Reporter gene protein genes reporter. Medical search. Frequent questions

NUTM1 gene) encodes (i.e. directs the synthesis of) a 1,132-amino acid protein termed NUT that is expressed almost exclusively in the testes, ovaries, and ciliary ganglion (i.e. a parasympathetic ganglion of nerve cells located just behind the eye). (wikipedia.org)
The BRD4-NUTM1 fusion gene is a translocation that encodes a fusion protein that has merged most of the protein coding region of the NUTM1 gene with a large part of the BRD4 gene located in band 13 on the short (i.e. "q") arm of chromosome 19. (wikipedia.org)
One of the well-known reporter genes is one that encodes for a protein called green fluorescent protein - or GFP. (jove.com)
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)
The early viral gene E2 encodes a protein involved in several key processes in HPV biology, such as replication, genome segregation, and viral gene transcription. (elis.sk)
This gene encodes a 210-amino-acid protein called frataxin. (medscape.com)
mutations high frequency of IDH1/2 mutations in oligodendrogliomas, astrocytomas and in alteRations in the RB1 pathway in The TET2 gene encodes the -KG- secondary glioblastomas derived thereof low-gRade diffuse gliomas lacking dependent enzyme that catalyses suggests that these tumours share a common genetic alteRations the conversion of 5-methylcytosine to common progenitor cell population. (who.int)

Plasmid transfection in bovine cells: Optimization using a realtime monitoring of green fluorescent protein and effect on gene reporter assay. (oregonstate.edu)
Genetic Luciferase Reporter System or Reporter gene assay has become an invaluable tool in studies of gene expression. (cdc.gov)
PTEN was validated by dual luciferase assay as a target gene of miR-183. (nature.com)
A luciferase reporter gene assay was performed to confirm the targeting associations of miR‑130a. (spandidos-publications.com)
The current studies provide novel insights into the pharmacology of GPR40 and indicate that G protein-coupled receptors which respond to fatty acids, and potentially to other lipid ligands, can be occupied by endogenous agonists before assay and that this may mask the pharmacology of the receptor and may be mistaken for high levels of constitutive activity. (aspetjournals.org)
Moreover, the Targetscan, dual-luciferase reporter assay, and Western blot were used to reveal the downstream target and regulation mechanism of miR-429 in OGD-induced HBMECs. (hindawi.com)
Here, we use a human cell-based reporter assay to characterize off- target cleavage of Cas9-based RGENs. (cdc.gov)
By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. (lu.se)

In this study, we have evaluated the ability of HIV vectors to transfer genes into retinal cells. (nih.gov)
The efficient gene transfer into photoreceptor cells by HIV vectors will be useful for gene therapy of retinal diseases such as retinitis pigmentosa. (nih.gov)
Ongoing anti-cancer gene therapy clinical trials have highlighted the need for more efficient and safer vectors. (europa.eu)
Thus, we will develop novel targeted viral vectors for applications to cancer gene therapy. (europa.eu)
All vectors will express a reporter/suicide gene, and they will be tested using in vivo models of liver and brain tumours. (europa.eu)
This proposal brings together European leaders with expertise covering from the development of novel viral vectors to the implementation of clinical trials of gene therapy. (europa.eu)
ii) gutless adenoviral vectors, by genetic modifications of the fibre and hexon proteins of the adenoviral capsids, as well as through the use of combined cell type specific and inducible promoters. (europa.eu)
A common suicide/reporter gene will first be used for all vectors, and then additional therapeutic genes will be tested. (europa.eu)
We thus aim to obtain well characterized, safe, and efficient gene therapy vectors, as well as pre-clinical data supporting the further testing of such vectors in clinical trials. (europa.eu)
This leads to Phase-III of this research programme in which the most powerful targeted vectors will be chosen to be developed further, by inserting novel powerful therapeutic genes into them. (europa.eu)

