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  • self-renewal
  • Epigenetic modifications of DNA-associated proteins and the influences of non-coding RNAs have been demonstrated to control the self-renewal of stem cell populations as well as regulate mineralised tissue development and repair. (frontiersin.org)
  • During mESC differentiation, miR-335 upregulation co-operates with the transcriptional repression of Oct4 to facilitate the collapse of the Oct4-Nipp1/Ccnf-PP1-pRb axis, pRb dephosphorylation, the exit from self-renewal, and the establishment of a pRb-regulated cell cycle program. (wiley.com)
  • Deciphering the role of non-coding RNAs in pluripotency, self-renewal and neural differentiation will reveal new molecular mechanisms involved in induction and maintenances of pluripotent state as well as triggering these cells toward clinically relevant cells for transplantation. (frontiersin.org)
  • Novel
  • Novel transcriptional networks regulated by CLOCK in human neurons. (nih.gov)
  • Notably, the stability of microRNAs and their relative ease of sampling from pulpal blood highlight their potential for application as diagnostic inflammatory biomarkers, while increased understanding of their actions will not only enhance our knowledge of pulpal disease and repair, but also identify novel molecular targets. (frontiersin.org)
  • humans
  • Until now, it was identified more than 600 and 450 miRNAs in humans and mice, respectively, ( http://www.microRNA.org/ ). (hindawi.com)
  • In humans there are two distinct microRNAs that share an identical mature sequence, these are called miR-1-1 and miR-1-2. (mirbase.org)
  • Many microRNAs now have been found in diverse plants and animals, including hundreds in humans. (bio-medicine.org)
  • specimens
  • Therefore, we isolated total RNA from 182 colorectal adenocarcinoma specimens and 86 paired non-cancerous colorectal mucosae. (degruyter.com)
  • translation
  • The whole or partial sequence of 5' UTR, which is called uORF (upstream Open Reading Frame), can be translated into single or several short peptides that can regulate translation of the main coding sequence of the same mRNA. (ajmb.org)
  • role
  • Another line of research in the lab is the investigation of the role non-coding RNAs in the innate immune response of skin cells. (ki.se)
  • Our aim is to explore the role of non-coding RNAs in the regulation of the innate immune response of keratinocytes. (ki.se)
  • function
  • We hope that experts on particular microRNA sequences will use the links to Wikipedia below to edit the annotation of individual microRNAs, to add information about function, evolution, discovery, and literature references, for example. (mirbase.org)
  • Several
  • My team has identified several non-coding RNAs that are expressed in the skin, however, their contribution to skin carcinogenesis remains poorly understood. (ki.se)
  • research
  • Our research is focused on skin non-coding RNAs (ncRNAs), in particular we investigate their involvement in the malignant transformation of skin cells as well as in the modulation of the innate immune response in the skin. (ki.se)