and protein levels were significantly decreased by using miR2911 treatment in HPV16/18-positive cervical cancer cells. (bvsalud.org)
- Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
Interaction5
- MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction. (wikipedia.org)
- This phenotype is associated with interaction of E2 with the Mitotic Checkpoint Complex (MCC) proteins Cdc20, MAD2 and BUBR1. (docksci.com)
- We have mapped the L1 binding region within E2 and show that the α -2 helices within the E2 DNA-binding domain mediate L1 interaction. (microbiologyresearch.org)
- Taken together, our findings suggest that the interaction between E2 and L1 is important for the regulation of E2 function during the late events of the HPV life cycle. (microbiologyresearch.org)
- A novel interaction between the human papillomavirus type 16 E2 and E1^E4 proteins leads to stabilization of E2. (microbiologyresearch.org)
Mediate1
- Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
Genome3
- Furthermore, co-distribution of E2 and L1 was detected in the nuclei of upper suprabasal cells in stratified epithelia of HPV16 genome-containing primary human keratinocytes. (microbiologyresearch.org)
- The central dogma of molecular biology states that the transfer of genetic information within cells transpires sequentially from DNA to RNA to proteins, whose coding sequences comprise a paltry 1.5-2% of the human genome [ 2 , 3 ]. (biomedcentral.com)
- Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)
Viral1
- The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)
GENES5
- Thus, the knock-down of c-MYC induced the upregulation of autophagic and lysosomal genes in HPV-positive HNC cells, as well as the increase of autophagic markers at the protein level. (bvsalud.org)
- The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
- The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
- Genes Dev 2007, 21:379-84) that can express the BrafV600E mutant protein following Cre-mediated recombination. (refine.bio)
- Two genes encoding putative internalin proteins were chosen for further study. (omictools.com)
Induces1
- Here, we challenge this view and show that HPV-18 E2 over-activates the Spindle Assembly Checkpoint (SAC) and induces DNA breaks in mitosis followed by aneuploidy. (docksci.com)
Bacteria1
- high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)
Gene expression1
- Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
Pathway1
- After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
Initiation1
- This work pinpoints E2 as a key protein in the initiation of HPV-induced cervical cancer and identifies the SAC as a target for oncogenic pathogens. (docksci.com)
Synthesis2
- In download Dopamine in the Pathophysiology and Treatment of Schizophrenia: to find the place of here shown early ligands, Rev clusters between the synthesis and storage-inducing resulting body homodimer protein proteins( suggested in Li et al. (evakoch.com)
- The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
Regulation1
- This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. (mdpi.com)
Organelles1
- Autophagy is important for the removal, degradation and recycling of damaged organelles, proteins, and lipids through the degradative action of lysosomes. (bvsalud.org)
Proteolytic2
- As a defense mechanism, tumor cells are able to avoid recognition of MICA by the immune system through proteolytic shedding of the surface expressed protein by the cooperation of disulfide isomerase (ERp5) and ADAM (a disintegrin and metalloproteinase) and MMP (matrix metalloproteinase) proteases targeting membrane-proximal α3 domain. (wikipedia.org)
- The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
Assembly2
- Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
- 574Structural Proteins: Translation, Processing, and Assembly. (vdocuments.net)
Human4
- The expression can be as well affected by some infectious agents such as human cytomegalovirus (HCMV), human adenovirus 5, M. tuberculosis, diarrheagenic E.coli, or human papillomavirus (HPV). (wikipedia.org)
- Universal protein resource accession number Q29983 for "MICA - MHC class I polypeptide-related sequence A precursor - Homo sapiens (Human) - MICA gene & protein" at UniProt. (wikipedia.org)
- The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. (microbiologyresearch.org)
- Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. (microbiologyresearch.org)
Expression2
- It is observed that MiR2911 directly binds to E6 and E7 oncogenes of HPV16/18, leading to the suppression of their protein expression. (bvsalud.org)
- Creating sequence-expression-activity maps accelerates the optimization of many protein systems and allows previous measurements to quantitatively inform future designs. (omictools.com)
Algorithm1
- ClusPro: a fully automated algorithm for protein-protein docking. (microbiologyresearch.org)
Markers1
- The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
Leads1
- Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
Genetic1
- Developing predictive models of multi-protein genetic systems to understand and optimize their behavior remains a combinatorial challenge, particularly when measurement throughput is limited. (omictools.com)
Domain1
- The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
Target2
- Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
- A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
Cells1
- Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
Levels2
- While BUBR1 silencing rescues the mitotic phenotype induced by E2, p53 silencing or presence of E6/E7 (inactivating p53 and increasing BUBR1 levels respectively) both amplify it. (docksci.com)
- Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)
Structure1
- This is referred to as the primary structure of proteins. (lookformedical.com)
Cell1
- Proteins found in the nucleus of a cell. (lookformedical.com)
Addition1
- NICD1, which not is a skeletal focus, can be controlled by docking to the hormone-bound addition 1-alpha( HIF1A) which serves in the protein when amine homodimers are progressive. (evakoch.com)