The gfp gene expression is now under the control of the promoter for the β-tubulin gene. (jove.com)
The GFP gene under the control of the cytomegalovirus promoter was efficiently expressed in both photoreceptor cells and retinal pigment epithelium. (nih.gov)
This is achieved by linking the firefly luciferase gene to a promoter sequence. (cdc.gov)
This transgenic line expresses a mCherry reporter under the control of a Gli responsive promoter, which can be followed by using fluorescent microscopy and in situ hybridization. (zfin.org)

Commonly used reporter genes are - GFP (green fluorescent protein gene), lacZ (β- galactosidase gene), RFP (red fluorescent protein gene), and Luc (luciferase gene). (jove.com)
The cells expressing the Luc gene produce luciferase enzymes that catalyze a reaction with luciferin to produce light. (jove.com)
Luciferase reporter system for studying the effect of nanoparticle s on gene expression. (cdc.gov)
Here we describe the Genetic Luciferase Reporter System as the method for detecting alteration of gene expression in response to external stimuli (e.g., nanoparticle s). (cdc.gov)
To facilitate the identification of potential antivirals, we developed two reporter-expressing ZIKVs, each capable of expressing an enhanced green fluorescent protein or an improved luminescent NanoLuc luciferase. (mdpi.com)

The PAT encoding gene (bar) was introduced into the soybean genome by micro-particle acceleration (biolistic) transformation, and the resulting soybean lines displayed field tolerance to phosphinothricin-containing herbicides, thereby permitting farmers to use this herbicide for weed control in soybean cultivation. (cbd.int)
With the exception of the first and last exons of genes, every other exon in the genome has splicing signals at its 5' and 3' ends and theoretically can circularize. (bcm.edu)
Lentivirus can effectively transduce both dividing and non-dividing mammalian cells, and integrate into the host genome, allowing stable long-term, high-level gene expression both in vivo and in vitro. (onenucleus.com)
First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
Scientists from Sun Yat-sen University in Guangzhou, China, led by Canquan Zhou and Junjiu Huang, used the CRISPR/Cas9 genome editing system in non-viable human zygotes to modify the gene that causes the hereditary blood disease beta-thalassemia. (genomeweb.com)
In the current study, genes encoding two related proteins, PnMas1 and PnMas3, were identified in the genome of P. parasitica . (springer.com)

MicroRNAs are a kind of small noncoding RNAs, which are involved in the posttranscriptional regulation of gene expression by binding the translation section and lead to either mRNA degradation or translational inhibition and have been found to regulate crucial biological processes, including proliferation, differentiation, and apoptosis [ 10 - 12 ]. (hindawi.com)
Deep sequencing has revealed thousands of eukaryotic protein-coding genes that defy the central dogma, producing circular noncoding RNAs rather than linear messenger RNAs. (bcm.edu)
For some genes, the abundance of the circular RNA exceeds that of the associated linear mRNA by a factor of 10, raising the interesting possibility that the function of some protein-coding genes may actually be to produce circular noncoding RNAs, not proteins. (bcm.edu)
In total, these results indicate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards circular RNAs, which likely helps explain why and how circular RNAs show tissue-specific expression profiles. (bcm.edu)
After testing three guide RNAs to target the gene, the scientists injected one of them along with Cas9 mRNA, GFP mRNA, and a single-stranded DNA oligonucleotide as a repair template. (genomeweb.com)

In addition, after transcription, a wide array of RNA-binding proteins interacts with cis -acting elements located mainly in the 3' untranslated region, determining the fate of mRNAs in eukaryotic cells. (frontiersin.org)

This was also observed when human embryonic kidney (HEK) 293 cells were transfected with a GPR40-Gα q fusion protein. (aspetjournals.org)
Aoki T, Takahashi Y, Koch KS, Leffert HL, Watabe H (1996) Construction of a fusion protein between protein a and green fluorescent protein and its application to Western blotting. (springer.com)

The development of methods for efficient gene transfer to terminally differentiated retinal cells is important to study the function of the retina as well as for gene therapy of retinal diseases. (nih.gov)
Western blots of retinal proteins showed a significant increase in BMP4 expression in diabetic humans and mice compared to the control groups (p (bvsalud.org)

Gene reporter technology (GRT) has opened several new avenues for monitoring biological events including the activation of transcription factors, which are central to the study of nutrigenomics. (oregonstate.edu)

For example, to study the expression of β-tubulin in C. elegans , the coding sequence of the β-tubulin gene was replaced by the gfp gene. (jove.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
This high rate of repair using endogenous sequences presents obvious obstacles to gene therapy strategies using CRISPR/Cas9, as pseudogenes and paralogs may effectively compete with exogenous templates (or endogenous wild-type sequences) during [homology directed repair], leading to unwanted mutations," the authors said. (genomeweb.com)
This study aimed to determine the prevalence of occult HBV infection among Egyptian chronic HCV patients, the genotype and occurrence of surface gene mutations of HBV and the impact of co-infection on early response to treatment. (who.int)
Mutations in the FOXL2 gene cause BPES types I and II. (medlineplus.gov)
It is difficult to predict the type of BPES that will result from the many FOXL2 gene mutations. (medlineplus.gov)
However, mutations that result in a partial loss of FOXL2 protein function generally cause BPES type II. (medlineplus.gov)
Mutations that lead to a complete loss of FOXL2 protein function often cause BPES type I. These mutations impair the regulation of eyelid development as well as various activities in the ovaries, resulting in eyelid malformation and abnormally accelerated maturation of certain ovarian cells and the premature death of egg cells. (medlineplus.gov)

A reporter gene codes for a protein that can be tracked, such as a protein with a known enzymatic activity or one that is fluorescent. (jove.com)
An HIV vector containing a gene encoding the green fluorescent protein (GFP) was injected into the subretinal space of rat eyes. (nih.gov)
Here a total of 14 constitutive promoters from S. cerevisiae were cloned and characterized using a green fluorescent protein (GFP) as a reporter in a 2 µ vector pRS426, under varying glucose and oxygen concentrations. (nih.gov)
To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)
When inducing long-term potentiation (LTP) in the hippocampus, we observed an increase of Arc protein highly correlated with an increase in fluorescent intensity and the number of mCherry-positive cells. (lu.se)

In this work, we introduce a new class of genetically encoded reporters for MRI that work by altering water diffusivity. (biorxiv.org)
Overall, our results establish AQP1 as a new, metal-free, nontoxic and sensitive genetically encoded reporter for diffusion weighted MRI. (biorxiv.org)

The pattern and timing of gene expression can be determined by creating recombinant DNA with a reporter gene under the control of a cis -regulatory sequence of interest and introducing it into cells or an organism. (jove.com)

As an example of application for these promoters in metabolic engineering, the genes involved in xylan degradation and zeaxanthin biosynthesis were subsequently cloned under the control of promoters with medium to high strength and assembled into a single pathway. (nih.gov)
Although the molecular mechanisms responsible for the selective vulnerability of these cells are not well understood, activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway has been implicated in neuroprotective responses to excitotoxicity in other neuronal populations. (jneurosci.org)
During pilocarpine-induced SE, in vivo disruption of STEP activity allowed activation of the MAPK pathway, leading to immediate-early gene expression and significant rescue from cell death. (jneurosci.org)
Along these lines, accumulating evidence shows that the p42/44 mitogen-activated protein kinase (MAPK) pathway plays an important role in neuronal cell survival. (jneurosci.org)
Our data reveal that the vulnerable cells express high levels of striatal-enriched protein tyrosine phosphatase (STEP), which is a key regulator of the extracellular signal-regulated kinase (ERK) pathway. (jneurosci.org)
Therefore, specific inhibitors targeting proteins of the PI3K/AKT pathway are now being evaluated in clinical trials as a new approach against breast cancer 14 . (nature.com)
Schwend, T., Loucks, E.J., and Ahlgren, S.C. (2010) Visualization of gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish. (zfin.org)
Gli transcription factors are regulated by Hh-signaling and act as downstream effectors of the pathway to activate Hh-target genes. (zfin.org)

Using RNAi screening in Drosophila cells, we identified many hnRNPs, SR proteins, core spliceosome, and transcription termination factors that control the outputs of reporter and endogenous genes. (bcm.edu)
We found that CRISPR/Cas9 could effectively cleave the endogenous beta-globin gene ( HBB ). (genomeweb.com)
Only four zygotes were edited with the single-stranded oligo as a repair template, while seven were repaired with the HBD gene, an endogenous homologous region, as a template. (genomeweb.com)

Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

In particular, we are interested in determining how cellular cues can alter the ratio of linear mRNA to circular RNA for a given gene. (bcm.edu)
MiRNAs are characterized by binding the 3 - UTR of special mRNA to regulate the expression of the related proteins [ 10 , 11 ]. (hindawi.com)
The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Polyadenylation is essential for the stability of the transcript, preventing the mRNA from being the target of posttranscriptional gene silencing (PTGS) via RNA-dependent RNA polymerase 6 (RDR6) in plants ( Luo and Chen, 2007 ). (frontiersin.org)
In HPV16 E2-positive cells, we observed a statistically significant increase in mRNA and protein levels of TAF1 and p27, a basal transcription factor and one of its target genes, respectively. (elis.sk)
The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)

Targeting viral vector particles to predetermined cell types will be obtained through genetic engineering of retroviral envelopes or adenoviral capsid proteins, by using single chain antibody fragments or tumour cell receptor ligands. (europa.eu)

The availability of multiple PAS in the same 3' regulatory region enables the inclusion or exclusion of 3' untranslated region (3'UTR) sequences, resulting in transcripts that may differ in particularities involving post-transcriptional processes such as stability, transport and translation ( Mayr, 2016 ), and even protein localization ( Berkovits and Mayr, 2015 ). (frontiersin.org)

Your second year builds on this knowledge and covers areas such as gene regulation, cell biology and metabolism. (kent.ac.uk)

The AMSBIO lentiviral system is a novel gene delivery tool using lentivectors for gene expression or knockdown. (onenucleus.com)
85% protein knockdown. (mskcc.org)

BRD4 protein recognizes acetylated lysine residues on proteins and by doing so participates in the regulation of DNA replication, DNA transcription, and thereby key cellular processes involved in the development of neoplasms (i.e. malignant or benign tissue growths). (wikipedia.org)
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)

Upon inhibiting RNA polymerase II termination, circular RNA levels were similarly increased due to readthrough transcripts extending into downstream genes and being subjected to backsplicing. (bcm.edu)

abstract = "The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)

Pseudotyping of lentivirus is available with wild type or mutant S proteins from a wide range of coronavirus species. (onenucleus.com)
Phylogenetic analyses using homologues of Mas genes from the genomes of 28 species of Stramenopiles give evidence of three Mas sub-families, namely Mas1, Mas2 and Mas3. (springer.com)
BLAST analyses showed that Mas genes only occur in flagellate species within the Stramenopile taxon. (springer.com)
To identify species-specific cuspal patterns, this study analyzed the cellular mechanisms in the EK that were related to bone morphogenetic protein (Bmp), which plays a crucial role in cell proliferation and apoptosis. (bvsalud.org)
Based on these, we performed protein-soaked bead implantation on tooth germs of the 2 different EK regions and compared the cellular behavior in the EKs of the 2 species. (bvsalud.org)

DNA-protein bundles) by histone acetyltransferase EP300 in testicular spermatids (cells that mature into sperms). (wikipedia.org)
In the early 1990's, this gene was implicated in the development of certain epithelial cell cancers that: a) occurred in the midline structures of young people, b) were rapidly fatal, and c) consisted of poorly differentiated (i.e. not resembling any particular cell type), immature-appearing cells containing a BRD4-NUTM1 fusion gene. (wikipedia.org)
The product of the BRD4-NUTM1 fusion gene, BRD4-NUT protein, stimulates the expression of at least 4 relevant genes, MYC, TP63, SOX2, and MYB in cultured cells. (wikipedia.org)
Overexpression of the MYC and SOX2 genes can also act to maintain cells in an undifferentiated stem cell-like state similar to the cells in the neoplasms driven by the BRD4-NUTM1 fusion gene. (wikipedia.org)
It is generally accepted that the BRD4-NUT protein promotes these neoplasms by maintaining their neoplastic cells in a perpetually undifferentiated, proliferative state. (wikipedia.org)
However, subsequent studies defined these carcinomas based on the presence of a NUT fusion gene in their malignant cells. (wikipedia.org)
Since the gene of interest and the reporter gene have the same cis -regulatory sequence, they are expressed in the same cells and at the same time. (jove.com)
Since these reporters are encoded into the cell's own DNA, it ensures that the MRI signal we detect is only from live cells. (parentsguidecordblood.org)
In summary, nanoparticles enable the non-invasive tracking of transplanted cells, and now, the new technology of reporter genes will allow us to monitor cellular viability and function as well. (parentsguidecordblood.org)
In cells lacking expression of Ca 2+ -mobilizing G proteins, coexpression of human GPR40 and Gα q allowed medium- and long-chain fatty acids to elevate intracellular [Ca 2+ ]. (aspetjournals.org)
To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
Before birth and in adulthood, the protein regulates the growth and development of certain ovarian cells and the breakdown of specific molecules. (medlineplus.gov)
All 10x Genomic services include a final report containing a Cell Ranger web summary file for quality control (QC) of the sequencing outcome, as well as FASTQ, BAM, gene count matrix containing all single cells or nuclei passing QC, basic visualization and clustering. (lu.se)
This team showed that injection of just three genes- Neurog3, Mafa, and Pdx1 -into the pancreatic parenchyma of mice leads to conversion of exocrine cells to functional beta cells, a process popularly known as "reprogramming. (medscape.com)
For example, how can genes be delivered at the precise dose to cells in humans? (medscape.com)
[ 7 , 8 ] As background, in 2009, Collombat and colleagues [ 9 ] showed that pancreatic misexpression of the gene Pax4 led to the conversion of glucagon -producing alpha cells into functional beta cells. (medscape.com)

Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. (cancerindex.org)
Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)

Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)

This recombinant gene is introduced into different cell types, and both the gene of interest and the reporter gene are allowed to express. (jove.com)
The protein produces a green fluorescence under ultraviolet light, which enables researchers to track its location within a cell. (jove.com)
Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. (jove.com)
Thus, reporter genes "report" the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell. (jove.com)
E2's presence also affects the expression of a variety of cellular genes involved in a wide range of biological processes, including cell cycle regulation and apoptosis, which are mediated by E2's interaction with cellular proteins. (elis.sk)
In this report, a lentiviral system was used to express the HPV16 E2 gene in the HPV-negative C-33A cell line for several weeks. (elis.sk)
NEW YORK (GenomeWeb) - No longer a rumor, human germline editing with CRISPR/Cas9 is now the subject of a study published today in Protein & Cell . (genomeweb.com)
Blackman LM, Cullerne DP, Torreña P, Taylor J, Hardham AR (2015) RNA-Seq analysis of the expression of genes encoding cell wall degrading enzymes during infection of lupin (Lupinus angustifolius) by Phytophthora parasitica . (springer.com)
The ability to monitor gene expression in intact, optically opaque animals is important for a multitude of applications including longitudinal imaging of transgene expression and long term tracking of cell based therapeutics. (biorxiv.org)
Many genes related with cell cycle, cell apoptosis, and cell proliferation were involved in BMP signaling in the EK during tooth development. (bvsalud.org)
This condition is typically inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)

Immunocytochemistry and GFP-tagging document the occurrence of all three PnMas proteins within the specialised compartments of the ER during mastigoneme formation, but only PnMas1 and PnMas2 occur in mature mastigonemes on the flagellar surface. (springer.com)

Anti-PnMas1 and anti-PnMas2 antibodies co-labelled two high-molecular-weight (~400 kDa) protein complexes in native gels but anti-PnMas3 antibodies labelled a 65 kDa protein complex. (springer.com)

In response to widespread demand, AMSBIO has developed a custom service to provide ready-to-use in vitro and in vivo grade lentiviral particles pseudotyped with coronavirus S protein. (onenucleus.com)
RNA-Seq analyses indicate that PnMas1 and PnMas2 genes have similar expression profiles both in vitro and in planta but that PnMas3 is expressed temporally prior to PnMas1 and PnMas2 during asexual development and plant infection. (springer.com)

E. coli is also used in order to generate the protein from the plasmid. (duke.edu)
Flasks of E. coli are given the plasmid and reproduce until they almost reach carrying capacity, at which point they are given a treatment to induce protein synthesis. (duke.edu)

The development of commercially available transfection reagents for gene transfer applications has revolutionized the field of molecular biology and scientific research. (mdpi.com)

Proteins were extracted from the retina of postmortem human eyes and 6-month diabetic Akita mice and age-matched control. (bvsalud.org)

The NUTM1 gene is located in band 14 on the long (or "q") arm of chromosome 15. (wikipedia.org)
FA is an autosomal recessive disorder caused by a mutation and abnormal expansion of a GAA repeat in intron 1 of the FXN gene, which is located on chromosome 9. (medscape.com)

In addition, the TNFSF11 was confirmed to be the target gene of miR-217. (hindawi.com)
While nine spCas9 gene editing sites surround the Arc start codon, the accuracy of the editing was highly sequence-dependent, with only a single target resulting in an in-frame reporter integration. (lu.se)

These reporters can be used to tag certain cellular proteins to monitor their function. (parentsguidecordblood.org)
It has been hypothesized that frataxin is a mitochondrial protein important for normal production of cellular energy and that a defect in its action may result in abnormal accumulation of iron in mitochondria, leading to excess production of free radicals, which then results in cellular damage and death. (medscape.com)

It is recommended to simultaneously attend the practical module BIO-M-PM-PBE Protein Biochemistry and Enzymology. (uni-regensburg.de)

A fusion gene is an abnormal gene consisting of parts from two different genes that form as a result of a large scale gene mutation such as a chromosomal translocation, interstitial deletion, or inversion. (wikipedia.org)

Fluorescence Reporters (GFP, dsRed, etc. (mskcc.org)

Recently our artificial reporter genes were proven as beneficial tools in preliminary studies in laboratory animals. (parentsguidecordblood.org)
ELPs are a kind of artificial intrinsically disordered protein (IDP), which are proteins that do not fold in the typical way but rather maintain an unfolded (disordered) form that permits multivalent behavior. (duke.edu)

The scientists directed the CRISPR/Cas9 editing system to the human beta-globin gene HBB, part of the beta-globin gene cluster and the gene that is mutated in beta-thalassemia, a blood disease that can be fatal, depending on the specific mutation. (genomeweb.com)
Parents of a child diagnosed with FA are both obligate carriers of an FXN gene mutation. (medscape.com)
However, these children only have a risk of being affected if the unaffected parent is a carrier of a mutation in the FXN gene. (medscape.com)

We demonstrate the utility of AQP1 in vivo by imaging gene expression in intracranial tumor xenografts. (biorxiv.org)

Phosphatase and tensin homolog (PTEN) is well recognized as a tumor suppressor gene. (nature.com)
OBJECTIVE- We identified lipocalin 2 ( Lcn2 ) as a gene induced by dexamethasone and tumor necrosis factor-α in cultured adipocytes. (diabetesjournals.org)

in the gene and occur in people with no history of the disorder in their family. (medlineplus.gov)

All four of these genes are oncogenes, i.e., genes that when overexpressed and/or overly active promote the development of certain types of cancers. (wikipedia.org)

To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)

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